Mediator function in plant metabolism revealed by large-scale biology

Mao, Xiangying; Weake, Vikki M.; Chapple, Clint; Raines, ed., Christine

doi:10.1093/jxb/erz372

Title: Mediator function in plant metabolism revealed by large-scale biology

Journal Article · 21 August 2019 · Journal of Experimental Botany

DOI: https://doi.org/10.1093/jxb/erz372 · OSTI ID:1574516

Mao, Xiangying ^[1]; Weake, Vikki M. ^[2]; Chapple, Clint ^[1]; Raines, ed., Christine ^[3]

Department of Biochemistry, Purdue University, West Lafayette, IN, USA, Purdue Center for Plant Biology, Purdue University, West Lafayette, IN, USA
Department of Biochemistry, Purdue University, West Lafayette, IN, USA, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA
University of Essex, UK

Abstract Mediator is a multisubunit transcriptional co-regulator that is involved in the regulation of an array of processes including plant metabolism. The pathways regulated by Mediator-dependent processes include those for the synthesis of phenylpropanoids (MED5), cellulose (MED16), lipids (MED15 and CDK8), and the regulation of iron homeostasis (MED16 and MED25). Traditional genetic and biochemical approaches laid the foundation for our understanding of Mediator function, but recent transcriptomic and metabolomic studies have provided deeper insights into how specific subunits cooperate in the regulation of plant metabolism. In this review, we highlight recent developments in the investigation of Mediator and plant metabolism, with particular emphasis on the large-scale biology studies of med mutants.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: FG02-07ER15905

OSTI ID:: 1574516

Journal Information:: Journal of Experimental Botany, Journal Name: Journal of Experimental Botany Journal Issue: 21 Vol. 70; ISSN 0022-0957

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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