Search Menu
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information
Search Scholarly Publications

Title: Unconventional Oil and Gas Energy Systems: An Unidentified Hotspot of Antimicrobial Resistance?

Abstract

Biocides used in unconventional oil and gas (UOG) practices, such as hydraulic fracturing, control microbial growth. Unwanted microbial growth can cause gas souring, pipeline clogging, and microbial-induced corrosion of equipment and transportation pipes. However, optimizing biocide use has not been a priority. Moreover, biocide efficacy has been questioned because microbial surveys show an active microbial community in hydraulic fracturing produced and flowback water. Hydraulic fracturing produced and flowback water increases risks to surface aquifers and rivers/lakes near the UOG operations compared with conventional oil and gas operations. While some biocides and biocide degradation products have been highlighted as chemicals of concern because of their toxicity to humans and the environment, the selective antimicrobial pressure they cause has not been considered seriously. This perspective article aims to promote research to determine if antimicrobial pressure in these systems is cause for concern. UOG practices could potentially create antimicrobial resistance hotspots under-appreciated in the literature, practice, and regulation arena, hotspots that should not be ignored. The article is distinctive in discussing antimicrobial resistance risks associated with UOG biocides from a biological risk, not a chemical toxicology, perspective. We outline potential risks and highlight important knowledge gaps that need to be addressed to properlymore » incorporate antimicrobial resistance emergence and selection into UOG environmental and health risk assessments.« less

Authors:
 [1];  [2];  [3];  [4];  [1]
+ Show Author Affiliations
  1. Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  3. Michigan Technological Univ., Houghton, MI (United States)
  4. Univ. of Tennessee, Knoxville, TN (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
National Science Foundation (NSF); USDOE
OSTI Identifier:
1581317
Alternate Identifier(s):
OSTI ID: 1606840
Grant/Contract Number:  
AC02-05CH11231; AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Frontiers in Microbiology
Additional Journal Information:
Journal Volume: 10; Journal Issue: OCT; Journal ID: ISSN 1664-302X
Publisher:
Frontiers Research Foundation
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; antimicrobial resistance; biocides; hydraulic fracturing; unconventional oil and gas; biological risk; resistome; resistome risk

Citation Formats

Campa, Maria Fernanda, Wolfe, Amy K., Techtmann, Stephen M., Harik, Ann-Marie, and Hazen, Terry C. Unconventional Oil and Gas Energy Systems: An Unidentified Hotspot of Antimicrobial Resistance?. United States: N. p., 2019. Web. doi:10.3389/fmicb.2019.02392.
Copy to clipboard
Campa, Maria Fernanda, Wolfe, Amy K., Techtmann, Stephen M., Harik, Ann-Marie, & Hazen, Terry C. Unconventional Oil and Gas Energy Systems: An Unidentified Hotspot of Antimicrobial Resistance?. United States. https://doi.org/10.3389/fmicb.2019.02392
Copy to clipboard
Campa, Maria Fernanda, Wolfe, Amy K., Techtmann, Stephen M., Harik, Ann-Marie, and Hazen, Terry C. Fri . "Unconventional Oil and Gas Energy Systems: An Unidentified Hotspot of Antimicrobial Resistance?". United States. https://doi.org/10.3389/fmicb.2019.02392. https://www.osti.gov/servlets/purl/1581317.
Copy to clipboard
@article{osti_1581317,
title = {Unconventional Oil and Gas Energy Systems: An Unidentified Hotspot of Antimicrobial Resistance?},
author = {Campa, Maria Fernanda and Wolfe, Amy K. and Techtmann, Stephen M. and Harik, Ann-Marie and Hazen, Terry C.},
abstractNote = {Biocides used in unconventional oil and gas (UOG) practices, such as hydraulic fracturing, control microbial growth. Unwanted microbial growth can cause gas souring, pipeline clogging, and microbial-induced corrosion of equipment and transportation pipes. However, optimizing biocide use has not been a priority. Moreover, biocide efficacy has been questioned because microbial surveys show an active microbial community in hydraulic fracturing produced and flowback water. Hydraulic fracturing produced and flowback water increases risks to surface aquifers and rivers/lakes near the UOG operations compared with conventional oil and gas operations. While some biocides and biocide degradation products have been highlighted as chemicals of concern because of their toxicity to humans and the environment, the selective antimicrobial pressure they cause has not been considered seriously. This perspective article aims to promote research to determine if antimicrobial pressure in these systems is cause for concern. UOG practices could potentially create antimicrobial resistance hotspots under-appreciated in the literature, practice, and regulation arena, hotspots that should not be ignored. The article is distinctive in discussing antimicrobial resistance risks associated with UOG biocides from a biological risk, not a chemical toxicology, perspective. We outline potential risks and highlight important knowledge gaps that need to be addressed to properly incorporate antimicrobial resistance emergence and selection into UOG environmental and health risk assessments.},
doi = {10.3389/fmicb.2019.02392},
journal = {Frontiers in Microbiology},
number = OCT,
volume = 10,
place = {United States},
year = {Fri Oct 18 00:00:00 EDT 2019},
month = {Fri Oct 18 00:00:00 EDT 2019}
}
Copy to clipboard
Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.3389/fmicb.2019.02392
Copyright Statement
Other availability
Search WorldCat Search WorldCat to find libraries that may hold this journal
Citation Metrics:
Cited by: 3 works
Citation information provided by
Web of Science
Save / Share:
Export Metadata
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.

Works referenced in this record:

Bacterial Biomarkers of Marcellus Shale Activity in Pennsylvania
journal, August 2018

  • Chen See, Jeremy R.; Ulrich, Nikea; Nwanosike, Hephzibah
  • Frontiers in Microbiology, Vol. 9
  • DOI: 10.3389/fmicb.2018.01697

Physical, chemical, and biological characteristics of compounds used in hydraulic fracturing
journal, June 2014

Water usage for natural gas production through hydraulic fracturing in the United States from 2008 to 2014
journal, April 2016

Call of the wild: antibiotic resistance genes in natural environments
journal, March 2010

  • Allen, Heather K.; Donato, Justin; Wang, Helena Huimi
  • Nature Reviews Microbiology, Vol. 8, Issue 4
  • DOI: 10.1038/nrmicro2312

In the Neighborhood of 18 Million: Estimating How Many People Live Near Oil and Gas Wells
journal, December 2017

  • Konkel, Lindsey
  • Environmental Health Perspectives, Vol. 125, Issue 12
  • DOI: 10.1289/ehp2553

Downhole Transformation of the Hydraulic Fracturing Fluid Biocide Glutaraldehyde: Implications for Flowback and Produced Water Quality
journal, September 2016

  • Kahrilas, Genevieve A.; Blotevogel, Jens; Corrin, Edward R.
  • Environmental Science & Technology, Vol. 50, Issue 20
  • DOI: 10.1021/acs.est.6b02881

Do Biocides Select for Antibiotic Resistance?*
journal, February 2000

An assay for determining minimal concentrations of antibiotics that drive horizontal transfer of resistance
journal, April 2016

Biocide abuse and antimicrobial resistance--a cause for concern?
journal, January 2002

  • Fraise, A. P.
  • Journal of Antimicrobial Chemotherapy, Vol. 49, Issue 1
  • DOI: 10.1093/jac/49.1.11

Quaternary ammonium compounds in soil: implications for antibiotic resistance development
journal, December 2017

  • Mulder, Ines; Siemens, Jan; Sentek, Valerie
  • Reviews in Environmental Science and Bio/Technology, Vol. 17, Issue 1
  • DOI: 10.1007/s11157-017-9457-7

Metagenomic applications in environmental monitoring and bioremediation
journal, August 2016

  • Techtmann, Stephen M.; Hazen, Terry C.
  • Journal of Industrial Microbiology & Biotechnology, Vol. 43, Issue 10
  • DOI: 10.1007/s10295-016-1809-8

Biocides in Hydraulic Fracturing Fluids: A Critical Review of Their Usage, Mobility, Degradation, and Toxicity
journal, December 2014

  • Kahrilas, Genevieve A.; Blotevogel, Jens; Stewart, Philip S.
  • Environmental Science & Technology, Vol. 49, Issue 1
  • DOI: 10.1021/es503724k

Origins and Evolution of Antibiotic Resistance
journal, August 2010

  • Davies, J.; Davies, D.
  • Microbiology and Molecular Biology Reviews, Vol. 74, Issue 3
  • DOI: 10.1128/MMBR.00016-10

Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance
journal, May 2015

  • Jennings, Megan C.; Minbiole, Kevin P. C.; Wuest, William M.
  • ACS Infectious Diseases, Vol. 1, Issue 7
  • DOI: 10.1021/acsinfecdis.5b00047

Assessing impacts of unconventional natural gas extraction on microbial communities in headwater stream ecosystems in Northwestern Pennsylvania
journal, November 2014

Toward Consistent Methodology to Quantify Populations in Proximity to Oil and Gas Development: A National Spatial Analysis and Review
journal, August 2017

  • Czolowski, Eliza D.; Santoro, Renee L.; Srebotnjak, Tanja
  • Environmental Health Perspectives, Vol. 125, Issue 8
  • DOI: 10.1289/EHP1535

Key Role for Efflux in the Preservative Susceptibility and Adaptive Resistance of Burkholderia cepacia Complex Bacteria
journal, April 2013

  • Rushton, Laura; Sass, Andrea; Baldwin, Adam
  • Antimicrobial Agents and Chemotherapy, Vol. 57, Issue 7
  • DOI: 10.1128/aac.00140-13

Effects of biocides on gene expression in the sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough
journal, May 2010

  • Lee, Meng-Hsin Phoebe; Caffrey, Sean M.; Voordouw, Johanna K.
  • Applied Microbiology and Biotechnology, Vol. 87, Issue 3
  • DOI: 10.1007/s00253-010-2596-1

Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: A review
journal, March 2013

Efflux as a Glutaraldehyde Resistance Mechanism in Pseudomonas fluorescens and Pseudomonas aeruginosa Biofilms
journal, March 2015

  • Vikram, Amit; Bomberger, Jennifer M.; Bibby, Kyle J.
  • Antimicrobial Agents and Chemotherapy, Vol. 59, Issue 6
  • DOI: 10.1128/aac.05152-14

Surface disposal of produced waters in western and southwestern Pennsylvania: Potential for accumulation of alkali-earth elements in sediments
journal, June 2014

  • Skalak, Katherine J.; Engle, Mark A.; Rowan, Elisabeth L.
  • International Journal of Coal Geology, Vol. 126
  • DOI: 10.1016/j.coal.2013.12.001

Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria
journal, March 2012

Elucidation of the mechanism and end products of glutaraldehyde crosslinking reaction by X-ray structure analysis
journal, January 2007

  • Wine, Yariv; Cohen-Hadar, Noa; Freeman, Amihay
  • Biotechnology and Bioengineering, Vol. 98, Issue 3
  • DOI: 10.1002/bit.21459

Temporal Changes in Microbial Ecology and Geochemistry in Produced Water from Hydraulically Fractured Marcellus Shale Gas Wells
journal, May 2014

  • Cluff, Maryam A.; Hartsock, Angela; MacRae, Jean D.
  • Environmental Science & Technology, Vol. 48, Issue 11
  • DOI: 10.1021/es501173p

Microbial metabolisms in a 2.5-km-deep ecosystem created by hydraulic fracturing in shales
journal, September 2016

What is a resistance gene? Ranking risk in resistomes
journal, December 2014

  • Martínez, José L.; Coque, Teresa M.; Baquero, Fernando
  • Nature Reviews Microbiology, Vol. 13, Issue 2
  • DOI: 10.1038/nrmicro3399

Antibiotic resistance genes in the environment: prioritizing risks
journal, April 2015

  • Bengtsson-Palme, Johan; Larsson, D. G. Joakim
  • Nature Reviews Microbiology, Vol. 13, Issue 6
  • DOI: 10.1038/nrmicro3399-c1

A communal catalogue reveals Earth’s multiscale microbial diversity
journal, November 2017

  • Thompson, Luke R.; Sanders, Jon G.; McDonald, Daniel
  • Nature, Vol. 551, Issue 7681
  • DOI: 10.1038/nature24621

Produced Water Exposure Alters Bacterial Response to Biocides
journal, October 2014

  • Vikram, Amit; Lipus, Daniel; Bibby, Kyle
  • Environmental Science & Technology, Vol. 48, Issue 21
  • DOI: 10.1021/es5036915

Hydraulic fracturing offers view of microbial life in the deep terrestrial subsurface
journal, August 2016

  • Mouser, Paula J.; Borton, Mikayla; Darrah, Thomas H.
  • FEMS Microbiology Ecology, Vol. 92, Issue 11
  • DOI: 10.1093/femsec/fiw166

Impact of UV and Peracetic Acid Disinfection on the Prevalence of Virulence and Antimicrobial Resistance Genes in Uropathogenic Escherichia coli in Wastewater Effluents
journal, April 2014

  • Biswal, Basanta Kumar; Khairallah, Ramzi; Bibi, Kareem
  • Applied and Environmental Microbiology, Vol. 80, Issue 12
  • DOI: 10.1128/aem.00418-14

Sampling the Antibiotic Resistome
journal, January 2006

  • D'Costa, Vanessa M.; McGrann, Katherine M.; Hughes, Donald W.
  • Science, Vol. 311, Issue 5759
  • DOI: 10.1126/science.1120800

Development of bacterial resistance to several biocides and effects on antibiotic susceptibility
journal, October 2003

Development of bacterial resistance to several biocides and effects on antibiotic susceptibility
journal, October 2003

Response of Aquatic Bacterial Communities to Hydraulic Fracturing in Northwestern Pennsylvania: A Five-Year Study
journal, April 2018

Antimicrobial resistance in humans, livestock and the wider environment
journal, June 2015

  • Woolhouse, Mark; Ward, Melissa; van Bunnik, Bram
  • Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 370, Issue 1670
  • DOI: 10.1098/rstb.2014.0083

Biofilms, homoserine lactones and biocide susceptibility
journal, January 2004

  • MacLehose, H. G.
  • Journal of Antimicrobial Chemotherapy, Vol. 53, Issue 2
  • DOI: 10.1093/jac/dkh090

Shifts in microbial community structure and function in surface waters impacted by unconventional oil and gas wastewater revealed by metagenomics
journal, February 2017

Methane contamination of drinking water accompanying gas-well drilling and hydraulic fracturing
journal, May 2011

  • Osborn, S. G.; Vengosh, A.; Warner, N. R.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 20
  • DOI: 10.1073/pnas.1100682108

Response of Aquatic Bacterial Communities to Hydraulic Fracturing in Northwestern Pennsylvania: A Five-Year Study
journal, April 2018

Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: A review
journal, March 2013

Comparison of chemical-use between hydraulic fracturing, acidizing, and routine oil and gas development
journal, April 2017

Transcriptional and Phenotypic Responses of Listeria monocytogenes to Chlorine Dioxide
journal, March 2014

  • Pleitner, A. M.; Trinetta, V.; Morgan, M. T.
  • Applied and Environmental Microbiology, Vol. 80, Issue 9
  • DOI: 10.1128/aem.00004-14

Proximity to Natural Gas Wells and Reported Health Status: Results of a Household Survey in Washington County, Pennsylvania
journal, January 2015

  • Rabinowitz, Peter M.; Slizovskiy, Ilya B.; Lamers, Vanessa
  • Environmental Health Perspectives, Vol. 123, Issue 1
  • DOI: 10.1289/ehp.1307732

A critical assessment of the efficacy of biocides used during the hydraulic fracturing process in shale natural gas wells
journal, July 2012

  • Struchtemeyer, Christopher G.; Morrison, Michael D.; Elshahed, Mostafa S.
  • International Biodeterioration & Biodegradation, Vol. 71
  • DOI: 10.1016/j.ibiod.2012.01.013

The antibiotic resistome: the nexus of chemical and genetic diversity
journal, March 2007

Toxicogenomic analysis of sodium hypochlorite antimicrobial mechanisms in Pseudomonas aeruginosa
journal, October 2006

  • Small, David A.; Chang, Wook; Toghrol, Freshteh
  • Applied Microbiology and Biotechnology, Vol. 74, Issue 1
  • DOI: 10.1007/s00253-006-0644-7

Analysis of hydraulic fracturing additives by LC/Q-TOF-MS
journal, June 2015

  • Ferrer, Imma; Thurman, E. Michael
  • Analytical and Bioanalytical Chemistry, Vol. 407, Issue 21
  • DOI: 10.1007/s00216-015-8780-5

Biocides in Hydraulic Fracturing Fluids: A Critical Review of Their Usage, Mobility, Degradation, and Toxicity
journal, December 2014

  • Kahrilas, Genevieve A.; Blotevogel, Jens; Stewart, Philip S.
  • Environmental Science & Technology, Vol. 49, Issue 1
  • DOI: 10.1021/es503724k

Antibiotic Resistance in Bacteria Isolated from the Deep Terrestrial Subsurface
journal, August 2008

The tradeoff between water and carbon footprints of Barnett Shale gas
journal, October 2018

Advances in monitoring environmental microbes
journal, June 2013

  • Hazen, Terry C.; Rocha, Andrea M.; Techtmann, Stephen M.
  • Current Opinion in Biotechnology, Vol. 24, Issue 3
  • DOI: 10.1016/j.copbio.2012.10.020

Assessing impacts of unconventional natural gas extraction on microbial communities in headwater stream ecosystems in Northwestern Pennsylvania
journal, November 2014

Bacterial communities associated with hydraulic fracturing fluids in thermogenic natural gas wells in North Central Texas, USA
journal, November 2011

CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database
journal, October 2016

  • Jia, Baofeng; Raphenya, Amogelang R.; Alcock, Brian
  • Nucleic Acids Research, Vol. 45, Issue D1
  • DOI: 10.1093/nar/gkw1004

Unconventional Oil and Gas Spills: Risks, Mitigation Priorities, and State Reporting Requirements
journal, February 2017

  • Patterson, Lauren A.; Konschnik, Katherine E.; Wiseman, Hannah
  • Environmental Science & Technology, Vol. 51, Issue 5
  • DOI: 10.1021/acs.est.6b05749

Similarities and differences in the responses of microorganisms to biocides
journal, September 2003

  • Russell, A. D.
  • Journal of Antimicrobial Chemotherapy, Vol. 52, Issue 5
  • DOI: 10.1093/jac/dkg422

Physical, chemical, and biological characteristics of compounds used in hydraulic fracturing
journal, June 2014

Bacterial Biomarkers of Marcellus Shale Activity in Pennsylvania
journal, August 2018

  • Chen See, Jeremy R.; Ulrich, Nikea; Nwanosike, Hephzibah
  • Frontiers in Microbiology, Vol. 9
  • DOI: 10.3389/fmicb.2018.01697

A communal catalogue reveals Earth’s multiscale microbial diversity
journal, November 2017

  • Thompson, Luke R.; Sanders, Jon G.; McDonald, Daniel
  • Nature, Vol. 551, Issue 7681
  • DOI: 10.1038/nature24621

Temporal Changes in Microbial Ecology and Geochemistry in Produced Water from Hydraulically Fractured Marcellus Shale Gas Wells
journal, May 2014

  • Cluff, Maryam A.; Hartsock, Angela; MacRae, Jean D.
  • Environmental Science & Technology, Vol. 48, Issue 11
  • DOI: 10.1021/es501173p

Water usage for natural gas production through hydraulic fracturing in the United States from 2008 to 2014
journal, April 2016

Biocide abuse and antimicrobial resistance--a cause for concern?
journal, January 2002

  • Fraise, A. P.
  • Journal of Antimicrobial Chemotherapy, Vol. 49, Issue 1
  • DOI: 10.1093/jac/49.1.11

Do Biocides Select for Antibiotic Resistance?*
journal, February 2000

Similarities and differences in the responses of microorganisms to biocides
journal, September 2003

  • Russell, A. D.
  • Journal of Antimicrobial Chemotherapy, Vol. 52, Issue 5
  • DOI: 10.1093/jac/dkg422

Unconventional Oil and Gas Spills: Risks, Mitigation Priorities, and State Reporting Requirements
journal, February 2017

  • Patterson, Lauren A.; Konschnik, Katherine E.; Wiseman, Hannah
  • Environmental Science & Technology, Vol. 51, Issue 5
  • DOI: 10.1021/acs.est.6b05749

Microbial communities in flowback water impoundments from hydraulic fracturing for recovery of shale gas
journal, August 2013

  • Murali Mohan, Arvind; Hartsock, Angela; Hammack, Richard W.
  • FEMS Microbiology Ecology, Vol. 86, Issue 3
  • DOI: 10.1111/1574-6941.12183

Metatranscriptome analysis of active microbial communities in produced water samples from the Marcellus Shale
journal, July 2016

Microbial metabolisms in a 2.5-km-deep ecosystem created by hydraulic fracturing in shales
journal, September 2016

Effects of biocides on gene expression in the sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough
journal, May 2010

  • Lee, Meng-Hsin Phoebe; Caffrey, Sean M.; Voordouw, Johanna K.
  • Applied Microbiology and Biotechnology, Vol. 87, Issue 3
  • DOI: 10.1007/s00253-010-2596-1

Call of the wild: antibiotic resistance genes in natural environments
journal, March 2010

  • Allen, Heather K.; Donato, Justin; Wang, Helena Huimi
  • Nature Reviews Microbiology, Vol. 8, Issue 4
  • DOI: 10.1038/nrmicro2312

Wastewater Disposal from Unconventional Oil and Gas Development Degrades Stream Quality at a West Virginia Injection Facility
journal, May 2016

  • Akob, Denise M.; Mumford, Adam C.; Orem, William
  • Environmental Science & Technology, Vol. 50, Issue 11
  • DOI: 10.1021/acs.est.6b00428

The antibiotic resistome: the nexus of chemical and genetic diversity
journal, March 2007

Metagenomic applications in environmental monitoring and bioremediation
journal, August 2016

  • Techtmann, Stephen M.; Hazen, Terry C.
  • Journal of Industrial Microbiology & Biotechnology, Vol. 43, Issue 10
  • DOI: 10.1007/s10295-016-1809-8

Analysis of hydraulic fracturing additives by LC/Q-TOF-MS
journal, June 2015

  • Ferrer, Imma; Thurman, E. Michael
  • Analytical and Bioanalytical Chemistry, Vol. 407, Issue 21
  • DOI: 10.1007/s00216-015-8780-5

The tradeoff between water and carbon footprints of Barnett Shale gas
journal, October 2018

Microbial Dynamics and Control in Shale Gas Production
journal, November 2014

  • Gaspar, Jason; Mathieu, Jacques; Yang, Yu
  • Environmental Science & Technology Letters, Vol. 1, Issue 12
  • DOI: 10.1021/ez5003242

Life Cycle Water Consumption and Wastewater Generation Impacts of a Marcellus Shale Gas Well
journal, January 2014

  • Jiang, Mohan; Hendrickson, Chris T.; VanBriesen, Jeanne M.
  • Environmental Science & Technology, Vol. 48, Issue 3
  • DOI: 10.1021/es4047654

Long-Term Exposure to Benzalkonium Chloride Disinfectants Results in Change of Microbial Community Structure and Increased Antimicrobial Resistance
journal, August 2013

  • Tandukar, Madan; Oh, Seungdae; Tezel, Ulas
  • Environmental Science & Technology, Vol. 47, Issue 17
  • DOI: 10.1021/es401507k

Sampling the Antibiotic Resistome
journal, January 2006

  • D'Costa, Vanessa M.; McGrann, Katherine M.; Hughes, Donald W.
  • Science, Vol. 311, Issue 5759
  • DOI: 10.1126/science.1120800

Comparison of chemical-use between hydraulic fracturing, acidizing, and routine oil and gas development
journal, April 2017

Downhole Transformation of the Hydraulic Fracturing Fluid Biocide Glutaraldehyde: Implications for Flowback and Produced Water Quality
journal, September 2016

  • Kahrilas, Genevieve A.; Blotevogel, Jens; Corrin, Edward R.
  • Environmental Science & Technology, Vol. 50, Issue 20
  • DOI: 10.1021/acs.est.6b02881

Produced Water Exposure Alters Bacterial Response to Biocides
journal, October 2014

  • Vikram, Amit; Lipus, Daniel; Bibby, Kyle
  • Environmental Science & Technology, Vol. 48, Issue 21
  • DOI: 10.1021/es5036915

A critical assessment of the efficacy of biocides used during the hydraulic fracturing process in shale natural gas wells
journal, July 2012

  • Struchtemeyer, Christopher G.; Morrison, Michael D.; Elshahed, Mostafa S.
  • International Biodeterioration & Biodegradation, Vol. 71
  • DOI: 10.1016/j.ibiod.2012.01.013

Biofilms, homoserine lactones and biocide susceptibility
journal, January 2004

  • MacLehose, H. G.
  • Journal of Antimicrobial Chemotherapy, Vol. 53, Issue 2
  • DOI: 10.1093/jac/dkh090

Inhibition of Biodegradation of Hydraulic Fracturing Compounds by Glutaraldehyde: Groundwater Column and Microcosm Experiments
journal, August 2017

  • Rogers, Jessica D.; Ferrer, Imma; Tummings, Shantal S.
  • Environmental Science & Technology, Vol. 51, Issue 17
  • DOI: 10.1021/acs.est.7b02316

Spills of Hydraulic Fracturing Chemicals on Agricultural Topsoil: Biodegradation, Sorption, and Co-contaminant Interactions
journal, May 2016

  • McLaughlin, Molly C.; Borch, Thomas; Blotevogel, Jens
  • Environmental Science & Technology, Vol. 50, Issue 11
  • DOI: 10.1021/acs.est.6b00240

Bacterial communities associated with hydraulic fracturing fluids in thermogenic natural gas wells in North Central Texas, USA
journal, November 2011

Methane contamination of drinking water caused by hydraulic fracturing remains unproven
journal, October 2011

Long-Term Exposure to Benzalkonium Chloride Disinfectants Results in Change of Microbial Community Structure and Increased Antimicrobial Resistance
journal, August 2013

  • Tandukar, Madan; Oh, Seungdae; Tezel, Ulas
  • Environmental Science & Technology, Vol. 47, Issue 17
  • DOI: 10.1021/es401507k

Antibiotic Resistance in Bacteria Isolated from the Deep Terrestrial Subsurface
journal, August 2008

Antibiotic resistance genes in the environment: prioritizing risks
journal, April 2015

  • Bengtsson-Palme, Johan; Larsson, D. G. Joakim
  • Nature Reviews Microbiology, Vol. 13, Issue 6
  • DOI: 10.1038/nrmicro3399-c1

Inhibition of Biodegradation of Hydraulic Fracturing Compounds by Glutaraldehyde: Groundwater Column and Microcosm Experiments
journal, August 2017

  • Rogers, Jessica D.; Ferrer, Imma; Tummings, Shantal S.
  • Environmental Science & Technology, Vol. 51, Issue 17
  • DOI: 10.1021/acs.est.7b02316

Advances in monitoring environmental microbes
journal, June 2013

  • Hazen, Terry C.; Rocha, Andrea M.; Techtmann, Stephen M.
  • Current Opinion in Biotechnology, Vol. 24, Issue 3
  • DOI: 10.1016/j.copbio.2012.10.020

Quaternary ammonium compounds (QACs): A review on occurrence, fate and toxicity in the environment
journal, June 2015

Tackling antibiotic resistance: the environmental framework
journal, March 2015

  • Berendonk, Thomas U.; Manaia, Célia M.; Merlin, Christophe
  • Nature Reviews Microbiology, Vol. 13, Issue 5
  • DOI: 10.1038/nrmicro3439

What is a resistance gene? Ranking risk in resistomes
journal, December 2014

  • Martínez, José L.; Coque, Teresa M.; Baquero, Fernando
  • Nature Reviews Microbiology, Vol. 13, Issue 2
  • DOI: 10.1038/nrmicro3399

Glutaraldehyde: behavior in aqueous solution, reaction with proteins, and application to enzyme crosslinking
journal, November 2004

  • Migneault, Isabelle; Dartiguenave, Catherine; Bertrand, Michel J.
  • BioTechniques, Vol. 37, Issue 5
  • DOI: 10.2144/04375RV01

Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria
journal, March 2012

Pseudomonas aeruginosa Biofilm Antibiotic Resistance Gene ndvB Expression Requires the RpoS Stationary-Phase Sigma Factor
journal, January 2018

  • Hall, Clayton W.; Hinz, Aaron J.; Gagnon, Luke B. -P.
  • Applied and Environmental Microbiology, Vol. 84, Issue 7
  • DOI: 10.1128/AEM.02762-17

Impacts of Glutaraldehyde on Microbial Community Structure and Degradation Potential in Streams Impacted by Hydraulic Fracturing
journal, April 2018

  • Campa, Maria Fernanda; Techtmann, Stephen M.; Gibson, Caleb M.
  • Environmental Science & Technology, Vol. 52, Issue 10
  • DOI: 10.1021/acs.est.8b00239

Elucidation of the mechanism and end products of glutaraldehyde crosslinking reaction by X-ray structure analysis
journal, January 2007

  • Wine, Yariv; Cohen-Hadar, Noa; Freeman, Amihay
  • Biotechnology and Bioengineering, Vol. 98, Issue 3
  • DOI: 10.1002/bit.21459

Microbial Dynamics and Control in Shale Gas Production
journal, November 2014

  • Gaspar, Jason; Mathieu, Jacques; Yang, Yu
  • Environmental Science & Technology Letters, Vol. 1, Issue 12
  • DOI: 10.1021/ez5003242

Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance
journal, May 2015

  • Jennings, Megan C.; Minbiole, Kevin P. C.; Wuest, William M.
  • ACS Infectious Diseases, Vol. 1, Issue 7
  • DOI: 10.1021/acsinfecdis.5b00047

Antibiotics and Bacterial Resistance in the 21st Century
journal, January 2014

  • Fair, Richard J.; Tor, Yitzhak
  • Perspectives in Medicinal Chemistry, Vol. 6
  • DOI: 10.4137/PMC.S14459

Plasmid Incidence in Bacteria from Deep Subsurface Sediments
journal, December 1988

    Sort by:
    [ × clear filter / sort ]

    Similar Records in DOE PAGES and OSTI.GOV collections: