skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

This content will become publicly available on January 8, 2021

Title: Deuteron Quadrupolar Chemical Exchange Saturation Transfer (Q‐CEST) Solid‐State NMR for Static Powder Samples: Approach and Applications to Amyloid‐β Fibrils

Authors:
ORCiD logo [1];  [2];  [3]
  1. Department of ChemistryUniversity of Colorado Denver Denver CO 80204 USA
  2. Department of MathematicsUniversity of Colorado Denver Denver CO 80204 USA
  3. National High Field Magnetic Laboratory Tallahassee FL 32310 USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1581839
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
ChemPhysChem
Additional Journal Information:
Journal Name: ChemPhysChem; Journal ID: ISSN 1439-4235
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
Germany
Language:
English

Citation Formats

Vugmeyster, Liliya, Ostrovsky, Dmitry, and Fu, Riqiang. Deuteron Quadrupolar Chemical Exchange Saturation Transfer (Q‐CEST) Solid‐State NMR for Static Powder Samples: Approach and Applications to Amyloid‐β Fibrils. Germany: N. p., 2020. Web. doi:10.1002/cphc.201901053.
Vugmeyster, Liliya, Ostrovsky, Dmitry, & Fu, Riqiang. Deuteron Quadrupolar Chemical Exchange Saturation Transfer (Q‐CEST) Solid‐State NMR for Static Powder Samples: Approach and Applications to Amyloid‐β Fibrils. Germany. doi:10.1002/cphc.201901053.
Vugmeyster, Liliya, Ostrovsky, Dmitry, and Fu, Riqiang. Thu . "Deuteron Quadrupolar Chemical Exchange Saturation Transfer (Q‐CEST) Solid‐State NMR for Static Powder Samples: Approach and Applications to Amyloid‐β Fibrils". Germany. doi:10.1002/cphc.201901053.
@article{osti_1581839,
title = {Deuteron Quadrupolar Chemical Exchange Saturation Transfer (Q‐CEST) Solid‐State NMR for Static Powder Samples: Approach and Applications to Amyloid‐β Fibrils},
author = {Vugmeyster, Liliya and Ostrovsky, Dmitry and Fu, Riqiang},
abstractNote = {},
doi = {10.1002/cphc.201901053},
journal = {ChemPhysChem},
number = ,
volume = ,
place = {Germany},
year = {2020},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on January 8, 2021
Publisher's Version of Record

Save / Share:

Works referenced in this record:

Using low-E resonators to reduce RF heating in biological samples for static solid-state NMR up to 900MHz
journal, March 2007

  • Gor’kov, Peter L.; Chekmenev, Eduard Y.; Li, Conggang
  • Journal of Magnetic Resonance, Vol. 185, Issue 1
  • DOI: 10.1016/j.jmr.2006.11.008

A Simple Mesh Generator in MATLAB
journal, January 2004


Rotational echo 14 N/ 13 C/ 1 H triple resonance solid‐state nuclear magnetic resonance: A probe of 13 C– 14 N internuclear distances
journal, May 1993

  • Grey, Clare P.; Veeman, Wiebren S.; Vega, Alexander J.
  • The Journal of Chemical Physics, Vol. 98, Issue 10
  • DOI: 10.1063/1.464579

Self-Propagating, Molecular-Level Polymorphism in Alzheimer's  -Amyloid Fibrils
journal, January 2005


Experimental Constraints on Quaternary Structure in Alzheimer's β-Amyloid Fibrils
journal, January 2006

  • Petkova, Aneta T.; Yau, Wai-Ming; Tycko, Robert
  • Biochemistry, Vol. 45, Issue 2
  • DOI: 10.1021/bi051952q

Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR
journal, October 2011

  • Fawzi, Nicolas L.; Ying, Jinfa; Ghirlando, Rodolfo
  • Nature, Vol. 480, Issue 7376
  • DOI: 10.1038/nature10577

Protein–ice interaction of an antifreeze protein observed with solid-state NMR
journal, September 2010

  • Siemer, Ansgar B.; Huang, Kuo-Ying; McDermott, Ann E.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 41
  • DOI: 10.1073/pnas.1009369107

Direct Determination of Motional Correlation Times by 1D MAS and 2D Exchange NMR Techniques
journal, October 1998

  • Favre, D. E.; Schaefer, D. J.; Chmelka, B. F.
  • Journal of Magnetic Resonance, Vol. 134, Issue 2
  • DOI: 10.1006/jmre.1998.1506

Solid‐state dynamic processes in complex systems analyzed by two‐dimensional isotropic–anisotropic correlation nuclear magnetic resonance
journal, July 1994

  • Frydman, L.; Vallabhaneni, S.; Lee, Y. K.
  • The Journal of Chemical Physics, Vol. 101, Issue 1
  • DOI: 10.1063/1.468185

The Principles of Nuclear Magnetism
journal, December 1961

  • Abragam, A.; Hebel, L. C.
  • American Journal of Physics, Vol. 29, Issue 12
  • DOI: 10.1119/1.1937646

The Unique Alzheimer’s β-Amyloid Triangular Fibril Has a Cavity along the Fibril Axis under Physiological Conditions
journal, March 2011

  • Miller, Yifat; Ma, Buyong; Nussinov, Ruth
  • Journal of the American Chemical Society, Vol. 133, Issue 8
  • DOI: 10.1021/ja1100273

The Scaling and Squaring Method for the Matrix Exponential Revisited
journal, January 2005

  • Higham, Nicholas J.
  • SIAM Journal on Matrix Analysis and Applications, Vol. 26, Issue 4
  • DOI: 10.1137/04061101X

Reaction Rates by Nuclear Magnetic Resonance
journal, March 1958

  • McConnell, Harden M.
  • The Journal of Chemical Physics, Vol. 28, Issue 3
  • DOI: 10.1063/1.1744152

Spin-locking of half-integer quadrupolar nuclei in NMR of solids: The far off-resonance case
journal, July 2017


Deuterium Rotating Frame NMR Relaxation Measurements in the Solid State under Static Conditions for Quantification of Dynamics
journal, August 2018


The relaxation dynamics of spin I =1 nuclei with a static quadrupolar coupling and a radio‐frequency field
journal, October 1993

  • van der Maarel, J. R. C.
  • The Journal of Chemical Physics, Vol. 99, Issue 8
  • DOI: 10.1063/1.465959

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils
journal, November 2008

  • Paravastu, A. K.; Leapman, R. D.; Yau, W. -M.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 47
  • DOI: 10.1073/pnas.0806270105

SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modeling
journal, January 1997


Probing the Dynamics of a Protein Hydrophobic Core by Deuteron Solid-State Nuclear Magnetic Resonance Spectroscopy
journal, September 2009

  • Vugmeyster, Liliya; Ostrovsky, Dmitry; Ford, Joseph J.
  • Journal of the American Chemical Society, Vol. 131, Issue 38
  • DOI: 10.1021/ja902977u

Measurement of Proton Chemical Shifts in Invisible States of Slowly Exchanging Protein Systems by Chemical Exchange Saturation Transfer
journal, November 2012

  • Bouvignies, Guillaume; Kay, Lewis E.
  • The Journal of Physical Chemistry B, Vol. 116, Issue 49
  • DOI: 10.1021/jp311109u

Fast Motions of Key Methyl Groups in Amyloid-β Fibrils
journal, November 2016

  • Vugmeyster, Liliya; Ostrovsky, Dmitry; Clark, Matthew A.
  • Biophysical Journal, Vol. 111, Issue 10
  • DOI: 10.1016/j.bpj.2016.10.001

Solid-state NMR reveals a comprehensive view of the dynamics of the flexible, disordered N-terminal domain of amyloid-β fibrils
journal, February 2019

  • Au, Dan Fai; Ostrovsky, Dmitry; Fu, Riqiang
  • Journal of Biological Chemistry, Vol. 294, Issue 15
  • DOI: 10.1074/jbc.RA118.006559

Microsecond Time Scale Proton Rotating-Frame Relaxation under Magic Angle Spinning
journal, June 2017


Fiber Diffraction Data Indicate a Hollow Core for the Alzheimer's Aβ 3-Fold Symmetric Fibril
journal, October 2012


MAS NMR spin locking of half-integer quadrupolar nuclei
journal, January 1992


ODESSA, a New 1D NMR Exchange Experiment for Chemically Equivalent Nuclei in Rotating Solids
journal, November 1996

  • Gérardy-Montouillout, V.; Malveau, C.; Tekely, P.
  • Journal of Magnetic Resonance, Series A, Vol. 123, Issue 1
  • DOI: 10.1006/jmra.1996.0208

Studying “Invisible” Excited Protein States in Slow Exchange with a Major State Conformation
journal, April 2012

  • Vallurupalli, Pramodh; Bouvignies, Guillaume; Kay, Lewis E.
  • Journal of the American Chemical Society, Vol. 134, Issue 19
  • DOI: 10.1021/ja3001419

Chemical exchange in biomacromolecules: Past, present, and future
journal, April 2014


Selective inversion investigations of slow molecular motion in solid state deuteron NMR spectroscopy
journal, April 1996

  • Brown, Marco J.; Void, Robert L.; Hoatson, Gina L.
  • Solid State Nuclear Magnetic Resonance, Vol. 6, Issue 2
  • DOI: 10.1016/0926-2040(95)01213-3

Deuterium quadrupole-echo NMR spectroscopy. III. Practical aspects of lineshape calculations for multiaxis rotational processes
journal, March 1987


Spin-locking of half-integer quadrupolar nuclei in nuclear magnetic resonance of solids: Creation and evolution of coherences
journal, February 2004

  • Ashbrook, Sharon E.; Wimperis, Stephen
  • The Journal of Chemical Physics, Vol. 120, Issue 6
  • DOI: 10.1063/1.1638995

Seeded growth of  -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure
journal, April 2009

  • Paravastu, A. K.; Qahwash, I.; Leapman, R. D.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 18
  • DOI: 10.1073/pnas.0812033106

Effects of jump dynamics on solid state nuclear magnetic resonance line shapes and spin relaxation times
journal, May 2009


Flexibility and Solvation of Amyloid-β Hydrophobic Core
journal, July 2016

  • Vugmeyster, Liliya; Clark, Matthew A.; Falconer, Isaac B.
  • Journal of Biological Chemistry, Vol. 291, Issue 35
  • DOI: 10.1074/jbc.M116.740530

Studying dynamics by magic-angle spinning solid-state NMR spectroscopy: Principles and applications to biomolecules
journal, August 2016