Quantitation of DNA reactive pyrrolic metabolites of senecionine – A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis

doi:10.1016/j.jfda.2019.12.001

Title: Quantitation of DNA reactive pyrrolic metabolites of senecionine – A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis

Full Record
Other Related Research

Authors:: Xia, Qingsu; He, Xiaobo; Shi, Qiang; Lin, Ge; Fu, Peter P.

Publication Date:: 2020-01-01

Sponsoring Org.:: USDOE

OSTI Identifier:: 1579432

Resource Type:: Published Article

Journal Name:: Journal of Food and Drug Analysis

Additional Journal Information:: Journal Name: Journal of Food and Drug Analysis Journal Volume: 28 Journal Issue: 1; Journal ID: ISSN 1021-9498

Publisher:: Elsevier

Country of Publication:: Country unknown/Code not available

Language:: English

Citation Formats


                    Xia, Qingsu, He, Xiaobo, Shi, Qiang, Lin, Ge, and Fu, Peter P. Quantitation of DNA reactive pyrrolic metabolites of senecionine – A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis.  Country unknown/Code not available: N. p., 2020. 
        Web.  doi:10.1016/j.jfda.2019.12.001.

Copy to clipboard


                    Xia, Qingsu, He, Xiaobo, Shi, Qiang, Lin, Ge, & Fu, Peter P. Quantitation of DNA reactive pyrrolic metabolites of senecionine – A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis.  Country unknown/Code not available.  doi:10.1016/j.jfda.2019.12.001.

Copy to clipboard


                    Xia, Qingsu, He, Xiaobo, Shi, Qiang, Lin, Ge, and Fu, Peter P. Wed .  
        "Quantitation of DNA reactive pyrrolic metabolites of senecionine – A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis".  Country unknown/Code not available.  doi:10.1016/j.jfda.2019.12.001.

Copy to clipboard


                    
@article{osti_1579432,

  title        = {Quantitation of DNA reactive pyrrolic metabolites of senecionine – A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis},

  author       = {Xia, Qingsu and He, Xiaobo and Shi, Qiang and Lin, Ge and Fu, Peter P.},

  abstractNote = {},

  doi          = {10.1016/j.jfda.2019.12.001},

  journal      = {Journal of Food and Drug Analysis},

  number       = 1,

  volume       = 28,

  place        = {Country unknown/Code not available},

  year         = {2020},

  month        = {1}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Publisher's Version of Record
DOI: 10.1016/j.jfda.2019.12.001

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

Red blood cells augment transport of reactive metabolites of monocrotaline from liver to lung in isolated and tandem liver and lung preparations

Journal Article Pan, L.C. ; Lame, M.W. ; Morin, D. ; ... - Toxicology and Applied Pharmacology; (United States)

Monocrotaline (MCT) is a pyrrolizidine alkaloid that causes pulmonary hypertension in rats by mechanisms which remain largely unknown. MCT is thought to be activated in the liver to a reactive intermediate that is transported to the lung where it causes endothelial injury. The authors previous pharmacokinetic work demonstrated significant sequestration of radioactivity in red blood cells (RBCs) of rats treated with (14C)MCT. To determine whether this RBC sequestration might be important in the transport of reactive MCT metabolites, they compared the effect of inclusion of RBCs in the perfusion buffer on the extent of covalent binding of (14C)MCT to ratmore »« less
DOI: 10.1016/S0041-008X(05)80016-X
The Impact of Glucuronidation on the Bioactivation and DNA Adduction of the Cooked-Food Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in vivo

Journal Article Malfatti, M A ; Ubick, E A ; Felton, J S - Carcinogenesis

UDP-glucuronosyltransferases (UGTs) catalyze the glucuronidation of many different chemicals. Glucuronidation is especially important for detoxifying reactive intermediates from metabolic reactions, which otherwise can be biotransformed into highly reactive cytotoxic or carcinogenic species. Detoxification of certain food-borne carcinogenic heterocyclic amines (HAs) is highly dependent on UGT1A-mediated glucuronidation. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most mass abundant carcinogenic HA found in well-done cooked meat, is extensively glucuronidated by UGT1A proteins. In humans, CYP1A2 catalyzed N-hydroxylation and subsequent UGT1A-mediated glucuronidation is a dominant pathway in the metabolism of PhIP. Therefore, changes in glucuronidation rates could significantly alter PhIP metabolism. To determine the importance of UGT1A-mediated glucuronidationmore »« less
DOI: 10.1093/carcin/bgi151

Full Text Available
Measurement of oxidative stress parameters using liquid chromatography-tandem mass spectroscopy (LC-MS/MS)

Journal Article Winnik, Witold M. ; Kitchin, Kirk T. - Toxicology and Applied Pharmacology

There is increasingly intense scientific and clinical interest in oxidative stress and the many parameters used to quantify the degree of oxidative stress. However, there remain many analytical limitations to currently available assays for oxidative stress markers. Recent improvements in software, hardware, and instrumentation design have made liquid chromatography and tandem mass spectroscopy (LC-MS/MS) methods optimal choices for the determination of many oxidative stress markers. In particular, LC-MS/MS often provides the advantages of higher specificity, higher sensitivity, and the capacity to determine multiple analytes (e.g. 4-11 oxidative stress markers per LC run) when compared to other available methods, such asmore »« less
DOI: 10.1016/j.taap.2008.05.003
Comparing identified and statistically significant lipids and polar metabolites in 15-year old serum and dried blood spot samples for longitudinal studies: Comparing lipids and metabolites in serum and DBS samples

Journal Article Kyle, Jennifer E. ; Casey, Cameron P. ; Stratton, Kelly G. ; ... - Rapid Communications in Mass Spectrometry

The use of dried blood spots (DBS) has many advantages over traditional plasma and serum samples such as smaller blood volume required, storage at room temperature, and ability for sampling in remote locations. However, understanding the robustness of different analytes in DBS samples is essential, especially in older samples collected for longitudinal studies. Here we analyzed DBS samples collected in 2000-2001 and stored at room temperature and compared them to matched serum samples stored at -80°C to determine if they could be effectively used as specific time points in a longitudinal study following metabolic disease. Four hundred small molecules weremore »« less
DOI: 10.1002/rcm.7808
Lack of effect of deferoxamine, dimethyl sulfoxide, and catalase on monocrotaline pyrrole pulmonary injury

Journal Article Bruner, L.H. ; Johnson, K. ; Carpenter, L.J. ; ... - J. Toxicol. Environ. Health; (United States)

Monocrotaline pyrrole (MCTP) is a reactive metabolite of the pyrrolizidine alkaloid monocrotaline. MCTP given intravenously to rats causes pulmonary hypertension and right ventricular hypertrophy. Lesions in lungs after MCTP treatment contain macrophages and neutrophils, which may contribute to the damage by generation of reactive oxygen metabolites. Rats were treated with MCTP and agents known to protect against oxygen radical-mediated damage in acute models of neutrophil-dependent lung injury. Rats received MCTP and deferoxamine mesylate (DF), dimethyl sulfoxide (DMSO), or polyethylene glycol-coupled catalase (PEG-CAT). MCTP/vehicle-treated controls developed lung injury manifested as increased lung weight, release of lactate dehydrogenase into the airway, andmore »« less
DOI: 10.1080/15287398709531013

Similar Records