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Title: Interfacing the Cell with “Biomimetic Membrane Proteins”

Abstract

Integral membrane proteins mediate a myriad of cellular processes and are the target of many therapeutic drugs. Enhancement and extension of the functional scope of membrane proteins can be realized by membrane incorporation of engineered nanoparticles designed for specific diagnostic and therapeutic applications. In contrast to hydrophobic insertion of small amphiphilic molecules, delivery and membrane incorporation of particles on the nanometric scale poses a crucial barrier for technological development. In this perspective, the transformative potential of biomimetic membrane proteins (BMPs), current state of the art, and the barriers that need to be overcome in order to advance the field are discussed.

Authors:
ORCiD logo [1];  [2];  [1];  [1];  [1];  [1]; ORCiD logo [1]; ORCiD logo [3]; ORCiD logo [4]
+ Show Author Affiliations
  1. Department of Physics Institute for Nanotechnology and Advanced Materials Bar‐Ilan University Ramat‐Gan 5290002 Israel, Institute for Nanotechnology and Advanced Materials Bar‐Ilan University Ramat‐Gan 5290002 Israel
  2. Agricultural Research Organization The Volcani Center Institute of Agricultural Engineering Rishon LeZion 7505101 Israel
  3. Institute for Nanotechnology and Advanced Materials Bar‐Ilan University Ramat‐Gan 5290002 Israel, School of Optometry and Vision Science Faculty of Life Sciences Bar‐Ilan University Ramat‐Gan 5290002 Israel
  4. Department of Physics Institute for Nanotechnology and Advanced Materials Bar‐Ilan University Ramat‐Gan 5290002 Israel, Institute for Nanotechnology and Advanced Materials Bar‐Ilan University Ramat‐Gan 5290002 Israel, Department of Chemistry and Biochemistry University of California Los Angeles Los Angeles CA 90095 USA, California NanoSystems Institute University of California Los Angeles Los Angeles CA 90095 USA
Publication Date:
Research Org.:
Univ. of California, Los Angeles, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
OSTI Identifier:
1580284
Alternate Identifier(s):
OSTI ID: 1580286; OSTI ID: 1831518
Grant/Contract Number:  
FC03-02ER63421
Resource Type:
Published Article
Journal Name:
Small
Additional Journal Information:
Journal Name: Small Journal Volume: 15 Journal Issue: 52; Journal ID: ISSN 1613-6810
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
Germany
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; biomimetic membrane proteins; membrane proteins; nanoparticles insertion into membranes; nanorods; quantum dots

Citation Formats

Grupi, Asaf, Ashur, Idan, Degani‐Katzav, Nurit, Yudovich, Shimon, Shapira, Zehavit, Marzouq, Adan, Morgenstein, Lion, Mandel, Yossi, and Weiss, Shimon. Interfacing the Cell with “Biomimetic Membrane Proteins”. Germany: N. p., 2019. Web. doi:10.1002/smll.201903006.
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Grupi, Asaf, Ashur, Idan, Degani‐Katzav, Nurit, Yudovich, Shimon, Shapira, Zehavit, Marzouq, Adan, Morgenstein, Lion, Mandel, Yossi, & Weiss, Shimon. Interfacing the Cell with “Biomimetic Membrane Proteins”. Germany. https://doi.org/10.1002/smll.201903006
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Grupi, Asaf, Ashur, Idan, Degani‐Katzav, Nurit, Yudovich, Shimon, Shapira, Zehavit, Marzouq, Adan, Morgenstein, Lion, Mandel, Yossi, and Weiss, Shimon. Mon . "Interfacing the Cell with “Biomimetic Membrane Proteins”". Germany. https://doi.org/10.1002/smll.201903006.
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@article{osti_1580284,
title = {Interfacing the Cell with “Biomimetic Membrane Proteins”},
author = {Grupi, Asaf and Ashur, Idan and Degani‐Katzav, Nurit and Yudovich, Shimon and Shapira, Zehavit and Marzouq, Adan and Morgenstein, Lion and Mandel, Yossi and Weiss, Shimon},
abstractNote = {Integral membrane proteins mediate a myriad of cellular processes and are the target of many therapeutic drugs. Enhancement and extension of the functional scope of membrane proteins can be realized by membrane incorporation of engineered nanoparticles designed for specific diagnostic and therapeutic applications. In contrast to hydrophobic insertion of small amphiphilic molecules, delivery and membrane incorporation of particles on the nanometric scale poses a crucial barrier for technological development. In this perspective, the transformative potential of biomimetic membrane proteins (BMPs), current state of the art, and the barriers that need to be overcome in order to advance the field are discussed.},
doi = {10.1002/smll.201903006},
journal = {Small},
number = 52,
volume = 15,
place = {Germany},
year = {2019},
month = {11}
}
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  • DOI: 10.1016/j.bbamem.2014.07.027

Shape control of CdSe nanocrystals
journal, March 2000

  • Peng, Xiaogang; Manna, Liberato; Yang, Weidong
  • Nature, Vol. 404, Issue 6773, p. 59-61
  • DOI: 10.1038/35003535

DNA-Tile Structures Induce Ionic Currents through Lipid Membranes
journal, April 2015

Reengineering the Optical Absorption Cross-Section of Photosynthetic Reaction Centers
journal, March 2014

  • Dutta, Palash K.; Lin, Su; Loskutov, Andrey
  • Journal of the American Chemical Society, Vol. 136, Issue 12
  • DOI: 10.1021/ja411843k

The Brain Activity Map Project and the Challenge of Functional Connectomics
journal, June 2012

Hydrophobic Gold Nanoparticle Self-Assembly with Phosphatidylcholine Lipid: Membrane-Loaded and Janus Vesicles
journal, September 2010

  • Rasch, Michael R.; Rossinyol, Emma; Hueso, Jose L.
  • Nano Letters, Vol. 10, Issue 9
  • DOI: 10.1021/nl102387n

A jump-start for electroceuticals
journal, April 2013

  • Famm, Kristoffer; Litt, Brian; Tracey, Kevin J.
  • Nature, Vol. 496, Issue 7444
  • DOI: 10.1038/496159a

Free energy change for insertion of charged, monolayer-protected nanoparticles into lipid bilayers
journal, January 2014

  • Van Lehn, Reid C.; Alexander-Katz, Alfredo
  • Soft Matter, Vol. 10, Issue 4
  • DOI: 10.1039/C3SM52329B

Colloidal Quantum Dots as Probes of Excitation Field Enhancement in Photonic Antennas
journal, July 2010

  • Aouani, Heykel; Itzhakov, Stella; Gachet, David
  • ACS Nano, Vol. 4, Issue 8
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Organic Bioelectronics: Bridging the Signaling Gap between Biology and Technology
journal, July 2016

Design of membrane proteins: toward functional systems
journal, December 2009

Surface-structure-regulated penetration of nanoparticles across a cell membrane
journal, January 2012

  • Li, Yinfeng; Li, Xuejin; Li, Zhonghua
  • Nanoscale, Vol. 4, Issue 12
  • DOI: 10.1039/c2nr30379e

Large-Conductance Transmembrane Porin Made from DNA Origami
journal, August 2016

Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory
journal, June 2015

  • Cournia, Zoe; Allen, Toby W.; Andricioaei, Ioan
  • The Journal of Membrane Biology, Vol. 248, Issue 4
  • DOI: 10.1007/s00232-015-9802-0

Nano-Bioelectronics
journal, December 2015

Energy landscape for the insertion of amphiphilic nanoparticles into lipid membranes: A computational study
journal, January 2019

Folding membrane proteins in vitro: A table and some comments
journal, December 2014

Fusion of Ligand-Coated Nanoparticles with Lipid Bilayers: Effect of Ligand Flexibility
journal, May 2014

  • Van Lehn, Reid C.; Alexander-Katz, Alfredo
  • The Journal of Physical Chemistry A, Vol. 118, Issue 31
  • DOI: 10.1021/jp411662c

Membrane sculpting by curved DNA origami scaffolds
journal, February 2018

  • Franquelim, Henri G.; Khmelinskaia, Alena; Sobczak, Jean-Philippe
  • Nature Communications, Vol. 9, Issue 1
  • DOI: 10.1038/s41467-018-03198-9

Trends in the exploitation of novel drug targets
journal, August 2011

  • Rask-Andersen, Mathias; Almén, Markus Sällman; Schiöth, Helgi B.
  • Nature Reviews Drug Discovery, Vol. 10, Issue 8
  • DOI: 10.1038/nrd3478

Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers
journal, August 2013

  • Van Lehn, Reid C.; Atukorale, Prabhani U.; Carney, Randy P.
  • Nano Letters, Vol. 13, Issue 9
  • DOI: 10.1021/nl401365n

Photocatalytic Hydrogen Production with Tunable Nanorod Heterostructures
journal, March 2010

  • Amirav, Lilac; Alivisatos, A. Paul
  • The Journal of Physical Chemistry Letters, Vol. 1, Issue 7
  • DOI: 10.1021/jz100075c

Synthetic and Natural Polycationic Polymer Nanoparticles Interact Selectively with Fluid-Phase Domains of DMPC Lipid Bilayers
journal, September 2005

  • Mecke, Almut; Lee, Dong-Kuk; Ramamoorthy, Ayyalusamy
  • Langmuir, Vol. 21, Issue 19
  • DOI: 10.1021/la051800w
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