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Title: Recent developments in pretreatment technologies on lignocellulosic biomass: Effect of key parameters, technological improvements, and challenges

Journal Article · · Bioresource Technology
 [1];  [2];  [2];  [3];  [4];  [5];  [6];  [2];  [7];  [1]
  1. Konkuk Univ., Seoul (Korea)
  2. Univ. of Illinois at Urbana-Champaign, IL (United States)
  3. Himachal Pradesh Univ. (India)
  4. Korea Univ., Seoul (Korea)
  5. Central Univ. of Haryana (India)
  6. Anna Univ. Regional Campus, Tirunelveli (India)
  7. Soongsil Univ., Seoul (Korea)

Lignocellulosic biomass is an inexpensive renewable source that can be used to produce biofuels and bioproducts. The recalcitrance nature of biomass hampers polysaccharide accessibility for enzymes and microbes. Several pretreatment methods have been developed for the conversion of lignocellulosic biomass into value-added products. Yet, these pretreatment methods also produce a wide range of secondary compounds, which are inhibitory to enzymes and microorganisms. The selection of an effective and efficient pretreatment method discussed in the review and its process optimization can significantly reduce the production of inhibitory compounds and may lead to enhanced production of fermentable sugars and biochemicals. Furthermore, evolutionary and genetic engineering approaches are being used for the improvement of microbial tolerance towards inhibitors. Advancements in pretreatment and detoxification technologies may help to increase the productivity of lignocellulose-based biorefinery. Here, we discuss the recent advancements in lignocellulosic biomass pretreatment technologies and strategies for the removal of inhibitors.

Research Organization:
Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER); National Research Foundation of Korea (NRF)
Grant/Contract Number:
SC0018420
OSTI ID:
1581310
Alternate ID(s):
OSTI ID: 1702887
Journal Information:
Bioresource Technology, Vol. 300; ISSN 0960-8524
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 363 works
Citation information provided by
Web of Science

References (136)

Simultaneous saccharification and fermentation of oil palm front for the production of 2,3-butanediol journal April 2019
Supercritical fluids as a green technology for the pretreatment of lignocellulosic biomass journal January 2016
Bioconversion of lignocellulose: inhibitors and detoxification journal January 2013
Characterization of a novel endo-β-1,4-glucanase from Armillaria gemina and its application in biomass hydrolysis journal April 2013
Stimulatory effect of in-situ detoxification on bioethanol production by rice straw journal September 2017
From lignin to valuable products–strategies, challenges, and prospects journal January 2019
Pretreatment of lignocellulose: Formation of inhibitory by-products and strategies for minimizing their effects journal January 2016
Recent updates on different methods of pretreatment of lignocellulosic feedstocks: a review journal January 2017
A review on lignin structure, pretreatments, fermentation reactions and biorefinery potential journal January 2019
Effect of microwave-assisted ionic liquid/acidic ionic liquid pretreatment on the morphology, structure, and enhanced delignification of rice straw journal December 2019
Furfural induces reactive oxygen species accumulation and cellular damage in Saccharomyces cerevisiae journal January 2010
Potential of Trametes maxima IIPLC-32 derived laccase for the detoxification of phenolic inhibitors in lignocellulosic biomass prehydrolysate journal September 2018
Biowaste-to-bioenergy using biological methods – A mini-review journal December 2018
Thermostable cellulases: Current status and perspectives journal May 2019
Physiological response of Saccharomyces cerevisiae to weak acids present in lignocellulosic hydrolysate journal November 2014
Pretreatment of food waste for methane and hydrogen recovery: A review journal February 2018
Efficient biomass pretreatment using ionic liquids derived from lignin and hemicellulose journal August 2014
Engineering glutathione biosynthesis of Saccharomyces cerevisiae increases robustness to inhibitors in pretreated lignocellulosic materials journal January 2013
Selective hydrolysis of wheat straw hemicellulose using high-pressure CO 2 as catalyst journal January 2015
Progress on the pre-treatment of lignocellulosic biomass employing ionic liquids journal May 2019
Bioconversion of plant biomass hydrolysate into bioplastic (polyhydroxyalkanoates) using Ralstonia eutropha 5119 journal January 2019
Conversion of Shizochitrium limacinum microalgae to biodiesel by non-catalytic transesterification using various supercritical fluids journal September 2019
Production of galactitol from galactose by the oleaginous yeast Rhodosporidium toruloides IFO0880 journal October 2019
Subcritical carbon dioxide-water hydrolysis of sugarcane bagasse pith for reducing sugars production journal March 2017
Detoxification of corn stover prehydrolyzate by trialkylamine extraction to improve the ethanol production with Pichia stipitis CBS 5776 journal January 2011
Adsorption of furfural from torrefaction condensate using torrefied biomass journal February 2018
Inhibitory effects of lignin on enzymatic hydrolysis: The role of lignin chemistry and molecular weight journal August 2018
Furfural Inhibits Growth by Limiting Sulfur Assimilation in Ethanologenic Escherichia coli Strain LY180 journal August 2009
High vanillin tolerance of an evolved Saccharomyces cerevisiae strain owing to its enhanced vanillin reduction and antioxidative capacity journal September 2014
Enhanced tolerance of Saccharomyces cerevisiae to multiple lignocellulose-derived inhibitors through modulation of spermidine contents journal May 2015
Fermentation of lignocellulosic hydrolysates. I: inhibition and detoxification journal August 2000
Removal of aromatic inhibitors produced from lignocellulosic hydrolysates by Acinetobacter baylyi ADP1 with formation of ethanol by Kluyveromyces marxianus journal April 2019
Increase in furfural tolerance by combinatorial overexpression of NAD salvage pathway enzymes in engineered isobutanol-producing E. coli journal December 2017
A review of lignocellulose bioconversion using enzymatic hydrolysis and synergistic cooperation between enzymes—Factors affecting enzymes, conversion and synergy journal November 2012
High-solids biphasic CO2-H2O pretreatment of lignocellulosic biomass journal June 2010
Strategies for enhancing microbial tolerance to inhibitors for biofuel production: A review journal June 2018
Genome-wide RNAi screen reveals the E3 SUMO-protein ligase gene SIZ1 as a novel determinant of furfural tolerance in Saccharomyces cerevisiae journal January 2014
Phenol-induced membrane changes in free and immobilized Escherichia coli journal April 1990
Molecular and physiological basis of Saccharomyces cerevisiae tolerance to adverse lignocellulose-based process conditions journal November 2018
Inhibition of lignin-derived phenolic compounds to cellulase journal March 2016
Simultaneous organosolv pretreatment and detoxification of municipal solid waste for efficient biobutanol production journal December 2018
Modification of Monolignol Biosynthetic Pathway in Jute: Different Gene, Different Consequence journal January 2017
Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from undetoxified corncob acid hydrolysate journal January 2019
Effect of pretreatment severity on the cellulose and lignin isolated from Salix using ionoSolv pretreatment journal January 2017
Phenolic compounds inhibit cellulase and xylanase activities of Cellulomonas flavigena PR-22 during saccharification of sugarcane bagasse journal May 2017
Genetic modification of wood quality for second-generation biofuel production journal July 2010
Microbial biodiesel production from oil palm biomass hydrolysate using marine Rhodococcus sp. YHY01 journal June 2017
Tolerance improvement of Corynebacterium glutamicum on lignocellulose derived inhibitors by adaptive evolution journal November 2017
Biomass recalcitrance. Part I: the chemical compositions and physical structures affecting the enzymatic hydrolysis of lignocellulose journal March 2012
Insights into exo -Cellulase Inhibition by the Hot Water Hydrolyzates of Rice Straw journal June 2016
Physico-Chemical Alternatives in Lignocellulosic Materials in Relation to the Kind of Component for Fermenting Purposes journal July 2016
Extent of Enzyme Inhibition by Phenolics Derived from Pretreated Biomass Is Significantly Influenced by the Size and Carbonyl Group Content of the Phenolics journal February 2018
Cellulose–hemicellulose interactions at elevated temperatures increase cellulose recalcitrance to biological conversion journal January 2018
One-pot integrated biofuel production using low-cost biocompatible protic ionic liquids journal January 2017
Medium engineering for enhanced production of undecylprodigiosin antibiotic in Streptomyces coelicolor using oil palm biomass hydrolysate as a carbon source journal October 2016
Metabolomic Study of Interactive Effects of Phenol, Furfural, and Acetic Acid on Saccharomyces cerevisiae journal October 2011
Catalyzed flash pretreatments improve saccharification of pine (Pinus radiata) sawdust journal January 1989
Aromatic inhibitors derived from ammonia-pretreated lignocellulose hinder bacterial ethanologenesis by activating regulatory circuits controlling inhibitor efflux and detoxification journal August 2014
Comparison of methods for detoxification of spruce hydrolysate for bacterial cellulose production journal January 2013
Pretreatment of Lignocellulosic Wastes to Improve Ethanol and Biogas Production: A Review journal September 2008
Increased Furfural Tolerance Due to Overexpression of NADH-Dependent Oxidoreductase FucO in Escherichia coli Strains Engineered for the Production of Ethanol and Lactate journal June 2011
Dry biodetoxification of acid pretreated wheat straw for cellulosic ethanol fermentation journal July 2019
Chemical Transformations of Poplar Lignin during Cosolvent Enhanced Lignocellulosic Fractionation Process journal May 2018
Current status and strategies for second generation biofuel production using microbial systems journal September 2017
Carbon Dioxide in Biomass Processing: Contributions to the Green Biorefinery Concept journal November 2014
Metabolic engineering of Clostridium beijerinckii to improve glycerol metabolism and furfural tolerance journal March 2019
Detoxification of Lignocellulose Hydrolysates with Ion-Exchange Resins journal January 2001
Genetic loci simultaneously controlling lignin monomers and biomass digestibility of rice straw journal February 2018
An overview of microdiesel — A sustainable future source of renewable energy journal November 2017
Detoxification of highly acidic hemicellulosic hydrolysate from wheat straw by diananofiltration with a focus on phenolic compounds journal November 2018
Innovative pretreatment strategies for biogas production journal January 2017
Laccases as a Potential Tool for the Efficient Conversion of Lignocellulosic Biomass: A Review journal May 2017
Omics-based analyses revealed metabolic responses of Clostridium acetobutylicum to lignocellulose-derived inhibitors furfural, formic acid and phenol stress for butanol fermentation journal April 2019
Cascade utilization of lignocellulosic biomass to high-value products journal January 2019
Silencing of NADPH-Dependent Oxidoreductase Genes (yqhD and dkgA) in Furfural-Resistant Ethanologenic Escherichia coli journal May 2009
Ionic liquid pretreatment of lignocellulosic biomass with ionic liquid–water mixtures journal January 2011
Detoxification of lignocellulosic hydrolysates using sodium borohydride journal May 2013
Coconut shell activated carbon as an alternative adsorbent of inhibitors from lignocellulosic biomass pretreatment journal October 2019
Adsorptive membranes and resins for acetic acid removal from biomass hydrolysates journal December 2008
Physico-Chemical Conversion of Lignocellulose: Inhibitor Effects and Detoxification Strategies: A Mini Review journal February 2018
Pyrochars from bioenergy residue as novel bio-adsorbents for lignocellulosic hydrolysate detoxification journal July 2015
Enhancing digestibility and ethanol yield of Populus wood via expression of an engineered monolignol 4-O-methyltransferase journal June 2016
A novel film–pore–surface diffusion model to explain the enhanced enzyme adsorption of corn stover pretreated by ultrafine grinding journal August 2016
Microbial conversion of xylose into useful bioproducts journal August 2018
Effect of SC-CO2 pretreatment in increasing rice straw biomass conversion journal August 2010
Adaptability of Trametes versicolor to the lignocellulosic inhibitors furfural, HMF, phenol and levulinic acid during ethanol fermentation journal July 2016
Evolutionary engineered Candida intermedia exhibits improved xylose utilization and robustness to lignocellulose-derived inhibitors and ethanol journal November 2018
Simultaneous concentration and detoxification of lignocellulosic hydrolysates by novel membrane filtration system for bioethanol production journal August 2019
Quantitative glucose release from softwood after pretreatment with low-cost ionic liquids journal January 2019
Production of d-arabitol from d-xylose by the oleaginous yeast Rhodosporidium toruloides IFO0880 journal November 2017
Biomass-derived molecules modulate the behavior of Streptomyces coelicolor for antibiotic production journal October 2016
Identification of a laccase Glac15 from Ganoderma lucidum 77002 and its application in bioethanol production journal March 2015
Separation of furfural from monosaccharides by nanofiltration journal July 2011
Enhancing the stability of ionic liquid media for cellulose processing: acetal protection or carbene suppression? journal January 2016
Enhanced production of glucose and xylose with partial dissolution of corn stover in ionic liquid, 1-Ethyl-3-methylimidazolium acetate journal June 2012
Supercritical CO2 pretreatment of lignocellulose enhances enzymatic cellulose hydrolysis journal April 2001
A comprehensive genome-scale model for Rhodosporidium toruloides IFO0880 accounting for functional genomics and phenotypic data journal December 2019
Development of a novel ultrasound-assisted alkali pretreatment strategy for the production of bioethanol and xylanases from chili post harvest residue journal October 2017
Butanol production from laccase-pretreated brewer’s spent grain journal March 2019
Delignification of Lignocellulosic Biomass and Its Effect on Subsequent Enzymatic Hydrolysis journal February 2015
Detoxification of furanic and phenolic lignocellulose derived inhibitors of yeast using laccase immobilized on bacterial cellulosic nanofibers journal December 2016
Soluble inhibitors/deactivators of cellulase enzymes from lignocellulosic biomass journal April 2011
RNAi-mediated suppression of p-coumaroyl-CoA 3'-hydroxylase in hybrid poplar impacts lignin deposition and soluble secondary metabolism journal March 2008
Survey of Lignin-Structure Changes and Depolymerization during Ionic Liquid Pretreatment journal September 2017
Bioconversion of barley straw lignin into biodiesel using Rhodococcus sp. YHY01 journal October 2019
Removal of furan and phenolic compounds from simulated biomass hydrolysates by batch adsorption and continuous fixed-bed column adsorption methods journal September 2016
The global regulator IrrE from Deinococcus radiodurans enhances the furfural tolerance of Saccharomyces cerevisiae journal August 2018
Co-solvent Pretreatment Reduces Costly Enzyme Requirements for High Sugar and Ethanol Yields from Lignocellulosic Biomass journal February 2015
Saccharification of poplar biomass by using lignocellulases from Pholiota adiposa journal September 2012
Acceleration of biodetoxification on dilute acid pretreated lignocellulose feedstock by aeration and the consequent ethanol fermentation evaluation journal January 2016
Proteomic Profiling, Transcription Factor Modeling, and Genomics of Evolved Tolerant Strains Elucidate Mechanisms of Vanillin Toxicity in Escherichia coli journal June 2019
Lignocellulosic biorefinery as a model for sustainable development of biofuels and value added products journal January 2018
Engineering Sugar Utilization and Microbial Tolerance toward Lignocellulose Conversion journal February 2015
Molecular-level driving forces in lignocellulosic biomass deconstruction for bioenergy journal October 2018
Monitoring and Analyzing Process Streams Towards Understanding Ionic Liquid Pretreatment of Switchgrass (Panicum virgatum L.) journal April 2010
Glycerol supplementation of the growth medium enhances in situ detoxification of furfural by Clostridium beijerinckii during butanol fermentation journal May 2014
The optimized CO2-added ammonia explosion pretreatment for bioethanol production from rice straw journal March 2014
Designing tailored microbial and enzymatic response in ionic liquids for lignocellulosic biorefineries journal April 2018
Genetic engineering of Arabidopsis to overproduce disinapoyl esters, potential lignin modification molecules journal February 2017
Deactivation of cellulases by phenols journal January 2011
Pretreatment of eucalyptus using subcritical CO 2 for sugar production: Pretreatment of eucalyptus using subcritical CO 2 journal July 2014
In situ detoxification of dry dilute acid pretreated corn stover by co-culture of xylose-utilizing and inhibitor-tolerant Saccharomyces cerevisiae increases ethanol production journal October 2016
Understanding biomass recalcitrance in grasses for their efficient utilization as biorefinery feedstock journal October 2018
Comparison of Different Methods for the Detoxification of Lignocellulose Hydrolyzates of Spruce journal January 1999
Environmental application of biochar: Current status and perspectives journal December 2017
Impact of engineered lignin composition on biomass recalcitrance and ionic liquid pretreatment efficiency journal January 2016
Membrane Filtration: Concentration and Purification of Hydrolyzates from Biomass journal June 2008
A review on the biomass pretreatment and inhibitor removal methods as key-steps towards efficient macroalgae-based biohydrogen production journal November 2017
Demonstrating a separation-free process coupling ionic liquid pretreatment, saccharification, and fermentation with Rhodosporidium toruloides to produce advanced biofuels journal January 2018
Structural changes of lignins in natural Populus variants during different pretreatments journal January 2020
Ultrafine grinding of poplar biomass: effect of particle morphology on the liquefaction of biomass for methyl glycosides and phenolics journal March 2019
Inhibitor tolerance of a recombinant flocculating industrial Saccharomyces cerevisiae strain during glucose and xylose co-fermentation journal October 2017
Overcoming factors limiting high-solids fermentation of lignocellulosic biomass to ethanol journal October 2017
Cellulase adsorption on lignin: A roadblock for economic hydrolysis of biomass journal December 2016
Efficient dehydration and recovery of ionic liquid after lignocellulosic processing using pervaporation journal June 2017
Isoprenoids Production from Lipid-Extracted Microalgal Biomass Residues Using Engineered E. coli journal June 2017

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