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Title: Advanced Bottom‐Up Engineering of Living Architectures


Abstract Bottom‐up tissue engineering is a promising approach for designing modular biomimetic structures that aim to recapitulate the intricate hierarchy and biofunctionality of native human tissues. In recent years, this field has seen exciting progress driven by an increasing knowledge of biological systems and their rational deconstruction into key core components. Relevant advances in the bottom‐up assembly of unitary living blocks toward the creation of higher order bioarchitectures based on multicellular‐rich structures or multicomponent cell–biomaterial synergies are described. An up‐to‐date critical overview of long‐term existing and rapidly emerging technologies for integrative bottom‐up tissue engineering is provided, including discussion of their practical challenges and required advances. It is envisioned that a combination of cell–biomaterial constructs with bioadaptable features and biospecific 3D designs will contribute to the development of more robust and functional humanized tissues for therapies and disease models, as well as tools for fundamental biological studies.

ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1]
  1. Department of Chemistry CICECO ‐ Aveiro Institute of Materials University of Aveiro Campus Universitário de Santiago 3810‐193 Aveiro Portugal
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Publisher's Accepted Manuscript
Journal Name:
Advanced Materials
Additional Journal Information:
Journal Name: Advanced Materials Journal Volume: 32 Journal Issue: 6; Journal ID: ISSN 0935-9648
Wiley Blackwell (John Wiley & Sons)
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Citation Formats

Gaspar, Vítor M., Lavrador, Pedro, Borges, João, Oliveira, Mariana B., and Mano, João F. Advanced Bottom‐Up Engineering of Living Architectures. Germany: N. p., 2019. Web. doi:10.1002/adma.201903975.
Gaspar, Vítor M., Lavrador, Pedro, Borges, João, Oliveira, Mariana B., & Mano, João F. Advanced Bottom‐Up Engineering of Living Architectures. Germany.
Gaspar, Vítor M., Lavrador, Pedro, Borges, João, Oliveira, Mariana B., and Mano, João F. Wed . "Advanced Bottom‐Up Engineering of Living Architectures". Germany.
title = {Advanced Bottom‐Up Engineering of Living Architectures},
author = {Gaspar, Vítor M. and Lavrador, Pedro and Borges, João and Oliveira, Mariana B. and Mano, João F.},
abstractNote = {Abstract Bottom‐up tissue engineering is a promising approach for designing modular biomimetic structures that aim to recapitulate the intricate hierarchy and biofunctionality of native human tissues. In recent years, this field has seen exciting progress driven by an increasing knowledge of biological systems and their rational deconstruction into key core components. Relevant advances in the bottom‐up assembly of unitary living blocks toward the creation of higher order bioarchitectures based on multicellular‐rich structures or multicomponent cell–biomaterial synergies are described. An up‐to‐date critical overview of long‐term existing and rapidly emerging technologies for integrative bottom‐up tissue engineering is provided, including discussion of their practical challenges and required advances. It is envisioned that a combination of cell–biomaterial constructs with bioadaptable features and biospecific 3D designs will contribute to the development of more robust and functional humanized tissues for therapies and disease models, as well as tools for fundamental biological studies.},
doi = {10.1002/adma.201903975},
journal = {Advanced Materials},
number = 6,
volume = 32,
place = {Germany},
year = {2019},
month = {12}

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