Synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions
Abstract
Recent advances in metabolic engineering have enabled the production of chemicals via bio-conversion using microbes. However, downstream separation accounts for 60–80% of the total production cost in many cases. Previous work on microbial production of extracellular chemicals has been mainly restricted to microbiology, biochemistry, metabolomics, or techno-economic analysis for specific product examples such as succinic acid, xanthan gum, lycopene, etc. In these studies, microbial production and separation technologies were selected apriori without considering any competing alternatives. However, technology selection in downstream separation and purification processes can have a major impact on the overall costs, product recovery, and purity. To this end, we apply a superstructure optimization based framework that enables the identification of critical technologies and their associated parameters in the synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions. We divide extracellular chemicals into three categories based on their physical properties, such as water solubility, physical state, relative density, volatility, etc. We analyze three major extracellular product categories (insoluble light, insoluble heavy and soluble) in detail and provide suggestions for additional product categories through extension of our analysis framework. The proposed analysis and results provide significant insights for technology selection and enable streamlined decision makingmore »
- Authors:
-
[2];
- Univ. of Wisconsin, Madison, WI (United States). Great Lakes Bioenergy Research Center
- Univ. of Wisconsin, Madison, WI (United States). Great Lakes Bioenergy Research Center; Rowan Univ., Glassboro, NJ (United States)
- Publication Date:
- Research Org.:
- Univ. of Wisconsin, Madison, WI (United States). Great Lakes Bioenergy Research Center
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1579537
- Grant/Contract Number:
- SC0018409
- Resource Type:
- Accepted Manuscript
- Journal Name:
- BMC Chemical Engineering
- Additional Journal Information:
- Journal Volume: 1; Journal Issue: 1; Journal ID: ISSN 2524-4175
- Publisher:
- Springer
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Process systems engineering; Downstream separation; Superstructure optimization; Technology selection; Bio-based chemicals
Citation Formats
Wu, Wenzhao, Yenkie, Kirti M., and Maravelias, Christos T. Synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions. United States: N. p., 2019.
Web. doi:10.1186/s42480-019-0022-8.
Wu, Wenzhao, Yenkie, Kirti M., & Maravelias, Christos T. Synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions. United States. doi:https://doi.org/10.1186/s42480-019-0022-8
Wu, Wenzhao, Yenkie, Kirti M., and Maravelias, Christos T. Mon .
"Synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions". United States. doi:https://doi.org/10.1186/s42480-019-0022-8. https://www.osti.gov/servlets/purl/1579537.
@article{osti_1579537,
title = {Synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions},
author = {Wu, Wenzhao and Yenkie, Kirti M. and Maravelias, Christos T.},
abstractNote = {Recent advances in metabolic engineering have enabled the production of chemicals via bio-conversion using microbes. However, downstream separation accounts for 60–80% of the total production cost in many cases. Previous work on microbial production of extracellular chemicals has been mainly restricted to microbiology, biochemistry, metabolomics, or techno-economic analysis for specific product examples such as succinic acid, xanthan gum, lycopene, etc. In these studies, microbial production and separation technologies were selected apriori without considering any competing alternatives. However, technology selection in downstream separation and purification processes can have a major impact on the overall costs, product recovery, and purity. To this end, we apply a superstructure optimization based framework that enables the identification of critical technologies and their associated parameters in the synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions. We divide extracellular chemicals into three categories based on their physical properties, such as water solubility, physical state, relative density, volatility, etc. We analyze three major extracellular product categories (insoluble light, insoluble heavy and soluble) in detail and provide suggestions for additional product categories through extension of our analysis framework. The proposed analysis and results provide significant insights for technology selection and enable streamlined decision making when faced with any microbial product that is released extracellularly. The parameter variability analysis for the product as well as the associated technologies and comparison with novel alternatives is a key feature which forms the basis for designing better bioseparation strategies that have potential for commercial scalability and can compete with traditional chemical production methods.},
doi = {10.1186/s42480-019-0022-8},
journal = {BMC Chemical Engineering},
number = 1,
volume = 1,
place = {United States},
year = {2019},
month = {10}
}
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journal, May 2016
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Recent advances in lactic acid production by microbial fermentation processes
journal, November 2013
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An optimization-based assessment framework for biomass-to-fuel conversion strategies
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A framework for the identification of promising bio‐based chemicals
journal, June 2018
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Synthesis of purification tags for optimal downstream processing
journal, July 2000
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Global Sensitivity Analysis for the determination of parameter importance in bio-manufacturing processes
journal, October 2008
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Biotechnological production of 2,3-butanediol—Current state and prospects
journal, November 2009
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- Biotechnology Advances, Vol. 27, Issue 6
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journal, January 2014
- Aikawa, Shimpei; Nishida, Atsumi; Ho, Shih-Hsin
- Biotechnology for Biofuels, Vol. 7, Issue 1
Review of xanthan gum production from unmodified starches by Xanthomonas comprestris sp.
journal, June 2006
- Rosalam, S.; England, R.
- Enzyme and Microbial Technology, Vol. 39, Issue 2
Design and optimization of energy efficient complex separation networks
journal, September 2010
- Ruiz, Gerardo J.; Kim, Seon B.; Moon, Jeonghwa
- Computers & Chemical Engineering, Vol. 34, Issue 9
Constraint-based models predict metabolic and associated cellular functions
journal, January 2014
- Bordbar, Aarash; Monk, Jonathan M.; King, Zachary A.
- Nature Reviews Genetics, Vol. 15, Issue 2
MINLP Models for the Synthesis of Optimal Peptide Tags and Downstream Protein Processing
journal, January 2005
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- Biotechnology Progress, Vol. 21, Issue 3
Aqueous two-phase extraction of 2,3-butanediol from fermentation broths using an ethanol/phosphate system
journal, January 2009
- Jiang, Bo; Li, Zhi-Gang; Dai, Jian-Ying
- Process Biochemistry, Vol. 44, Issue 1
Separate and Concentrate Lactic Acid Using Combination of Nanofiltration and Reverse Osmosis Membranes
journal, September 2007
- Li, Yebo; Shahbazi, Abolghasem; Williams, Karen
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Recovery of microalgal biomass and metabolites: process options and economics
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