Prostaglandin E 2 receptor EP4 regulates cell migration through Orai1

Osawa, Kohei; Umemura, Masanari; Nakakaji, Rina; Tanaka, Ryo; Islam, Rafikul Md; Nagasako, Akane; Fujita, Takayuki; Yokoyama, Utako; Koizumi, Toshiyuki; Mitsudo, Kenji; Ishikawa, Yoshihiro

doi:10.1111/cas.14247

Title: Prostaglandin E ₂ receptor EP4 regulates cell migration through Orai1

Authors:

Osawa, Kohei ^[1];

^[2]; Nakakaji, Rina ^[1]; Tanaka, Ryo ^[2]; Islam, Rafikul Md ^[2]; Nagasako, Akane ^[2]; Fujita, Takayuki ^[2]; Yokoyama, Utako ^[3]; Koizumi, Toshiyuki ^[4]; Mitsudo, Kenji ^[4]; Ishikawa, Yoshihiro ^[2]

Cardiovascular Research Institute Yokohama City University Graduate School of Medicine Yokohama Japan, Department of Oral and Maxillofacial Surgery Yokohama City University Graduate School of Medicine Yokohama Japan
Cardiovascular Research Institute Yokohama City University Graduate School of Medicine Yokohama Japan
Cardiovascular Research Institute Yokohama City University Graduate School of Medicine Yokohama Japan, Department of Physiology Tokyo Medical University Graduate School of Medicine Tokyo Japan
Department of Oral and Maxillofacial Surgery Yokohama City University Graduate School of Medicine Yokohama Japan

Publication Date:: 2019-12-18

Sponsoring Org.:: USDOE

OSTI Identifier:: 1579781

Alternate Identifier(s):: OSTI ID: 1579782

Resource Type:: Published Article

Journal Name:: Cancer Science

Additional Journal Information:: Journal Name: Cancer Science Journal Volume: 111 Journal Issue: 1; Journal ID: ISSN 1347-9032

Publisher:: Wiley-Blackwell

Country of Publication:: Japan

Language:: English

Citation Formats


                    Osawa, Kohei, Umemura, Masanari, Nakakaji, Rina, Tanaka, Ryo, Islam, Rafikul Md, Nagasako, Akane, Fujita, Takayuki, Yokoyama, Utako, Koizumi, Toshiyuki, Mitsudo, Kenji, and Ishikawa, Yoshihiro. Prostaglandin E 2 receptor EP4 regulates cell migration through Orai1.  Japan: N. p., 2019. 
Web.  doi:10.1111/cas.14247.

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                    Osawa, Kohei, Umemura, Masanari, Nakakaji, Rina, Tanaka, Ryo, Islam, Rafikul Md, Nagasako, Akane, Fujita, Takayuki, Yokoyama, Utako, Koizumi, Toshiyuki, Mitsudo, Kenji, & Ishikawa, Yoshihiro. Prostaglandin E 2 receptor EP4 regulates cell migration through Orai1.  Japan.  https://doi.org/10.1111/cas.14247

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                    Osawa, Kohei, Umemura, Masanari, Nakakaji, Rina, Tanaka, Ryo, Islam, Rafikul Md, Nagasako, Akane, Fujita, Takayuki, Yokoyama, Utako, Koizumi, Toshiyuki, Mitsudo, Kenji, and Ishikawa, Yoshihiro. Wed .  
"Prostaglandin E 2 receptor EP4 regulates cell migration through Orai1".  Japan.  https://doi.org/10.1111/cas.14247.

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@article{osti_1579781,

  title        = {Prostaglandin E 2 receptor EP4 regulates cell migration through Orai1},

  author       = {Osawa, Kohei and Umemura, Masanari and Nakakaji, Rina and Tanaka, Ryo and Islam, Rafikul Md and Nagasako, Akane and Fujita, Takayuki and Yokoyama, Utako and Koizumi, Toshiyuki and Mitsudo, Kenji and Ishikawa, Yoshihiro},

  abstractNote = {},

  doi          = {10.1111/cas.14247},

  journal      = {Cancer Science},

  number       = 1,

  volume       = 111,

  place        = {Japan},

  year         = {2019},

  month        = {12}

}

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https://doi.org/10.1111/cas.14247

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Works referenced in this record:

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Title: Prostaglandin E 2 receptor EP4 regulates cell migration through Orai1

Citation Formats

Misoprostol elevates intracellular calcium in Neuro-2a cells via protein kinase A journal, September 2010

Changes in Survival in Head and Neck Cancers in the Late 20th and Early 21st Century: A Period Analysis journal, August 2010

Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles journal, April 2016

Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling journal, May 2014

Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling journal, April 2018

Geraniin inhibits oral cancer cell migration by suppressing matrix metalloproteinase‐2 activation through the FAK/Src and ERK pathways journal, June 2019

Aspirin Use and Reduced Risk of Fatal Colon Cancer journal, December 1991

Prostaglandin E2 Promotes Lung Cancer Cell Migration via EP4- Arrestin1-c-Src Signalsome journal, March 2010

A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm journal, September 2018

Endothelin-1-induced Prostaglandin E2-EP2, EP4 Signaling Regulates Vascular Endothelial Growth Factor Production and Ovarian Carcinoma Cell Invasion journal, September 2004

ORAI channels in cellular remodeling of cardiorespiratory disease journal, May 2019

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function journal, April 2006

EP4 as a Therapeutic Target for Aggressive Human Breast Cancer journal, March 2018

Rab5a is overexpressed in oral cancer and promotes invasion through ERK/MMP signaling journal, August 2017

PGE2 promotes renal carcinoma cell invasion through activated RalA journal, May 2012

The Prostanoid EP4 Receptor and Its Signaling Pathway journal, June 2013

A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry journal, February 2009

Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2 journal, July 2011

Calcium regulates ERK signaling by modulating its protein-protein interactions journal, July 2008

CRAC channels and disease – From human CRAC channelopathies and animal models to novel drugs journal, June 2019

Crossroads of PI3K and Rac pathways journal, April 2015

Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis journal, June 2016

Downregulated expression of hepatoma-derived growth factor inhibits migration and invasion of prostate cancer cells by suppressing epithelial-mesenchymal transition and MMP2, MMP9 journal, January 2018

Orai proteins interact with TRPC channels and confer responsiveness to store depletion journal, March 2007

Calcium signalling: dynamics, homeostasis and remodelling journal, July 2003

Treatment of oral cancer using magnetized paclitaxel journal, February 2018

Current concepts in management of oral cancer – Surgery journal, April 2009

ERK signalling as a regulator of cell motility journal, July 2017

Prostaglandin E 2 Induced Functional Expression of Early Growth Response Factor-1 by EP 4 , but Not EP 2 , Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated Kinases journal, February 2003

Transient receptor potential cation 3 channel regulates melanoma proliferation and migration journal, September 2016

The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells journal, August 2007

EP4 receptor stimulation down-regulates human eosinophil function journal, March 2011

Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation journal, December 2015

Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation journal, May 2012

Targeting neddylation inhibits intravascular survival and extravasation of cancer cells to prevent lung-cancer metastasis journal, May 2019

Epidermal Growth Factor Receptor Activation of Calpain Is Required for Fibroblast Motility and Occurs via an ERK/MAP Kinase Signaling Pathway journal, January 2000

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The dynamic complexity of the TRPC1 channelosome journal, September 2011

Host and Direct Antitumor Effects and Profound Reduction in Tumor Metastasis with Selective EP4 Receptor Antagonism journal, October 2006

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Title: Prostaglandin E ₂ receptor EP4 regulates cell migration through Orai1

Misoprostol elevates intracellular calcium in Neuro-2a cells via protein kinase A
journal, September 2010

Changes in Survival in Head and Neck Cancers in the Late 20th and Early 21st Century: A Period Analysis
journal, August 2010

Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles
journal, April 2016

Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling
journal, May 2014

Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling
journal, April 2018

Geraniin inhibits oral cancer cell migration by suppressing matrix metalloproteinase‐2 activation through the FAK/Src and ERK pathways
journal, June 2019

Aspirin Use and Reduced Risk of Fatal Colon Cancer
journal, December 1991

Prostaglandin E2 Promotes Lung Cancer Cell Migration via EP4- Arrestin1-c-Src Signalsome
journal, March 2010

A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm
journal, September 2018

Endothelin-1-induced Prostaglandin E2-EP2, EP4 Signaling Regulates Vascular Endothelial Growth Factor Production and Ovarian Carcinoma Cell Invasion
journal, September 2004

ORAI channels in cellular remodeling of cardiorespiratory disease
journal, May 2019

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
journal, April 2006

EP4 as a Therapeutic Target for Aggressive Human Breast Cancer
journal, March 2018

Rab5a is overexpressed in oral cancer and promotes invasion through ERK/MMP signaling
journal, August 2017

PGE2 promotes renal carcinoma cell invasion through activated RalA
journal, May 2012

The Prostanoid EP4 Receptor and Its Signaling Pathway
journal, June 2013

A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry
journal, February 2009

Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2
journal, July 2011

Calcium regulates ERK signaling by modulating its protein-protein interactions
journal, July 2008

CRAC channels and disease – From human CRAC channelopathies and animal models to novel drugs
journal, June 2019

Crossroads of PI3K and Rac pathways
journal, April 2015

Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis
journal, June 2016

Downregulated expression of hepatoma-derived growth factor inhibits migration and invasion of prostate cancer cells by suppressing epithelial-mesenchymal transition and MMP2, MMP9
journal, January 2018

Orai proteins interact with TRPC channels and confer responsiveness to store depletion
journal, March 2007

Calcium signalling: dynamics, homeostasis and remodelling
journal, July 2003

Treatment of oral cancer using magnetized paclitaxel
journal, February 2018

Current concepts in management of oral cancer – Surgery
journal, April 2009

ERK signalling as a regulator of cell motility
journal, July 2017

Prostaglandin E ₂ Induced Functional Expression of Early Growth Response Factor-1 by EP ₄ , but Not EP ₂ , Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated Kinases
journal, February 2003

Transient receptor potential cation 3 channel regulates melanoma proliferation and migration
journal, September 2016

The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells
journal, August 2007

EP4 receptor stimulation down-regulates human eosinophil function
journal, March 2011

Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation
journal, December 2015

Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation
journal, May 2012

Targeting neddylation inhibits intravascular survival and extravasation of cancer cells to prevent lung-cancer metastasis
journal, May 2019

Epidermal Growth Factor Receptor Activation of Calpain Is Required for Fibroblast Motility and Occurs via an ERK/MAP Kinase Signaling Pathway
journal, January 2000

Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration
journal, February 2014

The dynamic complexity of the TRPC1 channelosome
journal, September 2011

Host and Direct Antitumor Effects and Profound Reduction in Tumor Metastasis with Selective EP4 Receptor Antagonism
journal, October 2006

Capacitative calcium entry
journal, May 2005

Alternating magnetic field enhances cytotoxicity of Compound C
journal, October 2018

Proneoplastic effects of PGE2mediated by EP4 receptor in colorectal cancer
journal, June 2009

PI3K and Calcium Signaling in Cardiovascular Disease
journal, July 2017

The Role of Nonerythroid Spectrin $α$ II in Cancer
journal, May 2019

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface
journal, December 2018

Hydrostatic pressure suppresses fibrotic changes via Akt/GSK-3 signaling in human cardiac fibroblasts
journal, May 2018

Prostaglandin E ₂ Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling
journal, January 2014

Prostaglandin E2 receptor EP4 agonist induces Bcl-xL and independently activates proliferation signals in mouse primary hepatocytes
journal, July 2005

Epac1 promotes melanoma metastasis via modification of heparan sulfate: Epac1 regulates melanoma metastasis
journal, May 2011

Prostaglandin E Receptors
journal, February 2007

Cancer Statistics, 2010
journal, July 2010

Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor
journal, December 2018