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Title: Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window

Abstract

With the attractive characteristics of low toxicity, narrow emission spectra, long fluorescence lifetime, and no photobleaching, rare-earth doped nanoparticles (RENPs) have become promising imaging nanoplatforms in the second near-infrared window (NIR-II, 1000–1700 nm). Many studies have been devoted to different surface modification strategies of RENPs to achieve good NIR-II tumor imaging property. However, the tumor imaging efficiency of these approaches remains disappointing. Herein, two methods were pursued to modify RENPs with either polyethylene glycol (PEG) or cancer-cell-membrane to generate PEGylated-RENPs and cancer-cell-membrane camouflaged RENPs (CC-RENPs), respectively. Furthermore, this study demonstrated that cancer-cell-membrane coating of RENPs greatly improved tumor imaging performance in NIR-II window than PEG coating. Besides, CC-RENPs uptakes in liver and spleen significantly decreased. Importantly, CC-RENPs was found to be capable to aid us to pursue precise resection of the tumor. In conclusion, CC-RENPs are capable of targeting tumors and show high tumor NIR-II imaging quality. They are highly promising nanomaterials for future medical applications.

Authors:
ORCiD logo [1];  [2];  [3];  [3];  [3];  [3];  [3];  [4];  [4];  [5];  [4]; ORCiD logo [3]
  1. Stanford University, CA (United States); Huazhong University of Science and Technology, Wuhan (China)
  2. Stanford University, CA (United States); Southern University of Science and Technology, Shenzhen (China)
  3. Stanford University, CA (United States)
  4. Huazhong University of Science and Technology, Wuhan (China)
  5. The Affiliated Tumor Hospital of Shanxi Medical University, Taiyuan (China)
Publication Date:
Research Org.:
Stanford Univ., CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER); National Natural Science Foundation of China (NSFC); China Scholarship Council (CSC)
OSTI Identifier:
1801816
Alternate Identifier(s):
OSTI ID: 1580799
Grant/Contract Number:  
SC0008397; 81630049; 81801738; 81901783; 81571747; 81371628; 201706160068
Resource Type:
Accepted Manuscript
Journal Name:
Chemical Engineering Journal
Additional Journal Information:
Journal Volume: 385; Journal Issue: C; Journal ID: ISSN 1385-8947
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; Engineering; NIR-II imaging; Rare-earth doped nanoparticles; Cancer cell membrane; Tumor imaging; Surgery navigation

Citation Formats

Zhang, Xiao, He, Shuqing, Ding, Bingbing, Qu, Chunrong, Zhang, Qing, Chen, Hao, Sun, Yu, Fang, Hanyi, Long, Yu, Zhang, Ruiping, Lan, Xiaoli, and Cheng, Zhen. Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window. United States: N. p., 2019. Web. doi:10.1016/j.cej.2019.123959.
Zhang, Xiao, He, Shuqing, Ding, Bingbing, Qu, Chunrong, Zhang, Qing, Chen, Hao, Sun, Yu, Fang, Hanyi, Long, Yu, Zhang, Ruiping, Lan, Xiaoli, & Cheng, Zhen. Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window. United States. https://doi.org/10.1016/j.cej.2019.123959
Zhang, Xiao, He, Shuqing, Ding, Bingbing, Qu, Chunrong, Zhang, Qing, Chen, Hao, Sun, Yu, Fang, Hanyi, Long, Yu, Zhang, Ruiping, Lan, Xiaoli, and Cheng, Zhen. Fri . "Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window". United States. https://doi.org/10.1016/j.cej.2019.123959. https://www.osti.gov/servlets/purl/1801816.
@article{osti_1801816,
title = {Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window},
author = {Zhang, Xiao and He, Shuqing and Ding, Bingbing and Qu, Chunrong and Zhang, Qing and Chen, Hao and Sun, Yu and Fang, Hanyi and Long, Yu and Zhang, Ruiping and Lan, Xiaoli and Cheng, Zhen},
abstractNote = {With the attractive characteristics of low toxicity, narrow emission spectra, long fluorescence lifetime, and no photobleaching, rare-earth doped nanoparticles (RENPs) have become promising imaging nanoplatforms in the second near-infrared window (NIR-II, 1000–1700 nm). Many studies have been devoted to different surface modification strategies of RENPs to achieve good NIR-II tumor imaging property. However, the tumor imaging efficiency of these approaches remains disappointing. Herein, two methods were pursued to modify RENPs with either polyethylene glycol (PEG) or cancer-cell-membrane to generate PEGylated-RENPs and cancer-cell-membrane camouflaged RENPs (CC-RENPs), respectively. Furthermore, this study demonstrated that cancer-cell-membrane coating of RENPs greatly improved tumor imaging performance in NIR-II window than PEG coating. Besides, CC-RENPs uptakes in liver and spleen significantly decreased. Importantly, CC-RENPs was found to be capable to aid us to pursue precise resection of the tumor. In conclusion, CC-RENPs are capable of targeting tumors and show high tumor NIR-II imaging quality. They are highly promising nanomaterials for future medical applications.},
doi = {10.1016/j.cej.2019.123959},
journal = {Chemical Engineering Journal},
number = C,
volume = 385,
place = {United States},
year = {Fri Dec 27 00:00:00 EST 2019},
month = {Fri Dec 27 00:00:00 EST 2019}
}

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