Reduction-dependent siderophore assimilation in a model pennate diatom
Abstract
Iron uptake by diatoms is a biochemical process with global biogeochemical implications. In large regions of the surface ocean diatoms are both responsible for the majority of primary production and frequently experiencing iron limitation of growth. The strategies used by these phytoplankton to extract iron from seawater constrain carbon flux into higher trophic levels and sequestration into sediments. In this study we use reverse genetic techniques to target putative iron-acquisition genes in the model pennate diatomPhaeodactylum tricornutum. We describe components of a reduction-dependent siderophore acquisition pathway that relies on a bacterial-derived receptor protein and provides a viable alternative to inorganic iron uptake under certain conditions. This form of iron uptake entails a close association between diatoms and siderophore-producing organisms during low-iron conditions. Homologs of these proteins are found distributed across diatom lineages, suggesting the significance of siderophore utilization by diatoms in the marine environment. Evaluation of specific proteins enables us to confirm independent iron-acquisition pathways in diatoms and characterize their preferred substrates. These findings refine our mechanistic understanding of the multiple iron-uptake systems used by diatoms and help us better predict the influence of iron speciation on taxa-specific iron bioavailability.
- Authors:
-
[1];
[1]
- Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093,, Microbial and Environmental Genomics, J. Craig Venter Institute, La Jolla, CA 92037,
- Biology Centre, Institute of Parasitology, Academy of Sciences of the Czech Republic, 370 05 České Budějovice, Czech Republic,, Faculty of Science, University of South Bohemia, 370 05 České Budějovice, Czech Republic
- Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093,
- Publication Date:
- Research Org.:
- J. Craig Venter Institute, Inc., Rockville, MD (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Science Foundation (NSF); Gordon and Betty Moore Foundation; Czech Science Foundation; European Regional Development Fund/European Social Fund
- OSTI Identifier:
- 1573107
- Alternate Identifier(s):
- OSTI ID: 1625043
- Grant/Contract Number:
- SC0018344; Grants NSF-OCE-1756884; NSF-OCE-1756860; NSF-MCB-1818390; GBMF3828; GBMF5006; 18-13458S; CZ.02.1.01/0.0/0.0/16_019/0000759
- Resource Type:
- Published Article
- Journal Name:
- Proceedings of the National Academy of Sciences of the United States of America
- Additional Journal Information:
- Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Volume: 116 Journal Issue: 47; Journal ID: ISSN 0027-8424
- Publisher:
- Proceedings of the National Academy of Sciences
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Science & Technology - Other Topics; diatom; iron acquisition; ferric reductase; siderophore; phytoplankton
Citation Formats
Coale, Tyler H., Moosburner, Mark, Horák, Aleš, Oborník, Miroslav, Barbeau, Katherine A., and Allen, Andrew E. Reduction-dependent siderophore assimilation in a model pennate diatom. United States: N. p., 2019.
Web. doi:10.1073/pnas.1907234116.
Coale, Tyler H., Moosburner, Mark, Horák, Aleš, Oborník, Miroslav, Barbeau, Katherine A., & Allen, Andrew E. Reduction-dependent siderophore assimilation in a model pennate diatom. United States. https://doi.org/10.1073/pnas.1907234116
Coale, Tyler H., Moosburner, Mark, Horák, Aleš, Oborník, Miroslav, Barbeau, Katherine A., and Allen, Andrew E. Mon .
"Reduction-dependent siderophore assimilation in a model pennate diatom". United States. https://doi.org/10.1073/pnas.1907234116.
@article{osti_1573107,
title = {Reduction-dependent siderophore assimilation in a model pennate diatom},
author = {Coale, Tyler H. and Moosburner, Mark and Horák, Aleš and Oborník, Miroslav and Barbeau, Katherine A. and Allen, Andrew E.},
abstractNote = {Iron uptake by diatoms is a biochemical process with global biogeochemical implications. In large regions of the surface ocean diatoms are both responsible for the majority of primary production and frequently experiencing iron limitation of growth. The strategies used by these phytoplankton to extract iron from seawater constrain carbon flux into higher trophic levels and sequestration into sediments. In this study we use reverse genetic techniques to target putative iron-acquisition genes in the model pennate diatomPhaeodactylum tricornutum. We describe components of a reduction-dependent siderophore acquisition pathway that relies on a bacterial-derived receptor protein and provides a viable alternative to inorganic iron uptake under certain conditions. This form of iron uptake entails a close association between diatoms and siderophore-producing organisms during low-iron conditions. Homologs of these proteins are found distributed across diatom lineages, suggesting the significance of siderophore utilization by diatoms in the marine environment. Evaluation of specific proteins enables us to confirm independent iron-acquisition pathways in diatoms and characterize their preferred substrates. These findings refine our mechanistic understanding of the multiple iron-uptake systems used by diatoms and help us better predict the influence of iron speciation on taxa-specific iron bioavailability.},
doi = {10.1073/pnas.1907234116},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = 47,
volume = 116,
place = {United States},
year = {2019},
month = {11}
}
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https://doi.org/10.1073/pnas.1907234116
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