skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Intra-axonal protein synthesis in development and beyond

Authors:
 [1];  [2]
  1. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga Portugal, ICVS/3B's, PT Associate Laboratory, Braga Guimarães Portugal, The Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Department for Pathology and Cell Biology, Columbia University, New York NY USA
  2. The Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Department for Pathology and Cell Biology, Columbia University, New York NY USA
Publication Date:
Sponsoring Org.:
USDOE Office of Nuclear Energy (NE), Fuel Cycle Technologies (NE-5)
OSTI Identifier:
1582489
Grant/Contract Number:  
SFRH/BD/52322/2013
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
International Journal of Developmental Neuroscience
Additional Journal Information:
Journal Name: International Journal of Developmental Neuroscience Journal Volume: 55 Journal Issue: C; Journal ID: ISSN 0736-5748
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
Country unknown/Code not available
Language:
English

Citation Formats

Batista, Andreia Filipa Rodrigues, and Hengst, Ulrich. Intra-axonal protein synthesis in development and beyond. Country unknown/Code not available: N. p., 2016. Web. doi:10.1016/j.ijdevneu.2016.03.004.
Batista, Andreia Filipa Rodrigues, & Hengst, Ulrich. Intra-axonal protein synthesis in development and beyond. Country unknown/Code not available. doi:10.1016/j.ijdevneu.2016.03.004.
Batista, Andreia Filipa Rodrigues, and Hengst, Ulrich. Wed . "Intra-axonal protein synthesis in development and beyond". Country unknown/Code not available. doi:10.1016/j.ijdevneu.2016.03.004.
@article{osti_1582489,
title = {Intra-axonal protein synthesis in development and beyond},
author = {Batista, Andreia Filipa Rodrigues and Hengst, Ulrich},
abstractNote = {},
doi = {10.1016/j.ijdevneu.2016.03.004},
journal = {International Journal of Developmental Neuroscience},
number = C,
volume = 55,
place = {Country unknown/Code not available},
year = {2016},
month = {3}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1016/j.ijdevneu.2016.03.004

Save / Share:

Works referenced in this record:

Neuropathological stageing of Alzheimer-related changes
journal, September 1991


Local translation of RhoA regulates growth cone collapse
journal, August 2005

  • Wu, Karen Y.; Hengst, Ulrich; Cox, Llewellyn J.
  • Nature, Vol. 436, Issue 7053
  • DOI: 10.1038/nature03885

Protein Synthesis in a Synaptosomal Fraction from Squid Brain
journal, August 1993

  • Crispino, M.; Castigli, E.; Perrone Capano, C.
  • Molecular and Cellular Neuroscience, Vol. 4, Issue 4
  • DOI: 10.1006/mcne.1993.1046

Rapid Assembly of Functional Presynaptic Boutons Triggered by Adhesive Contacts
journal, October 2009


Alzheimer's disease: synaptic dysfunction and Aβ
journal, January 2009

  • Shankar, Ganesh M.; Walsh, Dominic M.
  • Molecular Neurodegeneration, Vol. 4, Issue 1
  • DOI: 10.1186/1750-1326-4-48

The role of local protein synthesis and degradation in axon regeneration
journal, May 2010


Axoplasmic Importins Enable Retrograde Injury Signaling in Lesioned Nerve
journal, December 2003


Retrograde signaling in axonal regeneration
journal, May 2010


Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
journal, February 2014


APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly
journal, July 2014


Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses
journal, November 2009

  • Abramov, Efrat; Dolev, Iftach; Fogel, Hilla
  • Nature Neuroscience, Vol. 12, Issue 12
  • DOI: 10.1038/nn.2433

Axonal Membrane Proteins Are Transported in Distinct Carriers: A Two-Color Video Microscopy Study in Cultured Hippocampal Neurons
journal, April 2000

  • Kaether, Christoph; Skehel, Paul; Dotti, Carlos G.
  • Molecular Biology of the Cell, Vol. 11, Issue 4
  • DOI: 10.1091/mbc.11.4.1213

Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease
journal, April 2014


Identification of Process-Localized mRNAs from Cultured Rodent Hippocampal Neurons
journal, December 2006


Development of subcellular mRNA compartmentation in hippocampal neurons in culture
journal, March 1994


Axonal transport of neuropeptide encoding mRNAs within the hypothalamo-hypophyseal tract of rats.
journal, September 1991


A synaptic model of memory: long-term potentiation in the hippocampus
journal, January 1993

  • Bliss, T. V. P.; Collingridge, G. L.
  • Nature, Vol. 361, Issue 6407
  • DOI: 10.1038/361031a0

A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis
journal, October 1999


A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins
journal, February 2009

  • Merianda, Tanuja T.; Lin, Andrew C.; Lam, Joyce S. Y.
  • Molecular and Cellular Neuroscience, Vol. 40, Issue 2
  • DOI: 10.1016/j.mcn.2008.09.008

Axon–soma communication in neuronal injury
journal, December 2013

  • Rishal, Ida; Fainzilber, Mike
  • Nature Reviews Neuroscience, Vol. 15, Issue 1
  • DOI: 10.1038/nrn3609

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
journal, November 2008


Thematic Minireview Series: Molecular Mechanisms of Synaptic Plasticity
journal, October 2015


Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival
journal, January 2008

  • Cox, Llewellyn J.; Hengst, Ulrich; Gurskaya, Nadya G.
  • Nature Cell Biology, Vol. 10, Issue 2
  • DOI: 10.1038/ncb1677

Axonal cap-dependent translation regulates presynaptic p35: Translational Control of Bouton Function
journal, December 2013

  • Hsiao, Kuangfu; Bozdagi, Ozlem; Benson, Deanna L.
  • Developmental Neurobiology, Vol. 74, Issue 3
  • DOI: 10.1002/dneu.22154

Cell-type-Specific Labeling of Synapses In Vivo through Synaptic Tagging with Recombination
journal, January 2014


Synthesis of β-Tubulin, Actin, and Other Proteins in Axons of Sympathetic Neurons in Compartmented Cultures
journal, January 1999


Local synthesis of nuclear-encoded mitochondrial proteins in the presynaptic nerve terminal
journal, January 2001

  • Gioio, Anthony E.; Eyman, Maria; Zhang, Hengshan
  • Journal of Neuroscience Research, Vol. 64, Issue 5
  • DOI: 10.1002/jnr.1096

The fine Structure of the axon and Growth cone of the Dorsal root Neuroblast of the Rabbit Embryo
journal, January 1970


Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization
journal, November 2010


Memory--a Century of Consolidation
journal, January 2000


Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses
journal, May 2006

  • Antar, Laura N.; Li, Chanxia; Zhang, Honglai
  • Molecular and Cellular Neuroscience, Vol. 32, Issue 1-2
  • DOI: 10.1016/j.mcn.2006.02.001

The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
journal, November 2001


Global Analysis of mRNA Localization Reveals a Prominent Role in Organizing Cellular Architecture and Function
journal, October 2007


Habituation and Dishabituation of the GM-Withdrawal Reflex in Aplysia
journal, March 1970


Ultrastructure and Function of Growth Cones and Axons of Cultured Nerve Cells
journal, June 1971

  • Yamada, Kenneth M.; Spooner, Brian S.; Wessells, Norman K.
  • The Journal of Cell Biology, Vol. 49, Issue 3
  • DOI: 10.1083/jcb.49.3.614

Active polysomes in the axoplasm of the squid giant axon
journal, January 1991

  • Giuditta, Antonio; Menichini, E.; Capano, C. Perrone
  • Journal of Neuroscience Research, Vol. 28, Issue 1
  • DOI: 10.1002/jnr.490280103

A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity
journal, September 1996


Axonal Protein Synthesis and Degradation Are Necessary for Efficient Growth Cone Regeneration
journal, January 2005


Axonal Protein Synthesis Provides a Mechanism for Localized Regulation at an Intermediate Target
journal, July 2002


Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
journal, October 2008


Target Interaction Regulates Distribution and Stability of Specific mRNAs
journal, April 2002


Subcellular transcriptomics-Dissection of the mRNA composition in the axonal compartment of sensory neurons: The Axonal Transcriptome of DRG Neurons
journal, November 2013

  • Minis, Adi; Dahary, Dvir; Manor, Ohad
  • Developmental Neurobiology, Vol. 74, Issue 3
  • DOI: 10.1002/dneu.22140

Axonally Synthesized  -Actin and GAP-43 Proteins Support Distinct Modes of Axonal Growth
journal, February 2013


Subcellular Communication Through RNA Transport and Localized Protein Synthesis
journal, October 2010


Synapse Formation in the Absence of Cell Bodies Requires Protein Synthesis
journal, March 2002


Ribosomes in axons – scrounging from the neighbors?
journal, May 2009


Actinomycin D Blocks Formation of Memory of Shock-Avoidance in Goldfish
journal, December 1967


Local RNA Translation at the Synapse and in Disease
journal, November 2011


Sorting of β-Actin mRNA and Protein to Neurites and Growth Cones in Culture
journal, January 1998


NEUROTROPHINS: Mediators and Modulators of Pain
journal, July 2006


Local translation of TC10 is required for membrane expansion during axon outgrowth
journal, March 2014

  • Gracias, Neilia G.; Shirkey-Son, Nicole J.; Hengst, Ulrich
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms4506

Concentration-Dependent Requirement for Local Protein Synthesis in Motor Neuron Subtype-Specific Response to Axon Guidance Cues
journal, January 2012


Protein synthesis within neuronal growth cones
journal, December 1992


Ribosomes in myelinated axons of dorsal root ganglia
journal, January 1972

  • Zelen�, Ji?ina
  • Zeitschrift f�r Zellforschung und Mikroskopische Anatomie, Vol. 124, Issue 2
  • DOI: 10.1007/BF00335680

IL-6- and NGF-Induced Rapid Control of Protein Synthesis and Nociceptive Plasticity via Convergent Signaling to the eIF4F Complex
journal, November 2010


Presynaptic Fmr1 Genotype Influences the Degree of Synaptic Connectivity in a Mosaic Mouse Model of Fragile X Syndrome
journal, April 2007


Cryptic Peripheral Ribosomal Domains Distributed Intermittently along Mammalian Myelinated Axons
journal, November 2000


Protein synthesis in the isolated giant axon of the squid.
journal, April 1968

  • Giuditta, A.; Dettbarn, W. D.; Brzin, M.
  • Proceedings of the National Academy of Sciences, Vol. 59, Issue 4
  • DOI: 10.1073/pnas.59.4.1284

β-Actin and β-Tubulin are components of a heterogeneous mRNA population present in the squid giant axon
journal, April 1992

  • Kaplan, Barry B.; Gioio, Anthony E.; Capano, Carla Perrone
  • Molecular and Cellular Neuroscience, Vol. 3, Issue 2
  • DOI: 10.1016/1044-7431(92)90017-V

Moving messages: the intracellular localization of mRNAs
journal, May 2005

  • St Johnston, Daniel
  • Nature Reviews Molecular Cell Biology, Vol. 6, Issue 5
  • DOI: 10.1038/nrm1643

The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain Circuits
journal, February 2009


Maintenance of the axoplasm: Can neurones accord with the accepted notions?
journal, September 1992


Role of interleukin-6 in chronic muscle hyperalgesic priming
journal, March 2008


Functions and mechanisms of retrograde neurotrophin signalling
journal, August 2005

  • Zweifel, Larry S.; Kuruvilla, Rejji; Ginty, David D.
  • Nature Reviews Neuroscience, Vol. 6, Issue 8
  • DOI: 10.1038/nrn1727

The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model
journal, June 2014


Polyadenylic Acid-Containing rna from rat Brain Synaptosomes
journal, August 1975


Olfactory marker protein mRNA is found in axons of olfactory receptor neurons
journal, July 1995


Nerve terminals of squid photoreceptor neurons contain a heterogeneous population of mRNAs and translate a transfected reporter mRNA
journal, August 2004


Protein Synthesis in Distal Axons Is Not Required for Growth Cone Responses to Guidance Cues
journal, January 2009


Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer’s disease
journal, May 2015


Potassium ion stimulation triggers protein translation in synaptoneurosomal polyribosomes
journal, August 1991


On the nature and differential distribution of mRNAs in hippocampal neurites: implications for neuronal functioning.
journal, November 1994

  • Miyashiro, K.; Dichter, M.; Eberwine, J.
  • Proceedings of the National Academy of Sciences, Vol. 91, Issue 23
  • DOI: 10.1073/pnas.91.23.10800

The TC10-Exo70 Complex Is Essential for Membrane Expansion and Axonal Specification in Developing Neurons
journal, October 2009


Rapid important paper
journal, January 1986


Function and translational regulation of mRNA in developing axons
journal, April 2007


Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons
journal, April 2009


Axon Viability and Mitochondrial Function are Dependent on Local Protein Synthesis in Sympathetic Neurons
journal, July 2007

  • Hillefors, Mi; Gioio, Anthony E.; Mameza, Marie G.
  • Cellular and Molecular Neurobiology, Vol. 27, Issue 6
  • DOI: 10.1007/s10571-007-9148-y

Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation
journal, January 2011


Targeting Axonal Protein Synthesis in Neuroregeneration and Degeneration
journal, November 2014


Ultrastructural evidence for the axonal localization of caudodorsal cell hormone mRNA in the central nervous system of the molluscLymnaea stagnalis
journal, May 1993

  • Dirks, Roeland W.; van Dorp, Annette G. M.; van Minnen, Jan
  • Microscopy Research and Technique, Vol. 25, Issue 1
  • DOI: 10.1002/jemt.1070250104

Local Gene Expression in Axons and Nerve Endings: The Glia-Neuron Unit
journal, April 2008


Cortical plaque-like structures identify ribosome-containing domains in the Mauthner cell axon
journal, February 1996


Ribosomal RNA in the Axoplasm of the Squid Giant Axon
journal, June 1980


mRNAs and Protein Synthetic Machinery Localize into Regenerating Spinal Cord Axons When They Are Provided a Substrate That Supports Growth
journal, July 2015


Synapse Formation and mRNA Localization in Cultured Aplysia Neurons
journal, February 2006


Insights into the roles of local translation from the axonal transcriptome
journal, June 2012

  • Deglincerti, Alessia; Jaffrey, Samie R.
  • Open Biology, Vol. 2, Issue 6
  • DOI: 10.1098/rsob.120079

The physiological significance of  -actin mRNA localization in determining cell polarity and directional motility
journal, June 2001

  • Shestakova, E. A.; Singer, R. H.; Condeelis, J.
  • Proceedings of the National Academy of Sciences, Vol. 98, Issue 13
  • DOI: 10.1073/pnas.121146098

A Functional Role for Intra-Axonal Protein Synthesis during Axonal Regeneration from Adult Sensory Neurons
journal, December 2001


Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions
journal, September 2012

  • Akins, Michael R.; LeBlanc, Hannah F.; Stackpole, Emily E.
  • The Journal of Comparative Neurology, Vol. 520, Issue 16
  • DOI: 10.1002/cne.23123

BC1 RNA and Vasopressin mRNA in Rat Neurohypophysis: Axonal Compartmentalization and Differential Regulation during Dehydration and Rehydration
journal, November 1995


Mitochondria Coordinate Sites of Axon Branching through Localized Intra-axonal Protein Synthesis
journal, December 2013


Protein Synthesis in the Isolated Mauthner Nerve Fibre of Goldfish
journal, January 1969


The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging
journal, May 2012


Active Polysomes Are Present in the Large Presynaptic Endings of the Synaptosomal Fraction from Squid Brain
journal, October 1997


Acetylcholinesterase Regeneration in Peripheral Nerve after Irreversible Inactivation
journal, October 1960


Memory in Mice as Affected by Intracerebral Puromycin
journal, July 1963


Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice
journal, October 2013


Axonal mRNA transport and localized translational regulation of  -opioid receptor in primary neurons of dorsal root ganglia
journal, December 2006

  • Bi, J.; Tsai, N. -P.; Lin, Y. -P.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 52
  • DOI: 10.1073/pnas.0607394104

Evolution: The Advantage of ‘Maladaptive’ Pain Plasticity
journal, May 2014


The Role of Protein Synthesis in Striatal Long-Term Depression
journal, November 2006


An essential role for β-actin mRNA localization and translation in Ca2+-dependent growth cone guidance
journal, September 2006

  • Yao, Jiaqi; Sasaki, Yukio; Wen, Zhexing
  • Nature Neuroscience, Vol. 9, Issue 10
  • DOI: 10.1038/nn1773

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons
journal, October 2013


SMN regulates axonal local translation via miR-183/mTOR pathway
journal, July 2014

  • Kye, Min Jeong; Niederst, Emily D.; Wertz, Mary H.
  • Human Molecular Genetics, Vol. 23, Issue 23
  • DOI: 10.1093/hmg/ddu350

Asymmetrical β-actin mRNA translation in growth cones mediates attractive turning to netrin-1
journal, September 2006

  • Leung, Kin-Mei; van Horck, Francisca PG; Lin, Andrew C.
  • Nature Neuroscience, Vol. 9, Issue 10
  • DOI: 10.1038/nn1775

Local Translation in Primary Afferent Fibers Regulates Nociception
journal, April 2008


Rapid Changes in the Translatome during the Conversion of Growth Cones to Synaptic Terminals
journal, February 2016


Local Translation of Extranuclear Lamin B Promotes Axon Maintenance
journal, February 2012


An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons
journal, January 2010

  • Andreassi, Catia; Zimmermann, Carola; Mitter, Richard
  • Nature Neuroscience, Vol. 13, Issue 3
  • DOI: 10.1038/nn.2486

Evidence for Developmentally Regulated Local Translation of Odorant Receptor mRNAs in the Axons of Olfactory Sensory Neurons
journal, August 2009


Fine Structure of Nerve Fibers and Growth Cones of Isolated Sympathetic Neurons in Culture
journal, March 1973


Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions
journal, August 2014


Axonal elongation triggered by stimulus-induced local translation of a polarity complex protein
journal, July 2009

  • Hengst, Ulrich; Deglincerti, Alessia; Kim, Hyung Joon
  • Nature Cell Biology, Vol. 11, Issue 8
  • DOI: 10.1038/ncb1916

Dendritic protein synthesis in the normal and diseased brain
journal, March 2013


Localized Synaptic Potentiation by BDNF Requires Local Protein Synthesis in the Developing Axon
journal, November 2002


Is Alzheimer's Disease a Result of Presynaptic Failure? - Synaptic Dysfunctions Induced by Oligomeric β-Amyloid
journal, January 2009


Spatial regulation of β-actin translation by Src-dependent phosphorylation of ZBP1
journal, November 2005

  • Hüttelmaier, Stefan; Zenklusen, Daniel; Lederer, Marcell
  • Nature, Vol. 438, Issue 7067
  • DOI: 10.1038/nature04115

Dendritic Protein Synthesis, Synaptic Plasticity, and Memory
journal, October 2006


Formalin-Induced Behavioural Hypersensitivity and Neuronal Hyperexcitability are Mediated by Rapid Protein Synthesis at the Spinal Level
journal, January 2009

  • Asante, Curtis O.; Wallace, Victoria C.; Dickenson, Anthony H.
  • Molecular Pain, Vol. 5
  • DOI: 10.1186/1744-8069-5-27

FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1
journal, December 2015


The eIF2α kinases: their structures and functions
journal, January 2013

  • Donnelly, Neysan; Gorman, Adrienne M.; Gupta, Sanjeev
  • Cellular and Molecular Life Sciences, Vol. 70, Issue 19
  • DOI: 10.1007/s00018-012-1252-6

Netrin-1-Induced Local  -Actin Synthesis and Growth Cone Guidance Requires Zipcode Binding Protein 1
journal, July 2011


Axonal Translation of  -Catenin Regulates Synaptic Vesicle Dynamics
journal, March 2013


Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network
journal, November 2010


Axonal transcription factors signal retrogradely in lesioned peripheral nerve: Axonal transcription factors in lesioned nerve
journal, January 2012

  • Ben-Yaakov, Keren; Dagan, Shachar Y.; Segal-Ruder, Yael
  • The EMBO Journal, Vol. 31, Issue 6
  • DOI: 10.1038/emboj.2011.494

Regulation of axonal trafficking of cytochrome c oxidase IV mRNA
journal, April 2010

  • Aschrafi, Armaz; Natera-Naranjo, Orlangie; Gioio, Anthony E.
  • Molecular and Cellular Neuroscience, Vol. 43, Issue 4
  • DOI: 10.1016/j.mcn.2010.01.009

Fragile X: Translation in Action
journal, October 2007

  • Bear, Mark F.; Dölen, Gül; Osterweil, Emily
  • Neuropsychopharmacology, Vol. 33, Issue 1
  • DOI: 10.1038/sj.npp.1301610

An Analysis of Dishabituation and Sensitization of The Gill-Withdrawal Reflex In Aplysia
journal, January 1971

  • Carew, Thomas J.; Castellucci, Vincent F.; Kandel, Eric R.
  • International Journal of Neuroscience, Vol. 2, Issue 2
  • DOI: 10.3109/00207457109146995

Translation-Independent Localization of mRNA in E. coli
journal, February 2011


Messenger RNAs in synaptosomal fractions from rat brain
journal, December 2001


The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance
journal, November 2010

  • Dent, E. W.; Gupton, S. L.; Gertler, F. B.
  • Cold Spring Harbor Perspectives in Biology, Vol. 3, Issue 3
  • DOI: 10.1101/cshperspect.a001800

Signaling Mechanisms Underlying Slit2-Induced Collapse of Xenopus Retinal Growth Cones
journal, January 2006


Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation
journal, May 2010


Decreased Nociceptive Sensitization in Mice Lacking the Fragile X Mental Retardation Protein: Role of mGluR1/5 and mTOR
journal, December 2007


Chemotropic Responses of Retinal Growth Cones Mediated by Rapid Local Protein Synthesis and Degradation
journal, December 2001


Protein synthesis at synapse versus cell body: Enhanced but transient expression of long-term facilitation at isolated synapses
journal, July 2003

  • Liu, Ke; Hu, Jiang-Yuan; Wang, Denong
  • Journal of Neurobiology, Vol. 56, Issue 3
  • DOI: 10.1002/neu.10242

Adaptation in the chemotactic guidance of nerve growth cones
journal, May 2002

  • Ming, Guo-li; Wong, Scott T.; Henley, John
  • Nature, Vol. 417, Issue 6887
  • DOI: 10.1038/nature745

Association of poly(A) mRNA with microtubules in cultured neurons
journal, March 1994


Protein synthesis in axons and terminals: significance for maintenance, plasticity and regulation of phenotype
journal, September 2000


Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling
journal, July 2012


Ribosome-like particles in myelinated axons of the rat
journal, December 1970


Activation of the AMP-Activated Protein Kinase Reduces Inflammatory Nociception
journal, November 2013

  • Russe, Otto Quintus; Möser, Christine V.; Kynast, Katharina L.
  • The Journal of Pain, Vol. 14, Issue 11
  • DOI: 10.1016/j.jpain.2013.05.012

Classical conditioning in a simple withdrawal reflex in Aplysia californica
journal, December 1981


The Autistic Neuron: Troubled Translation?
journal, October 2008


Protein synthesis in synaptosomes: a proteomics analysis: Protein synthesis in synaptosomes
journal, May 2002


Subcellular Profiling Reveals Distinct and Developmentally Regulated Repertoire of Growth Cone mRNAs
journal, November 2010


Spinal muscular atrophy: The role of SMN in axonal mRNA regulation
journal, June 2012


Expression and Branch-Specific Export of mRNA Are Regulated by Synapse Formation and Interaction with Specific Postsynaptic Targets
journal, August 1999


Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
journal, June 2010

  • Palop, Jorge J.; Mucke, Lennart
  • Nature Neuroscience, Vol. 13, Issue 7
  • DOI: 10.1038/nn.2583

Ribosomal distributions in axons of mammalian myelinated fibers
journal, January 2007

  • Kun, Alejandra; Otero, Leonardo; Sotelo-Silveira, José R.
  • Journal of Neuroscience Research, Vol. 85, Issue 10
  • DOI: 10.1002/jnr.21340

A Suggestive Relationship of Nerve cell rna with Specific Synaptic Sites
journal, February 1965

  • Bodian, D.
  • Proceedings of the National Academy of Sciences, Vol. 53, Issue 2
  • DOI: 10.1073/pnas.53.2.418

mRNA coding for oxytocin is present in axons of the hypothalamo-neurohypophysial tract.
journal, October 1990

  • Jirikowski, G. F.; Sanna, P. P.; Bloom, F. E.
  • Proceedings of the National Academy of Sciences, Vol. 87, Issue 19
  • DOI: 10.1073/pnas.87.19.7400

Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve
journal, February 2016

  • González, Carolina; Cánovas, José; Fresno, Javiera
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 7
  • DOI: 10.1073/pnas.1514943113

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
journal, March 2003


Local protein synthesis and its role in synapse-specific plasticity
journal, October 2000


Local translational control in dendrites and its role in long-term synaptic plasticity
journal, January 2005

  • Sutton, Michael A.; Schuman, Erin M.
  • Journal of Neurobiology, Vol. 64, Issue 1
  • DOI: 10.1002/neu.20152

Diversity of mRNAs in the Axonal Compartment of Peptidergic Neurons in the Rat
journal, September 1992