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Title: Within-host mathematical models of hepatitis B virus infection: Past, present, and future

Journal Article · · Current Opinion in Systems Biology

Mathematical modeling has been instrumental in enhancing our understanding of the viral dynamics of hepatitis B virus (HBV) infection. We give a primer on HBV infection in humans and a brief overview of the development of within-host mathematical models of HBV infection. In the last decade, models have advanced from considering chronic HBV infections under therapy to the pathogenesis of infection. We also summarize estimates of key viral dynamic parameters that have varied greatly among studies, and show that they impact model predictions. Here, future directions for mathematical modeling of HBV infection are proposed to better understand emerging therapies, the HBV life cycle, predicting cure, and the mechanisms involved in the immune response to HBV.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
National Institutes of Health (NIH); USDOE
Grant/Contract Number:
89233218CNA000001
OSTI ID:
1573998
Alternate ID(s):
OSTI ID: 1704019
Report Number(s):
LA-UR-19-24820
Journal Information:
Current Opinion in Systems Biology, Vol. 18; ISSN 2452-3100
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English