Raman mapping of fentanyl transdermal delivery systems with off-label modifications

Xu, Teng; Yilmaz, Huzeyfe; Willett, Daniel R.; Strasinger, Caroline; Rodriguez, Jason D.; Keire, David A.; Wokovich, Anna M.

doi:10.1039/C9AN01289C

Title: Raman mapping of fentanyl transdermal delivery systems with off-label modifications

Abstract

Raman mapping and chemometric models were used to characterize crystal formation in fentanyl transdermal delivery systems resulting from off-label modifications.

Authors:

Xu, Teng ^[1];

^[1];

^[1]; Strasinger, Caroline ^[2];

^[1];

^[1]; Wokovich, Anna M. ^[1]

Food and Drug Administration (FDA)/Center for Drug Evaluation and Research (CDER)/Office of Pharmaceutical Quality (OPQ)/Office of Testing and Research (OTR)/Division of Pharmaceutical Analysis (DPA), St Louis, USA
FDA/CDER/OPQ/Office of New Drug Products (ONDP), Silver Spring, USA

Publication Date:: 2020-02-03

Sponsoring Org.:: USDOE

OSTI Identifier:: 1579278

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Analyst

Additional Journal Information:: Journal Name: Analyst Journal Volume: 145 Journal Issue: 3; Journal ID: ISSN 0003-2654

Publisher:: Royal Society of Chemistry (RSC)

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Xu, Teng, Yilmaz, Huzeyfe, Willett, Daniel R., Strasinger, Caroline, Rodriguez, Jason D., Keire, David A., and Wokovich, Anna M. Raman mapping of fentanyl transdermal delivery systems with off-label modifications.  United Kingdom: N. p., 2020. 
Web.  doi:10.1039/C9AN01289C.

Copy to clipboard


                    Xu, Teng, Yilmaz, Huzeyfe, Willett, Daniel R., Strasinger, Caroline, Rodriguez, Jason D., Keire, David A., & Wokovich, Anna M. Raman mapping of fentanyl transdermal delivery systems with off-label modifications.  United Kingdom.  https://doi.org/10.1039/C9AN01289C

Copy to clipboard


                    Xu, Teng, Yilmaz, Huzeyfe, Willett, Daniel R., Strasinger, Caroline, Rodriguez, Jason D., Keire, David A., and Wokovich, Anna M. Mon .  
"Raman mapping of fentanyl transdermal delivery systems with off-label modifications".  United Kingdom.  https://doi.org/10.1039/C9AN01289C.

Copy to clipboard


                    
@article{osti_1579278,

  title        = {Raman mapping of fentanyl transdermal delivery systems with off-label modifications},

  author       = {Xu, Teng and Yilmaz, Huzeyfe and Willett, Daniel R. and Strasinger, Caroline and Rodriguez, Jason D. and Keire, David A. and Wokovich, Anna M.},

  abstractNote = {Raman mapping and chemometric models were used to characterize crystal formation in fentanyl transdermal delivery systems resulting from off-label modifications.},

  doi          = {10.1039/C9AN01289C},

  journal      = {Analyst},

  number       = 3,

  volume       = 145,

  place        = {United Kingdom},

  year         = {2020},

  month        = {2}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (Publisher)

Publisher's Version of Record
https://doi.org/10.1039/C9AN01289C

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Induction and Inhibition of Crystallization in Drug-in-Adhesive-Type Transdermal Patches
journal, October 2012

Jain, Piyush; Banga, Ajay K.
Pharmaceutical Research, Vol. 30, Issue 2
DOI: 10.1007/s11095-012-0901-7

Formulation and optimization of desogestrel transdermal contraceptive patch using crystallization studies
journal, January 2013

Sachdeva, Vishal; Bai, Yun; Kydonieus, Agis
International Journal of Pharmaceutics, Vol. 441, Issue 1-2
DOI: 10.1016/j.ijpharm.2012.12.014

Identification of new psychoactive substances (NPS) by Raman spectroscopy
journal, October 2018

Omar, Jone; Slowikowski, Boleslaw; Guillou, Claude
Journal of Raman Spectroscopy, Vol. 50, Issue 1
DOI: 10.1002/jrs.5496

Pharmaceutics: Selection and Use of Crystallization Inhibitors for Matrix-type Transdermal Drug-delivery Systems Containing Sex Steroids*
journal, December 1998

Lipp, Ralph
Journal of Pharmacy and Pharmacology, Vol. 50, Issue 12
DOI: 10.1111/j.2042-7158.1998.tb03357.x

Applications of Raman spectroscopy in skin research — From skin physiology and diagnosis up to risk assessment and dermal drug delivery
journal, July 2015

Franzen, Lutz; Windbergs, Maike
Advanced Drug Delivery Reviews, Vol. 89
DOI: 10.1016/j.addr.2015.04.002

Use of isothermal heat conduction microcalorimetry, X-ray diffraction, and optical microscopy for characterisation of crystals grown in steroid combination-containing transdermal drug delivery systems
journal, March 2004

Latsch, Silvia; Selzer, Torsten; Fink, Lothar
European Journal of Pharmaceutics and Biopharmaceutics, Vol. 57, Issue 2
DOI: 10.1016/S0939-6411(03)00120-6

The effect of drug concentration on solvent activity in silicone membranes
journal, July 2009

Santos, P.; Machado, M.; Watkinson, A. C.
International Journal of Pharmaceutics, Vol. 377, Issue 1-2
DOI: 10.1016/j.ijpharm.2009.05.002

Formulation Study of Oxybutynin Patches
journal, January 2007

Minghetti, Paola; Cilurzo, Francesco; Pagani, Stefania
Pharmaceutical Development and Technology, Vol. 12, Issue 3
DOI: 10.1080/10837450701212701

Characterization of melt extruded and conventional Isoptin formulations using Raman chemical imaging and chemometrics
journal, October 2011

Vajna, Balázs; Pataki, Hajnalka; Nagy, Zsombor
International Journal of Pharmaceutics, Vol. 419, Issue 1-2
DOI: 10.1016/j.ijpharm.2011.07.023

Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies
journal, January 2014

Belsey, Natalie A.; Garrett, Natalie L.; Contreras-Rojas, L. Rodrigo
Journal of Controlled Release, Vol. 174
DOI: 10.1016/j.jconrel.2013.11.002

Controlled Transdermal Delivery of Fentanyl: Characterizations of Pressure-Sensitive Adhesives for Matrix Patch Design
journal, May 1996

Roy, Samir D.; Gutierrez, Marc; Flynn, Gordon L.
Journal of Pharmaceutical Sciences, Vol. 85, Issue 5
DOI: 10.1021/js950415w

A graphical user-friendly interface for MCR-ALS: a new tool for multivariate curve resolution in MATLAB
journal, March 2005

Jaumot, Joaquim; Gargallo, Raimundo; de Juan, Anna
Chemometrics and Intelligent Laboratory Systems, Vol. 76, Issue 1
DOI: 10.1016/j.chemolab.2004.12.007

Experiences with Cutting Matrix Fentanyl Patches as a Method of Dose Titration in Cancer Patients
journal, December 2017

Cheng, Phoebe Tsz Man; Hawley, Philippa
Journal of Palliative Medicine, Vol. 20, Issue 12
DOI: 10.1089/jpm.2017.0368

Curve resolution for multivariate images with applications to TOF-SIMS and Raman
journal, September 2004

Gallagher, Neal B.; Shaver, Jeremy M.; Martin, Elaine B.
Chemometrics and Intelligent Laboratory Systems, Vol. 73, Issue 1
DOI: 10.1016/j.chemolab.2004.04.003

Vibrational spectroscopic image analysis of biological material using multivariate curve resolution–alternating least squares (MCR-ALS)
journal, January 2015

Felten, Judith; Hall, Hardy; Jaumot, Joaquim
Nature Protocols, Vol. 10, Issue 2
DOI: 10.1038/nprot.2015.008

Preparation and characterization of hydroxypropyl methyl cellulose films containing stable BCS Class II drug nanoparticles for pharmaceutical applications
journal, February 2012

Sievens-Figueroa, Lucas; Bhakay, Anagha; Jerez-Rozo, Jackeline I.
International Journal of Pharmaceutics, Vol. 423, Issue 2
DOI: 10.1016/j.ijpharm.2011.12.001

Transdermal patches: history, development and pharmacology: History of transdermal patches
journal, March 2015

Pastore, Michael N.; Kalia, Yogeshvar N.; Horstmann, Michael
British Journal of Pharmacology, Vol. 172, Issue 9
DOI: 10.1111/bph.13059

Vibrational Spectroscopic Analysis of Silicones: A Fourier Transform-Raman and Inelastic Neutron Scattering Investigation
journal, February 2003

Jayes, Linda; Hard, Andrew P.; Séné, Christophe
Analytical Chemistry, Vol. 75, Issue 4
DOI: 10.1021/ac026012f

Infrared spectra of high polymers
journal, January 1959

Liang, C. Y.; Krimm, S.
Journal of Molecular Spectroscopy, Vol. 3, Issue 1-6
DOI: 10.1016/0022-2852(59)90048-7

Polymethacrylates as crystallization inhibitors in monolayer transdermal patches containing ibuprofen
journal, May 2005

Cilurzo, Francesco; Minghetti, Paola; Casiraghi, Antonella
European Journal of Pharmaceutics and Biopharmaceutics, Vol. 60, Issue 1
DOI: 10.1016/j.ejpb.2005.02.001

Fourier transform Raman microscopic study of drug distribution in a transdermal drug delivery device
journal, May 1996

Armstrong, Clare L.; Edwards, Howell G. M.; Farwell, Dennis W.
Vibrational Spectroscopy, Vol. 11, Issue 2
DOI: 10.1016/0924-2031(95)00066-6

Comparison of different chemometric methods to extract chemical and physical information from Raman images of homogeneous and heterogeneous semi-solid pharmaceutical formulations
journal, December 2018

Mitsutake, Hery; Castro, Simone R.; de Paula, Eneida
International Journal of Pharmaceutics, Vol. 552, Issue 1-2
DOI: 10.1016/j.ijpharm.2018.09.058

Hot Spot-Localized Artificial Antibodies for Label-Free Plasmonic Biosensing
journal, November 2012

Abbas, Abdennour; Tian, Limei; Morrissey, Jeremiah J.
Advanced Functional Materials, Vol. 23, Issue 14
DOI: 10.1002/adfm.201202370

Libraries, classifiers, and quantifiers: A comparison of chemometric methods for the analysis of Raman spectra of contaminated pharmaceutical materials
journal, March 2012

Gryniewicz-Ruzicka, Connie M.; Rodriguez, Jason D.; Arzhantsev, Sergey
Journal of Pharmaceutical and Biomedical Analysis, Vol. 61
DOI: 10.1016/j.jpba.2011.12.002

Determination of the physical state of norethindrone acetate containing transdermal drug delivery systems by isothermal microcalorimetry, X-ray diffraction, and optical microscopy
journal, March 2004

Latsch, Silvia; Selzer, Torsten; Fink, Lothar
European Journal of Pharmaceutics and Biopharmaceutics, Vol. 57, Issue 2
DOI: 10.1016/S0939-6411(03)00158-9

Crystallisation of estradiol containing TDDS determined by isothermal microcalorimetry, X-ray diffraction, and optical microscopy
journal, July 2003

Latsch, Silvia; Selzer, Torsten; Fink, Lothar
European Journal of Pharmaceutics and Biopharmaceutics, Vol. 56, Issue 1
DOI: 10.1016/S0939-6411(03)00042-0

Pressure-sensitive adhesives for transdermal drug delivery systems
journal, February 1999

Tan, Hock S.; Pfister, William R.
Pharmaceutical Science & Technology Today, Vol. 2, Issue 2
DOI: 10.1016/S1461-5347(99)00119-4

SERS hyperspectral imaging assisted by MCR-ALS for studying polymeric microfilms loaded with paracetamol
journal, November 2015

Mamián-López, Mónica B.; Poppi, Ronei J.
Microchemical Journal, Vol. 123
DOI: 10.1016/j.microc.2015.07.003

New discrimination method combining hit quality index based spectral matching and voting
journal, January 2013

Lee, Sanguk; Lee, Hyeseon; Chung, Hoeil
Analytica Chimica Acta, Vol. 758
DOI: 10.1016/j.aca.2012.10.058

Raman mapping of pharmaceuticals
journal, September 2011

Gordon, Keith C.; McGoverin, Cushla M.
International Journal of Pharmaceutics, Vol. 417, Issue 1-2
DOI: 10.1016/j.ijpharm.2010.12.030

Redispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility
journal, April 2017

Andrade, Diego Fontana de; Vukosavljevic, Branko; Benvenutti, Edilson Valmir
Pharmaceutical Development and Technology, Vol. 23, Issue 4
DOI: 10.1080/10837450.2017.1400559

Stabilization of supersaturated solutions of a lipophilic drug for dermal delivery
journal, August 2001

Moser, Katrin; Kriwet, Katrin; Kalia, Yogeshvar N.
International Journal of Pharmaceutics, Vol. 224, Issue 1-2
DOI: 10.1016/S0378-5173(01)00762-1

Area correlation constraint for the MCR−ALS quantification of cholesterol using EEM fluorescence data: A new approach
journal, September 2016

Neves, Ana Carolina de Oliveira; Tauler, Romá; de Lima, Kássio Michell Gomes
Analytica Chimica Acta, Vol. 937
DOI: 10.1016/j.aca.2016.08.011

Application of Raman Microscopy to Biodegradable Double-Walled Microspheres
journal, February 2010

Widjaja, Effendi; Lee, Wei Li; Loo, Say Chye Joachim
Analytical Chemistry, Vol. 82, Issue 4
DOI: 10.1021/ac9022549

Expressions of supersaturation in crystallization studies
journal, January 1977

Mullin, J. W.; Söhnel, O.
Chemical Engineering Science, Vol. 32, Issue 7
DOI: 10.1016/0009-2509(77)80114-0

Growth of calcium carbonate in polyacrylamide hydrogel: Investigation of the influence of polymer content
journal, May 2008

Helbig, Uta
Journal of Crystal Growth, Vol. 310, Issue 11
DOI: 10.1016/j.jcrysgro.2008.02.022

Recent advances in the applications of vibrational spectroscopic imaging and mapping to pharmaceutical formulations
journal, May 2018

Ewing, Andrew V.; Kazarian, Sergei G.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 197
DOI: 10.1016/j.saa.2017.12.055

Inhibition of crystallization in drug-in-adhesive-type transdermal patches
journal, July 2010

Jain, Piyush; Banga, Ajay K.
International Journal of Pharmaceutics, Vol. 394, Issue 1-2
DOI: 10.1016/j.ijpharm.2010.04.042

Raman imaging of drug delivery systems
journal, July 2015

Smith, Geoffrey P. S.; McGoverin, Cushla M.; Fraser, Sara J.
Advanced Drug Delivery Reviews, Vol. 89
DOI: 10.1016/j.addr.2015.01.005

Use of X-ray crystallography for the characterization of single crystals grown in steroid containing transdermal drug delivery systems1Presented in part at the 11th AAPS meeting, San Diego, CA, USA, November 6–10, 1994.1
journal, March 1999

Lipp, Ralph; Müller-Fahrnow, Anke
European Journal of Pharmaceutics and Biopharmaceutics, Vol. 47, Issue 2
DOI: 10.1016/S0939-6411(98)00055-1

Multivariate curve resolution applied to second order data
journal, November 1995

Tauler, Roma
Chemometrics and Intelligent Laboratory Systems, Vol. 30, Issue 1
DOI: 10.1016/0169-7439(95)00047-X

Crystallization of ?-estradiol in an acrylic transdermal drug delivery system
journal, March 1999

Variankaval, N. E.; Jacob, K. I.; Dinh, S. M.
Journal of Biomedical Materials Research, Vol. 44, Issue 4
DOI: 10.1002/(SICI)1097-4636(19990315)44:4<397::AID-JBM5>3.0.CO;2-Q

Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute
journal, August 2006

Wokovich, A.; Prodduturi, S.; Doub, W.
European Journal of Pharmaceutics and Biopharmaceutics, Vol. 64, Issue 1
DOI: 10.1016/j.ejpb.2006.03.009

Effect of supersaturation on membrane transport: 2. Piroxicam
journal, October 1994

Pellett, M.; Davis, A.; Hadgraft, J.
International Journal of Pharmaceutics, Vol. 111, Issue 1
DOI: 10.1016/0378-5173(94)90395-6

Selectivity, local rank, three-way data analysis and ambiguity in multivariate curve resolution
journal, January 1995

Tauler, Romà; Smilde, Age; Kowalski, Bruce
Journal of Chemometrics, Vol. 9, Issue 1
DOI: 10.1002/cem.1180090105

Quantitative Evaluation of the Sensitivity of Library-Based Raman Spectral Correlation Methods
journal, June 2011

Rodriguez, Jason D.; Westenberger, Benjamin J.; Buhse, Lucinda F.
Analytical Chemistry, Vol. 83, Issue 11
DOI: 10.1021/ac200040b

Isopropyl Myristate-Modified Polyether-Urethane Coatings as Protective Barriers for Implantable Medical Devices
journal, June 2009

Roohpour, Nima; Wasikiewicz, Jaroslaw; Moshaverinia, Alireza
Materials, Vol. 2, Issue 3
DOI: 10.3390/ma2030719

Plasticized Drug‐Loaded Melt Electrospun Polymer Mats: Characterization, Thermal Degradation, and Release Kinetics
journal, April 2014

Balogh, Attila; Drávavölgyi, Gábor; Faragó, Kornél
Journal of Pharmaceutical Sciences, Vol. 103, Issue 4
DOI: 10.1002/jps.23904

Drug permeability of modified silicone polymers. III. Hydrophilic pressure-sensitive adhesives for transdermal controlled drug release applications
journal, December 1989

Ulman, K.; Chilong, L.
Journal of Controlled Release, Vol. 10, Issue 3
DOI: 10.1016/0168-3659(89)90077-1

An In-Depth Analysis of Raman and Near-Infrared Chemical Images of Common Pharmaceutical Tablets
journal, March 2007

Šašić, Slobodan
Applied Spectroscopy, Vol. 61, Issue 3
DOI: 10.1366/000370207780220769

Quantification and visualization of α-tocopherol in oil-in-water emulsion based delivery systems by Raman microspectroscopy
journal, October 2018

Wang, Kaiqiang; Sun, Da-Wen; Wei, Qingyi
LWT, Vol. 96
DOI: 10.1016/j.lwt.2018.05.017

Silicone sealants and structural adhesives
journal, January 2001

de Buyl, François
International Journal of Adhesion and Adhesives, Vol. 21, Issue 5
DOI: 10.1016/S0143-7496(01)00018-5

Effect of supersaturation on membrane transport: 1. Hydrocortisone acetate
journal, September 1991

Davis, A. F.; Hadgraft, J.
International Journal of Pharmaceutics, Vol. 76, Issue 1-2
DOI: 10.1016/0378-5173(91)90337-N

FTIR microscopy and confocal Raman microscopy for studying lateral drug diffusion from a semisolid formulation
journal, January 2010

Gotter, B.; Faubel, W.; Neubert, R. H. H.
European Journal of Pharmaceutics and Biopharmaceutics, Vol. 74, Issue 1
DOI: 10.1016/j.ejpb.2009.07.006

Drug release and adhesive properties of crospovidone-containing matrix patches based on polyisobutene and acrylic adhesives
journal, December 2010

Schulz, Martin; Fussnegger, Bernhard; Bodmeier, Roland
European Journal of Pharmaceutical Sciences, Vol. 41, Issue 5
DOI: 10.1016/j.ejps.2010.09.011

Similar Records in DOE PAGES and OSTI.GOV collections:

Drug Delivery Through the Skin: Molecular Simulations of Barrier Lipids to Design more Effective Noninvasive Dermal and Transdermal Delivery Systems for Small Molecules Biologics and Cosmetics

Journal Article Huzil, J Torin ; Sivaloganathan, S ; Kohandel, M ; ... - WIREs Nanomedicine and Nanobiotechnology

The delivery of drugs through the skin provides a convenient route of administration that is often preferable to injection because it is noninvasive and can typically be self-administered. These two factors alone result in a significant reduction of medical complications and improvement in patient compliance. Unfortunately, a significant obstacle to dermal and transdermal drug delivery alike is the resilient barrier that the epidermal layers of the skin, primarily the stratum corneum, presents for the diffusion of exogenous chemical agents. Further advancement of transdermal drug delivery requires the development of novel delivery systems that are suitable for modern, macromolecular protein andmore »« less
https://doi.org/10.1002/wnan.147
Coherent Anti-Stokes Raman Scattering Spectroscopy of Single Molecules in Solution

Technical Report Sunney Xie, Wei Min, Chris Freudiger, Sijia Lu

During this funding period, we have developed two breakthrough techniques. The first is stimulated Raman scattering microscopy, providing label-free chemical contrast for chemical and biomedical imaging based on vibrational spectroscopy. Spontaneous Raman microscopy provides specific vibrational signatures of chemical bonds, but is often hindered by low sensitivity. We developed a three-dimensional multiphoton vibrational imaging technique based on stimulated Raman scattering (SRS). The sensitivity of SRS imaging is significantly greater than that of spontaneous Raman microscopy, which is achieved by implementing high-frequency (megahertz) phase-sensitive detection. SRS microscopy has a major advantage over previous coherent Raman techniques in that it offers background-freemore »« less
https://doi.org/10.2172/1033507

Full Text Available
Probabilistic modeling of percutaneous absorption for risk-based exposure assessments and transdermal drug delivery.

Journal Article Ho, Clifford Kuofei - Proposed for publication in Statistical Methodology.

Chemical transport through human skin can play a significant role in human exposure to toxic chemicals in the workplace, as well as to chemical/biological warfare agents in the battlefield. The viability of transdermal drug delivery also relies on chemical transport processes through the skin. Models of percutaneous absorption are needed for risk-based exposure assessments and drug-delivery analyses, but previous mechanistic models have been largely deterministic. A probabilistic, transient, three-phase model of percutaneous absorption of chemicals has been developed to assess the relative importance of uncertain parameters and processes that may be important to risk-based assessments. Penetration routes through the skinmore »« less
https://doi.org/10.1016/j.stamet.2004.07.001
Transdermal Delivery of Nicotine Using Pectin Isolated from Durian Fruit-Hulls-Based Polymer Blends as a Matrix Layer

Journal Article Suksaeree, Jirapornchai ; Karnsopa, Phatipan ; Wannaphruek, Nannapat ; ... - Journal of Polymers and the Environment

Many natural polymers with various chemical structures are used to prepare transdermal patches. Pectin is a one interesting type of polymer because it can control drug release when used in transdermal patches. In Thailand, the waste from durian fruit-hulls is a major problem for the environment. However, the pectin from it can be isolated under acid conditions and used to prepare transdermal patches for nicotine delivery which has not yet been reported. As the isolated pectin is a natural polymer, the film made from isolated pectin is a brittle; therefore, adding a low protein natural rubber latex (LPNRL) polymer wasmore »« less
https://doi.org/10.1007/S10924-018-1203-X
Structural modification of fentanyls for their retrospective identification by gas chromatographic analysis using chloroformate chemistry

Journal Article Valdez, Carlos A. ; Leif, Roald N. ; Sanner, Robert D. ; ... - Scientific Reports

Abstract The one-step breakdown and derivatization of a panel of nine fentanyls to yield uniquely tagged products that can be detected by Electron Ionization Gas Chromatography-Mass Spectrometry (EI-GC-MS) is presented. The method involves the treatment of the synthetic opioids with 2,2,2-trichloroethoxycarbonyl chloride (TrocCl) at 60 °C for 3 h in dichloromethane and furnishes two products from one fentanyl molecule that can be used to retrospectively identify the original opioid. Parameters that were studied and fully optimized for the method included temperature, solvent, nature of scavenging base and reaction time. One of the two resulting products from the reaction bears the trichloroethoxycarbonyl (Troc)more »« less
https://doi.org/10.1038/s41598-021-01896-x

Similar Records

Title: Raman mapping of fentanyl transdermal delivery systems with off-label modifications

Abstract

Citation Formats

Induction and Inhibition of Crystallization in Drug-in-Adhesive-Type Transdermal Patches journal, October 2012

Formulation and optimization of desogestrel transdermal contraceptive patch using crystallization studies journal, January 2013

Identification of new psychoactive substances (NPS) by Raman spectroscopy journal, October 2018

Pharmaceutics: Selection and Use of Crystallization Inhibitors for Matrix-type Transdermal Drug-delivery Systems Containing Sex Steroids* journal, December 1998

Applications of Raman spectroscopy in skin research — From skin physiology and diagnosis up to risk assessment and dermal drug delivery journal, July 2015

Use of isothermal heat conduction microcalorimetry, X-ray diffraction, and optical microscopy for characterisation of crystals grown in steroid combination-containing transdermal drug delivery systems journal, March 2004

The effect of drug concentration on solvent activity in silicone membranes journal, July 2009

Formulation Study of Oxybutynin Patches journal, January 2007

Characterization of melt extruded and conventional Isoptin formulations using Raman chemical imaging and chemometrics journal, October 2011

Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies journal, January 2014

Controlled Transdermal Delivery of Fentanyl: Characterizations of Pressure-Sensitive Adhesives for Matrix Patch Design journal, May 1996

A graphical user-friendly interface for MCR-ALS: a new tool for multivariate curve resolution in MATLAB journal, March 2005

Experiences with Cutting Matrix Fentanyl Patches as a Method of Dose Titration in Cancer Patients journal, December 2017

Curve resolution for multivariate images with applications to TOF-SIMS and Raman journal, September 2004

Vibrational spectroscopic image analysis of biological material using multivariate curve resolution–alternating least squares (MCR-ALS) journal, January 2015

Preparation and characterization of hydroxypropyl methyl cellulose films containing stable BCS Class II drug nanoparticles for pharmaceutical applications journal, February 2012

Transdermal patches: history, development and pharmacology: History of transdermal patches journal, March 2015

Vibrational Spectroscopic Analysis of Silicones: A Fourier Transform-Raman and Inelastic Neutron Scattering Investigation journal, February 2003

Infrared spectra of high polymers journal, January 1959

Polymethacrylates as crystallization inhibitors in monolayer transdermal patches containing ibuprofen journal, May 2005

Fourier transform Raman microscopic study of drug distribution in a transdermal drug delivery device journal, May 1996

Comparison of different chemometric methods to extract chemical and physical information from Raman images of homogeneous and heterogeneous semi-solid pharmaceutical formulations journal, December 2018

Hot Spot-Localized Artificial Antibodies for Label-Free Plasmonic Biosensing journal, November 2012

Libraries, classifiers, and quantifiers: A comparison of chemometric methods for the analysis of Raman spectra of contaminated pharmaceutical materials journal, March 2012

Determination of the physical state of norethindrone acetate containing transdermal drug delivery systems by isothermal microcalorimetry, X-ray diffraction, and optical microscopy journal, March 2004

Crystallisation of estradiol containing TDDS determined by isothermal microcalorimetry, X-ray diffraction, and optical microscopy journal, July 2003

Pressure-sensitive adhesives for transdermal drug delivery systems journal, February 1999

SERS hyperspectral imaging assisted by MCR-ALS for studying polymeric microfilms loaded with paracetamol journal, November 2015

New discrimination method combining hit quality index based spectral matching and voting journal, January 2013

Raman mapping of pharmaceuticals journal, September 2011

Redispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility journal, April 2017

Stabilization of supersaturated solutions of a lipophilic drug for dermal delivery journal, August 2001

Area correlation constraint for the MCR−ALS quantification of cholesterol using EEM fluorescence data: A new approach journal, September 2016

Application of Raman Microscopy to Biodegradable Double-Walled Microspheres journal, February 2010

Expressions of supersaturation in crystallization studies journal, January 1977

Growth of calcium carbonate in polyacrylamide hydrogel: Investigation of the influence of polymer content journal, May 2008

Recent advances in the applications of vibrational spectroscopic imaging and mapping to pharmaceutical formulations journal, May 2018

Inhibition of crystallization in drug-in-adhesive-type transdermal patches journal, July 2010

Raman imaging of drug delivery systems journal, July 2015

Use of X-ray crystallography for the characterization of single crystals grown in steroid containing transdermal drug delivery systems1Presented in part at the 11th AAPS meeting, San Diego, CA, USA, November 6–10, 1994.1 journal, March 1999

Multivariate curve resolution applied to second order data journal, November 1995

Crystallization of ?-estradiol in an acrylic transdermal drug delivery system journal, March 1999

Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute journal, August 2006

Effect of supersaturation on membrane transport: 2. Piroxicam journal, October 1994

Selectivity, local rank, three-way data analysis and ambiguity in multivariate curve resolution journal, January 1995

Quantitative Evaluation of the Sensitivity of Library-Based Raman Spectral Correlation Methods journal, June 2011

Isopropyl Myristate-Modified Polyether-Urethane Coatings as Protective Barriers for Implantable Medical Devices journal, June 2009

Plasticized Drug‐Loaded Melt Electrospun Polymer Mats: Characterization, Thermal Degradation, and Release Kinetics journal, April 2014

Drug permeability of modified silicone polymers. III. Hydrophilic pressure-sensitive adhesives for transdermal controlled drug release applications journal, December 1989

An In-Depth Analysis of Raman and Near-Infrared Chemical Images of Common Pharmaceutical Tablets journal, March 2007

Quantification and visualization of α-tocopherol in oil-in-water emulsion based delivery systems by Raman microspectroscopy journal, October 2018

Silicone sealants and structural adhesives journal, January 2001

Effect of supersaturation on membrane transport: 1. Hydrocortisone acetate journal, September 1991

FTIR microscopy and confocal Raman microscopy for studying lateral drug diffusion from a semisolid formulation journal, January 2010

Drug release and adhesive properties of crospovidone-containing matrix patches based on polyisobutene and acrylic adhesives journal, December 2010

Induction and Inhibition of Crystallization in Drug-in-Adhesive-Type Transdermal Patches
journal, October 2012

Formulation and optimization of desogestrel transdermal contraceptive patch using crystallization studies
journal, January 2013

Identification of new psychoactive substances (NPS) by Raman spectroscopy
journal, October 2018

Pharmaceutics: Selection and Use of Crystallization Inhibitors for Matrix-type Transdermal Drug-delivery Systems Containing Sex Steroids*
journal, December 1998

Applications of Raman spectroscopy in skin research — From skin physiology and diagnosis up to risk assessment and dermal drug delivery
journal, July 2015

Use of isothermal heat conduction microcalorimetry, X-ray diffraction, and optical microscopy for characterisation of crystals grown in steroid combination-containing transdermal drug delivery systems
journal, March 2004

The effect of drug concentration on solvent activity in silicone membranes
journal, July 2009

Formulation Study of Oxybutynin Patches
journal, January 2007

Characterization of melt extruded and conventional Isoptin formulations using Raman chemical imaging and chemometrics
journal, October 2011

Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies
journal, January 2014

Controlled Transdermal Delivery of Fentanyl: Characterizations of Pressure-Sensitive Adhesives for Matrix Patch Design
journal, May 1996

A graphical user-friendly interface for MCR-ALS: a new tool for multivariate curve resolution in MATLAB
journal, March 2005

Experiences with Cutting Matrix Fentanyl Patches as a Method of Dose Titration in Cancer Patients
journal, December 2017

Curve resolution for multivariate images with applications to TOF-SIMS and Raman
journal, September 2004

Vibrational spectroscopic image analysis of biological material using multivariate curve resolution–alternating least squares (MCR-ALS)
journal, January 2015

Preparation and characterization of hydroxypropyl methyl cellulose films containing stable BCS Class II drug nanoparticles for pharmaceutical applications
journal, February 2012

Transdermal patches: history, development and pharmacology: History of transdermal patches
journal, March 2015

Vibrational Spectroscopic Analysis of Silicones: A Fourier Transform-Raman and Inelastic Neutron Scattering Investigation
journal, February 2003

Infrared spectra of high polymers
journal, January 1959

Polymethacrylates as crystallization inhibitors in monolayer transdermal patches containing ibuprofen
journal, May 2005

Fourier transform Raman microscopic study of drug distribution in a transdermal drug delivery device
journal, May 1996

Comparison of different chemometric methods to extract chemical and physical information from Raman images of homogeneous and heterogeneous semi-solid pharmaceutical formulations
journal, December 2018

Hot Spot-Localized Artificial Antibodies for Label-Free Plasmonic Biosensing
journal, November 2012

Libraries, classifiers, and quantifiers: A comparison of chemometric methods for the analysis of Raman spectra of contaminated pharmaceutical materials
journal, March 2012

Determination of the physical state of norethindrone acetate containing transdermal drug delivery systems by isothermal microcalorimetry, X-ray diffraction, and optical microscopy
journal, March 2004

Crystallisation of estradiol containing TDDS determined by isothermal microcalorimetry, X-ray diffraction, and optical microscopy
journal, July 2003

Pressure-sensitive adhesives for transdermal drug delivery systems
journal, February 1999

SERS hyperspectral imaging assisted by MCR-ALS for studying polymeric microfilms loaded with paracetamol
journal, November 2015

New discrimination method combining hit quality index based spectral matching and voting
journal, January 2013

Raman mapping of pharmaceuticals
journal, September 2011

Redispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility
journal, April 2017

Stabilization of supersaturated solutions of a lipophilic drug for dermal delivery
journal, August 2001

Area correlation constraint for the MCR−ALS quantification of cholesterol using EEM fluorescence data: A new approach
journal, September 2016

Application of Raman Microscopy to Biodegradable Double-Walled Microspheres
journal, February 2010

Expressions of supersaturation in crystallization studies
journal, January 1977

Growth of calcium carbonate in polyacrylamide hydrogel: Investigation of the influence of polymer content
journal, May 2008

Recent advances in the applications of vibrational spectroscopic imaging and mapping to pharmaceutical formulations
journal, May 2018

Inhibition of crystallization in drug-in-adhesive-type transdermal patches
journal, July 2010

Raman imaging of drug delivery systems
journal, July 2015

Use of X-ray crystallography for the characterization of single crystals grown in steroid containing transdermal drug delivery systems1Presented in part at the 11th AAPS meeting, San Diego, CA, USA, November 6–10, 1994.1
journal, March 1999

Multivariate curve resolution applied to second order data
journal, November 1995

Crystallization of ?-estradiol in an acrylic transdermal drug delivery system
journal, March 1999

Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute
journal, August 2006

Effect of supersaturation on membrane transport: 2. Piroxicam
journal, October 1994

Selectivity, local rank, three-way data analysis and ambiguity in multivariate curve resolution
journal, January 1995

Quantitative Evaluation of the Sensitivity of Library-Based Raman Spectral Correlation Methods
journal, June 2011

Isopropyl Myristate-Modified Polyether-Urethane Coatings as Protective Barriers for Implantable Medical Devices
journal, June 2009

Plasticized Drug‐Loaded Melt Electrospun Polymer Mats: Characterization, Thermal Degradation, and Release Kinetics
journal, April 2014

Drug permeability of modified silicone polymers. III. Hydrophilic pressure-sensitive adhesives for transdermal controlled drug release applications
journal, December 1989

An In-Depth Analysis of Raman and Near-Infrared Chemical Images of Common Pharmaceutical Tablets
journal, March 2007

Quantification and visualization of α-tocopherol in oil-in-water emulsion based delivery systems by Raman microspectroscopy
journal, October 2018

Silicone sealants and structural adhesives
journal, January 2001

Effect of supersaturation on membrane transport: 1. Hydrocortisone acetate
journal, September 1991

FTIR microscopy and confocal Raman microscopy for studying lateral drug diffusion from a semisolid formulation
journal, January 2010

Drug release and adhesive properties of crospovidone-containing matrix patches based on polyisobutene and acrylic adhesives
journal, December 2010