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Title: Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets

Abstract

Cyclotron-produced astatine-211 ( 211At) shows tremendous promise in targeted alpha therapy (TAT) applications due to its attractive half-life and its 100% α-emission from nearly simultaneous branched alpha decay. Astatine-211 is produced by alpha beam bombardment of naturally monoisotopic bismuth metal ( 209Bi) via the (α, 2n) reaction. In order to isolate the small mass of 211At (specific activity = 76 GBq·µg –1) from several grams of acid-dissolved Bi metal, a manual milliliter-scale solvent extraction process using diisopropyl ether (DIPE) is routinely performed at the University of Washington. As this process is complex and time consuming, we have developed a fluidic workstation that can perform the method autonomously. The workstation employs two pumps to concurrently deliver the aqueous and organic phases to a mixing tee and in-line phase mixer. The mixed phases are routed to a phase settling reservoir, where they gravity settle. Lastly, each respective phase is withdrawn into its respective pump. However, development of a phase boundary sensor, placed in tandem with the phase settling reservoir, was necessary to communicate to the system when withdrawal of the denser aqueous phase was complete (i.e., the intersection of the two phases was located). The development and optimization of the autonomous solventmore » extraction system is described, and the 211At yields from several ~1.1 GBq-level 211At processing runs are reported.« less

Authors:
ORCiD logo [1]; ORCiD logo [1];  [2]; ORCiD logo [2];  [2];  [2]
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  2. Univ. of Washington, Seattle, WA (United States)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
OSTI Identifier:
1581621
Report Number(s):
PNNL-SA-146485
Journal ID: ISSN 2045-2322
Grant/Contract Number:  
AC05-76RL01830; LAB-12-743; SC0018013
Resource Type:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 9; Journal Issue: 1; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; laboratory automation; solvent extraction; phase boundary; medical radionuclide; 211At; cyclotron target

Citation Formats

O’Hara, Matthew J., Krzysko, Anthony J., Hamlin, Donald K., Li, Yawen, Dorman, Eric F., and Wilbur, D. Scott. Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets. United States: N. p., 2019. Web. doi:10.1038/s41598-019-56272-7.
O’Hara, Matthew J., Krzysko, Anthony J., Hamlin, Donald K., Li, Yawen, Dorman, Eric F., & Wilbur, D. Scott. Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets. United States. doi:10.1038/s41598-019-56272-7.
O’Hara, Matthew J., Krzysko, Anthony J., Hamlin, Donald K., Li, Yawen, Dorman, Eric F., and Wilbur, D. Scott. Mon . "Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets". United States. doi:10.1038/s41598-019-56272-7. https://www.osti.gov/servlets/purl/1581621.
@article{osti_1581621,
title = {Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets},
author = {O’Hara, Matthew J. and Krzysko, Anthony J. and Hamlin, Donald K. and Li, Yawen and Dorman, Eric F. and Wilbur, D. Scott},
abstractNote = {Cyclotron-produced astatine-211 (211At) shows tremendous promise in targeted alpha therapy (TAT) applications due to its attractive half-life and its 100% α-emission from nearly simultaneous branched alpha decay. Astatine-211 is produced by alpha beam bombardment of naturally monoisotopic bismuth metal (209Bi) via the (α, 2n) reaction. In order to isolate the small mass of 211At (specific activity = 76 GBq·µg–1) from several grams of acid-dissolved Bi metal, a manual milliliter-scale solvent extraction process using diisopropyl ether (DIPE) is routinely performed at the University of Washington. As this process is complex and time consuming, we have developed a fluidic workstation that can perform the method autonomously. The workstation employs two pumps to concurrently deliver the aqueous and organic phases to a mixing tee and in-line phase mixer. The mixed phases are routed to a phase settling reservoir, where they gravity settle. Lastly, each respective phase is withdrawn into its respective pump. However, development of a phase boundary sensor, placed in tandem with the phase settling reservoir, was necessary to communicate to the system when withdrawal of the denser aqueous phase was complete (i.e., the intersection of the two phases was located). The development and optimization of the autonomous solvent extraction system is described, and the 211At yields from several ~1.1 GBq-level 211At processing runs are reported.},
doi = {10.1038/s41598-019-56272-7},
journal = {Scientific Reports},
number = 1,
volume = 9,
place = {United States},
year = {2019},
month = {12}
}

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