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Title: Polyelectrolyte Conformation Controlled by a Trivalent-Rich Ion Jacket

Abstract

The configuration of charged polymers is heavily dependent on interactions with surrounding salt ions, typically manifesting as a sensitivity to the bulk ionic strength. In this work, we use single-molecule mechanical measurements to show that a charged polysaccharide, hyaluronic acid, reflects an interesting regime of insensitivity to ionic strength in the presence of trivalent ions. Using simulations and theory, we propose that this is caused by the formation of a “jacket” of ions, tightly associated with the polymer, whose charge (and thus effect on configuration) is robust against changes in solution composition.

Authors:
ORCiD logo [1];  [1];  [2];  [1]
  1. Univ. of California, Santa Barbara, CA (United States)
  2. Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA); National Science Foundation (NSF)
OSTI Identifier:
1574458
Report Number(s):
SAND-2019-12489J
Journal ID: ISSN 0031-9007; PRLTAO; 680392
Grant/Contract Number:  
AC04-94AL85000; NA-0003525
Resource Type:
Accepted Manuscript
Journal Name:
Physical Review Letters
Additional Journal Information:
Journal Volume: 123; Journal Issue: 18; Journal ID: ISSN 0031-9007
Publisher:
American Physical Society (APS)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Innes-Gold, Sarah N., Pincus, Philip A., Stevens, Mark J., and Saleh, Omar A. Polyelectrolyte Conformation Controlled by a Trivalent-Rich Ion Jacket. United States: N. p., 2019. Web. doi:10.1103/PhysRevLett.123.187801.
Innes-Gold, Sarah N., Pincus, Philip A., Stevens, Mark J., & Saleh, Omar A. Polyelectrolyte Conformation Controlled by a Trivalent-Rich Ion Jacket. United States. doi:10.1103/PhysRevLett.123.187801.
Innes-Gold, Sarah N., Pincus, Philip A., Stevens, Mark J., and Saleh, Omar A. Tue . "Polyelectrolyte Conformation Controlled by a Trivalent-Rich Ion Jacket". United States. doi:10.1103/PhysRevLett.123.187801.
@article{osti_1574458,
title = {Polyelectrolyte Conformation Controlled by a Trivalent-Rich Ion Jacket},
author = {Innes-Gold, Sarah N. and Pincus, Philip A. and Stevens, Mark J. and Saleh, Omar A.},
abstractNote = {The configuration of charged polymers is heavily dependent on interactions with surrounding salt ions, typically manifesting as a sensitivity to the bulk ionic strength. In this work, we use single-molecule mechanical measurements to show that a charged polysaccharide, hyaluronic acid, reflects an interesting regime of insensitivity to ionic strength in the presence of trivalent ions. Using simulations and theory, we propose that this is caused by the formation of a “jacket” of ions, tightly associated with the polymer, whose charge (and thus effect on configuration) is robust against changes in solution composition.},
doi = {10.1103/PhysRevLett.123.187801},
journal = {Physical Review Letters},
number = 18,
volume = 123,
place = {United States},
year = {2019},
month = {10}
}

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