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Title: Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework

Journal Article · · Crystal Growth and Design
ORCiD logo [1];  [2]; ORCiD logo [2];  [3];  [3];  [4]; ORCiD logo [5]
  1. Univ. of New Brunswick, Fredericton NB (Canada); Univ. of Kent, Canterbury (United States)
  2. Univ. of Kent, Canterbury (United States)
  3. Univ. of New Brunswick, Fredericton NB (Canada)
  4. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)
  5. Univ. of Kent, Canterbury, KY (United States)

β-Cyclodextrin is well-known in cellular biology for its ability to moderate cholesterol levels in lipid bilayer membranes. Its use in extended network solids remains elusive due to the low symmetry of this macrocyclic system. Self-assembly of two different β-cyclodextrin metal–organic frameworks (MOFs) with extended nanotube structures is achieved by crystallization with excess potassium hydroxide, one in the presence of cholesterol. Here, we then further demonstrate the proclivity of one of these MOFs to absorb cholesterol and two other sterols from solution using NMR and confocal microscopy techniques. Finally, this work demonstrates that these network solids show great potential in both substrate delivery and/or extraction.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); Univ. of Kent, Canterbury (United States)
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1580424
Journal Information:
Crystal Growth and Design, Journal Name: Crystal Growth and Design Journal Issue: 1 Vol. 20; ISSN 1528-7483
Publisher:
American Chemical SocietyCopyright Statement
Country of Publication:
United States
Language:
English

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