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Title: Self–Destruction of Cancer Induced by Ag 2S Amorphous Nanodots

Abstract

Studies on distinctive performances and novel applications of amorphous inorganic nanomaterials are becoming attractive. Herein, Ag 2S amorphous and crystalline nanodots (ANDs and CNDs) are prepared via facile methods. In vitro and in vivo studies indicate that Ag 2S ANDs, rather than CNDs, can induce the self-destruction of tumors, which can be attributed to their distinctive chemical properties, e.g., the higher electrochemical active surface area and lower redox potential well matching with the redox reaction requirement in the tumor microenvironment. Ag 2S ANDs can be oxidized by intracellular reactive oxygen species (ROS) to release Ag +, which further stimulates high generation of intracellular ROS. This mutual stimulation damages the mitochondria, induces apoptosis, and leads to the self-destruction of the tumor. Moreover, Ag 2S ANDs do not show observable in vitro and in vivo side effects. Furthermore, these findings provide a promising self-destructive strategy for cancer therapy by utilizing distinctive chemical properties of inorganic nanomaterials, while avoiding complicated external assistance.

Authors:
 [1];  [2];  [3];  [2];  [3];  [2];  [2];  [3]; ORCiD logo [4]
  1. Henan Normal Univ., Henan (China). School of Chemistry and Chemical Engineering; Xinxiang Medical Univ., Henan (China). School of Basic Medical Sciences
  2. Henan Normal Univ., Henan (China). School of Chemistry and Chemical Engineering
  3. Henan Normal Univ., Henan (China). Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and Reactions, Ministry of Education
  4. Argonne National Lab. (ANL), Lemont, IL (United States). Chemical Sciences and Engineering Div.
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Energy Efficiency and Renewable Energy (EERE)
OSTI Identifier:
1575249
Alternate Identifier(s):
OSTI ID: 1562550
Grant/Contract Number:  
AC02-06CH11357; AC02‐06CH11357
Resource Type:
Accepted Manuscript
Journal Name:
Small
Additional Journal Information:
Journal Volume: 15; Journal Issue: 44; Journal ID: ISSN 1613-6810
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; amorphous; cancer therapy; redox; self-destruction; silver sulfide

Citation Formats

Wang, Ge, Liu, Jing, Zhu, Lin, Ma, Xiaoming, Wang, Xiaobing, Yang, Xiaoli, Guo, Yuming, Yang, Lin, and Lu, Jun. Self–Destruction of Cancer Induced by Ag2S Amorphous Nanodots. United States: N. p., 2019. Web. doi:10.1002/smll.201902945.
Wang, Ge, Liu, Jing, Zhu, Lin, Ma, Xiaoming, Wang, Xiaobing, Yang, Xiaoli, Guo, Yuming, Yang, Lin, & Lu, Jun. Self–Destruction of Cancer Induced by Ag2S Amorphous Nanodots. United States. doi:10.1002/smll.201902945.
Wang, Ge, Liu, Jing, Zhu, Lin, Ma, Xiaoming, Wang, Xiaobing, Yang, Xiaoli, Guo, Yuming, Yang, Lin, and Lu, Jun. Wed . "Self–Destruction of Cancer Induced by Ag2S Amorphous Nanodots". United States. doi:10.1002/smll.201902945.
@article{osti_1575249,
title = {Self–Destruction of Cancer Induced by Ag2S Amorphous Nanodots},
author = {Wang, Ge and Liu, Jing and Zhu, Lin and Ma, Xiaoming and Wang, Xiaobing and Yang, Xiaoli and Guo, Yuming and Yang, Lin and Lu, Jun},
abstractNote = {Studies on distinctive performances and novel applications of amorphous inorganic nanomaterials are becoming attractive. Herein, Ag2S amorphous and crystalline nanodots (ANDs and CNDs) are prepared via facile methods. In vitro and in vivo studies indicate that Ag2S ANDs, rather than CNDs, can induce the self-destruction of tumors, which can be attributed to their distinctive chemical properties, e.g., the higher electrochemical active surface area and lower redox potential well matching with the redox reaction requirement in the tumor microenvironment. Ag2S ANDs can be oxidized by intracellular reactive oxygen species (ROS) to release Ag+, which further stimulates high generation of intracellular ROS. This mutual stimulation damages the mitochondria, induces apoptosis, and leads to the self-destruction of the tumor. Moreover, Ag2S ANDs do not show observable in vitro and in vivo side effects. Furthermore, these findings provide a promising self-destructive strategy for cancer therapy by utilizing distinctive chemical properties of inorganic nanomaterials, while avoiding complicated external assistance.},
doi = {10.1002/smll.201902945},
journal = {Small},
number = 44,
volume = 15,
place = {United States},
year = {2019},
month = {9}
}

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