skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

This content will become publicly available on October 30, 2020

Title: Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration

Abstract

This scientific commentary refers to ‘Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptors’, by Carvalho et al. (doi:10.1093/brain/awz288).

Authors:
ORCiD logo [1]
  1. Center for Neurosciences and Cell Biology and Faculty of Medicine, University of Coimbra, Portugal
Publication Date:
Sponsoring Org.:
USDOE Office of Nuclear Energy (NE), Fuel Cycle Technologies (NE-5)
OSTI Identifier:
1572438
Grant/Contract Number:  
POCI-01-0145-FEDER-03127
Resource Type:
Published Article
Journal Name:
Brain (Journal of Neurology)
Additional Journal Information:
Journal Name: Brain (Journal of Neurology) Journal Volume: 142 Journal Issue: 11; Journal ID: ISSN 0006-8950
Publisher:
Oxford University Press
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Cunha, Rodrigo A. Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration. United Kingdom: N. p., 2019. Web. doi:10.1093/brain/awz335.
Cunha, Rodrigo A. Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration. United Kingdom. doi:10.1093/brain/awz335.
Cunha, Rodrigo A. Wed . "Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration". United Kingdom. doi:10.1093/brain/awz335.
@article{osti_1572438,
title = {Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration},
author = {Cunha, Rodrigo A.},
abstractNote = {This scientific commentary refers to ‘Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptors’, by Carvalho et al. (doi:10.1093/brain/awz288).},
doi = {10.1093/brain/awz335},
journal = {Brain (Journal of Neurology)},
number = 11,
volume = 142,
place = {United Kingdom},
year = {2019},
month = {10}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on October 30, 2020
Publisher's Version of Record

Save / Share:

Works referenced in this record:

How does adenosine control neuronal dysfunction and neurodegeneration?
journal, August 2016

  • Cunha, Rodrigo A.
  • Journal of Neurochemistry, Vol. 139, Issue 6
  • DOI: 10.1111/jnc.13724

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption
journal, March 2018


Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors
journal, June 2018


Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor
journal, October 2019

  • Carvalho, Kevin; Faivre, Emilie; Pietrowski, Marie J.
  • Brain, Vol. 142, Issue 11
  • DOI: 10.1093/brain/awz288

Alzheimer's Disease Is a Synaptic Failure
journal, October 2002


Blockade of adenosine A 2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease
journal, September 2018

  • Silva, António C.; Lemos, Cristina; Gonçalves, Francisco Q.
  • Neurobiology of Disease, Vol. 117
  • DOI: 10.1016/j.nbd.2018.05.024

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
journal, November 2018


A complement–microglial axis drives synapse loss during virus-induced memory impairment
journal, June 2016

  • Vasek, Michael J.; Garber, Charise; Dorsey, Denise
  • Nature, Vol. 534, Issue 7608
  • DOI: 10.1038/nature18283

Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
journal, July 2018

  • Faivre, Emilie; Coelho, Joana E.; Zornbach, Katja
  • Frontiers in Molecular Neuroscience, Vol. 11
  • DOI: 10.3389/fnmol.2018.00235

Caffeine Intake and Dementia: Systematic Review and Meta-Analysis
journal, April 2010

  • Santos, Catarina; Costa, João; Santos, João
  • Journal of Alzheimer's Disease, Vol. 20, Issue s1
  • DOI: 10.3233/JAD-2010-091387