Sensitivity of tumor versus normal cell migration and morphology to cold atmospheric plasma‐treated media in varying culture conditions
Abstract
Abstract Cold atmospheric plasma (CAP) produces reactive oxygen species and reactive nitrogen species, which may disproportionally damage tumor cells, resulting in potentially selective cancer therapy. Here, we compare the effects of two CAP sources, that is, the atmospheric pressure plasma jet and the surface micro discharge, on the selectivity of CAP‐treated cell‐culture media. CAP‐treated media were applied to metastatic breast tumor cells and their normal breast epithelial cell counterparts to assess treatment selectivity, while systematically varying common cell‐culture media and cell‐matrix binding moieties. We show that media compositions are crucial in a CAP‐treated media selectivity, while binding moieties (specifically, collagen I, fibronectin, and poly‐ d ‐lysine) play a lesser role. These data have further implications in the translation of CAP to in vivo use.
- Authors:
-
[2];
[4]
- Fischell Department of Bioengineering University of Maryland College Park Maryland
- Department of Materials Science and Engineering, Institute for Research in Electronics and Applied Physics University of Maryland College Park Maryland, College of Polymer Science and Engineering National Polymer Innovation Center Akron Ohio
- Department of Materials Science and Engineering, Institute for Research in Electronics and Applied Physics University of Maryland College Park Maryland
- Fischell Department of Bioengineering University of Maryland College Park Maryland, Biophysics Program University of Maryland College Park Maryland, Center for Stem Cell Biology and Regenerative Medicine University of Maryland–Baltimore Baltimore Maryland, Marlene and Stewart Greenbaum Comprehensive Cancer Center University of Maryland–Baltimore Baltimore Maryland
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1573876
- Grant/Contract Number:
- DE‐SC0001939
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Plasma Processes and Polymers
- Additional Journal Information:
- Journal Name: Plasma Processes and Polymers Journal Volume: 17 Journal Issue: 2; Journal ID: ISSN 1612-8850
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- Germany
- Language:
- English
Citation Formats
Pranda, Marina A., Murugesan, Brittney J., Knoll, Andrew J., Oehrlein, Gottlieb S., and Stroka, Kimberly M. Sensitivity of tumor versus normal cell migration and morphology to cold atmospheric plasma‐treated media in varying culture conditions. Germany: N. p., 2019.
Web. doi:10.1002/ppap.201900103.
Pranda, Marina A., Murugesan, Brittney J., Knoll, Andrew J., Oehrlein, Gottlieb S., & Stroka, Kimberly M. Sensitivity of tumor versus normal cell migration and morphology to cold atmospheric plasma‐treated media in varying culture conditions. Germany. https://doi.org/10.1002/ppap.201900103
Pranda, Marina A., Murugesan, Brittney J., Knoll, Andrew J., Oehrlein, Gottlieb S., and Stroka, Kimberly M. Mon .
"Sensitivity of tumor versus normal cell migration and morphology to cold atmospheric plasma‐treated media in varying culture conditions". Germany. https://doi.org/10.1002/ppap.201900103.
@article{osti_1573876,
title = {Sensitivity of tumor versus normal cell migration and morphology to cold atmospheric plasma‐treated media in varying culture conditions},
author = {Pranda, Marina A. and Murugesan, Brittney J. and Knoll, Andrew J. and Oehrlein, Gottlieb S. and Stroka, Kimberly M.},
abstractNote = {Abstract Cold atmospheric plasma (CAP) produces reactive oxygen species and reactive nitrogen species, which may disproportionally damage tumor cells, resulting in potentially selective cancer therapy. Here, we compare the effects of two CAP sources, that is, the atmospheric pressure plasma jet and the surface micro discharge, on the selectivity of CAP‐treated cell‐culture media. CAP‐treated media were applied to metastatic breast tumor cells and their normal breast epithelial cell counterparts to assess treatment selectivity, while systematically varying common cell‐culture media and cell‐matrix binding moieties. We show that media compositions are crucial in a CAP‐treated media selectivity, while binding moieties (specifically, collagen I, fibronectin, and poly‐ d ‐lysine) play a lesser role. These data have further implications in the translation of CAP to in vivo use.},
doi = {10.1002/ppap.201900103},
journal = {Plasma Processes and Polymers},
number = 2,
volume = 17,
place = {Germany},
year = {Mon Nov 11 00:00:00 EST 2019},
month = {Mon Nov 11 00:00:00 EST 2019}
}
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