Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework

doi:10.1021/acs.cgd.9b01457

Title: Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework

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Abstract

β-Cyclodextrin is well-known in cellular biology for its ability to moderate cholesterol levels in lipid bilayer membranes. Its use in extended network solids remains elusive due to the low symmetry of this macrocyclic system. Self-assembly of two different β-cyclodextrin metal–organic frameworks (MOFs) with extended nanotube structures is achieved by crystallization with excess potassium hydroxide, one in the presence of cholesterol. Here, we then further demonstrate the proclivity of one of these MOFs to absorb cholesterol and two other sterols from solution using NMR and confocal microscopy techniques. Finally, this work demonstrates that these network solids show great potential in both substrate delivery and/or extraction.

Authors:

^[1]; Ahmad, Towseef I. ^[2];

^[2]; Jennings, Christopher S. ^[3]; Ferland, Livia I. ^[3]; Teat, Simon J. ^[4];

^[5]

Univ. of New Brunswick, Fredericton NB (Canada); Univ. of Kent, Canterbury (United States)
Univ. of Kent, Canterbury (United States)
Univ. of New Brunswick, Fredericton NB (Canada)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)
Univ. of Kent, Canterbury, KY (United States)

Publication Date:: 2019-11-15

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES); Univ. of Kent, Canterbury (United States)

OSTI Identifier:: 1580424

Grant/Contract Number:: AC02-05CH11231

Resource Type:: Accepted Manuscript

Journal Name:: Crystal Growth and Design

Additional Journal Information:: Journal Volume: 20; Journal Issue: 1; Journal ID: ISSN 1528-7483

Publisher:: American Chemical Society

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; coordination networks; metal-organic frameworks; cyclodextrin; cholesterol; organic molecule absorption

Citation Formats


                    Blight, Barry A., Ahmad, Towseef I., Shepherd, Helena J., Jennings, Christopher S., Ferland, Livia I., Teat, Simon J., and Rossman, Jeremy S. Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework.  United States: N. p., 2019. 
        Web.  doi:10.1021/acs.cgd.9b01457.

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                    Blight, Barry A., Ahmad, Towseef I., Shepherd, Helena J., Jennings, Christopher S., Ferland, Livia I., Teat, Simon J., & Rossman, Jeremy S. Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework.  United States.  doi:https://doi.org/10.1021/acs.cgd.9b01457

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                    Blight, Barry A., Ahmad, Towseef I., Shepherd, Helena J., Jennings, Christopher S., Ferland, Livia I., Teat, Simon J., and Rossman, Jeremy S. Fri .  
        "Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework".  United States.  doi:https://doi.org/10.1021/acs.cgd.9b01457.  https://www.osti.gov/servlets/purl/1580424.

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@article{osti_1580424,

  title        = {Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework},

  author       = {Blight, Barry A. and Ahmad, Towseef I. and Shepherd, Helena J. and Jennings, Christopher S. and Ferland, Livia I. and Teat, Simon J. and Rossman, Jeremy S.},

  abstractNote = {β-Cyclodextrin is well-known in cellular biology for its ability to moderate cholesterol levels in lipid bilayer membranes. Its use in extended network solids remains elusive due to the low symmetry of this macrocyclic system. Self-assembly of two different β-cyclodextrin metal–organic frameworks (MOFs) with extended nanotube structures is achieved by crystallization with excess potassium hydroxide, one in the presence of cholesterol. Here, we then further demonstrate the proclivity of one of these MOFs to absorb cholesterol and two other sterols from solution using NMR and confocal microscopy techniques. Finally, this work demonstrates that these network solids show great potential in both substrate delivery and/or extraction.},

  doi          = {10.1021/acs.cgd.9b01457},

  journal      = {Crystal Growth and Design},

  number       = 1,

  volume       = 20,

  place        = {United States},

  year         = {2019},

  month        = {11}

}

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DOI: https://doi.org/10.1021/acs.cgd.9b01457

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