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Title: Novel four-disulfide insulin analog with high aggregation stability and potency

Abstract

A novel four-disulfide insulin analog was designed with retained bioactivity and increased fibrillation stability.

Authors:
ORCiD logo [1]; ORCiD logo [1];  [2];  [3];  [1];  [1];  [1]; ORCiD logo [3];  [2]; ORCiD logo [1]; ORCiD logo [1]
  1. Department of Biochemistry, University of Utah, Salt Lake City UT 84112, USA
  2. Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City UT 84112, USA
  3. Department of Chemical & Biomolecular Engineering, University of Notre Dame, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1574037
Grant/Contract Number:  
AC02-76SF00515
Resource Type:
Published Article
Journal Name:
Chemical Science
Additional Journal Information:
Journal Name: Chemical Science Journal Volume: 11 Journal Issue: 1; Journal ID: ISSN 2041-6520
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Xiong, Xiaochun, Blakely, Alan, Karra, Prasoona, VandenBerg, Michael A., Ghabash, Gabrielle, Whitby, Frank, Zhang, Yi Wolf, Webber, Matthew J., Holland, William L., Hill, Christopher P., and Chou, Danny Hung-Chieh. Novel four-disulfide insulin analog with high aggregation stability and potency. United Kingdom: N. p., 2020. Web. doi:10.1039/C9SC04555D.
Xiong, Xiaochun, Blakely, Alan, Karra, Prasoona, VandenBerg, Michael A., Ghabash, Gabrielle, Whitby, Frank, Zhang, Yi Wolf, Webber, Matthew J., Holland, William L., Hill, Christopher P., & Chou, Danny Hung-Chieh. Novel four-disulfide insulin analog with high aggregation stability and potency. United Kingdom. doi:10.1039/C9SC04555D.
Xiong, Xiaochun, Blakely, Alan, Karra, Prasoona, VandenBerg, Michael A., Ghabash, Gabrielle, Whitby, Frank, Zhang, Yi Wolf, Webber, Matthew J., Holland, William L., Hill, Christopher P., and Chou, Danny Hung-Chieh. Wed . "Novel four-disulfide insulin analog with high aggregation stability and potency". United Kingdom. doi:10.1039/C9SC04555D.
@article{osti_1574037,
title = {Novel four-disulfide insulin analog with high aggregation stability and potency},
author = {Xiong, Xiaochun and Blakely, Alan and Karra, Prasoona and VandenBerg, Michael A. and Ghabash, Gabrielle and Whitby, Frank and Zhang, Yi Wolf and Webber, Matthew J. and Holland, William L. and Hill, Christopher P. and Chou, Danny Hung-Chieh},
abstractNote = {A novel four-disulfide insulin analog was designed with retained bioactivity and increased fibrillation stability.},
doi = {10.1039/C9SC04555D},
journal = {Chemical Science},
number = 1,
volume = 11,
place = {United Kingdom},
year = {2020},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1039/C9SC04555D

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