Self–Destruction of Cancer Induced by Ag2S Amorphous Nanodots

Wang, Ge; Liu, Jing; Zhu, Lin; Ma, Xiaoming; Wang, Xiaobing; Yang, Xiaoli; Guo, Yuming; Yang, Lin; Lu, Jun

doi:10.1002/smll.201902945

Title: Self–Destruction of Cancer Induced by Ag₂S Amorphous Nanodots

Journal Article · 17 September 2019 · Small

DOI: https://doi.org/10.1002/smll.201902945 · OSTI ID:1575249

Wang, Ge ^[1]; Liu, Jing ^[2]; Zhu, Lin ^[3]; Ma, Xiaoming ^[2]; Wang, Xiaobing ^[3]; Yang, Xiaoli ^[2]; Guo, Yuming ^[2]; Yang, Lin ^[3];

^[4]

Henan Normal Univ., Henan (China). School of Chemistry and Chemical Engineering; Xinxiang Medical Univ., Henan (China). School of Basic Medical Sciences
Henan Normal Univ., Henan (China). School of Chemistry and Chemical Engineering
Henan Normal Univ., Henan (China). Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and Reactions, Ministry of Education
Argonne National Lab. (ANL), Lemont, IL (United States). Chemical Sciences and Engineering Div.

Studies on distinctive performances and novel applications of amorphous inorganic nanomaterials are becoming attractive. Herein, Ag₂S amorphous and crystalline nanodots (ANDs and CNDs) are prepared via facile methods. In vitro and in vivo studies indicate that Ag₂S ANDs, rather than CNDs, can induce the self-destruction of tumors, which can be attributed to their distinctive chemical properties, e.g., the higher electrochemical active surface area and lower redox potential well matching with the redox reaction requirement in the tumor microenvironment. Ag₂S ANDs can be oxidized by intracellular reactive oxygen species (ROS) to release Ag⁺, which further stimulates high generation of intracellular ROS. This mutual stimulation damages the mitochondria, induces apoptosis, and leads to the self-destruction of the tumor. Moreover, Ag₂S ANDs do not show observable in vitro and in vivo side effects. Furthermore, these findings provide a promising self-destructive strategy for cancer therapy by utilizing distinctive chemical properties of inorganic nanomaterials, while avoiding complicated external assistance.

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1575249

Journal Information:: Small, Journal Name: Small Journal Issue: 44 Vol. 15; ISSN 1613-6810

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
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cancer therapy
redox
self-destruction
silver sulfide

Title: Self–Destruction of Cancer Induced by Ag2S Amorphous Nanodots

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Title: Self–Destruction of Cancer Induced by Ag₂S Amorphous Nanodots