Synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions
Abstract
Recent advances in metabolic engineering have enabled the production of chemicals via bio-conversion using microbes. However, downstream separation accounts for 60–80% of the total production cost in many cases. Previous work on microbial production of extracellular chemicals has been mainly restricted to microbiology, biochemistry, metabolomics, or techno-economic analysis for specific product examples such as succinic acid, xanthan gum, lycopene, etc. In these studies, microbial production and separation technologies were selected apriori without considering any competing alternatives. However, technology selection in downstream separation and purification processes can have a major impact on the overall costs, product recovery, and purity. To this end, we apply a superstructure optimization based framework that enables the identification of critical technologies and their associated parameters in the synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions. We divide extracellular chemicals into three categories based on their physical properties, such as water solubility, physical state, relative density, volatility, etc. We analyze three major extracellular product categories (insoluble light, insoluble heavy and soluble) in detail and provide suggestions for additional product categories through extension of our analysis framework. The proposed analysis and results provide significant insights for technology selection and enable streamlined decision makingmore »
- Authors:
-
- Univ. of Wisconsin, Madison, WI (United States). Great Lakes Bioenergy Research Center
- Univ. of Wisconsin, Madison, WI (United States). Great Lakes Bioenergy Research Center; Rowan Univ., Glassboro, NJ (United States)
- Publication Date:
- Research Org.:
- Univ. of Wisconsin, Madison, WI (United States). Great Lakes Bioenergy Research Center
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1579537
- Grant/Contract Number:
- SC0018409
- Resource Type:
- Accepted Manuscript
- Journal Name:
- BMC Chemical Engineering
- Additional Journal Information:
- Journal Volume: 1; Journal Issue: 1; Journal ID: ISSN 2524-4175
- Publisher:
- Springer
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Process systems engineering; Downstream separation; Superstructure optimization; Technology selection; Bio-based chemicals
Citation Formats
Wu, Wenzhao, Yenkie, Kirti M., and Maravelias, Christos T. Synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions. United States: N. p., 2019.
Web. doi:10.1186/s42480-019-0022-8.
Wu, Wenzhao, Yenkie, Kirti M., & Maravelias, Christos T. Synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions. United States. doi:https://doi.org/10.1186/s42480-019-0022-8
Wu, Wenzhao, Yenkie, Kirti M., and Maravelias, Christos T. Mon .
"Synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions". United States. doi:https://doi.org/10.1186/s42480-019-0022-8. https://www.osti.gov/servlets/purl/1579537.
@article{osti_1579537,
title = {Synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions},
author = {Wu, Wenzhao and Yenkie, Kirti M. and Maravelias, Christos T.},
abstractNote = {Recent advances in metabolic engineering have enabled the production of chemicals via bio-conversion using microbes. However, downstream separation accounts for 60–80% of the total production cost in many cases. Previous work on microbial production of extracellular chemicals has been mainly restricted to microbiology, biochemistry, metabolomics, or techno-economic analysis for specific product examples such as succinic acid, xanthan gum, lycopene, etc. In these studies, microbial production and separation technologies were selected apriori without considering any competing alternatives. However, technology selection in downstream separation and purification processes can have a major impact on the overall costs, product recovery, and purity. To this end, we apply a superstructure optimization based framework that enables the identification of critical technologies and their associated parameters in the synthesis and analysis of separation processes for extracellular chemicals generated from microbial conversions. We divide extracellular chemicals into three categories based on their physical properties, such as water solubility, physical state, relative density, volatility, etc. We analyze three major extracellular product categories (insoluble light, insoluble heavy and soluble) in detail and provide suggestions for additional product categories through extension of our analysis framework. The proposed analysis and results provide significant insights for technology selection and enable streamlined decision making when faced with any microbial product that is released extracellularly. The parameter variability analysis for the product as well as the associated technologies and comparison with novel alternatives is a key feature which forms the basis for designing better bioseparation strategies that have potential for commercial scalability and can compete with traditional chemical production methods.},
doi = {10.1186/s42480-019-0022-8},
journal = {BMC Chemical Engineering},
number = 1,
volume = 1,
place = {United States},
year = {2019},
month = {10}
}
Works referenced in this record:
A systems engineering perspective on process integration in industrial biotechnology: Process integration in industrial biotechnology
journal, November 2014
- Kiss, Anton A.; Grievink, Johan; Rito-Palomares, Marco
- Journal of Chemical Technology & Biotechnology, Vol. 90, Issue 3
Botryococcus braunii : A Renewable Source of Hydrocarbons and Other Chemicals
journal, January 2002
- Banerjee, Anirban; Sharma, Rohit; Chisti, Yusuf
- Critical Reviews in Biotechnology, Vol. 22, Issue 3
A Hybrid Modelling Approach for Separation Systems Involving Distillation
journal, September 1999
- Schenk, M.; Gani, R.; Bogle, D.
- Chemical Engineering Research and Design, Vol. 77, Issue 6
Comparison of two lipid extraction methods produced by yeast in cheese whey
journal, August 2013
- Castanha, Rodrigo Fernandes; Morais, Lilia Aparecida Salgado de; Mariano, Adriano Pinto
- Brazilian Archives of Biology and Technology, Vol. 56, Issue 4
The future of metabolic engineering and synthetic biology: Towards a systematic practice
journal, May 2012
- Yadav, Vikramaditya G.; De Mey, Marjan; Giaw Lim, Chin
- Metabolic Engineering, Vol. 14, Issue 3
Soft sensor assisted dynamic bioprocess control: Efficient tools for bioprocess development
journal, June 2013
- Sagmeister, Patrick; Wechselberger, Patrick; Jazini, Mohammadhadi
- Chemical Engineering Science, Vol. 96
Recent trends in lactic acid biotechnology: A brief review on production to purification
journal, April 2014
- Ghaffar, Tayyba; Irshad, Muhammad; Anwar, Zahid
- Journal of Radiation Research and Applied Sciences, Vol. 7, Issue 2
Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via β-alanine
journal, January 2015
- Borodina, Irina; Kildegaard, Kanchana R.; Jensen, Niels B.
- Metabolic Engineering, Vol. 27
Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production
journal, February 2012
- Zhou, Yongjin J.; Gao, Wei; Rong, Qixian
- Journal of the American Chemical Society, Vol. 134, Issue 6
Repulsive effect of salt on solvent extraction of 2,3-butanediol from aqueous fermentation solution: Repulsive effect of salt on solvent extraction of 2,3-butanediol
journal, June 2014
- Birajdar, Snehal D.; Padmanabhan, Sasisanker; Rajagopalan, Srinivasan
- Journal of Chemical Technology & Biotechnology, Vol. 90, Issue 8
Knowledge-Based Conceptual Synthesis of Industrial-Scale Downstream Processes for Biochemical Products
journal, February 2015
- Backhaus, Karin; Lochmüller, Mirka; Arndt, Markus Christian
- Chemical Engineering & Technology, Vol. 38, Issue 3
Constraint-based models predict metabolic and associated cellular functions
journal, January 2014
- Bordbar, Aarash; Monk, Jonathan M.; King, Zachary A.
- Nature Reviews Genetics, Vol. 15, Issue 2
Development and design of bio-pharmaceutical processes
journal, November 2013
- Kontoravdi, Cleo; Samsatli, Nouri J.; Shah, Nilay
- Current Opinion in Chemical Engineering, Vol. 2, Issue 4
Synthesis and techno-economic assessment of microbial-based processes for terpenes production
journal, October 2018
- Wu, Wenzhao; Maravelias, Christos T.
- Biotechnology for Biofuels, Vol. 11, Issue 1
Challenges and trends in bioseparations
journal, January 2008
- Asenjo, Juan A.; Andrews, Barbara A.
- Journal of Chemical Technology & Biotechnology, Vol. 83, Issue 2
MINLP Models for the Synthesis of Optimal Peptide Tags and Downstream Protein Processing
journal, January 2005
- Simeonidis, Evangelos; Pinto, Jose M.; Lienqueo, M. Elena
- Biotechnology Progress, Vol. 21, Issue 3
Recovery of microalgal biomass and metabolites: process options and economics
journal, January 2003
- Molina Grima, E.; Belarbi, E.-H.; Acién Fernández, F. G.
- Biotechnology Advances, Vol. 20, Issue 7-8, p. 491-515
Efflux systems in bacteria and their metabolic engineering applications
journal, September 2015
- Jones, Christopher M.; Hernández Lozada, Néstor J.; Pfleger, Brian F.
- Applied Microbiology and Biotechnology, Vol. 99, Issue 22
Microbial production of isoprenoids
journal, September 2011
- Chandran, Sunil S.; Kealey, James T.; Reeves, Christopher D.
- Process Biochemistry, Vol. 46, Issue 9
Terpenoids: Opportunities for Biosynthesis of Natural Product Drugs Using Engineered Microorganisms
journal, January 2008
- Ajikumar, Parayil Kumaran; Tyo, Keith; Carlsen, Simon
- Molecular Pharmaceutics, Vol. 5, Issue 2
Engineering of cyanobacteria for the photosynthetic production of limonene from CO2
journal, September 2014
- Kiyota, Hiroshi; Okuda, Yukiko; Ito, Michiho
- Journal of Biotechnology, Vol. 185
Use of expert systems for the synthesis of downstream protein processes
journal, October 2000
- Lienqueo, M. Elena; Asenjo, Juan A.
- Computers & Chemical Engineering, Vol. 24, Issue 9-10
Purification performance index and separation cost indicator for experimentally based systematic downstream process development
journal, March 2010
- Winkelnkemper, T.; Schembecker, G.
- Separation and Purification Technology, Vol. 72, Issue 1
Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals
journal, November 2015
- Jullesson, David; David, Florian; Pfleger, Brian
- Biotechnology Advances, Vol. 33, Issue 7
Theory of Centrifugation
journal, June 1961
- Ambler, Charles
- Industrial & Engineering Chemistry, Vol. 53, Issue 6
Lactic Acid
journal, November 1930
- Garrett, J. F.
- Industrial & Engineering Chemistry, Vol. 22, Issue 11
Production Rate-Dependent Key Performance Indicators for a Systematic Design of Biochemical Downstream Processes
journal, January 2016
- Brandt, Katrin; Schembecker, Gerhard
- Chemical Engineering & Technology, Vol. 39, Issue 2
A framework for the identification of promising bio‐based chemicals
journal, June 2018
- Wu, Wenzhao; Long, Matthew R.; Zhang, Xiaolin
- Biotechnology and Bioengineering, Vol. 115, Issue 9
Metabolic Engineering: Past and Future
journal, June 2013
- Woolston, Benjamin M.; Edgar, Steven; Stephanopoulos, Gregory
- Annual Review of Chemical and Biomolecular Engineering, Vol. 4, Issue 1
Exploiting integrality in the global optimization of mixed-integer nonlinear programming problems with BARON
journal, July 2017
- Kılınç, Mustafa R.; Sahinidis, Nikolaos V.
- Optimization Methods and Software, Vol. 33, Issue 3
Process synthesis for particle separations using centrifuges
journal, February 1998
- Agena, Sabine M.; Bogle, I. David L.; Cornish, Alan R. H.
- Computers & Chemical Engineering, Vol. 22, Issue 3
Towards computer-aided separation synthesis
journal, January 2006
- Zhang, Libin; Linninger, Andreas A.
- AIChE Journal, Vol. 52, Issue 4
Lactic acid
journal, July 1965
- Lockwood, Lewis B.; Yoder, David E.; Zienty, Mitchell
- Annals of the New York Academy of Sciences, Vol. 119, Issue 3
Production of biofuels, limonene and pectin from citrus wastes
journal, June 2010
- Pourbafrani, Mohammad; Forgács, Gergely; Horváth, Ilona Sárvári
- Bioresource Technology, Vol. 101, Issue 11
Aqueous Two-Phase Systems: A General Overview
journal, January 2001
- Hatti-Kaul, Rajni
- Molecular Biotechnology, Vol. 19, Issue 3
New trends in optimization-based approaches to process synthesis
journal, June 1996
- Grossmann, Ignacio E.; Daichendt, Mark M.
- Computers & Chemical Engineering, Vol. 20, Issue 6-7
Xanthan gum: production, recovery, and properties
journal, November 2000
- Garcı́a-Ochoa, F.; Santos, V. E.; Casas, J. A.
- Biotechnology Advances, Vol. 18, Issue 7, p. 549-579
Tunable recombinant protein expression in E. coli: enabler for continuous processing?
journal, May 2016
- Marschall, Lukas; Sagmeister, Patrick; Herwig, Christoph
- Applied Microbiology and Biotechnology, Vol. 100, Issue 13
A platform technology of recovery of lactic acid from a fermentation broth of novel substrate Zizyphus oenophlia
journal, August 2014
- Bishai, Moumita; De, Swarnalok; Adhikari, Basudam
- 3 Biotech, Vol. 5, Issue 4
Systems biology as a foundation for genome-scale synthetic biology
journal, October 2006
- Barrett, Christian L.; Kim, Tae Yong; Kim, Hyun Uk
- Current Opinion in Biotechnology, Vol. 17, Issue 5
Global Sensitivity Analysis for the determination of parameter importance in bio-manufacturing processes
journal, October 2008
- Chhatre, Sunil; Francis, Richard; Newcombe, Anthony R.
- Biotechnology and Applied Biochemistry, Vol. 51, Issue 2
A novel efficient optimisation system for purification process synthesis
journal, August 2012
- Polykarpou, Eleftheria M.; Dalby, Paul A.; Papageorgiou, Lazaros G.
- Biochemical Engineering Journal, Vol. 67
Synthesis and analysis of separation networks for the recovery of intracellular chemicals generated from microbial-based conversions
journal, May 2017
- Yenkie, Kirti M.; Wu, Wenzhao; Maravelias, Christos T.
- Biotechnology for Biofuels, Vol. 10, Issue 1
An optimization-based assessment framework for biomass-to-fuel conversion strategies
journal, January 2013
- Kim, Jiyong; Sen, S. Murat; Maravelias, Christos T.
- Energy & Environmental Science, Vol. 6, Issue 4
Fermentation optimization for the production of poly(β-hydroxybutyric acid) microbial thermoplastic
journal, July 1999
- Grothe, Enrico; Moo-Young, Murray; Chisti, Yusuf
- Enzyme and Microbial Technology, Vol. 25, Issue 1-2
Biotechnological production of 2,3-butanediol—Current state and prospects
journal, November 2009
- Celińska, E.; Grajek, W.
- Biotechnology Advances, Vol. 27, Issue 6
Optimization of ultrafiltration/diafiltration processes for partially bound impurities
journal, January 2004
- Shao, Jiahui; Zydney, Andrew L.
- Biotechnology and Bioengineering, Vol. 87, Issue 3
Bioprocessing aspects of fuels and chemicals from biomass
journal, July 2012
- Lee, Sun Uk; Jung, Kwonsu; Park, Gwon Woo
- Korean Journal of Chemical Engineering, Vol. 29, Issue 7
Bioseparations
journal, January 2004
- Lightfoot, E. N.; Moscariello, J. S.
- Biotechnology and Bioengineering, Vol. 87, Issue 3
Bioprocess membrane technology
journal, July 2007
- van Reis, Robert; Zydney, Andrew
- Journal of Membrane Science, Vol. 297, Issue 1-2
Multicriteria process synthesis for generating sustainable and economic bioprocesses
journal, December 1999
- Steffens, M. A.; Fraga, E. S.; Bogle, I. D. L.
- Computers & Chemical Engineering, Vol. 23, Issue 10
Hyaluronic Acid Production in Bacillus subtilis
journal, July 2005
- Widner, B.; Behr, R.; Von Dollen, S.
- Applied and Environmental Microbiology, Vol. 71, Issue 7
A systematic modeling framework of superstructure optimization in process synthesis
journal, June 1999
- Yeomans, Hector; Grossmann, Ignacio E.
- Computers & Chemical Engineering, Vol. 23, Issue 6
Separate and Concentrate Lactic Acid Using Combination of Nanofiltration and Reverse Osmosis Membranes
journal, September 2007
- Li, Yebo; Shahbazi, Abolghasem; Williams, Karen
- Applied Biochemistry and Biotechnology, Vol. 147, Issue 1-3
A small metabolic flux model to identify transient metabolic regulations in Saccharomyces cerevisiae
journal, March 2002
- Herwig, Christoph; von Stockar, Urs
- Bioprocess and Biosystems Engineering, Vol. 24, Issue 6
Biofuels from microalgae—A review of technologies for production, processing, and extractions of biofuels and co-products
journal, February 2010
- Brennan, Liam; Owende, Philip
- Renewable and Sustainable Energy Reviews, Vol. 14, Issue 2, p. 557-577
Optimal synthesis of chromatographic trains for downstream protein processing
journal, September 2011
- Polykarpou, Eleftheria M.; Dalby, Paul A.; Papageorgiou, Lazaros G.
- Biotechnology Progress, Vol. 27, Issue 6
A polyhedral branch-and-cut approach to global optimization
journal, May 2005
- Tawarmalani, Mohit; Sahinidis, Nikolaos V.
- Mathematical Programming, Vol. 103, Issue 2
In situ recovery of 2,3-butanediol from fermentation by liquid–liquid extraction
journal, November 2008
- Anvari, Masumeh; Khayati, Gholam
- Journal of Industrial Microbiology & Biotechnology, Vol. 36, Issue 2
Biodiesel production from waste cooking oil: 2. Economic assessment and sensitivity analysis
journal, December 2003
- Zhang, Y.; Dubé, M. A.; McLean, D. D.
- Bioresource Technology, Vol. 90, Issue 3
Microbial production and downstream processing of 2,3-butanediol
journal, February 1993
- Afschar, A. S.; Vaz Rossell, C. E.; Jonas, R.
- Journal of Biotechnology, Vol. 27, Issue 3
A superstructure-based framework for bio-separation network synthesis
journal, January 2017
- Wu, Wenzhao; Yenkie, Kirti; Maravelias, Christos T.
- Computers & Chemical Engineering, Vol. 96
Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries
journal, March 2012
- Hong, Kuk-Ki; Nielsen, Jens
- Cellular and Molecular Life Sciences, Vol. 69, Issue 16
Synthesis of purification tags for optimal downstream processing
journal, July 2000
- Steffens, M. A.; Fraga, E. S.; Bogle, I. D. L.
- Computers & Chemical Engineering, Vol. 24, Issue 2-7
Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3-butanediol
journal, March 2008
- Xiu, Zhi-Long; Zeng, An-Ping
- Applied Microbiology and Biotechnology, Vol. 78, Issue 6, p. 917-926
Design of integrated biorefineries
journal, October 2015
- Kokossis, A. C.; Tsakalova, M.; Pyrgakis, K.
- Computers & Chemical Engineering, Vol. 81
Optimal processing pathway for the production of biodiesel from microalgal biomass: A superstructure based approach
journal, November 2013
- Rizwan, Muhammad; Lee, Jay H.; Gani, Rafiqul
- Computers & Chemical Engineering, Vol. 58
Bioprocesses: Modeling needs for process evaluation and sustainability assessment
journal, July 2010
- Jiménez-González, Concepción; Woodley, John M.
- Computers & Chemical Engineering, Vol. 34, Issue 7
Optimization of a biotechnological multiproduct batch plant design for the manufacture of four different products: A real case scenario: Optimization of a Biotechnological Multiproduct Batch Plant Design
journal, March 2017
- Sandoval, Gabriela; Espinoza, Daniel; Figueroa, Nicolas
- Biotechnology and Bioengineering, Vol. 114, Issue 6
Metabolic engineering approaches for production of biochemicals in food and medicinal plants
journal, April 2014
- Wilson, Sarah A.; Roberts, Susan C.
- Current Opinion in Biotechnology, Vol. 26
A property-based optimization of direct recycle networks and wastewater treatment processes
journal, September 2009
- Ponce-Ortega, José María; Hortua, Ana Carolina; El-Halwagi, Mahmoud
- AIChE Journal, Vol. 55, Issue 9
Synthesis of bioprocesses using physical properties data
journal, April 2000
- Steffens, M. A.; Fraga, E. S.; Bogle, I. D. L.
- Biotechnology and Bioengineering, Vol. 68, Issue 2
A perspective on process synthesis: Challenges and prospects
journal, October 2015
- Cremaschi, Selen
- Computers & Chemical Engineering, Vol. 81
Review of xanthan gum production from unmodified starches by Xanthomonas comprestris sp.
journal, June 2006
- Rosalam, S.; England, R.
- Enzyme and Microbial Technology, Vol. 39, Issue 2
A framework for efficient large scale equation-oriented flowsheet optimization
journal, January 2015
- Dowling, Alexander W.; Biegler, Lorenz T.
- Computers & Chemical Engineering, Vol. 72
Perspectives of microbial oils for biodiesel production
journal, August 2008
- Li, Qiang; Du, Wei; Liu, Dehua
- Applied Microbiology and Biotechnology, Vol. 80, Issue 5, p. 749-756
A roadmap for the synthesis of separation networks for the recovery of bio-based chemicals: Matching biological and process feasibility
journal, December 2016
- Yenkie, Kirti M.; Wu, WenZhao; Clark, Ryan L.
- Biotechnology Advances, Vol. 34, Issue 8
Economic Analysis of Integrated Continuous and Batch Pharmaceutical Manufacturing: A Case Study
journal, September 2011
- Schaber, Spencer D.; Gerogiorgis, Dimitrios I.; Ramachandran, Rohit
- Industrial & Engineering Chemistry Research, Vol. 50, Issue 17
Industry-wide energy saving by complex separation networks
journal, December 2009
- Linninger, Andreas A.
- Computers & Chemical Engineering, Vol. 33, Issue 12
Microbial production of hyaluronic acid: current state, challenges, and perspectives
journal, January 2011
- Liu, Long; Liu, Yanfeng; Li, Jianghua
- Microbial Cell Factories, Vol. 10, Issue 1
Aqueous two-phase extraction of 2,3-butanediol from fermentation broths using an ethanol/phosphate system
journal, January 2009
- Jiang, Bo; Li, Zhi-Gang; Dai, Jian-Ying
- Process Biochemistry, Vol. 44, Issue 1
An efficient process for production and purification of hyaluronic acid from Streptococcus equi subsp. zooepidemicus
journal, October 2007
- Rangaswamy, Vidhya; Jain, Dharmendra
- Biotechnology Letters, Vol. 30, Issue 3
Production, purification, characterization, and applications of lipases
journal, December 2001
- Sharma, Rohit; Chisti, Yusuf; Banerjee, Uttam Chand
- Biotechnology Advances, Vol. 19, Issue 8
Editorial overview: Chemical biotechnology: Interdisciplinary concepts for modern biotechnological production of biochemicals and biofuels
journal, December 2015
- Bornscheuer, Uwe T.; Nielsen, Alex Toftgaard
- Current Opinion in Biotechnology, Vol. 35
Glycogen production for biofuels by the euryhaline cyanobacteria Synechococcus sp. strain PCC 7002 from an oceanic environment
journal, January 2014
- Aikawa, Shimpei; Nishida, Atsumi; Ho, Shih-Hsin
- Biotechnology for Biofuels, Vol. 7, Issue 1
Design and optimization of energy efficient complex separation networks
journal, September 2010
- Ruiz, Gerardo J.; Kim, Seon B.; Moon, Jeonghwa
- Computers & Chemical Engineering, Vol. 34, Issue 9
Process synthesis prospective
journal, April 2004
- Barnicki, Scott D.; Siirola, Jeffrey J.
- Computers & Chemical Engineering, Vol. 28, Issue 4
Recent advances in lactic acid production by microbial fermentation processes
journal, November 2013
- Abdel-Rahman, Mohamed Ali; Tashiro, Yukihiro; Sonomoto, Kenji
- Biotechnology Advances, Vol. 31, Issue 6
Efficient MILP formulations for the simultaneous optimal peptide tag design and downstream processing synthesis
journal, September 2009
- Natali, João M.; Pinto, José M.; Papageorgiou, Lazaros G.
- AIChE Journal, Vol. 55, Issue 9
Simplified two-stage method to B-phycoerythrin recovery from Porphyridium cruentum☆
journal, November 2006
- Benavides, J.; Ritopalomares, M.
- Journal of Chromatography B, Vol. 844, Issue 1
Development of a topology of microalgae-based biorefinery: process synthesis and optimization using a combined forward–backward screening and superstructure approach
journal, March 2015
- González-Delgado, Ángel-Darío; Kafarov, Viatcheslav; El-Halwagi, Mahmoud
- Clean Technologies and Environmental Policy, Vol. 17, Issue 8
Optimal Synthesis of Protein Purification Processes
journal, August 2001
- Vasquez-Alvarez, E.; Lienqueo, M. E.; Pinto, J. M.
- Biotechnology Progress, Vol. 17, Issue 4
Bioprocess design: Study of a case
journal, March 1996
- Sato, Rony Akio; da Costa, Maria Helena Bueno
- Biotechnology Letters, Vol. 18, Issue 3
Works referencing / citing this record:
Tunable recombinant protein expression in E. coli: enabler for continuous processing?
journal, May 2016
- Marschall, Lukas; Sagmeister, Patrick; Herwig, Christoph
- Applied Microbiology and Biotechnology, Vol. 100, Issue 13
A platform technology of recovery of lactic acid from a fermentation broth of novel substrate Zizyphus oenophlia
journal, August 2014
- Bishai, Moumita; De, Swarnalok; Adhikari, Basudam
- 3 Biotech, Vol. 5, Issue 4
Bioprocesses: Modeling needs for process evaluation and sustainability assessment
journal, July 2010
- Jiménez-González, Concepción; Woodley, John M.
- Computers & Chemical Engineering, Vol. 34, Issue 7
Design of integrated biorefineries
journal, October 2015
- Kokossis, A. C.; Tsakalova, M.; Pyrgakis, K.
- Computers & Chemical Engineering, Vol. 81
Optimal Synthesis of Protein Purification Processes
journal, August 2001
- Vasquez-Alvarez, E.; Lienqueo, M. E.; Pinto, J. M.
- Biotechnology Progress, Vol. 17, Issue 4
Theory of Centrifugation
journal, June 1961
- Ambler, Charles
- Industrial & Engineering Chemistry, Vol. 53, Issue 6
A polyhedral branch-and-cut approach to global optimization
journal, May 2005
- Tawarmalani, Mohit; Sahinidis, Nikolaos V.
- Mathematical Programming, Vol. 103, Issue 2
Exploiting integrality in the global optimization of mixed-integer nonlinear programming problems with BARON
journal, July 2017
- Kılınç, Mustafa R.; Sahinidis, Nikolaos V.
- Optimization Methods and Software, Vol. 33, Issue 3
Recent advances in lactic acid production by microbial fermentation processes
journal, November 2013
- Abdel-Rahman, Mohamed Ali; Tashiro, Yukihiro; Sonomoto, Kenji
- Biotechnology Advances, Vol. 31, Issue 6
An optimization-based assessment framework for biomass-to-fuel conversion strategies
journal, January 2013
- Kim, Jiyong; Sen, S. Murat; Maravelias, Christos T.
- Energy & Environmental Science, Vol. 6, Issue 4
Metabolic Engineering: Past and Future
journal, June 2013
- Woolston, Benjamin M.; Edgar, Steven; Stephanopoulos, Gregory
- Annual Review of Chemical and Biomolecular Engineering, Vol. 4, Issue 1
A framework for the identification of promising bio‐based chemicals
journal, June 2018
- Wu, Wenzhao; Long, Matthew R.; Zhang, Xiaolin
- Biotechnology and Bioengineering, Vol. 115, Issue 9
Synthesis of purification tags for optimal downstream processing
journal, July 2000
- Steffens, M. A.; Fraga, E. S.; Bogle, I. D. L.
- Computers & Chemical Engineering, Vol. 24, Issue 2-7
Global Sensitivity Analysis for the determination of parameter importance in bio-manufacturing processes
journal, October 2008
- Chhatre, Sunil; Francis, Richard; Newcombe, Anthony R.
- Biotechnology and Applied Biochemistry, Vol. 51, Issue 2
Biotechnological production of 2,3-butanediol—Current state and prospects
journal, November 2009
- Celińska, E.; Grajek, W.
- Biotechnology Advances, Vol. 27, Issue 6
Glycogen production for biofuels by the euryhaline cyanobacteria Synechococcus sp. strain PCC 7002 from an oceanic environment
journal, January 2014
- Aikawa, Shimpei; Nishida, Atsumi; Ho, Shih-Hsin
- Biotechnology for Biofuels, Vol. 7, Issue 1
Review of xanthan gum production from unmodified starches by Xanthomonas comprestris sp.
journal, June 2006
- Rosalam, S.; England, R.
- Enzyme and Microbial Technology, Vol. 39, Issue 2
Design and optimization of energy efficient complex separation networks
journal, September 2010
- Ruiz, Gerardo J.; Kim, Seon B.; Moon, Jeonghwa
- Computers & Chemical Engineering, Vol. 34, Issue 9
Constraint-based models predict metabolic and associated cellular functions
journal, January 2014
- Bordbar, Aarash; Monk, Jonathan M.; King, Zachary A.
- Nature Reviews Genetics, Vol. 15, Issue 2
MINLP Models for the Synthesis of Optimal Peptide Tags and Downstream Protein Processing
journal, January 2005
- Simeonidis, Evangelos; Pinto, Jose M.; Lienqueo, M. Elena
- Biotechnology Progress, Vol. 21, Issue 3
Aqueous two-phase extraction of 2,3-butanediol from fermentation broths using an ethanol/phosphate system
journal, January 2009
- Jiang, Bo; Li, Zhi-Gang; Dai, Jian-Ying
- Process Biochemistry, Vol. 44, Issue 1
Separate and Concentrate Lactic Acid Using Combination of Nanofiltration and Reverse Osmosis Membranes
journal, September 2007
- Li, Yebo; Shahbazi, Abolghasem; Williams, Karen
- Applied Biochemistry and Biotechnology, Vol. 147, Issue 1-3
Recovery of microalgal biomass and metabolites: process options and economics
journal, January 2003
- Molina Grima, E.; Belarbi, E.-H.; Acién Fernández, F. G.
- Biotechnology Advances, Vol. 20, Issue 7-8, p. 491-515
In situ recovery of 2,3-butanediol from fermentation by liquid–liquid extraction
journal, November 2008
- Anvari, Masumeh; Khayati, Gholam
- Journal of Industrial Microbiology & Biotechnology, Vol. 36, Issue 2
Multicriteria process synthesis for generating sustainable and economic bioprocesses
journal, December 1999
- Steffens, M. A.; Fraga, E. S.; Bogle, I. D. L.
- Computers & Chemical Engineering, Vol. 23, Issue 10
An efficient process for production and purification of hyaluronic acid from Streptococcus equi subsp. zooepidemicus
journal, October 2007
- Rangaswamy, Vidhya; Jain, Dharmendra
- Biotechnology Letters, Vol. 30, Issue 3
Development of a topology of microalgae-based biorefinery: process synthesis and optimization using a combined forward–backward screening and superstructure approach
journal, March 2015
- González-Delgado, Ángel-Darío; Kafarov, Viatcheslav; El-Halwagi, Mahmoud
- Clean Technologies and Environmental Policy, Vol. 17, Issue 8
Terpenoids: Opportunities for Biosynthesis of Natural Product Drugs Using Engineered Microorganisms
journal, January 2008
- Ajikumar, Parayil Kumaran; Tyo, Keith; Carlsen, Simon
- Molecular Pharmaceutics, Vol. 5, Issue 2
Biofuels from microalgae—A review of technologies for production, processing, and extractions of biofuels and co-products
journal, February 2010
- Brennan, Liam; Owende, Philip
- Renewable and Sustainable Energy Reviews, Vol. 14, Issue 2, p. 557-577
Process synthesis for particle separations using centrifuges
journal, February 1998
- Agena, Sabine M.; Bogle, I. David L.; Cornish, Alan R. H.
- Computers & Chemical Engineering, Vol. 22, Issue 3
Efficient MILP formulations for the simultaneous optimal peptide tag design and downstream processing synthesis
journal, September 2009
- Natali, João M.; Pinto, José M.; Papageorgiou, Lazaros G.
- AIChE Journal, Vol. 55, Issue 9
Recent trends in lactic acid biotechnology: A brief review on production to purification
journal, April 2014
- Ghaffar, Tayyba; Irshad, Muhammad; Anwar, Zahid
- Journal of Radiation Research and Applied Sciences, Vol. 7, Issue 2
Editorial overview: Chemical biotechnology: Interdisciplinary concepts for modern biotechnological production of biochemicals and biofuels
journal, December 2015
- Bornscheuer, Uwe T.; Nielsen, Alex Toftgaard
- Current Opinion in Biotechnology, Vol. 35
Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via β-alanine
journal, January 2015
- Borodina, Irina; Kildegaard, Kanchana R.; Jensen, Niels B.
- Metabolic Engineering, Vol. 27
Economic Analysis of Integrated Continuous and Batch Pharmaceutical Manufacturing: A Case Study
journal, September 2011
- Schaber, Spencer D.; Gerogiorgis, Dimitrios I.; Ramachandran, Rohit
- Industrial & Engineering Chemistry Research, Vol. 50, Issue 17
Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries
journal, March 2012
- Hong, Kuk-Ki; Nielsen, Jens
- Cellular and Molecular Life Sciences, Vol. 69, Issue 16
A small metabolic flux model to identify transient metabolic regulations in Saccharomyces cerevisiae
journal, March 2002
- Herwig, Christoph; von Stockar, Urs
- Bioprocess and Biosystems Engineering, Vol. 24, Issue 6
Bioprocessing aspects of fuels and chemicals from biomass
journal, July 2012
- Lee, Sun Uk; Jung, Kwonsu; Park, Gwon Woo
- Korean Journal of Chemical Engineering, Vol. 29, Issue 7
A roadmap for the synthesis of separation networks for the recovery of bio-based chemicals: Matching biological and process feasibility
journal, December 2016
- Yenkie, Kirti M.; Wu, WenZhao; Clark, Ryan L.
- Biotechnology Advances, Vol. 34, Issue 8
A perspective on process synthesis: Challenges and prospects
journal, October 2015
- Cremaschi, Selen
- Computers & Chemical Engineering, Vol. 81
A Hybrid Modelling Approach for Separation Systems Involving Distillation
journal, September 1999
- Schenk, M.; Gani, R.; Bogle, D.
- Chemical Engineering Research and Design, Vol. 77, Issue 6
Simplified two-stage method to B-phycoerythrin recovery from Porphyridium cruentum☆
journal, November 2006
- Benavides, J.; Ritopalomares, M.
- Journal of Chromatography B, Vol. 844, Issue 1
Synthesis of bioprocesses using physical properties data
journal, April 2000
- Steffens, M. A.; Fraga, E. S.; Bogle, I. D. L.
- Biotechnology and Bioengineering, Vol. 68, Issue 2
A novel efficient optimisation system for purification process synthesis
journal, August 2012
- Polykarpou, Eleftheria M.; Dalby, Paul A.; Papageorgiou, Lazaros G.
- Biochemical Engineering Journal, Vol. 67
Synthesis and techno-economic assessment of microbial-based processes for terpenes production
journal, October 2018
- Wu, Wenzhao; Maravelias, Christos T.
- Biotechnology for Biofuels, Vol. 11, Issue 1
A property-based optimization of direct recycle networks and wastewater treatment processes
journal, September 2009
- Ponce-Ortega, José María; Hortua, Ana Carolina; El-Halwagi, Mahmoud
- AIChE Journal, Vol. 55, Issue 9
Metabolic engineering approaches for production of biochemicals in food and medicinal plants
journal, April 2014
- Wilson, Sarah A.; Roberts, Susan C.
- Current Opinion in Biotechnology, Vol. 26
Engineering of cyanobacteria for the photosynthetic production of limonene from CO2
journal, September 2014
- Kiyota, Hiroshi; Okuda, Yukiko; Ito, Michiho
- Journal of Biotechnology, Vol. 185
Synthesis and analysis of separation networks for the recovery of intracellular chemicals generated from microbial-based conversions
journal, May 2017
- Yenkie, Kirti M.; Wu, Wenzhao; Maravelias, Christos T.
- Biotechnology for Biofuels, Vol. 10, Issue 1
Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals
journal, November 2015
- Jullesson, David; David, Florian; Pfleger, Brian
- Biotechnology Advances, Vol. 33, Issue 7
A framework for efficient large scale equation-oriented flowsheet optimization
journal, January 2015
- Dowling, Alexander W.; Biegler, Lorenz T.
- Computers & Chemical Engineering, Vol. 72
Xanthan gum: production, recovery, and properties
journal, November 2000
- Garcı́a-Ochoa, F.; Santos, V. E.; Casas, J. A.
- Biotechnology Advances, Vol. 18, Issue 7, p. 549-579
Process synthesis prospective
journal, April 2004
- Barnicki, Scott D.; Siirola, Jeffrey J.
- Computers & Chemical Engineering, Vol. 28, Issue 4
Comparison of two lipid extraction methods produced by yeast in cheese whey
journal, August 2013
- Castanha, Rodrigo Fernandes; Morais, Lilia Aparecida Salgado de; Mariano, Adriano Pinto
- Brazilian Archives of Biology and Technology, Vol. 56, Issue 4
Aqueous Two-Phase Systems: A General Overview
journal, January 2001
- Hatti-Kaul, Rajni
- Molecular Biotechnology, Vol. 19, Issue 3
Development and design of bio-pharmaceutical processes
journal, November 2013
- Kontoravdi, Cleo; Samsatli, Nouri J.; Shah, Nilay
- Current Opinion in Chemical Engineering, Vol. 2, Issue 4
Production of biofuels, limonene and pectin from citrus wastes
journal, June 2010
- Pourbafrani, Mohammad; Forgács, Gergely; Horváth, Ilona Sárvári
- Bioresource Technology, Vol. 101, Issue 11
Optimization of a biotechnological multiproduct batch plant design for the manufacture of four different products: A real case scenario: Optimization of a Biotechnological Multiproduct Batch Plant Design
journal, March 2017
- Sandoval, Gabriela; Espinoza, Daniel; Figueroa, Nicolas
- Biotechnology and Bioengineering, Vol. 114, Issue 6
A systematic modeling framework of superstructure optimization in process synthesis
journal, June 1999
- Yeomans, Hector; Grossmann, Ignacio E.
- Computers & Chemical Engineering, Vol. 23, Issue 6
A systems engineering perspective on process integration in industrial biotechnology: Process integration in industrial biotechnology
journal, November 2014
- Kiss, Anton A.; Grievink, Johan; Rito-Palomares, Marco
- Journal of Chemical Technology & Biotechnology, Vol. 90, Issue 3
Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production
journal, February 2012
- Zhou, Yongjin J.; Gao, Wei; Rong, Qixian
- Journal of the American Chemical Society, Vol. 134, Issue 6
Biodiesel production from waste cooking oil: 2. Economic assessment and sensitivity analysis
journal, December 2003
- Zhang, Y.; Dubé, M. A.; McLean, D. D.
- Bioresource Technology, Vol. 90, Issue 3
Challenges and trends in bioseparations
journal, January 2008
- Asenjo, Juan A.; Andrews, Barbara A.
- Journal of Chemical Technology & Biotechnology, Vol. 83, Issue 2
Industry-wide energy saving by complex separation networks
journal, December 2009
- Linninger, Andreas A.
- Computers & Chemical Engineering, Vol. 33, Issue 12
Repulsive effect of salt on solvent extraction of 2,3-butanediol from aqueous fermentation solution: Repulsive effect of salt on solvent extraction of 2,3-butanediol
journal, June 2014
- Birajdar, Snehal D.; Padmanabhan, Sasisanker; Rajagopalan, Srinivasan
- Journal of Chemical Technology & Biotechnology, Vol. 90, Issue 8
Fermentation optimization for the production of poly(β-hydroxybutyric acid) microbial thermoplastic
journal, July 1999
- Grothe, Enrico; Moo-Young, Murray; Chisti, Yusuf
- Enzyme and Microbial Technology, Vol. 25, Issue 1-2
Bioprocess membrane technology
journal, July 2007
- van Reis, Robert; Zydney, Andrew
- Journal of Membrane Science, Vol. 297, Issue 1-2
Hyaluronic Acid Production in Bacillus subtilis
journal, July 2005
- Widner, B.; Behr, R.; Von Dollen, S.
- Applied and Environmental Microbiology, Vol. 71, Issue 7
Optimal synthesis of chromatographic trains for downstream protein processing
journal, September 2011
- Polykarpou, Eleftheria M.; Dalby, Paul A.; Papageorgiou, Lazaros G.
- Biotechnology Progress, Vol. 27, Issue 6
Bioprocess design: Study of a case
journal, March 1996
- Sato, Rony Akio; da Costa, Maria Helena Bueno
- Biotechnology Letters, Vol. 18, Issue 3
Microbial production of isoprenoids
journal, September 2011
- Chandran, Sunil S.; Kealey, James T.; Reeves, Christopher D.
- Process Biochemistry, Vol. 46, Issue 9
Efflux systems in bacteria and their metabolic engineering applications
journal, September 2015
- Jones, Christopher M.; Hernández Lozada, Néstor J.; Pfleger, Brian F.
- Applied Microbiology and Biotechnology, Vol. 99, Issue 22
New trends in optimization-based approaches to process synthesis
journal, June 1996
- Grossmann, Ignacio E.; Daichendt, Mark M.
- Computers & Chemical Engineering, Vol. 20, Issue 6-7
A superstructure-based framework for bio-separation network synthesis
journal, January 2017
- Wu, Wenzhao; Yenkie, Kirti; Maravelias, Christos T.
- Computers & Chemical Engineering, Vol. 96
Production, purification, characterization, and applications of lipases
journal, December 2001
- Sharma, Rohit; Chisti, Yusuf; Banerjee, Uttam Chand
- Biotechnology Advances, Vol. 19, Issue 8
Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3-butanediol
journal, March 2008
- Xiu, Zhi-Long; Zeng, An-Ping
- Applied Microbiology and Biotechnology, Vol. 78, Issue 6, p. 917-926
Systems biology as a foundation for genome-scale synthetic biology
journal, October 2006
- Barrett, Christian L.; Kim, Tae Yong; Kim, Hyun Uk
- Current Opinion in Biotechnology, Vol. 17, Issue 5
Bioseparations
journal, January 2004
- Lightfoot, E. N.; Moscariello, J. S.
- Biotechnology and Bioengineering, Vol. 87, Issue 3
Soft sensor assisted dynamic bioprocess control: Efficient tools for bioprocess development
journal, June 2013
- Sagmeister, Patrick; Wechselberger, Patrick; Jazini, Mohammadhadi
- Chemical Engineering Science, Vol. 96
Production Rate-Dependent Key Performance Indicators for a Systematic Design of Biochemical Downstream Processes
journal, January 2016
- Brandt, Katrin; Schembecker, Gerhard
- Chemical Engineering & Technology, Vol. 39, Issue 2
The future of metabolic engineering and synthetic biology: Towards a systematic practice
journal, May 2012
- Yadav, Vikramaditya G.; De Mey, Marjan; Giaw Lim, Chin
- Metabolic Engineering, Vol. 14, Issue 3
Optimal processing pathway for the production of biodiesel from microalgal biomass: A superstructure based approach
journal, November 2013
- Rizwan, Muhammad; Lee, Jay H.; Gani, Rafiqul
- Computers & Chemical Engineering, Vol. 58
Botryococcus braunii : A Renewable Source of Hydrocarbons and Other Chemicals
journal, January 2002
- Banerjee, Anirban; Sharma, Rohit; Chisti, Yusuf
- Critical Reviews in Biotechnology, Vol. 22, Issue 3
Microbial production and downstream processing of 2,3-butanediol
journal, February 1993
- Afschar, A. S.; Vaz Rossell, C. E.; Jonas, R.
- Journal of Biotechnology, Vol. 27, Issue 3
Towards computer-aided separation synthesis
journal, January 2006
- Zhang, Libin; Linninger, Andreas A.
- AIChE Journal, Vol. 52, Issue 4