Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework

Blight, Barry A.; Ahmad, Towseef I.; Shepherd, Helena J.; Jennings, Christopher S.; Ferland, Livia I.; Teat, Simon J.; Rossman, Jeremy S.

doi:10.1021/acs.cgd.9b01457

Title: Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework

Journal Article · 14 November 2019 · Crystal Growth and Design

DOI: https://doi.org/10.1021/acs.cgd.9b01457 · OSTI ID:1580424

^[1]; Ahmad, Towseef I. ^[2];

^[2]; Jennings, Christopher S. ^[3]; Ferland, Livia I. ^[3]; Teat, Simon J. ^[4];

^[5]

Univ. of New Brunswick, Fredericton NB (Canada); Univ. of Kent, Canterbury (United States)
Univ. of Kent, Canterbury (United States)
Univ. of New Brunswick, Fredericton NB (Canada)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)
Univ. of Kent, Canterbury, KY (United States)

β-Cyclodextrin is well-known in cellular biology for its ability to moderate cholesterol levels in lipid bilayer membranes. Its use in extended network solids remains elusive due to the low symmetry of this macrocyclic system. Self-assembly of two different β-cyclodextrin metal–organic frameworks (MOFs) with extended nanotube structures is achieved by crystallization with excess potassium hydroxide, one in the presence of cholesterol. Here, we then further demonstrate the proclivity of one of these MOFs to absorb cholesterol and two other sterols from solution using NMR and confocal microscopy techniques. Finally, this work demonstrates that these network solids show great potential in both substrate delivery and/or extraction.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); Univ. of Kent, Canterbury (United States)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1580424

Journal Information:: Crystal Growth and Design, Journal Name: Crystal Growth and Design Journal Issue: 1 Vol. 20; ISSN 1528-7483

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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CCDC 1959833: Experimental Crystal Structure Determination A., Blight, Barry; I., Ahmad, Towseef; J., Shepherd, Helena https://doi.org/10.5517/ccdc.csd.cc23scfq The current record is supplemented by this dataset	dataset	January 2019
CCDC 1959832: Experimental Crystal Structure Determination A., Blight, Barry; I., Ahmad, Towseef; J., Shepherd, Helena https://doi.org/10.5517/ccdc.csd.cc23scdp The current record is supplemented by this dataset	dataset	January 2019

Title: Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework

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