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Title: Mediator function in plant metabolism revealed by large-scale biology

Abstract

Abstract Mediator is a multisubunit transcriptional co-regulator that is involved in the regulation of an array of processes including plant metabolism. The pathways regulated by Mediator-dependent processes include those for the synthesis of phenylpropanoids (MED5), cellulose (MED16), lipids (MED15 and CDK8), and the regulation of iron homeostasis (MED16 and MED25). Traditional genetic and biochemical approaches laid the foundation for our understanding of Mediator function, but recent transcriptomic and metabolomic studies have provided deeper insights into how specific subunits cooperate in the regulation of plant metabolism. In this review, we highlight recent developments in the investigation of Mediator and plant metabolism, with particular emphasis on the large-scale biology studies of med mutants.

Authors:
 [1];  [2];  [1];  [3]
  1. Department of Biochemistry, Purdue University, West Lafayette, IN, USA, Purdue Center for Plant Biology, Purdue University, West Lafayette, IN, USA
  2. Department of Biochemistry, Purdue University, West Lafayette, IN, USA, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA
  3. University of Essex, UK
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1574516
Alternate Identifier(s):
OSTI ID: 1570482
Grant/Contract Number:  
FG02-07ER15905
Resource Type:
Published Article
Journal Name:
Journal of Experimental Botany
Additional Journal Information:
Journal Name: Journal of Experimental Botany Journal Volume: 70 Journal Issue: 21; Journal ID: ISSN 0022-0957
Publisher:
Oxford University Press
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Mao, Xiangying, Weake, Vikki M., Chapple, Clint, and Raines, ed., Christine. Mediator function in plant metabolism revealed by large-scale biology. United Kingdom: N. p., 2019. Web. doi:10.1093/jxb/erz372.
Mao, Xiangying, Weake, Vikki M., Chapple, Clint, & Raines, ed., Christine. Mediator function in plant metabolism revealed by large-scale biology. United Kingdom. doi:10.1093/jxb/erz372.
Mao, Xiangying, Weake, Vikki M., Chapple, Clint, and Raines, ed., Christine. Wed . "Mediator function in plant metabolism revealed by large-scale biology". United Kingdom. doi:10.1093/jxb/erz372.
@article{osti_1574516,
title = {Mediator function in plant metabolism revealed by large-scale biology},
author = {Mao, Xiangying and Weake, Vikki M. and Chapple, Clint and Raines, ed., Christine},
abstractNote = {Abstract Mediator is a multisubunit transcriptional co-regulator that is involved in the regulation of an array of processes including plant metabolism. The pathways regulated by Mediator-dependent processes include those for the synthesis of phenylpropanoids (MED5), cellulose (MED16), lipids (MED15 and CDK8), and the regulation of iron homeostasis (MED16 and MED25). Traditional genetic and biochemical approaches laid the foundation for our understanding of Mediator function, but recent transcriptomic and metabolomic studies have provided deeper insights into how specific subunits cooperate in the regulation of plant metabolism. In this review, we highlight recent developments in the investigation of Mediator and plant metabolism, with particular emphasis on the large-scale biology studies of med mutants.},
doi = {10.1093/jxb/erz372},
journal = {Journal of Experimental Botany},
number = 21,
volume = 70,
place = {United Kingdom},
year = {2019},
month = {8}
}

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