Engineering of Saccharomyces cerevisiae for efficient fermentation of cellulose
Abstract
ABSTRACT Conversion of lignocellulosic biomass to biofuels using microbial fermentation is an attractive option to substitute petroleum-based production economically and sustainably. The substantial efforts to design yeast strains for biomass hydrolysis have led to industrially applicable biological routes. Saccharomyces cerevisiae is a robust microbial platform widely used in biofuel production, based on its amenability to systems and synthetic biology tools. The critical challenges for the efficient microbial conversion of lignocellulosic biomass by engineered S. cerevisiae include heterologous expression of cellulolytic enzymes, co-fermentation of hexose and pentose sugars, and robustness against various stresses. Scientists developed many engineering strategies for cellulolytic S. cerevisiae strains, bringing the application of consolidated bioprocess at an industrial scale. Recent advances in the development and implementation of engineered yeast strains capable of assimilating lignocellulose will be reviewed.
- Authors:
-
[2]
- Renewable and Sustainable Energy Institute (RASEI), University of Colorado Boulder, 4001 Discovery Dr., CO 80303, USA
- Department of Food Science and Human Nutrition, 905 S. Goodwin Ave., IL 61801, USA, 1105 Carl R. Woese Institute for Genomic Biology, 1206 W. Gregory Dr. Urbana, IL 61801. USA, DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, 1206 W. Gregory Dr. Urbana, IL 61801, USA
- Publication Date:
- Research Org.:
- Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1592780
- Alternate Identifier(s):
- OSTI ID: 1595946
- Grant/Contract Number:
- SC0018420
- Resource Type:
- Published Article
- Journal Name:
- FEMS Yeast Research
- Additional Journal Information:
- Journal Name: FEMS Yeast Research Journal Volume: 20 Journal Issue: 1; Journal ID: ISSN 1567-1356
- Country of Publication:
- United Kingdom
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Saccharomyces cerevisiae; lignocellulosic biomass; biofuel
Citation Formats
Oh, Eun Joong, and Jin, Yong-Su. Engineering of Saccharomyces cerevisiae for efficient fermentation of cellulose. United Kingdom: N. p., 2020.
Web. doi:10.1093/femsyr/foz089.
Oh, Eun Joong, & Jin, Yong-Su. Engineering of Saccharomyces cerevisiae for efficient fermentation of cellulose. United Kingdom. doi:10.1093/femsyr/foz089.
Oh, Eun Joong, and Jin, Yong-Su. Thu .
"Engineering of Saccharomyces cerevisiae for efficient fermentation of cellulose". United Kingdom. doi:10.1093/femsyr/foz089.
@article{osti_1592780,
title = {Engineering of Saccharomyces cerevisiae for efficient fermentation of cellulose},
author = {Oh, Eun Joong and Jin, Yong-Su},
abstractNote = {ABSTRACT Conversion of lignocellulosic biomass to biofuels using microbial fermentation is an attractive option to substitute petroleum-based production economically and sustainably. The substantial efforts to design yeast strains for biomass hydrolysis have led to industrially applicable biological routes. Saccharomyces cerevisiae is a robust microbial platform widely used in biofuel production, based on its amenability to systems and synthetic biology tools. The critical challenges for the efficient microbial conversion of lignocellulosic biomass by engineered S. cerevisiae include heterologous expression of cellulolytic enzymes, co-fermentation of hexose and pentose sugars, and robustness against various stresses. Scientists developed many engineering strategies for cellulolytic S. cerevisiae strains, bringing the application of consolidated bioprocess at an industrial scale. Recent advances in the development and implementation of engineered yeast strains capable of assimilating lignocellulose will be reviewed.},
doi = {10.1093/femsyr/foz089},
journal = {FEMS Yeast Research},
number = 1,
volume = 20,
place = {United Kingdom},
year = {2020},
month = {1}
}
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DOI: 10.1093/femsyr/foz089
DOI: 10.1093/femsyr/foz089
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