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Title: Computational tools for discovering and engineering natural product biosynthetic pathways

Abstract

Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents. Recent advances in DNA sequencing technologies and bioinformatics unveiled nature’s great potential for synthesizing numerous NPs that may confer unprecedented structural and biological features. However, discovering novel bioactive NPs by genome mining remains a challenge. Moreover, even with interesting bioactivity, the low productivity of many NPs significantly limits their practical applications. Here we discuss the progress in developing bioinformatics tools for efficient discovery of bioactive NPs. In addition, we highlight computational methods for optimizing the productivity of NPs with pharmaceutical importance.

Authors:
 [1];  [1];  [1]
  1. Univ. of Illinois at Urbana-Champaign, Urbana, IL (United States)
Publication Date:
Research Org.:
Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1581825
Alternate Identifier(s):
OSTI ID: 1581188
Grant/Contract Number:  
SC0018420; SC0018260; GM077596; AI144967
Resource Type:
Published Article
Journal Name:
iScience
Additional Journal Information:
Journal Name: iScience; Journal ID: ISSN 2589-0042
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
biosynthesis; natural products; biosynthetic gene clusters; biosynthetic pathways; synthetic biology

Citation Formats

Ren, Hengqian, Shi, Chengyou, and Zhao, Huimin. Computational tools for discovering and engineering natural product biosynthetic pathways. United States: N. p., 2019. Web. doi:10.1016/j.isci.2019.100795.
Ren, Hengqian, Shi, Chengyou, & Zhao, Huimin. Computational tools for discovering and engineering natural product biosynthetic pathways. United States. doi:10.1016/j.isci.2019.100795.
Ren, Hengqian, Shi, Chengyou, and Zhao, Huimin. Fri . "Computational tools for discovering and engineering natural product biosynthetic pathways". United States. doi:10.1016/j.isci.2019.100795.
@article{osti_1581825,
title = {Computational tools for discovering and engineering natural product biosynthetic pathways},
author = {Ren, Hengqian and Shi, Chengyou and Zhao, Huimin},
abstractNote = {Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents. Recent advances in DNA sequencing technologies and bioinformatics unveiled nature’s great potential for synthesizing numerous NPs that may confer unprecedented structural and biological features. However, discovering novel bioactive NPs by genome mining remains a challenge. Moreover, even with interesting bioactivity, the low productivity of many NPs significantly limits their practical applications. Here we discuss the progress in developing bioinformatics tools for efficient discovery of bioactive NPs. In addition, we highlight computational methods for optimizing the productivity of NPs with pharmaceutical importance.},
doi = {10.1016/j.isci.2019.100795},
journal = {iScience},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {12}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1016/j.isci.2019.100795

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