Raman mapping of fentanyl transdermal delivery systems with off-label modifications

doi:10.1039/C9AN01289C

Title: Raman mapping of fentanyl transdermal delivery systems with off-label modifications

Abstract

Raman mapping and chemometric models were used to characterize crystal formation in fentanyl transdermal delivery systems resulting from off-label modifications.

Authors:

Xu, Teng ^[1];

^[1];

^[1]; Strasinger, Caroline ^[2];

^[1];

^[1]; Wokovich, Anna M. ^[1]

Food and Drug Administration (FDA)/Center for Drug Evaluation and Research (CDER)/Office of Pharmaceutical Quality (OPQ)/Office of Testing and Research (OTR)/Division of Pharmaceutical Analysis (DPA), St Louis, USA
FDA/CDER/OPQ/Office of New Drug Products (ONDP), Silver Spring, USA

Publication Date:: 2020-02-03

Sponsoring Org.:: USDOE

OSTI Identifier:: 1579278

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Analyst

Additional Journal Information:: Journal Name: Analyst Journal Volume: 145 Journal Issue: 3; Journal ID: ISSN 0003-2654

Publisher:: Royal Society of Chemistry (RSC)

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Xu, Teng, Yilmaz, Huzeyfe, Willett, Daniel R., Strasinger, Caroline, Rodriguez, Jason D., Keire, David A., and Wokovich, Anna M. Raman mapping of fentanyl transdermal delivery systems with off-label modifications.  United Kingdom: N. p., 2020. 
        Web.  doi:10.1039/C9AN01289C.

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                    Xu, Teng, Yilmaz, Huzeyfe, Willett, Daniel R., Strasinger, Caroline, Rodriguez, Jason D., Keire, David A., & Wokovich, Anna M. Raman mapping of fentanyl transdermal delivery systems with off-label modifications.  United Kingdom.  doi:10.1039/C9AN01289C.

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                    Xu, Teng, Yilmaz, Huzeyfe, Willett, Daniel R., Strasinger, Caroline, Rodriguez, Jason D., Keire, David A., and Wokovich, Anna M. Mon .  
        "Raman mapping of fentanyl transdermal delivery systems with off-label modifications".  United Kingdom.  doi:10.1039/C9AN01289C.

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@article{osti_1579278,

  title        = {Raman mapping of fentanyl transdermal delivery systems with off-label modifications},

  author       = {Xu, Teng and Yilmaz, Huzeyfe and Willett, Daniel R. and Strasinger, Caroline and Rodriguez, Jason D. and Keire, David A. and Wokovich, Anna M.},

  abstractNote = {Raman mapping and chemometric models were used to characterize crystal formation in fentanyl transdermal delivery systems resulting from off-label modifications.},

  doi          = {10.1039/C9AN01289C},

  journal      = {Analyst},

  number       = 3,

  volume       = 145,

  place        = {United Kingdom},

  year         = {2020},

  month        = {2}

}

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DOI: 10.1039/C9AN01289C

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Title: Raman mapping of fentanyl transdermal delivery systems with off-label modifications

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Multivariate curve resolution applied to second order data
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Selectivity, local rank, three-way data analysis and ambiguity in multivariate curve resolution
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Quantitative Evaluation of the Sensitivity of Library-Based Raman Spectral Correlation Methods
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