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Title: The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

Abstract

Transformative technologies are enabling the construction of three dimensional (3D) maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) aims to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping. HuBMAP will integrate its efforts with other funding agencies, programs, and the biomedical research community at large towards the shared vision of a comprehensive, accessible 3D molecular and cellular atlas of the human body, in health and various disease settings.

Authors:
 [1];  [2];  [3];  [3];  [4];  [5];  [5];  [5];  [5];  [6];  [7];  [2];  [8];  [1];  [9];  [9];  [10];  [11];  [12];  [13] more »;  [14];  [14];  [14];  [14];  [14];  [14];  [15];  [2];  [2];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [11];  [13];  [11];  [16];  [7];  [17];  [3];  [3];  [3];  [3];  [3];  [3];  [3];  [17];  [18];  [19];  [19];  [19];  [19];  [19];  [19];  [19];  [20];  [19];  [21];  [21];  [21];  [22];  [22];  [22];  [22];  [22];  [23]; ORCiD logo [24]; ORCiD logo [24];  [24]; ORCiD logo [24];  [1];  [1];  [1];  [1];  [25];  [26];  [10];  [10];  [25];  [10];  [10];  [25];  [10];  [10];  [7];  [7];  [12];  [27];  [12];  [12];  [12];  [12];  [12];  [12];  [7];  [28];  [28];  [9];  [28];  [29];  [30];  [30];  [31];  [25];  [6];  [6];  [32];  [32];  [6];  [5];  [33];  [34];  [35];  [35];  [14];  [14] « less
+ Show Author Affiliations
  1. Stanford University
  2. University of Washington
  3. University of Florida
  4. Broad Institute
  5. Broad Institute of MIT and Harvard
  6. New York Genome Center
  7. Harvard Medical School
  8. Purdue University
  9. University of Pittsburgh
  10. Carnegie Mellon University
  11. University of California, San Diego
  12. Indiana University-Bloomington
  13. Washington University In Saint Louis
  14. National Institute of Health
  15. California Institute of Technology
  16. University of Rochester
  17. Institute of Molecular Life Sciences
  18. VISITORS
  19. Vanderbilt University
  20. Delft University of Technology
  21. Dana-Farber Cancer Institute
  22. Harvard University
  23. Marquette University,
  24. BATTELLE (PACIFIC NW LAB)
  25. Wellcome Sanger Institute
  26. Jack Baskin School of Engineering
  27. Opto-Knowledge Systems, Inc
  28. Pittsburgh Supercomputing Center
  29. University of South Dakota
  30. University of North Carolina at Chapel Hill
  31. Knowinnovation Inc
  32. University of Cambridge
  33. Massachusetts Institute of Technology
  34. National Heart, Lung, and Blood Institute
  35. National Institute of Diabetes and Digestive and Kidney Diseases
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
Contributing Org.:
HuBMAP Consortium
OSTI Identifier:
1577443
Report Number(s):
PNNL-SA-146510
Journal ID: ISSN 0028-0836
Grant/Contract Number:  
AC05-76RL01830
Resource Type:
Accepted Manuscript
Journal Name:
Nature (London)
Additional Journal Information:
Journal Name: Nature (London); Journal Volume: 574; Journal Issue: 7777; Journal ID: ISSN 0028-0836
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Snyder, Michael, Lin, Shin, Posgai, Amanda, Atkinson, Mark A., Regev, Aviv, Rood, Jennifer, Rozenblatt-Rosen, Orit, Gaffney, Leslie, Hupalowska, Anna, Satija, Rahul, Gehlenborg, Nils, Shendure, Jay, Laskin, Julia, Harbury, Pehr, Nystrom, Nicholas, Silverstein, Jonathan C., Bar-Joseph, Ziv, Zhang, Kun, Borner, Katy, Lin, Yiin, Conroy, Richard, Procaccini, Dena, Roy, Ananda, Pillai, Ajay, Brown, Marishka, Galis, Zorina S., Long, Cai, Trapnell, Cole, Jackson, Dana, Nolan, Garry, Greenleaf, William J., Plevritis, Sylvia K., Ahadi, Sara, Nevins, Stephanie A., Lee, Hayan, Schuerch, Christian M., Black, Sarah, Venkataraaman, Vishal G., Esplin, Edward D., Horning, Aaron, Bahmani, Amir, Sun, Xin, Jain, Sanjay, Hagood, James, Pryhuber, Gloria, Kharchenko, Peter, Bodenmiller, Bernd, Brusko, Todd, Clare-Salzler, Micheal, Nick, Harry, Otto, Kevin, Wasserfall, Clive, Jorgensen, Marda, Brusko, Maigan, Maffioletti, Sergio, Caprioli, Richard M., Spraggins, Jeffrey, Gutierrez, Dainelle, Patterson, Nathan H., Neumann, Elizabeth K., Harris, Raymond, deCaestecker, Mark, Fogo, Agnes B., Van de Plas, Raf, Lau, Ken, Yuan, Guo-Cheng, Zhu, Qian, Dries, Ruben, Yin, Peng, Saka, Sinem K., Kishi, Jocelyn Y., Wang, Yu, Goldaracena, Isabel, Ye, DongeHye, Burnum-Johnson, Kristin E., Piehowski, Paul D., Ansong, Charles K., Zhu, Ying, Tushar, Desai, Mulye, Jay, Chou, Peter, Nagendran, Monica, Teichmann, Sarah A., Paten, Benedict, Murphy, Robert F., Ma, Jian, Kiselev, Vladimir, Kingsford, Carl, Ricarte, Allyson, Keays, Maria, Akoju, Sushma A., Ruffalo, Matthew, Vella, Margaret, McCallum, Chuck, Cross, Leonard, Friedman, Samuel H., Heiland, Randy, Herr, Bruce, Macklin, Paul, Quardokus, Ellen M., Record, Lisel, Sluka, James P., Weber, Griffin M., Blood, Philip D., Ropelewski, Alexander J., Shirley, William E., Scibek, Robin M., Mabee, Paula, Lenhardt, Christopher C., Robasky, Kimberly, Michailidis, Stravos, Marioni, John, Butler, Andrew, Stuart, Tim, Fisher, Eyal, Ghazanfar, Shila, Eraslan, Gocken, Biancalani, Tommaso, Vaishnav, Eeshit D., Srinivas, Pothur R., Pawlyk, Aaron, Sechi, Salvatore, Wilder, Elizabeth, and Anderson, James. The human body at cellular resolution: the NIH Human Biomolecular Atlas Program. United States: N. p., 2019. Web. doi:10.1038/s41586-019-1629-x.
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Snyder, Michael, Lin, Shin, Posgai, Amanda, Atkinson, Mark A., Regev, Aviv, Rood, Jennifer, Rozenblatt-Rosen, Orit, Gaffney, Leslie, Hupalowska, Anna, Satija, Rahul, Gehlenborg, Nils, Shendure, Jay, Laskin, Julia, Harbury, Pehr, Nystrom, Nicholas, Silverstein, Jonathan C., Bar-Joseph, Ziv, Zhang, Kun, Borner, Katy, Lin, Yiin, Conroy, Richard, Procaccini, Dena, Roy, Ananda, Pillai, Ajay, Brown, Marishka, Galis, Zorina S., Long, Cai, Trapnell, Cole, Jackson, Dana, Nolan, Garry, Greenleaf, William J., Plevritis, Sylvia K., Ahadi, Sara, Nevins, Stephanie A., Lee, Hayan, Schuerch, Christian M., Black, Sarah, Venkataraaman, Vishal G., Esplin, Edward D., Horning, Aaron, Bahmani, Amir, Sun, Xin, Jain, Sanjay, Hagood, James, Pryhuber, Gloria, Kharchenko, Peter, Bodenmiller, Bernd, Brusko, Todd, Clare-Salzler, Micheal, Nick, Harry, Otto, Kevin, Wasserfall, Clive, Jorgensen, Marda, Brusko, Maigan, Maffioletti, Sergio, Caprioli, Richard M., Spraggins, Jeffrey, Gutierrez, Dainelle, Patterson, Nathan H., Neumann, Elizabeth K., Harris, Raymond, deCaestecker, Mark, Fogo, Agnes B., Van de Plas, Raf, Lau, Ken, Yuan, Guo-Cheng, Zhu, Qian, Dries, Ruben, Yin, Peng, Saka, Sinem K., Kishi, Jocelyn Y., Wang, Yu, Goldaracena, Isabel, Ye, DongeHye, Burnum-Johnson, Kristin E., Piehowski, Paul D., Ansong, Charles K., Zhu, Ying, Tushar, Desai, Mulye, Jay, Chou, Peter, Nagendran, Monica, Teichmann, Sarah A., Paten, Benedict, Murphy, Robert F., Ma, Jian, Kiselev, Vladimir, Kingsford, Carl, Ricarte, Allyson, Keays, Maria, Akoju, Sushma A., Ruffalo, Matthew, Vella, Margaret, McCallum, Chuck, Cross, Leonard, Friedman, Samuel H., Heiland, Randy, Herr, Bruce, Macklin, Paul, Quardokus, Ellen M., Record, Lisel, Sluka, James P., Weber, Griffin M., Blood, Philip D., Ropelewski, Alexander J., Shirley, William E., Scibek, Robin M., Mabee, Paula, Lenhardt, Christopher C., Robasky, Kimberly, Michailidis, Stravos, Marioni, John, Butler, Andrew, Stuart, Tim, Fisher, Eyal, Ghazanfar, Shila, Eraslan, Gocken, Biancalani, Tommaso, Vaishnav, Eeshit D., Srinivas, Pothur R., Pawlyk, Aaron, Sechi, Salvatore, Wilder, Elizabeth, & Anderson, James. The human body at cellular resolution: the NIH Human Biomolecular Atlas Program. United States. doi:10.1038/s41586-019-1629-x.
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Snyder, Michael, Lin, Shin, Posgai, Amanda, Atkinson, Mark A., Regev, Aviv, Rood, Jennifer, Rozenblatt-Rosen, Orit, Gaffney, Leslie, Hupalowska, Anna, Satija, Rahul, Gehlenborg, Nils, Shendure, Jay, Laskin, Julia, Harbury, Pehr, Nystrom, Nicholas, Silverstein, Jonathan C., Bar-Joseph, Ziv, Zhang, Kun, Borner, Katy, Lin, Yiin, Conroy, Richard, Procaccini, Dena, Roy, Ananda, Pillai, Ajay, Brown, Marishka, Galis, Zorina S., Long, Cai, Trapnell, Cole, Jackson, Dana, Nolan, Garry, Greenleaf, William J., Plevritis, Sylvia K., Ahadi, Sara, Nevins, Stephanie A., Lee, Hayan, Schuerch, Christian M., Black, Sarah, Venkataraaman, Vishal G., Esplin, Edward D., Horning, Aaron, Bahmani, Amir, Sun, Xin, Jain, Sanjay, Hagood, James, Pryhuber, Gloria, Kharchenko, Peter, Bodenmiller, Bernd, Brusko, Todd, Clare-Salzler, Micheal, Nick, Harry, Otto, Kevin, Wasserfall, Clive, Jorgensen, Marda, Brusko, Maigan, Maffioletti, Sergio, Caprioli, Richard M., Spraggins, Jeffrey, Gutierrez, Dainelle, Patterson, Nathan H., Neumann, Elizabeth K., Harris, Raymond, deCaestecker, Mark, Fogo, Agnes B., Van de Plas, Raf, Lau, Ken, Yuan, Guo-Cheng, Zhu, Qian, Dries, Ruben, Yin, Peng, Saka, Sinem K., Kishi, Jocelyn Y., Wang, Yu, Goldaracena, Isabel, Ye, DongeHye, Burnum-Johnson, Kristin E., Piehowski, Paul D., Ansong, Charles K., Zhu, Ying, Tushar, Desai, Mulye, Jay, Chou, Peter, Nagendran, Monica, Teichmann, Sarah A., Paten, Benedict, Murphy, Robert F., Ma, Jian, Kiselev, Vladimir, Kingsford, Carl, Ricarte, Allyson, Keays, Maria, Akoju, Sushma A., Ruffalo, Matthew, Vella, Margaret, McCallum, Chuck, Cross, Leonard, Friedman, Samuel H., Heiland, Randy, Herr, Bruce, Macklin, Paul, Quardokus, Ellen M., Record, Lisel, Sluka, James P., Weber, Griffin M., Blood, Philip D., Ropelewski, Alexander J., Shirley, William E., Scibek, Robin M., Mabee, Paula, Lenhardt, Christopher C., Robasky, Kimberly, Michailidis, Stravos, Marioni, John, Butler, Andrew, Stuart, Tim, Fisher, Eyal, Ghazanfar, Shila, Eraslan, Gocken, Biancalani, Tommaso, Vaishnav, Eeshit D., Srinivas, Pothur R., Pawlyk, Aaron, Sechi, Salvatore, Wilder, Elizabeth, and Anderson, James. Wed . "The human body at cellular resolution: the NIH Human Biomolecular Atlas Program". United States. doi:10.1038/s41586-019-1629-x. https://www.osti.gov/servlets/purl/1577443.
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@article{osti_1577443,
title = {The human body at cellular resolution: the NIH Human Biomolecular Atlas Program},
author = {Snyder, Michael and Lin, Shin and Posgai, Amanda and Atkinson, Mark A. and Regev, Aviv and Rood, Jennifer and Rozenblatt-Rosen, Orit and Gaffney, Leslie and Hupalowska, Anna and Satija, Rahul and Gehlenborg, Nils and Shendure, Jay and Laskin, Julia and Harbury, Pehr and Nystrom, Nicholas and Silverstein, Jonathan C. and Bar-Joseph, Ziv and Zhang, Kun and Borner, Katy and Lin, Yiin and Conroy, Richard and Procaccini, Dena and Roy, Ananda and Pillai, Ajay and Brown, Marishka and Galis, Zorina S. and Long, Cai and Trapnell, Cole and Jackson, Dana and Nolan, Garry and Greenleaf, William J. and Plevritis, Sylvia K. and Ahadi, Sara and Nevins, Stephanie A. and Lee, Hayan and Schuerch, Christian M. and Black, Sarah and Venkataraaman, Vishal G. and Esplin, Edward D. and Horning, Aaron and Bahmani, Amir and Sun, Xin and Jain, Sanjay and Hagood, James and Pryhuber, Gloria and Kharchenko, Peter and Bodenmiller, Bernd and Brusko, Todd and Clare-Salzler, Micheal and Nick, Harry and Otto, Kevin and Wasserfall, Clive and Jorgensen, Marda and Brusko, Maigan and Maffioletti, Sergio and Caprioli, Richard M. and Spraggins, Jeffrey and Gutierrez, Dainelle and Patterson, Nathan H. and Neumann, Elizabeth K. and Harris, Raymond and deCaestecker, Mark and Fogo, Agnes B. and Van de Plas, Raf and Lau, Ken and Yuan, Guo-Cheng and Zhu, Qian and Dries, Ruben and Yin, Peng and Saka, Sinem K. and Kishi, Jocelyn Y. and Wang, Yu and Goldaracena, Isabel and Ye, DongeHye and Burnum-Johnson, Kristin E. and Piehowski, Paul D. and Ansong, Charles K. and Zhu, Ying and Tushar, Desai and Mulye, Jay and Chou, Peter and Nagendran, Monica and Teichmann, Sarah A. and Paten, Benedict and Murphy, Robert F. and Ma, Jian and Kiselev, Vladimir and Kingsford, Carl and Ricarte, Allyson and Keays, Maria and Akoju, Sushma A. and Ruffalo, Matthew and Vella, Margaret and McCallum, Chuck and Cross, Leonard and Friedman, Samuel H. and Heiland, Randy and Herr, Bruce and Macklin, Paul and Quardokus, Ellen M. and Record, Lisel and Sluka, James P. and Weber, Griffin M. and Blood, Philip D. and Ropelewski, Alexander J. and Shirley, William E. and Scibek, Robin M. and Mabee, Paula and Lenhardt, Christopher C. and Robasky, Kimberly and Michailidis, Stravos and Marioni, John and Butler, Andrew and Stuart, Tim and Fisher, Eyal and Ghazanfar, Shila and Eraslan, Gocken and Biancalani, Tommaso and Vaishnav, Eeshit D. and Srinivas, Pothur R. and Pawlyk, Aaron and Sechi, Salvatore and Wilder, Elizabeth and Anderson, James},
abstractNote = {Transformative technologies are enabling the construction of three dimensional (3D) maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) aims to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping. HuBMAP will integrate its efforts with other funding agencies, programs, and the biomedical research community at large towards the shared vision of a comprehensive, accessible 3D molecular and cellular atlas of the human body, in health and various disease settings.},
doi = {10.1038/s41586-019-1629-x},
journal = {Nature (London)},
number = 7777,
volume = 574,
place = {United States},
year = {2019},
month = {10}
}
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DOI:  10.1038/s41586-019-1629-x
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