Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration

Cunha, Rodrigo A.

doi:10.1093/brain/awz335

Title: Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration

Journal Article · 30 October 2019 · Brain

DOI: https://doi.org/10.1093/brain/awz335 · OSTI ID:1572438

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Center for Neurosciences and Cell Biology and Faculty of Medicine, University of Coimbra, Portugal

This scientific commentary refers to ‘Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptors’, by Carvalho et al. (doi:10.1093/brain/awz288).

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Sponsoring Organization:: USDOE Office of Nuclear Energy (NE), Nuclear Fuel Cycle and Supply Chain

OSTI ID:: 1572438

Journal Information:: Brain, Journal Name: Brain Journal Issue: 11 Vol. 142; ISSN 0006-8950

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (10)

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors Lopes, João P.; Pliássova, Anna; Cunha, Rodrigo A. Biochemical Pharmacology, Vol. 166 https://doi.org/10.1016/j.bcp.2019.06.008	journal	August 2019
Blockade of adenosine A 2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease Silva, António C.; Lemos, Cristina; Gonçalves, Francisco Q. Neurobiology of Disease, Vol. 117 https://doi.org/10.1016/j.nbd.2018.05.024	journal	September 2018
A complement–microglial axis drives synapse loss during virus-induced memory impairment Vasek, Michael J.; Garber, Charise; Dorsey, Denise Nature, Vol. 534, Issue 7608 https://doi.org/10.1038/nature18283	journal	June 2016
Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor Carvalho, Kevin; Faivre, Emilie; Pietrowski, Marie J. Brain, Vol. 142, Issue 11 https://doi.org/10.1093/brain/awz288	journal	October 2019
How does adenosine control neuronal dysfunction and neurodegeneration? Cunha, Rodrigo A. Journal of Neurochemistry, Vol. 139, Issue 6 https://doi.org/10.1111/jnc.13724	journal	August 2016
Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption Nehlig, Astrid Pharmacological Reviews, Vol. 70, Issue 2 https://doi.org/10.1124/pr.117.014407	journal	March 2018
Alzheimer's Disease Is a Synaptic Failure Selkoe, D. J. Science, Vol. 298, Issue 5594 https://doi.org/10.1126/science.1074069	journal	October 2002
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions Canas, Paula M.; Porciúncula, Lisiane O.; Simões, Ana Patrícia eneuro, Vol. 5, Issue 6 https://doi.org/10.1523/ENEURO.0385-18.2018	journal	November 2018
Caffeine Intake and Dementia: Systematic Review and Meta-Analysis Santos, Catarina; Costa, João; Santos, João Journal of Alzheimer's Disease, Vol. 20, Issue s1 https://doi.org/10.3233/JAD-2010-091387	journal	April 2010
Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease Faivre, Emilie; Coelho, Joana E.; Zornbach, Katja Frontiers in Molecular Neuroscience, Vol. 11 https://doi.org/10.3389/fnmol.2018.00235	journal	July 2018

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