18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes

Tsai, Richard M.; Bejanin, Alexandre; Lesman-Segev, Orit; LaJoie, Renaud; Visani, Adrienne; Bourakova, Viktoriya; O’Neil, James P.; Janabi, Mustafa; Baker, Suzanne; Lee, Suzee E.; Perry, David C.; Bajorek, Lynn; Karydas, Anna; Spina, Salvatore; Grinberg, Lea T.; Seeley, William W.; Ramos, Eliana M.; Coppola, Giovanni; Gorno-Tempini, Maria Luisa; Miller, Bruce L.; Rosen, Howard J.; Jagust, William; Boxer, Adam L.; Rabinovici, Gil D.

doi:10.1186/s13195-019-0470-7

Title: ¹⁸F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes

Journal Article · 30 January 2019 · Alzheimer's Research & Therapy

DOI: https://doi.org/10.1186/s13195-019-0470-7 · OSTI ID:1579333

^[1]; Bejanin, Alexandre ^[1]; Lesman-Segev, Orit ^[1]; LaJoie, Renaud ^[1]; Visani, Adrienne ^[1]; Bourakova, Viktoriya ^[1]; O’Neil, James P. ^[2]; Janabi, Mustafa ^[2]; Baker, Suzanne ^[2]; Lee, Suzee E. ^[1]; Perry, David C. ^[1]; Bajorek, Lynn ^[1]; Karydas, Anna ^[1]; Spina, Salvatore ^[1]; Grinberg, Lea T. ^[1]; Seeley, William W. ^[1]; Ramos, Eliana M. ^[3]; Coppola, Giovanni ^[3]; Gorno-Tempini, Maria Luisa ^[1]; Miller, Bruce L. ^[1] more »

Univ. of California, San Francisco, CA (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Univ. of California, Los Angeles, CA (United States)
Univ. of California, San Francisco, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

The tau positron emission tomography (PET) ligand ¹⁸F-flortaucipir binds to paired helical filaments of tau in aging and Alzheimer's disease (AD), but its utility in detecting tau aggregates in frontotemporal dementia (FTD) is uncertain. We performed ¹⁸F-flortaucipir imaging in patients with the FTD syndromes (n = 45): nonfluent variant primary progressive aphasia (nfvPPA) (n = 11), corticobasal syndrome (CBS) (n = 10), behavioral variant frontotemporal dementia (bvFTD) (n = 10), semantic variant primary progressive aphasia (svPPA) (n = 2) and FTD associated pathogenic genetic mutations microtubule-associated protein tau (MAPT) (n = 6), chromosome 9 open reading frame 72 (C9ORF72) (n = 5), and progranulin (GRN) (n = 1). All patients underwent MRI and β-amyloid biomarker testing via ¹¹C-PiB or cerebrospinal fluid. ¹⁸F-flortaucipir uptake in patients was compared to 53 β-amyloid negative normal controls using voxelwise and pre-specified region of interest approaches. On qualitative assessment, patients with nfvPPA showed elevated ¹⁸F-flortacupir binding in the left greater than right inferior frontal gyrus. Patients with CBS showed elevated binding in frontal white matter, with higher cortical gray matter uptake in a subset of β-amyloid-positive patients. Five of ten patients with sporadic bvFTD demonstrated increased frontotemporal binding. MAPT mutation carriers had elevated ¹⁸F-flortaucipir retention primarily, but not exclusively, in mutations with Alzheimer's-like neurofibrillary tangles. However, tracer retention was also seen in patients with svPPA, and the mutations C9ORF72, GRN predicted to have TDP-43 pathology. Quantitative region-of-interest differences between patients and controls were seen only in inferior frontal gyrus in nfvPPA and left insula and bilateral temporal poles in MAPT carriers. No significant regional differences were found in CBS or sporadic bvFTD. Two patients underwent postmortem neuropathological examination. A patient with C9ORF72, TDP-43-type B pathology, and incidental co-pathology of scattered neurofibrillary tangles in the middle frontal, inferior temporal gyrus showed corresponding mild ¹⁸F-flortaucipir retention without additional uptake matching the widespread TDP-43 type B pathology. A patient with sporadic bvFTD demonstrated punctate inferior temporal and hippocampus tracer retention, corresponding to the area of severe argyrophilic grain disease pathology. ¹⁸F-flortaucipir in patients with FTD and predicted tauopathy or TDP-43 pathology demonstrated limited sensitivity and specificity. Further postmortem pathological confirmation and development of FTD tau-specific ligands are needed.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1579333

Journal Information:: Alzheimer's Research & Therapy, Journal Name: Alzheimer's Research & Therapy Journal Issue: 1 Vol. 11; ISSN 1758-9193

Country of Publication:: United States

Language:: English

References (123)

Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia Seeley, William W.; Crawford, Richard; Rascovsky, Katya Archives of Neurology, Vol. 65, Issue 2 https://doi.org/10.1001/archneurol.2007.38	journal	February 2008
Prevalence of Amyloid PET Positivity in Dementia Syndromes: A Meta-analysis Ossenkoppele, Rik; Jansen, Willemijn J.; Rabinovici, Gil D. JAMA, Vol. 313, Issue 19 https://doi.org/10.1001/jama.2015.4669	journal	May 2015
Clinicopathological correlations in corticobasal degeneration Lee, Suzee E.; Rabinovici, Gil D.; Mayo, Mary Catherine Annals of Neurology, Vol. 70, Issue 2 https://doi.org/10.1002/ana.22424	journal	August 2011
Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue: Validation of PET Tracer Marquié, Marta; Normandin, Marc D.; Vanderburg, Charles R. Annals of Neurology, Vol. 78, Issue 5 https://doi.org/10.1002/ana.24517	journal	September 2015
Typical and atypical pathology in primary progressive aphasia variants: Pathology in PPA Variants Spinelli, Edoardo G.; Mandelli, Maria Luisa; Miller, Zachary A. Annals of Neurology, Vol. 81, Issue 3 https://doi.org/10.1002/ana.24885	journal	March 2017
18 F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study : Flortaucipir Tau PET in PSP Schonhaut, Daniel R.; McMillan, Corey T.; Spina, Salvatore Annals of Neurology, Vol. 82, Issue 4 https://doi.org/10.1002/ana.25060	journal	October 2017
Abnormal Tau-Containing Filaments in Neurodegenerative Diseases Crowther, R. A.; Goedert, M. Journal of Structural Biology, Vol. 130, Issue 2-3 https://doi.org/10.1006/jsbi.2000.4270	journal	June 2000
True ultra-low-dose amyloid PET/MRI enhanced with deep learning for clinical interpretation Chen, Kevin T.; Toueg, Tyler N.; Koran, Mary Ellen Irene European Journal of Nuclear Medicine and Molecular Imaging, Vol. 48, Issue 8 https://doi.org/10.1007/s00259-020-05151-9	journal	January 2021
MAPT S305I mutation: implications for argyrophilic grain disease Kovacs, Gabor G.; Pittman, Alan; Revesz, Tamas Acta Neuropathologica, Vol. 116, Issue 1 https://doi.org/10.1007/s00401-007-0322-6	journal	December 2007
A harmonized classification system for FTLD-TDP pathology Mackenzie, Ian R. A.; Neumann, Manuela; Baborie, Atik Acta Neuropathologica, Vol. 122, Issue 1 https://doi.org/10.1007/s00401-011-0845-8	journal	June 2011
Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion Bieniek, Kevin F.; Murray, Melissa E.; Rutherford, Nicola J. Acta Neuropathologica, Vol. 125, Issue 2 https://doi.org/10.1007/s00401-012-1048-7	journal	September 2012
Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration McMillan, Corey T.; Irwin, David J.; Nasrallah, Ilya Acta Neuropathologica, Vol. 132, Issue 6 https://doi.org/10.1007/s00401-016-1640-3	journal	November 2016
National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease Hyman, Bradley T.; Phelps, Creighton H.; Beach, Thomas G. Alzheimer's & Dementia, Vol. 8, Issue 1 https://doi.org/10.1016/j.jalz.2011.10.007	journal	January 2012
Prominent phenotypic variability associated with mutations in Progranulin Kelley, Brendan J.; Haidar, Wael; Boeve, Bradley F. Neurobiology of Aging, Vol. 30, Issue 5 https://doi.org/10.1016/j.neurobiolaging.2007.08.022	journal	May 2009
A probabilistic MR atlas of the human cerebellum Diedrichsen, Jörn; Balsters, Joshua H.; Flavell, Jonathan NeuroImage, Vol. 46, Issue 1 https://doi.org/10.1016/j.neuroimage.2009.01.045	journal	May 2009
PET Imaging of Tau Deposition in the Aging Human Brain Schöll, Michael; Lockhart, Samuel N.; Schonhaut, Daniel R. Neuron, Vol. 89, Issue 5 https://doi.org/10.1016/j.neuron.2016.01.028	journal	March 2016
The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service Hughes, Andrew J.; Daniel, Susan E.; Ben‐Shlomo, Yoav Brain, Vol. 125, Issue 4 https://doi.org/10.1093/brain/awf080	journal	April 2002
The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family Spina, Salvatore; Farlow, Martin R.; Unverzagt, Frederick W. Brain, Vol. 131, Issue 1 https://doi.org/10.1093/brain/awm280	journal	December 2007
Does corticobasal degeneration exist? A clinicopathological re-evaluation Ling, H.; O'Sullivan, S. S.; Holton, J. L. Brain, Vol. 133, Issue 7 https://doi.org/10.1093/brain/awq123	journal	June 2010
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia Rascovsky, Katya; Hodges, John R.; Knopman, David Brain, Vol. 134, Issue 9 https://doi.org/10.1093/brain/awr179	journal	August 2011
Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p Hsiung, G. -Y. R.; DeJesus-Hernandez, M.; Feldman, H. H. Brain, Vol. 135, Issue 3 https://doi.org/10.1093/brain/awr354	journal	February 2012
Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features Mahoney, C. J.; Beck, J.; Rohrer, J. D. Brain, Vol. 135, Issue 3 https://doi.org/10.1093/brain/awr361	journal	February 2012
Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation Villeneuve, Sylvia; Rabinovici, Gil D.; Cohn-Sheehy, Brendan I. Brain, Vol. 138, Issue 7 https://doi.org/10.1093/brain/awv112	journal	May 2015
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease Ossenkoppele, Rik; Schonhaut, Daniel R.; Schöll, Michael Brain, Vol. 139, Issue 5 https://doi.org/10.1093/brain/aww027	journal	March 2016
Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies Mackenzie, Ian R. A.; Neumann, Manuela Journal of Neurochemistry, Vol. 138 https://doi.org/10.1111/jnc.13588	journal	June 2016
Patterns of Frontal Lobe Atrophy in Frontotemporal Dementia: A Volumetric MRI Study Perry, Richard J.; Graham, Andrew; Williams, Guy Dementia and Geriatric Cognitive Disorders, Vol. 22, Issue 4 https://doi.org/10.1159/000095128	journal	January 2006
An autoradiographic evaluation of AV-1451 Tau PET in dementia Lowe, Val J.; Curran, Geoffry; Fang, Ping Acta Neuropathologica Communications, Vol. 4, Issue 1 https://doi.org/10.1186/s40478-016-0315-6	journal	June 2016
The natural history of temporal variant frontotemporal dementia Seeley, W. W.; Bauer, A. M.; Miller, B. L. Neurology, Vol. 64, Issue 8 https://doi.org/10.1212/01.wnl.0000158425.46019.5c	journal	April 2005
Elevated 18 F-AV-1451 PET tracer uptake detected in incidental imaging findings Lockhart, Samuel N.; Ayakta, Nagehan; Winer, Joseph R. Neurology, Vol. 88, Issue 11 https://doi.org/10.1212/wnl.0000000000003724	journal	February 2017
Classification of primary progressive aphasia and its variants Gorno-Tempini, M. L.; Hillis, A. E.; Weintraub, S. Neurology, Vol. 76, Issue 11 https://doi.org/10.1212/wnl.0b013e31821103e6	journal	February 2011
Criteria for the diagnosis of corticobasal degeneration Armstrong, M. J.; Litvan, I.; Lang, A. E. Neurology, Vol. 80, Issue 5 https://doi.org/10.1212/wnl.0b013e31827f0fd1	journal	January 2013
Procedures for setting normal values O'Brien, Peter C.; Dyck, Peter J. Neurology, Vol. 45, Issue 1 https://doi.org/10.1212/wnl.45.1.17	journal	January 1995
Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease Jack, C. R.; Petersen, R. C.; Xu, Y. C. Neurology, Vol. 49, Issue 3 https://doi.org/10.1212/wnl.49.3.786	journal	September 1997
Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p Stewart, Heather; Rutherford, Nicola J.; Briemberg, Hannah Acta Neuropathologica https://doi.org/10.14288/1.0103498	text	January 2012
Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study. Cash, David M.; Bocchetta, Martina; Thomas, David L. Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.18700	text	January 2018
Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles Hostetler, E. D.; Walji, A. M.; Zeng, Z. Journal of Nuclear Medicine, Vol. 57, Issue 10 https://doi.org/10.2967/jnumed.115.171678	journal	May 2016
Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia Seeley, William W.; Crawford, Richard; Rascovsky, Katya Archives of Neurology, Vol. 65, Issue 2 https://doi.org/10.1001/archneurol.2007.38	journal	February 2008
Prevalence of Amyloid PET Positivity in Dementia Syndromes: A Meta-analysis Ossenkoppele, Rik; Jansen, Willemijn J.; Rabinovici, Gil D. JAMA, Vol. 313, Issue 19 https://doi.org/10.1001/jama.2015.4669	journal	May 2015
[ 18 F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation Bevan Jones, W. Richard; Cope, Thomas E.; Passamonti, Luca Annals of Clinical and Translational Neurology, Vol. 3, Issue 12 https://doi.org/10.1002/acn3.366	journal	October 2016
Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects Shaw, Leslie M.; Vanderstichele, Hugo; Knapik-Czajka, Malgorzata Annals of Neurology, Vol. 65, Issue 4 https://doi.org/10.1002/ana.21610	journal	April 2009
Clinicopathological correlations in corticobasal degeneration Lee, Suzee E.; Rabinovici, Gil D.; Mayo, Mary Catherine Annals of Neurology, Vol. 70, Issue 2 https://doi.org/10.1002/ana.22424	journal	August 2011
Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue: Validation of PET Tracer Marquié, Marta; Normandin, Marc D.; Vanderburg, Charles R. Annals of Neurology, Vol. 78, Issue 5 https://doi.org/10.1002/ana.24517	journal	September 2015
Tau positron emission tomographic imaging in aging and early Alzheimer disease: Tau PET in Aging and Early AD Johnson, Keith A.; Schultz, Aaron; Betensky, Rebecca A. Annals of Neurology, Vol. 79, Issue 1 https://doi.org/10.1002/ana.24546	journal	December 2015
Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies: Tau Imaging: Pathological Correlations Marquié, Marta; Normandin, Marc D.; Meltzer, Avery C. Annals of Neurology, Vol. 81, Issue 1 https://doi.org/10.1002/ana.24844	journal	January 2017
Typical and atypical pathology in primary progressive aphasia variants: Pathology in PPA Variants Spinelli, Edoardo G.; Mandelli, Maria Luisa; Miller, Zachary A. Annals of Neurology, Vol. 81, Issue 3 https://doi.org/10.1002/ana.24885	journal	March 2017
18 F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study : Flortaucipir Tau PET in PSP Schonhaut, Daniel R.; McMillan, Corey T.; Spina, Salvatore Annals of Neurology, Vol. 82, Issue 4 https://doi.org/10.1002/ana.25060	journal	October 2017
Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease: Origin and Spread of Atrophy in AD Variants Ossenkoppele, Rik; Cohn-Sheehy, Brendan I.; La Joie, Renaud Human Brain Mapping, Vol. 36, Issue 11 https://doi.org/10.1002/hbm.22927	journal	August 2015
Elevated in vivo [18F]-AV-1451 uptake in a patient with progressive supranuclear palsy: Elevated [18F]-AV-1451 Uptake in PSP Hammes, Jochen; Bischof, Gérard N.; Giehl, Kathrin Movement Disorders, Vol. 32, Issue 1 https://doi.org/10.1002/mds.26727	journal	August 2016
[ 18 F]AV-1451 tau positron emission tomography in progressive supranuclear palsy : Tau-pet in Progressive Supranuclear Palsy Whitwell, Jennifer L.; Lowe, Val J.; Tosakulwong, Nirubol Movement Disorders, Vol. 32, Issue 1 https://doi.org/10.1002/mds.26834	journal	October 2016
Abnormal Tau-Containing Filaments in Neurodegenerative Diseases Crowther, R. A.; Goedert, M. Journal of Structural Biology, Vol. 130, Issue 2-3 https://doi.org/10.1006/jsbi.2000.4270	journal	June 2000
Head to head comparison of [18F] AV-1451 and [18F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia Jang, Young Kyoung; Lyoo, Chul Hyoung; Park, Seongbeom European Journal of Nuclear Medicine and Molecular Imaging, Vol. 45, Issue 3 https://doi.org/10.1007/s00259-017-3876-0	journal	November 2017
MAPT S305I mutation: implications for argyrophilic grain disease Kovacs, Gabor G.; Pittman, Alan; Revesz, Tamas Acta Neuropathologica, Vol. 116, Issue 1 https://doi.org/10.1007/s00401-007-0322-6	journal	December 2007
A harmonized classification system for FTLD-TDP pathology Mackenzie, Ian R. A.; Neumann, Manuela; Baborie, Atik Acta Neuropathologica, Vol. 122, Issue 1 https://doi.org/10.1007/s00401-011-0845-8	journal	June 2011
Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p Stewart, Heather; Rutherford, Nicola J.; Briemberg, Hannah Acta Neuropathologica, Vol. 123, Issue 3 https://doi.org/10.1007/s00401-011-0937-5	journal	January 2012
Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion Bieniek, Kevin F.; Murray, Melissa E.; Rutherford, Nicola J. Acta Neuropathologica, Vol. 125, Issue 2 https://doi.org/10.1007/s00401-012-1048-7	journal	September 2012
Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation Grinberg, Lea Tenenholz; Wang, Xuehua; Wang, Chao Acta Neuropathologica, Vol. 125, Issue 4 https://doi.org/10.1007/s00401-013-1080-2	journal	January 2013
Differential clinicopathologic and genetic features of late-onset amnestic dementias Murray, Melissa E.; Cannon, Ashley; Graff-Radford, Neill R. Acta Neuropathologica, Vol. 128, Issue 3 https://doi.org/10.1007/s00401-014-1302-2	journal	June 2014
[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration Josephs, Keith A.; Whitwell, Jennifer L.; Tacik, Pawel Acta Neuropathologica, Vol. 132, Issue 6 https://doi.org/10.1007/s00401-016-1618-1	journal	September 2016
Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration McMillan, Corey T.; Irwin, David J.; Nasrallah, Ilya Acta Neuropathologica, Vol. 132, Issue 6 https://doi.org/10.1007/s00401-016-1640-3	journal	November 2016
[18F] AV-1451 uptake in corticobasal syndrome: the influence of beta-amyloid and clinical presentation Ali, F.; Whitwell, J. L.; Martin, P. R. Journal of Neurology, Vol. 265, Issue 5 https://doi.org/10.1007/s00415-018-8815-x	journal	March 2018
The non-fluent/agrammatic variant of primary progressive aphasia Grossman, Murray The Lancet Neurology, Vol. 11, Issue 6 https://doi.org/10.1016/S1474-4422(12)70099-6	journal	June 2012
Considerations and code for partial volume correcting [ 18 F]-AV-1451 tau PET data Baker, Suzanne L.; Maass, Anne; Jagust, William J. Data in Brief, Vol. 15 https://doi.org/10.1016/j.dib.2017.10.024	journal	December 2017
National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease Hyman, Bradley T.; Phelps, Creighton H.; Beach, Thomas G. Alzheimer's & Dementia, Vol. 8, Issue 1 https://doi.org/10.1016/j.jalz.2011.10.007	journal	January 2012
[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease Xia, Chun-Fang; Arteaga, Janna; Chen, Gang Alzheimer's & Dementia, Vol. 9, Issue 6 https://doi.org/10.1016/j.jalz.2012.11.008	journal	November 2013
Characterization of tau positron emission tomography tracer [ 18 F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias Sander, Kerstin; Lashley, Tammaryn; Gami, Priya Alzheimer's & Dementia, Vol. 12, Issue 11 https://doi.org/10.1016/j.jalz.2016.01.003	journal	November 2016
Prominent phenotypic variability associated with mutations in Progranulin Kelley, Brendan J.; Haidar, Wael; Boeve, Bradley F. Neurobiology of Aging, Vol. 30, Issue 5 https://doi.org/10.1016/j.neurobiolaging.2007.08.022	journal	May 2009
Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study Cash, David M.; Bocchetta, Martina; Thomas, David L. Neurobiology of Aging, Vol. 62 https://doi.org/10.1016/j.neurobiolaging.2017.10.008	journal	February 2018
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest Desikan, Rahul S.; Ségonne, Florent; Fischl, Bruce NeuroImage, Vol. 31, Issue 3 https://doi.org/10.1016/j.neuroimage.2006.01.021	journal	July 2006
Regional white matter volume differences in nondemented aging and Alzheimer's disease Salat, D.; Greve, D.; Pacheco, J. NeuroImage, Vol. 44, Issue 4 https://doi.org/10.1016/j.neuroimage.2008.10.030	journal	February 2009
A probabilistic MR atlas of the human cerebellum Diedrichsen, Jörn; Balsters, Joshua H.; Flavell, Jonathan NeuroImage, Vol. 46, Issue 1 https://doi.org/10.1016/j.neuroimage.2009.01.045	journal	May 2009
Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease Maass, Anne; Landau, Susan; Baker, Suzanne L. NeuroImage, Vol. 157 https://doi.org/10.1016/j.neuroimage.2017.05.058	journal	August 2017
PET Imaging of Tau Deposition in the Aging Human Brain Schöll, Michael; Lockhart, Samuel N.; Schonhaut, Daniel R. Neuron, Vol. 89, Issue 5 https://doi.org/10.1016/j.neuron.2016.01.028	journal	March 2016
A probabilistic MR atlas of the human cerebellum Diedrichsen, J.; Balsters, Jh; Flavell, J. NeuroImage, Vol. 47 https://doi.org/10.1016/s1053-8119(09)71166-8	journal	July 2009
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease Sevigny, Jeff; Chiao, Ping; Bussière, Thierry Nature, Vol. 537, Issue 7618 https://doi.org/10.1038/nature19323	journal	August 2016
Advances in understanding the molecular basis of frontotemporal dementia Rademakers, Rosa; Neumann, Manuela; Mackenzie, Ian R. Nature Reviews Neurology, Vol. 8, Issue 8 https://doi.org/10.1038/nrneurol.2012.117	journal	June 2012
Ancient genomes reveal social and genetic structure of Late Neolithic Switzerland Furtwängler, Anja; Rohrlach, A. B.; Lamnidis, Thiseas C. Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-15560-x	journal	April 2020
The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service Hughes, Andrew J.; Daniel, Susan E.; Ben‐Shlomo, Yoav Brain, Vol. 125, Issue 4 https://doi.org/10.1093/brain/awf080	journal	April 2002
The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene Mackenzie, I. R. A.; Baker, M.; Pickering-Brown, S. Brain, Vol. 129, Issue 11 https://doi.org/10.1093/brain/awl271	journal	September 2006
The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family Spina, Salvatore; Farlow, Martin R.; Unverzagt, Frederick W. Brain, Vol. 131, Issue 1 https://doi.org/10.1093/brain/awm280	journal	December 2007
Does corticobasal degeneration exist? A clinicopathological re-evaluation Ling, H.; O'Sullivan, S. S.; Holton, J. L. Brain, Vol. 133, Issue 7 https://doi.org/10.1093/brain/awq123	journal	June 2010
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia Rascovsky, Katya; Hodges, John R.; Knopman, David Brain, Vol. 134, Issue 9 https://doi.org/10.1093/brain/awr179	journal	August 2011
Neuropathological features of corticobasal degeneration presenting as corticobasal syndrome or Richardson syndrome Kouri, Naomi; Murray, Melissa E.; Hassan, Anhar Brain, Vol. 134, Issue 11 https://doi.org/10.1093/brain/awr234	journal	September 2011
Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p Hsiung, G. -Y. R.; DeJesus-Hernandez, M.; Feldman, H. H. Brain, Vol. 135, Issue 3 https://doi.org/10.1093/brain/awr354	journal	February 2012
Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features Mahoney, C. J.; Beck, J.; Rohrer, J. D. Brain, Vol. 135, Issue 3 https://doi.org/10.1093/brain/awr361	journal	February 2012
Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease Lehmann, Manja; Ghosh, Pia M.; Madison, Cindee Brain, Vol. 136, Issue 3 https://doi.org/10.1093/brain/aws327	journal	January 2013
Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation Villeneuve, Sylvia; Rabinovici, Gil D.; Cohn-Sheehy, Brendan I. Brain, Vol. 138, Issue 7 https://doi.org/10.1093/brain/awv112	journal	May 2015
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease Ossenkoppele, Rik; Schonhaut, Daniel R.; Schöll, Michael Brain, Vol. 139, Issue 5 https://doi.org/10.1093/brain/aww027	journal	March 2016
18 F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers Smith, Ruben; Puschmann, Andreas; Schöll, Michael Brain, Vol. 139, Issue 9 https://doi.org/10.1093/brain/aww163	journal	June 2016
18 F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy Passamonti, Luca; Vázquez Rodríguez, Patricia; Hong, Young T. Brain https://doi.org/10.1093/brain/aww340	journal	January 2017
Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer’s disease Bejanin, Alexandre; Schonhaut, Daniel R.; La Joie, Renaud Brain, Vol. 140, Issue 12 https://doi.org/10.1093/brain/awx243	journal	October 2017
Clinicopathological correlations in behavioural variant frontotemporal dementia Perry, David C.; Brown, Jesse A.; Possin, Katherine L. Brain, Vol. 140, Issue 12 https://doi.org/10.1093/brain/awx254	journal	October 2017
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data McKenna, A.; Hanna, M.; Banks, E. Genome Research, Vol. 20, Issue 9 https://doi.org/10.1101/gr.107524.110	journal	July 2010
Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies Mackenzie, Ian R. A.; Neumann, Manuela Journal of Neurochemistry, Vol. 138 https://doi.org/10.1111/jnc.13588	journal	June 2016
Therapy and clinical trials in frontotemporal dementia: past, present, and future Tsai, Richard M.; Boxer, Adam L. Journal of Neurochemistry, Vol. 138 https://doi.org/10.1111/jnc.13640	journal	June 2016
Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene ( MAPT ) mutations: a chameleon for neuropathology and neuroimaging Ghetti, Bernardino; Oblak, Adrian L.; Boeve, Bradley F. Neuropathology and Applied Neurobiology, Vol. 41, Issue 1 https://doi.org/10.1111/nan.12213	journal	January 2015
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Neumann, M.; Sampathu, D. M.; Kwong, L. K. Science, Vol. 314, Issue 5796 https://doi.org/10.1126/science.1134108	journal	October 2006
[ 18 F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia Bevan-Jones, W. R.; Cope, Thomas E.; Jones, P. Simon Journal of Neurology, Neurosurgery & Psychiatry, Vol. 89, Issue 10 https://doi.org/10.1136/jnnp-2017-316402	journal	September 2017
Flortaucipir tau PET imaging in semantic variant primary progressive aphasia Makaretz, Sara J.; Quimby, Megan; Collins, Jessica Journal of Neurology, Neurosurgery & Psychiatry, Vol. 89, Issue 10 https://doi.org/10.1136/jnnp-2017-316409	journal	October 2017
Patterns of Frontal Lobe Atrophy in Frontotemporal Dementia: A Volumetric MRI Study Perry, Richard J.; Graham, Andrew; Williams, Guy Dementia and Geriatric Cognitive Disorders, Vol. 22, Issue 4 https://doi.org/10.1159/000095128	journal	January 2006
Positron emission tomography imaging of tau pathology in progressive supranuclear palsy Coakeley, Sarah; Cho, Sang Soo; Koshimori, Yuko Journal of Cerebral Blood Flow & Metabolism, Vol. 37, Issue 9 https://doi.org/10.1177/0271678X16683695	journal	December 2016
An autoradiographic evaluation of AV-1451 Tau PET in dementia Lowe, Val J.; Curran, Geoffry; Fang, Ping Acta Neuropathologica Communications, Vol. 4, Issue 1 https://doi.org/10.1186/s40478-016-0315-6	journal	June 2016
The natural history of temporal variant frontotemporal dementia Seeley, W. W.; Bauer, A. M.; Miller, B. L. Neurology, Vol. 64, Issue 8 https://doi.org/10.1212/01.WNL.0000158425.46019.5C	journal	April 2005
Frontotemporal dementia with the V337M MAPT mutation : Tau-PET and pathology correlations Spina, Salvatore; Schonhaut, Daniel R.; Boeve, Bradley F. Neurology, Vol. 88, Issue 8 https://doi.org/10.1212/WNL.0000000000003636	journal	January 2017
Elevated 18 F-AV-1451 PET tracer uptake detected in incidental imaging findings Lockhart, Samuel N.; Ayakta, Nagehan; Winer, Joseph R. Neurology, Vol. 88, Issue 11 https://doi.org/10.1212/WNL.0000000000003724	journal	February 2017
In vivo retention of 18 F-AV-1451 in corticobasal syndrome Smith, Ruben; Schöll, Michael; Widner, Håkan Neurology, Vol. 89, Issue 8 https://doi.org/10.1212/WNL.0000000000004264	journal	July 2017
18 F-AV-1451 binds to motor-related subcortical gray and white matter in corticobasal syndrome Cho, Hanna; Baek, Min Seok; Choi, Jae Yong Neurology, Vol. 89, Issue 11 https://doi.org/10.1212/WNL.0000000000004364	journal	August 2017
Associations between [ 18 F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample La Joie, Renaud; Bejanin, Alexandre; Fagan, Anne M. Neurology, Vol. 90, Issue 4 https://doi.org/10.1212/WNL.0000000000004860	journal	December 2017
In vivo 18 F-AV-1451 tau PET signal in MAPT mutation carriers varies by expected tau isoforms Jones, David T.; Knopman, David S.; Graff-Radford, Jonathan Neurology, Vol. 90, Issue 11 https://doi.org/10.1212/WNL.0000000000005117	journal	February 2018
Classification of primary progressive aphasia and its variants Gorno-Tempini, M. L.; Hillis, A. E.; Weintraub, S. Neurology, Vol. 76, Issue 11 https://doi.org/10.1212/WNL.0b013e31821103e6	journal	February 2011
Criteria for the diagnosis of corticobasal degeneration Armstrong, M. J.; Litvan, I.; Lang, A. E. Neurology, Vol. 80, Issue 5 https://doi.org/10.1212/WNL.0b013e31827f0fd1	journal	January 2013
Procedures for setting normal values O'Brien, Peter C.; Dyck, Peter J. Neurology, Vol. 45, Issue 1 https://doi.org/10.1212/WNL.45.1.17	journal	January 1995
Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease Jack, C. R.; Petersen, R. C.; Xu, Y. C. Neurology, Vol. 49, Issue 3 https://doi.org/10.1212/WNL.49.3.786	journal	September 1997
Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p Stewart, Heather; Rutherford, Nicola J.; Briemberg, Hannah Acta Neuropathologica https://doi.org/10.14288/1.0103498	text	January 2012
Region-Specific Hierarchy between Atrophy, Hypometabolism, and -Amyloid (A ) Load in Alzheimer's Disease Dementia La Joie, R.; Perrotin, A.; Barre, L. Journal of Neuroscience, Vol. 32, Issue 46 https://doi.org/10.1523/JNEUROSCI.2170-12.2012	journal	November 2012
[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation Bevan Jones, Wr; Cope, Thomas; Passamonti, Luca Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.13266	text	January 2016
[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia Bevan-Jones, William Richard; Cope, Thomas Edmund; Jones, Ps ${dspace.name} https://doi.org/10.17863/cam.13435	text	January 2017
Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study. Cash, David M.; Bocchetta, Martina; Thomas, David L. Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.18700	text	January 2018
[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia Bevan-Jones, William; Cope, Thomas; Jones, Simon BMJ Publishing Group https://doi.org/10.17863/cam.20229	journalarticle	January 2017
[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation Bevan Jones, Wr; Cope, Thomas; Passamonti, Luca Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.6334	text	January 2016
Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles Hostetler, E. D.; Walji, A. M.; Zeng, Z. Journal of Nuclear Medicine, Vol. 57, Issue 10 https://doi.org/10.2967/jnumed.115.171678	journal	May 2016
A harmonized classification system for FTLD-TDP pathology Mackenzie, I. R. A.; Neumann, M.; Baborie, A. Springer https://doi.org/10.5167/uzh-55579	text	January 2011
Advances in understanding the molecular basis of frontotemporal dementia Rosa, Rademakers,; Manuela, Neumann,; R., Mackenzie, Ian Nature Publishing Group https://doi.org/10.5167/uzh-68439	text	January 2012
An autoradiographic evaluation of AV-1451 Tau PET in dementia Lowe, Val; Curran, Geoffry; Fang, Ping Figshare https://doi.org/10.6084/m9.figshare.c.3645467	collection	January 2016

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Additional file 1: of 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes Tsai, Richard; Bejanin, Alexandre; Lesman-Segev, Orit https://doi.org/10.6084/m9.figshare.7659659 The current record is supplemented by this image	image	January 2019
Additional file 1: of 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes Tsai, Richard; Bejanin, Alexandre; Lesman-Segev, Orit https://doi.org/10.6084/m9.figshare.7659659.v1 The current record is supplemented by this image	image	January 2019
Additional file 2: of 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes Tsai, Richard; Bejanin, Alexandre; Lesman-Segev, Orit https://doi.org/10.6084/m9.figshare.7659665 The current record is supplemented by this image	image	January 2019
Additional file 2: of 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes Tsai, Richard; Bejanin, Alexandre; Lesman-Segev, Orit https://doi.org/10.6084/m9.figshare.7659665.v1 The current record is supplemented by this image	image	January 2019
Additional file 3: of 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes Tsai, Richard; Bejanin, Alexandre; Lesman-Segev, Orit https://doi.org/10.6084/m9.figshare.7659677 The current record is supplemented by this image	image	January 2019
Additional file 3: of 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes Tsai, Richard; Bejanin, Alexandre; Lesman-Segev, Orit https://doi.org/10.6084/m9.figshare.7659677.v1 The current record is supplemented by this image	image	January 2019
18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes Tsai, Richard; Bejanin, Alexandre; Lesman-Segev, Orit https://doi.org/10.6084/m9.figshare.c.4386029 The current record is supplemented by this collection	collection	January 2019
18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes Tsai, Richard; Bejanin, Alexandre; Lesman-Segev, Orit https://doi.org/10.6084/m9.figshare.c.4386029.v1 The current record is supplemented by this collection	collection	January 2019

Title: 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes

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