Insight Into the Molecular Mechanisms for Microcystin Biodegradation in Lake Erie and Lake Taihu

Krausfeldt, Lauren E.; Steffen, Morgan M.; McKay, Robert M.; Bullerjahn, George S.; Boyer, Gregory L.; Wilhelm, Steven W.

doi:10.3389/fmicb.2019.02741

Title: Insight Into the Molecular Mechanisms for Microcystin Biodegradation in Lake Erie and Lake Taihu

Journal Article · 09 December 2019 · Frontiers in Microbiology

DOI: https://doi.org/10.3389/fmicb.2019.02741 · OSTI ID:1577901

Krausfeldt, Lauren E.; Steffen, Morgan M.; McKay, Robert M.; Bullerjahn, George S.; Boyer, Gregory L.; Wilhelm, Steven W.

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Research Organization:: USDOE Joint Genome Institute (JGI), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1577901

Journal Information:: Frontiers in Microbiology, Journal Name: Frontiers in Microbiology Vol. 10; ISSN 1664-302X

Publisher:: Frontiers Media SACopyright Statement

Country of Publication:: Switzerland

Language:: English

References (92)

Characterisation of a gene cluster involved in bacterial degradation of the cyanobacterial toxin microcystin LR Bourne, David G.; Riddles, Peter; Jones, Gary J. Environmental Toxicology, Vol. 16, Issue 6 https://doi.org/10.1002/tox.10013	journal	January 2001
Removal of microcystins by slow sand filtration: Microcystin Removal by Sand Filtration Grützmacher, Gesche; Böttcher, Gabriele; Chorus, Ingrid Environmental Toxicology, Vol. 17, Issue 4 https://doi.org/10.1002/tox.10062	journal	January 2002
Isolation and Characterization of Microcystin-Degrading Bacteria from Lake Erie Krishnan, Anjali; Zhang, Yu-Qin; Mou, Xiaozhen Bulletin of Environmental Contamination and Toxicology, Vol. 101, Issue 5 https://doi.org/10.1007/s00128-018-2468-4	journal	October 2018
Biodegradation of microcystin-LR and-RR by a novel microcystin-degrading bacterium isolated from Lake Taihu Yang, Fei; Zhou, Yuanlong; Sun, Rongli Biodegradation, Vol. 25, Issue 3 https://doi.org/10.1007/s10532-013-9673-y	journal	November 2013
GST transcriptional changes induced by a toxic Microcystis aeruginosa strain in two bivalve species during exposure and recovery phases Antas, Paulo; Carneiro, Mariana; Reis, Bruno Ecotoxicology, Vol. 27, Issue 9 https://doi.org/10.1007/s10646-018-1980-y	journal	September 2018
Metatranscriptomics analysis of cyanobacterial aggregates during cyanobacterial bloom period in Lake Taihu, China Chen, Zhenzhu; Zhang, Junyi; Li, Rui Environmental Science and Pollution Research, Vol. 25, Issue 5 https://doi.org/10.1007/s11356-017-0733-4	journal	December 2017
Biodegradation of microcystin-LR by indigenous mixed bacterial populations Cousins, I. T.; Bealing, D. J.; James, H. A. Water Research, Vol. 30, Issue 2 https://doi.org/10.1016/0043-1354(95)00189-1	journal	February 1996
The removal of cyanobacteria and their metabolites through anoxic biodegradation in drinking water sludge Ma, Guangxiang; Pei, Haiyan; Hu, Wenrong Bioresource Technology, Vol. 165 https://doi.org/10.1016/j.biortech.2014.03.068	journal	August 2014
Biodegradation of microcystins and nodularin in freshwaters Edwards, Christine; Graham, Douglas; Fowler, Nicholas Chemosphere, Vol. 73, Issue 8 https://doi.org/10.1016/j.chemosphere.2008.07.015	journal	November 2008
Cyanobacterial toxins: Modes of actions, fate in aquatic and soil ecosystems, phytotoxicity and bioaccumulation in agricultural crops Corbel, Sylvain; Mougin, Christian; Bouaïcha, Noureddine Chemosphere, Vol. 96 https://doi.org/10.1016/j.chemosphere.2013.07.056	journal	February 2014
Mode of action and fate of microcystins in the complex soil-plant ecosystems Redouane, El Mahdi; El Amrani Zerrifi, Soukaina; El Khalloufi, Fatima Chemosphere, Vol. 225 https://doi.org/10.1016/j.chemosphere.2019.03.008	journal	June 2019
Biodegradation of microcystins by aquatic Burkholderia sp. from a South Brazilian coastal lagoon Lemes, Gilmar A. F.; Kersanach, Ralf; da S. Pinto, Luciano Ecotoxicology and Environmental Safety, Vol. 69, Issue 3 https://doi.org/10.1016/j.ecoenv.2007.03.013	journal	March 2008
Possible mechanism for the foodweb transfer of covalently bound microcystins Smith, Juliette L.; Schulz, Kimberly L.; Zimba, Paul V. Ecotoxicology and Environmental Safety, Vol. 73, Issue 5 https://doi.org/10.1016/j.ecoenv.2009.12.003	journal	July 2010
Discerning biodegradation and adsorption of microcystin-LR in a shallow semi-enclosed bay and bacterial community shifts in response to associated process Li, Jieming; Li, Ji; Shi, Ge Ecotoxicology and Environmental Safety, Vol. 132 https://doi.org/10.1016/j.ecoenv.2016.05.033	journal	October 2016
The biodegradation of microcystins in temperate freshwater bodies with previous cyanobacterial history Dziga, Dariusz; Maksylewicz, Anna; Maroszek, Magdalena Ecotoxicology and Environmental Safety, Vol. 145 https://doi.org/10.1016/j.ecoenv.2017.07.046	journal	November 2017
Effects of light, microorganisms, farming chemicals and water content on the degradation of microcystin-LR in agricultural soils Cao, Qing; Steinman, Alan D.; Yao, Lei Ecotoxicology and Environmental Safety, Vol. 156 https://doi.org/10.1016/j.ecoenv.2018.03.030	journal	July 2018
Evaluating the contamination of microcystins in Lake Taihu, China: The application of equivalent total MC-LR concentration Su, Xiaomei; Steinman, Alan D.; Xue, Qingju Ecological Indicators, Vol. 89 https://doi.org/10.1016/j.ecolind.2017.11.042	journal	June 2018
Acute animal and human poisonings from cyanotoxin exposure — A review of the literature Wood, Roslyn Environment International, Vol. 91 https://doi.org/10.1016/j.envint.2016.02.026	journal	May 2016
Effects of microcystins contamination on soil enzyme activities and microbial community in two typical lakeside soils Cao, Qing; Steinman, Alan D.; Su, Xiaomei Environmental Pollution, Vol. 231 https://doi.org/10.1016/j.envpol.2017.08.013	journal	December 2017
Heterologous expression of mlrA in a photoautotrophic host – Engineering cyanobacteria to degrade microcystins Dexter, Jason; Dziga, Dariusz; Lv, Jing Environmental Pollution, Vol. 237 https://doi.org/10.1016/j.envpol.2018.01.071	journal	June 2018
A novel pathway for the anaerobic biotransformation of microcystin-LR using enrichment cultures Zhu, Fan-Ping; Han, Zhen-Lian; Duan, Jian-Lu Environmental Pollution, Vol. 247 https://doi.org/10.1016/j.envpol.2019.02.013	journal	April 2019
Toxic cyanobacteria and drinking water: Impacts, detection, and treatment He, Xuexiang; Liu, Yen-Ling; Conklin, Amanda Harmful Algae, Vol. 54 https://doi.org/10.1016/j.hal.2016.01.001	journal	April 2016
Health impacts from cyanobacteria harmful algae blooms: Implications for the North American Great Lakes Carmichael, Wayne W.; Boyer, Gregory L. Harmful Algae, Vol. 54 https://doi.org/10.1016/j.hal.2016.02.002	journal	April 2016
Seasonal dynamics of microcystin-degrading bacteria and toxic cyanobacterial blooms: Interaction and influence of abiotic factors Lezcano, María Ángeles; Quesada, Antonio; El-Shehawy, Rehab Harmful Algae, Vol. 71 https://doi.org/10.1016/j.hal.2017.11.002	journal	January 2018
Ammonium recycling supports toxic Planktothrix blooms in Sandusky Bay, Lake Erie: Evidence from stable isotope and metatranscriptome data Hampel, Justyna J.; McCarthy, Mark J.; Neudeck, Michelle Harmful Algae, Vol. 81 https://doi.org/10.1016/j.hal.2018.11.011	journal	January 2019
Biodegradation mechanism of microcystin-LR by a novel isolate of Rhizobium sp. TH and the evolutionary origin of the mlrA gene Zhu, Xiaoyun; Shen, Yitian; Chen, Xiaoguo International Biodeterioration & Biodegradation, Vol. 115 https://doi.org/10.1016/j.ibiod.2016.07.011	journal	November 2016
Aerobic biodegradation of microcystin-LR by an indigenous bacterial mixed culture isolated in Taiwan Tsao, Sha; Wei, Da-Jiun; Chang, Yi-Tang International Biodeterioration & Biodegradation, Vol. 124 https://doi.org/10.1016/j.ibiod.2017.04.011	journal	October 2017
A laboratory study on risk assessment of microcystin-RR in cropland Bibo, Liu; Yan, Gong; Bangding, Xiao Journal of Environmental Management, Vol. 86, Issue 3 https://doi.org/10.1016/j.jenvman.2006.12.040	journal	February 2008
Adaptations to photoautotrophy associated with seasonal ice cover in a large lake revealed by metatranscriptome analysis of a winter diatom bloom Edgar, R. E.; Morris, P. F.; Rozmarynowycz, M. J. Journal of Great Lakes Research, Vol. 42, Issue 5 https://doi.org/10.1016/j.jglr.2016.07.025	journal	October 2016
Isolation and characterization of Lake Erie bacteria that degrade the cyanobacterial microcystin toxin MC-LR Thees, Alison; Atari, Ealla; Birbeck, Johnna Journal of Great Lakes Research, Vol. 45, Issue 1 https://doi.org/10.1016/j.jglr.2018.10.013	journal	February 2019
Evaluation of the potential of anoxic biodegradation of intracellular and dissolved microcystins in lake sediments Wu, Xingqiang; Wang, Chunbo; Tian, Cuicui Journal of Hazardous Materials, Vol. 286 https://doi.org/10.1016/j.jhazmat.2015.01.015	journal	April 2015
Expansion of Type II CAAX Proteases Reveals Evolutionary Origin of γ-Secretase Subunit APH-1 Pei, Jimin; Mitchell, Douglas A.; Dixon, Jack E. Journal of Molecular Biology, Vol. 410, Issue 1 https://doi.org/10.1016/j.jmb.2011.04.066	journal	July 2011
Microcystins from tap water could be a risk factor for liver and colorectal cancer: A risk intensified by global change Hernández, Juan Martínez; López-Rodas, V.; Costas, E. Medical Hypotheses, Vol. 72, Issue 5 https://doi.org/10.1016/j.mehy.2008.11.041	journal	May 2009
Isolation of a Methylobacillus sp. that degrades microcystin toxins associated with cyanobacteria Hu, Liang Bin; Yang, Jing Dong; Zhou, Wei New Biotechnology, Vol. 26, Issue 3-4 https://doi.org/10.1016/j.nbt.2009.09.001	journal	October 2009
Fate of cyanobacteria and their metabolites during water treatment sludge management processes Ho, Lionel; Dreyfus, Jennifer; Boyer, Justine Science of The Total Environment, Vol. 424 https://doi.org/10.1016/j.scitotenv.2012.02.025	journal	May 2012
Current research scenario for microcystins biodegradation – A review on fundamental knowledge, application prospects and challenges Li, Jieming; Li, Renhui; Li, Ji Science of The Total Environment, Vol. 595 https://doi.org/10.1016/j.scitotenv.2017.03.285	journal	October 2017
Agro-industrial residues as a unique support in a sand filter to enhance the bioactivity to remove microcystin-Leucine aRginine and organics Kumar, Pratik; Rubio, Heidi Dayana Pascagaza; Hegde, Krishnamoorthy Science of The Total Environment, Vol. 670 https://doi.org/10.1016/j.scitotenv.2019.03.260	journal	June 2019
Cyanobacteria and prawn farming in northern New South Wales, Australia—a case study on cyanobacteria diversity and hepatotoxin bioaccumulation Kankaanpää, Harri T.; Holliday, Jon; Schröder, Helge Toxicology and Applied Pharmacology, Vol. 203, Issue 3 https://doi.org/10.1016/j.taap.2004.04.012	journal	March 2005
Bacterial degradation of microcystin toxins in drinking water eliminates their toxicity Ho, Lionel; Gaudieux, Anne-Laure; Fanok, Stella Toxicon, Vol. 50, Issue 3 https://doi.org/10.1016/j.toxicon.2007.03.021	journal	September 2007
Biodegradation studies and sequencing of microcystin-LR degrading bacteria isolated from a drinking water biofilter and a fresh water lake Eleuterio, Lazaro; Batista, Jacimaria R. Toxicon, Vol. 55, Issue 8 https://doi.org/10.1016/j.toxicon.2010.02.020	journal	July 2010
Characterization of microcystin-LR removal process in the presence of probiotic bacteria Nybom, S. M. K.; Dziga, D.; Heikkilä, J. E. Toxicon, Vol. 59, Issue 1 https://doi.org/10.1016/j.toxicon.2011.11.008	journal	January 2012
Heterologous expression and characterisation of microcystinase Dziga, Dariusz; Wladyka, Benedykt; Zielińska, Gabriela Toxicon, Vol. 59, Issue 5 https://doi.org/10.1016/j.toxicon.2012.01.001	journal	April 2012
Contribution of sediments in the removal of microcystin-LR from water Song, Haihong; Reichwaldt, Elke S.; Ghadouani, Anas Toxicon, Vol. 83 https://doi.org/10.1016/j.toxicon.2014.02.019	journal	June 2014
Bacterial degradation of microcystin toxins within a biologically active sand filter Ho, Lionel; Meyn, Thomas; Keegan, Alexandra Water Research, Vol. 40, Issue 4 https://doi.org/10.1016/j.watres.2005.12.009	journal	February 2006
Biodegradation of the cyanobacterial toxin microcystin LR in natural water and biologically active slow sand filters Bourne, David G.; Blakeley, Robert L.; Riddles, Peter Water Research, Vol. 40, Issue 6 https://doi.org/10.1016/j.watres.2006.01.022	journal	March 2006
Distribution and bioaccumulation of microcystins in water columns: A systematic investigation into the environmental fate and the risks associated with microcystins in Meiliang Bay, Lake Taihu Song, Lirong; Chen, Wei; Peng, Liang Water Research, Vol. 41, Issue 13 https://doi.org/10.1016/j.watres.2007.02.013	journal	July 2007
Reduction in microcystin concentrations in large and shallow lakes: Water and sediment-interface contributions Chen, Wei; Song, Lirong; Peng, Liang Water Research, Vol. 42, Issue 3 https://doi.org/10.1016/j.watres.2007.08.007	journal	February 2008
An effective pathway for the removal of microcystin LR via anoxic biodegradation in lake sediments Chen, Xiaoguo; Yang, Xia; Yang, Lili Water Research, Vol. 44, Issue 6 https://doi.org/10.1016/j.watres.2009.11.025	journal	March 2010
Degradation of microcystin in sediments at oxic and anoxic, denitrifying conditions Holst, Thomas; Jørgensen, Niels O. G.; Jørgensen, Claus Water Research, Vol. 37, Issue 19 https://doi.org/10.1016/s0043-1354(03)00413-5	journal	November 2003
Microcystin LR degradation by Pseudomonas aeruginosa alkaline protease Takenaka, Shigeyuki; Watanabe, Mariyo F. Chemosphere, Vol. 34, Issue 4 https://doi.org/10.1016/s0045-6535(97)00002-7	journal	February 1997
Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication Pflugmacher, Stephan; Wiegand, Claudia; Oberemm, Axel Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1425, Issue 3 https://doi.org/10.1016/s0304-4165(98)00107-x	journal	November 1998
Detection and sequencing of the microcystin LR-degrading gene, mlrA , from new bacteria isolated from Japanese lakes Saito, Takeshi; Okano, Kunihiro; Park, Ho-Dong FEMS Microbiology Letters, Vol. 229, Issue 2 https://doi.org/10.1016/s0378-1097(03)00847-4	journal	December 2003
Ecophysiological Examination of the Lake Erie Microcystis Bloom in 2014: Linkages between Biology and the Water Supply Shutdown of Toledo, OH Steffen, Morgan M.; Davis, Timothy W.; McKay, R. Michael L. Environmental Science & Technology, Vol. 51, Issue 12 https://doi.org/10.1021/acs.est.7b00856	journal	June 2017
Seasonal Gene Expression and the Ecophysiological Implications of Toxic Microcystis aeruginosa Blooms in Lake Taihu Tang, Xiangming; Krausfeldt, Lauren E.; Shao, Keqiang Environmental Science & Technology, Vol. 52, Issue 19 https://doi.org/10.1021/acs.est.8b01066	journal	August 2018
Transcriptomic Analysis Reveals the Pathways Associated with Resisting and Degrading Microcystin in Ochromonas Zhang, Lu; Lyu, Kai; Wang, Na Environmental Science & Technology, Vol. 52, Issue 19 https://doi.org/10.1021/acs.est.8b03106	journal	September 2018
Biotransformation of the Cyanobacterial Hepatotoxin Microcystin-LR, as Determined by HPLC and Protein Phosphatase Bioassay Lam, Angeline K. -Y.; Fedorak, Phillip M.; Prepas, Ellie E. Environmental Science & Technology, Vol. 29, Issue 1 https://doi.org/10.1021/es00001a030	journal	January 1995
Stability of microcystins from cyanobacteria: effect of light on decomposition and isomerization Tsuji, Kiyomi.; Naito, Shoji.; Kondo, Fumio. Environmental Science & Technology, Vol. 28, Issue 1 https://doi.org/10.1021/es00050a024	journal	January 1994
Microcystin Elimination During Sediment Contact Grützmacher, Gesche; Wessel, Gabriele; Klitzke, Sondra Environmental Science & Technology, Vol. 44, Issue 2 https://doi.org/10.1021/es9016816	journal	January 2010
Cyanotoxin degradation activity and mlr gene expression profiles of a Sphingopyxis sp. isolated from Lake Champlain, Canada Maghsoudi, Ehsan; Fortin, Nathalie; Greer, Charles Environmental Science: Processes & Impacts, Vol. 18, Issue 11 https://doi.org/10.1039/c6em00001k	journal	January 2016
Biodegradation of microcystis and microcystins by indigenous nanoflagellates on biofilm in a practical treatment facility Saito, T.; Sugiura, N.; Itayama, T. Environmental Technology, Vol. 24, Issue 2 https://doi.org/10.1080/09593330309385545	journal	February 2003
Freshwater Cyanobacterial Blooms and Primary Liver Cancer Epidemiological Studies in Serbia SvirČEv, Zorica; KrstiČ, Svetislav; Miladinov-Mikov, Marica Journal of Environmental Science and Health, Part C, Vol. 27, Issue 1 https://doi.org/10.1080/10590500802668016	journal	February 2009
Hepatotoxic Cyanobacteria: A Review of the Biological Importance of Microcystins in Freshwater Environments Zurawell, Ronald W.; Chen, Huirong; Burke, Janice M. Journal of Toxicology and Environmental Health, Part B, Vol. 8, Issue 1 https://doi.org/10.1080/10937400590889412	journal	December 2005
Microcystin-LR degradation utilizing a novel effective indigenous bacterial community YFMCD1 from Lake Taihu Yang, Fei; Massey, Isaac Yaw; Guo, Jian Journal of Toxicology and Environmental Health, Part A, Vol. 81, Issue 7 https://doi.org/10.1080/15287394.2018.1423803	journal	January 2018
Health Effects of Toxin-Producing Cyanobacteria: “The CyanoHABs” Carmichael, Wayne W. Human and Ecological Risk Assessment: An International Journal, Vol. 7, Issue 5 https://doi.org/10.1080/20018091095087	journal	September 2001
Spatial and temporal variability in the nitrogen cyclers of hypereutrophic Lake Taihu Krausfeldt, Lauren E.; Tang, Xiangming; van de Kamp, Jodie FEMS Microbiology Ecology, Vol. 93, Issue 4 https://doi.org/10.1093/femsec/fix024	journal	February 2017
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0 Tamura, K.; Dudley, J.; Nei, M. Molecular Biology and Evolution, Vol. 24, Issue 8 https://doi.org/10.1093/molbev/msm092	journal	April 2007
New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0 Guindon, Stéphane; Dufayard, Jean-François; Lefort, Vincent Systematic Biology, Vol. 59, Issue 3 https://doi.org/10.1093/sysbio/syq010	journal	March 2010
How microcystin-degrading bacteria express microcystin degradation activity: Induction of bacterial MC degradation Shimizu, Kazuya; Maseda, Hideaki; Okano, Kunihiro Lakes & Reservoirs: Research & Management, Vol. 16, Issue 3 https://doi.org/10.1111/j.1440-1770.2011.00480.x	journal	September 2011
Biodegradability and adsorption on lake sediments of cyanobacterial hepatotoxins and anatoxin-a Rapala, J.; Lahti, K.; Sivonen, K. Letters in Applied Microbiology, Vol. 19, Issue 6 https://doi.org/10.1111/j.1472-765x.1994.tb00972.x	journal	December 1994
Active and silent members in the mlr gene cluster of a microcystin-degrading bacterium isolated from Lake Taihu, China: Active mlrA and silent mlrB* in Novosphingobium sp. THN1 Jiang, Yongguang; Shao, Jihai; Wu, Xingqiang FEMS Microbiology Letters, Vol. 322, Issue 2 https://doi.org/10.1111/j.1574-6968.2011.02337.x	journal	July 2011
Glutathione transferases in bacteria: Bacterial GSTs Allocati, Nerino; Federici, Luca; Masulli, Michele FEBS Journal, Vol. 276, Issue 1 https://doi.org/10.1111/j.1742-4658.2008.06743.x	journal	November 2008
Development of an mlrA Gene-Directed TaqMan PCR Assay for Quantitative Assessment of Microcystin-Degrading Bacteria within Water Treatment Plant Sand Filter Biofilms Hoefel, D.; Adriansen, C. M. M.; Bouyssou, M. A. C. Applied and Environmental Microbiology, Vol. 75, Issue 15 https://doi.org/10.1128/AEM.00036-09	journal	June 2009
Ecological Dynamics of Toxic Microcystis spp. and Microcystin-Degrading Bacteria in Dianchi Lake, China Zhu, Lin; Wu, Yanlong; Song, Lirong Applied and Environmental Microbiology, Vol. 80, Issue 6 https://doi.org/10.1128/AEM.02972-13	journal	January 2014
Metatranscriptomic Evidence for Co-Occurring Top-Down and Bottom-Up Controls on Toxic Cyanobacterial Communities Steffen, Morgan M.; Belisle, B. Shafer; Watson, Sue B. Applied and Environmental Microbiology, Vol. 81, Issue 9 https://doi.org/10.1128/AEM.04101-14	journal	February 2015
Comparative analysis of terrestrial arthropod community and biomass in differently managed rice fields in Korea Lee, Sue-Yeon; Kim, Myung-Hyun; Eo, Jinu Environmental Biology Research, Vol. 37, Issue 3 https://doi.org/10.11626/KJEB.2019.37.3.317	journal	September 2019
The metagenomics RAST server – a public resource for the automatic phylogenetic and functional analysis of metagenomes Meyer, F.; Paarmann, D.; D'Souza, M. BMC Bioinformatics, Vol. 9, Issue 1 https://doi.org/10.1186/1471-2105-9-386	journal	September 2008
Comparative Metagenomics of Toxic Freshwater Cyanobacteria Bloom Communities on Two Continents Steffen, Morgan M.; Li, Zhou; Effler, T. Chad PLoS ONE, Vol. 7, Issue 8 https://doi.org/10.1371/journal.pone.0044002	journal	August 2012
Metagenomic Identification of Bacterioplankton Taxa and Pathways Involved in Microcystin Degradation in Lake Erie Mou, Xiaozhen; Lu, Xinxin; Jacob, Jisha PLoS ONE, Vol. 8, Issue 4 https://doi.org/10.1371/journal.pone.0061890	journal	April 2013
Microcystin-Degrading Activity of an Indigenous Bacterial Strain Stenotrophomonas acidaminiphila MC-LTH2 Isolated from Lake Taihu Yang, Fei; Zhou, Yuanlong; Yin, Lihong PLoS ONE, Vol. 9, Issue 1 https://doi.org/10.1371/journal.pone.0086216	journal	January 2014
Molecular prediction of lytic vs lysogenic states for Microcystis phage: Metatranscriptomic evidence of lysogeny during large bloom events Stough, Joshua M. A.; Tang, Xiangming; Krausfeldt, Lauren E. PLOS ONE, Vol. 12, Issue 9 https://doi.org/10.1371/journal.pone.0184146	journal	September 2017
Degradation of cyanobacterial hepatotoxins in batch experiments Miller, M. J.; Fallowfield, H. J. Water Science and Technology, Vol. 43, Issue 12 https://doi.org/10.2166/wst.2001.0745	journal	June 2001
MlrA Located in the Inner Membrane Is Essential for Initial Degradation of Microcystin in Sphingopyxis sp. C－1 Maseda, Hideaki; Shimizu, Kazuya; Doi, Yoshiaki Japanese Journal of Water Treatment Biology, Vol. 48, Issue 3 https://doi.org/10.2521/jswtb.48.99	journal	January 2012
Persistence and Decomposition of Hepatotoxic Microcystins Produced by Cyanobacteria in Natural Environment Harada, Ken-Ichi; Tsuji, Kiyomi Journal of Toxicology: Toxin Reviews, Vol. 17, Issue 3 https://doi.org/10.3109/15569549809040400	journal	January 1998
Degradation of microcystins by water and bottom sediment bacterial communities from a eutrophic freshwater lake Bukowska, A.; Kaliński, T.; Chróst, Rj Aquatic Microbial Ecology, Vol. 82, Issue 2 https://doi.org/10.3354/ame01887	journal	November 2018
Comparative Genomics of Degradative Novosphingobium Strains With Special Reference to Microcystin-Degrading Novosphingobium sp. THN1 Wang, Juanping; Wang, Chang; Li, Jionghui Frontiers in Microbiology, Vol. 9 https://doi.org/10.3389/fmicb.2018.02238	journal	September 2018
Metatranscriptomic Analyses of Diel Metabolic Functions During a Microcystis Bloom in Western Lake Erie (United States) Davenport, Emily J.; Neudeck, Michelle J.; Matson, Paul G. Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.02081	journal	September 2019
Molecular Mechanisms of Microcystin Toxicity in Animal Cells Campos, Alexandre; Vasconcelos, Vitor International Journal of Molecular Sciences, Vol. 11, Issue 1 https://doi.org/10.3390/ijms11010268	journal	January 2010
Degradation of Microcystin-LR and RR by a Stenotrophomonas sp. Strain EMS Isolated from Lake Taihu, China Chen, Jian; Hu, Liang Bin; Zhou, Wei International Journal of Molecular Sciences, Vol. 11, Issue 3 https://doi.org/10.3390/ijms11030896	journal	March 2010
Removal of Microcystin-LR by a Novel Native Effective Bacterial Community Designated as YFMCD4 Isolated from Lake Taihu Yang, Fei; Guo, Jian; Huang, Feiyu Toxins, Vol. 10, Issue 9 https://doi.org/10.3390/toxins10090363	journal	September 2018
Characterization of Enzymatic Activity of MlrB and MlrC Proteins Involved in Bacterial Degradation of Cyanotoxins Microcystins Dziga, Dariusz; Zielinska, Gabriela; Wladyka, Benedykt Toxins, Vol. 8, Issue 3 https://doi.org/10.3390/toxins8030076	journal	March 2016
Presence or Absence of mlr Genes and Nutrient Concentrations Co-Determine the Microcystin Biodegradation Efficiency of a Natural Bacterial Community Lezcano, María; Morón-López, Jesús; Agha, Ramsy Toxins, Vol. 8, Issue 11 https://doi.org/10.3390/toxins8110318	journal	November 2016
Microcystin-LR Biodegradation by Bacillus sp.: Reaction Rates and Possible Genes Involved in the Degradation Kansole, Michelline; Lin, Tsair-Fuh Water, Vol. 8, Issue 11 https://doi.org/10.3390/w8110508	journal	November 2016

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