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Title: Laser-Induced CO 2 Generation from Gold Nanorod-Containing Poly(propylene carbonate)-Based Block Polymer Micelles for Ultrasound Contrast Enhancement

Abstract

Poly(propylene carbonate) (PPC) decomposes at high temperature to release CO 2. Here, this CO 2-generation temperature of PPC can be reduced down to less than 80 °C with the aid of a photoacid generator (PAG). In the present work, we demonstrate that using an additional helper component, surface plasmonic gold nanorods (GNRs), the PPC degradation reaction can also be initiated by near infrared (NIR) irradiation. For this purpose, a PPC-containing nanoparticle formulation was developed in which PPC-based amphiphilic block copolymers (BCPs), poly(poly(ethylene glycol) methacrylate-b-propylene carbonate-b-poly(ethylene glycol) methacrylate) (PPEGMA-PPC-PPEGMA), were self-assembled with GNRs and PAG molecules via solvent exchange; under NIR irradiation GNRs produce heat that can cause PPC to decompose into CO 2, and PAG (after UV pre-treatment) catalyzes this PPC degradation process.

Authors:
 [1];  [2];  [3];  [2];  [3];  [3];  [3]; ORCiD logo [4]
  1. Purdue Univ., West Lafayette, IN (United States); Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  2. Korea Inst. of Science and Technology (KIST), Seoul (South Korea)
  3. Purdue Univ., West Lafayette, IN (United States)
  4. Purdue Univ., West Lafayette, IN (United States); Korea Inst. of Science and Technology (KIST), Seoul (South Korea); Purdue University Center for Cancer Research, West Lafayette, IN (United States)
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1572974
Report Number(s):
PNNL-SA-136641
Journal ID: ISSN 1944-8244
Grant/Contract Number:  
AC05-76RL01830
Resource Type:
Accepted Manuscript
Journal Name:
ACS Applied Materials and Interfaces
Additional Journal Information:
Journal Volume: 10; Journal Issue: 31; Journal ID: ISSN 1944-8244
Publisher:
American Chemical Society (ACS)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; ultrasound contrast; gas-generating nanoparticle; poly(propylene carbonate); block copolymer; photoacid generator; gold nanorod; plasmonic heat generation; IR irradiation

Citation Formats

Lee, Jaewon, Jo, Sung Duk, Chung, Haejun, Um, Wooram, Chandrasekar, Rohith, Choi, Yun Hwa, Shalaev, Vladimir M., and Won, You-Yeon. Laser-Induced CO2 Generation from Gold Nanorod-Containing Poly(propylene carbonate)-Based Block Polymer Micelles for Ultrasound Contrast Enhancement. United States: N. p., 2018. Web. doi:10.1021/acsami.8b09630.
Lee, Jaewon, Jo, Sung Duk, Chung, Haejun, Um, Wooram, Chandrasekar, Rohith, Choi, Yun Hwa, Shalaev, Vladimir M., & Won, You-Yeon. Laser-Induced CO2 Generation from Gold Nanorod-Containing Poly(propylene carbonate)-Based Block Polymer Micelles for Ultrasound Contrast Enhancement. United States. doi:10.1021/acsami.8b09630.
Lee, Jaewon, Jo, Sung Duk, Chung, Haejun, Um, Wooram, Chandrasekar, Rohith, Choi, Yun Hwa, Shalaev, Vladimir M., and Won, You-Yeon. Mon . "Laser-Induced CO2 Generation from Gold Nanorod-Containing Poly(propylene carbonate)-Based Block Polymer Micelles for Ultrasound Contrast Enhancement". United States. doi:10.1021/acsami.8b09630. https://www.osti.gov/servlets/purl/1572974.
@article{osti_1572974,
title = {Laser-Induced CO2 Generation from Gold Nanorod-Containing Poly(propylene carbonate)-Based Block Polymer Micelles for Ultrasound Contrast Enhancement},
author = {Lee, Jaewon and Jo, Sung Duk and Chung, Haejun and Um, Wooram and Chandrasekar, Rohith and Choi, Yun Hwa and Shalaev, Vladimir M. and Won, You-Yeon},
abstractNote = {Poly(propylene carbonate) (PPC) decomposes at high temperature to release CO2. Here, this CO2-generation temperature of PPC can be reduced down to less than 80 °C with the aid of a photoacid generator (PAG). In the present work, we demonstrate that using an additional helper component, surface plasmonic gold nanorods (GNRs), the PPC degradation reaction can also be initiated by near infrared (NIR) irradiation. For this purpose, a PPC-containing nanoparticle formulation was developed in which PPC-based amphiphilic block copolymers (BCPs), poly(poly(ethylene glycol) methacrylate-b-propylene carbonate-b-poly(ethylene glycol) methacrylate) (PPEGMA-PPC-PPEGMA), were self-assembled with GNRs and PAG molecules via solvent exchange; under NIR irradiation GNRs produce heat that can cause PPC to decompose into CO2, and PAG (after UV pre-treatment) catalyzes this PPC degradation process.},
doi = {10.1021/acsami.8b09630},
journal = {ACS Applied Materials and Interfaces},
number = 31,
volume = 10,
place = {United States},
year = {2018},
month = {7}
}

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