Disposable ultrasound-sensing chronic cranial window by soft nanoimprinting lithography
Abstract
Chronic cranial window (CCW) is an essential tool in enabling longitudinal imaging and manipulation of various brain activities in live animals. However, an active CCW capable of sensing the concealed in vivo environment while simultaneously providing longitudinal optical access to the brain is not currently available. Here we report a disposable ultrasound-sensing CCW (usCCW) featuring an integrated transparent nanophotonic ultrasonic detector fabricated using soft nanoimprint lithography process. We optimize the sensor design and the associated fabrication process to significantly improve detection sensitivity and reliability, which are critical for the intend longitudinal in vivo investigations. Surgically implanting the usCCW on the skull creates a self-contained environment, maintaining optical access while eliminating the need for external ultrasound coupling medium for photoacoustic imaging. Using this usCCW, we demonstrate photoacoustic microscopy of cortical vascular network in live mice over 28 days. Finally, this work establishes the foundation for integrating photoacoustic imaging with modern brain research.
- Authors:
-
[2];
[4];
[1];
[2]
- Northwestern Univ., Evanston, IL (United States). Biomedical Engineering Dept.
- Northwestern Univ., Evanston, IL (United States). Mechanical Engineering Dept.
- Northwestern Univ., Evanston, IL (United States). Biomedical Engineering Dept.; HuaZhong Univ. of Science and Technology, Wuhan, Hubei (China). Tongji Medical College, Dept. of Ophthalmology
- Argonne National Lab. (ANL), Argonne, IL (United States). Center for Nanoscale Materials
- Publication Date:
- Research Org.:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- National Science Foundation (NSF); National Institutes of Health (NIH); USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
- OSTI Identifier:
- 1574377
- Grant/Contract Number:
- AC02-06CH11357
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Nature Communications
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 2041-1723
- Publisher:
- Nature Publishing Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Li, Hao, Dong, Biqin, Zhang, Xian, Shu, Xiao, Chen, Xiangfan, Hai, Rihan, Czaplewski, David A., Zhang, Hao F., and Sun, Cheng. Disposable ultrasound-sensing chronic cranial window by soft nanoimprinting lithography. United States: N. p., 2019.
Web. doi:10.1038/s41467-019-12178-6.
Li, Hao, Dong, Biqin, Zhang, Xian, Shu, Xiao, Chen, Xiangfan, Hai, Rihan, Czaplewski, David A., Zhang, Hao F., & Sun, Cheng. Disposable ultrasound-sensing chronic cranial window by soft nanoimprinting lithography. United States. doi:10.1038/s41467-019-12178-6.
Li, Hao, Dong, Biqin, Zhang, Xian, Shu, Xiao, Chen, Xiangfan, Hai, Rihan, Czaplewski, David A., Zhang, Hao F., and Sun, Cheng. Thu .
"Disposable ultrasound-sensing chronic cranial window by soft nanoimprinting lithography". United States. doi:10.1038/s41467-019-12178-6. https://www.osti.gov/servlets/purl/1574377.
@article{osti_1574377,
title = {Disposable ultrasound-sensing chronic cranial window by soft nanoimprinting lithography},
author = {Li, Hao and Dong, Biqin and Zhang, Xian and Shu, Xiao and Chen, Xiangfan and Hai, Rihan and Czaplewski, David A. and Zhang, Hao F. and Sun, Cheng},
abstractNote = {Chronic cranial window (CCW) is an essential tool in enabling longitudinal imaging and manipulation of various brain activities in live animals. However, an active CCW capable of sensing the concealed in vivo environment while simultaneously providing longitudinal optical access to the brain is not currently available. Here we report a disposable ultrasound-sensing CCW (usCCW) featuring an integrated transparent nanophotonic ultrasonic detector fabricated using soft nanoimprint lithography process. We optimize the sensor design and the associated fabrication process to significantly improve detection sensitivity and reliability, which are critical for the intend longitudinal in vivo investigations. Surgically implanting the usCCW on the skull creates a self-contained environment, maintaining optical access while eliminating the need for external ultrasound coupling medium for photoacoustic imaging. Using this usCCW, we demonstrate photoacoustic microscopy of cortical vascular network in live mice over 28 days. Finally, this work establishes the foundation for integrating photoacoustic imaging with modern brain research.},
doi = {10.1038/s41467-019-12178-6},
journal = {Nature Communications},
number = 1,
volume = 10,
place = {United States},
year = {2019},
month = {9}
}
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