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Title: Quality of life trajectories during the first three years after diagnosis of breast cancer: the NEON-BC study

Abstract

Abstract Background We aimed to identify and characterize quality of life trajectories up to 3 years after breast cancer diagnosis. Methods A total of 460 patients were evaluated at baseline (before treatments), and after 1- and 3-years. Patient-reported outcomes, including quality of life (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30, QLQ-C30), anxiety, depression and sleep quality, were assessed in all evaluations. Model-based clustering was used to identify quality of life trajectories. Results We identified four trajectories without intersection during 3 years. The two trajectories characterized by better quality of life depicted relatively stable scores; in the other trajectories, quality of life worsened until 1 year, though in one of them the score at 3 years improved. Sociodemographic and clinical characteristics at baseline did not differ between trajectories, except for mastectomy, which was higher in the worst trajectory. Anxiety, depression and poor sleep quality increased from the best to the worst trajectory. Conclusions The type of surgery and the variation of other patient-reported outcomes were associated with the course of quality of life over 3 years. More research to understand the heterogeneity of individual trajectories within these major patterns of variation is needed.

Authors:
 [1];  [2];  [1];  [1];  [3];  [1];  [4];  [4]; ORCiD logo [1]
  1. EPIUnit—Instituto de Saúde Pública, Universidade do Porto, 4050-600 Porto, Portugal, Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal
  2. EPIUnit—Instituto de Saúde Pública, Universidade do Porto, 4050-600 Porto, Portugal, Academic Promoting Team, Institut Jules Bordet, 1000 Brussels, Belgium
  3. Instituto Português de Oncologia do Porto, Rua Dr. António Bernardino de Almeida, 4200-075 Porto, Portugal
  4. EPIUnit—Instituto de Saúde Pública, Universidade do Porto, 4050-600 Porto, Portugal, Instituto Português de Oncologia do Porto, Rua Dr. António Bernardino de Almeida, 4200-075 Porto, Portugal
Publication Date:
Sponsoring Org.:
USDOE Office of Nuclear Energy (NE), Fuel Cycle Technologies (NE-5)
OSTI Identifier:
1580607
Resource Type:
Published Article
Journal Name:
Journal of Public Health
Additional Journal Information:
Journal Name: Journal of Public Health; Journal ID: ISSN 1741-3842
Publisher:
Oxford University Press
Country of Publication:
Country unknown/Code not available
Language:
English

Citation Formats

Lopes-Conceição, Luisa, Brandão, Mariana, Araújo, Natália, Severo, Milton, Dias, Teresa, Peleteiro, Bárbara, Fontes, Filipa, Pereira, Susana, and Lunet, Nuno. Quality of life trajectories during the first three years after diagnosis of breast cancer: the NEON-BC study. Country unknown/Code not available: N. p., 2019. Web. doi:10.1093/pubmed/fdz159.
Lopes-Conceição, Luisa, Brandão, Mariana, Araújo, Natália, Severo, Milton, Dias, Teresa, Peleteiro, Bárbara, Fontes, Filipa, Pereira, Susana, & Lunet, Nuno. Quality of life trajectories during the first three years after diagnosis of breast cancer: the NEON-BC study. Country unknown/Code not available. doi:10.1093/pubmed/fdz159.
Lopes-Conceição, Luisa, Brandão, Mariana, Araújo, Natália, Severo, Milton, Dias, Teresa, Peleteiro, Bárbara, Fontes, Filipa, Pereira, Susana, and Lunet, Nuno. Fri . "Quality of life trajectories during the first three years after diagnosis of breast cancer: the NEON-BC study". Country unknown/Code not available. doi:10.1093/pubmed/fdz159.
@article{osti_1580607,
title = {Quality of life trajectories during the first three years after diagnosis of breast cancer: the NEON-BC study},
author = {Lopes-Conceição, Luisa and Brandão, Mariana and Araújo, Natália and Severo, Milton and Dias, Teresa and Peleteiro, Bárbara and Fontes, Filipa and Pereira, Susana and Lunet, Nuno},
abstractNote = {Abstract Background We aimed to identify and characterize quality of life trajectories up to 3 years after breast cancer diagnosis. Methods A total of 460 patients were evaluated at baseline (before treatments), and after 1- and 3-years. Patient-reported outcomes, including quality of life (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30, QLQ-C30), anxiety, depression and sleep quality, were assessed in all evaluations. Model-based clustering was used to identify quality of life trajectories. Results We identified four trajectories without intersection during 3 years. The two trajectories characterized by better quality of life depicted relatively stable scores; in the other trajectories, quality of life worsened until 1 year, though in one of them the score at 3 years improved. Sociodemographic and clinical characteristics at baseline did not differ between trajectories, except for mastectomy, which was higher in the worst trajectory. Anxiety, depression and poor sleep quality increased from the best to the worst trajectory. Conclusions The type of surgery and the variation of other patient-reported outcomes were associated with the course of quality of life over 3 years. More research to understand the heterogeneity of individual trajectories within these major patterns of variation is needed.},
doi = {10.1093/pubmed/fdz159},
journal = {Journal of Public Health},
number = ,
volume = ,
place = {Country unknown/Code not available},
year = {2019},
month = {12}
}

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