Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration

Cunha, Rodrigo A.

doi:10.1093/brain/awz335

Title: Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration

Abstract

This scientific commentary refers to ‘Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptors’, by Carvalho et al. (doi:10.1093/brain/awz288).

Authors:

^[1]

Center for Neurosciences and Cell Biology and Faculty of Medicine, University of Coimbra, Portugal

Publication Date:: Wed Oct 30 00:00:00 EDT 2019

Sponsoring Org.:: USDOE Office of Nuclear Energy (NE), Nuclear Fuel Cycle and Supply Chain

OSTI Identifier:: 1572438

Grant/Contract Number:: POCI-01-0145-FEDER-03127

Resource Type:: Published Article

Journal Name:: Brain

Additional Journal Information:: Journal Name: Brain Journal Volume: 142 Journal Issue: 11; Journal ID: ISSN 0006-8950

Publisher:: Oxford University Press

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Cunha, Rodrigo A. Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration.  United Kingdom: N. p., 2019. 
Web.  doi:10.1093/brain/awz335.

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                    Cunha, Rodrigo A. Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration.  United Kingdom.  https://doi.org/10.1093/brain/awz335

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                    Cunha, Rodrigo A. Wed .  
"Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration".  United Kingdom.  https://doi.org/10.1093/brain/awz335.

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@article{osti_1572438,

  title        = {Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration},

  author       = {Cunha, Rodrigo A.},

  abstractNote = {This scientific commentary refers to ‘Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptors’, by Carvalho et al. (doi:10.1093/brain/awz288).},

  doi          = {10.1093/brain/awz335},

  journal      = {Brain},

  number       = 11,

  volume       = 142,

  place        = {United Kingdom},

  year         = {Wed Oct 30 00:00:00 EDT 2019},

  month        = {Wed Oct 30 00:00:00 EDT 2019}

}

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https://doi.org/10.1093/brain/awz335

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Cited by: 5 works

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Works referenced in this record:

How does adenosine control neuronal dysfunction and neurodegeneration?
journal, August 2016

Cunha, Rodrigo A.
Journal of Neurochemistry, Vol. 139, Issue 6
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Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption
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Nehlig, Astrid
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Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor
journal, October 2019

Carvalho, Kevin; Faivre, Emilie; Pietrowski, Marie J.
Brain, Vol. 142, Issue 11
DOI: 10.1093/brain/awz288

Alzheimer's Disease Is a Synaptic Failure
journal, October 2002

Selkoe, D. J.
Science, Vol. 298, Issue 5594
DOI: 10.1126/science.1074069

Blockade of adenosine A 2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease
journal, September 2018

Silva, António C.; Lemos, Cristina; Gonçalves, Francisco Q.
Neurobiology of Disease, Vol. 117
DOI: 10.1016/j.nbd.2018.05.024

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors
journal, August 2019

Lopes, João P.; Pliássova, Anna; Cunha, Rodrigo A.
Biochemical Pharmacology, Vol. 166
DOI: 10.1016/j.bcp.2019.06.008

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
journal, November 2018

Canas, Paula M.; Porciúncula, Lisiane O.; Simões, Ana Patrícia
eneuro, Vol. 5, Issue 6
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A complement–microglial axis drives synapse loss during virus-induced memory impairment
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Vasek, Michael J.; Garber, Charise; Dorsey, Denise
Nature, Vol. 534, Issue 7608
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Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
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Faivre, Emilie; Coelho, Joana E.; Zornbach, Katja
Frontiers in Molecular Neuroscience, Vol. 11
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Caffeine Intake and Dementia: Systematic Review and Meta-Analysis
journal, April 2010

Santos, Catarina; Costa, João; Santos, João
Journal of Alzheimer's Disease, Vol. 20, Issue s1
DOI: 10.3233/JAD-2010-091387

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Similar Records

Title: Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration

Abstract

Citation Formats

How does adenosine control neuronal dysfunction and neurodegeneration? journal, August 2016

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption journal, March 2018

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor journal, October 2019

Alzheimer's Disease Is a Synaptic Failure journal, October 2002

Blockade of adenosine A 2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease journal, September 2018

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors journal, August 2019

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions journal, November 2018

A complement–microglial axis drives synapse loss during virus-induced memory impairment journal, June 2016

Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease journal, July 2018

Caffeine Intake and Dementia: Systematic Review and Meta-Analysis journal, April 2010

How does adenosine control neuronal dysfunction and neurodegeneration?
journal, August 2016

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption
journal, March 2018

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor
journal, October 2019

Alzheimer's Disease Is a Synaptic Failure
journal, October 2002

Blockade of adenosine A 2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease
journal, September 2018

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors
journal, August 2019

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
journal, November 2018

A complement–microglial axis drives synapse loss during virus-induced memory impairment
journal, June 2016

Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
journal, July 2018

Caffeine Intake and Dementia: Systematic Review and Meta-Analysis
journal, April 2010