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Title: Nuclear localization of dirhodium (II) complexes in breast cancer cells by X-ray fluorescence microscopy

Abstract

X-ray fluorescence microscopy confirms the necessity of vacant axial sites in dirhodium(II) carboxylates for their cellular uptake and cytotoxicity.

Authors:
 [1];  [2];  [1]; ORCiD logo [3];  [1]; ORCiD logo [1]
  1. Univ. of Calgary, Calgary, AB (Canada)
  2. Argonne National Lab. (ANL), Argonne, IL (United States)
  3. The Univ. of Adelaide (Australia)
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES); Natural Science and Engineering Research Council of Canada; Australian Synchrotron, International Synchrotron Access Program (ISAP)
OSTI Identifier:
1572348
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Accepted Manuscript
Journal Name:
ChemComm
Additional Journal Information:
Journal Volume: 55; Journal Issue: 57; Journal ID: ISSN 1359-7345
Publisher:
Royal Society of Chemistry
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Garcia, Alejandra Enriquez, Lai, Barry, Gopinathan, Sesha Gopal, Harris, Hugh H., Shemanko, Carrie S., and Jalilehvand, Farideh. Nuclear localization of dirhodium (II) complexes in breast cancer cells by X-ray fluorescence microscopy. United States: N. p., 2019. Web. doi:10.1039/c9cc00521h.
Garcia, Alejandra Enriquez, Lai, Barry, Gopinathan, Sesha Gopal, Harris, Hugh H., Shemanko, Carrie S., & Jalilehvand, Farideh. Nuclear localization of dirhodium (II) complexes in breast cancer cells by X-ray fluorescence microscopy. United States. https://doi.org/10.1039/c9cc00521h
Garcia, Alejandra Enriquez, Lai, Barry, Gopinathan, Sesha Gopal, Harris, Hugh H., Shemanko, Carrie S., and Jalilehvand, Farideh. Wed . "Nuclear localization of dirhodium (II) complexes in breast cancer cells by X-ray fluorescence microscopy". United States. https://doi.org/10.1039/c9cc00521h. https://www.osti.gov/servlets/purl/1572348.
@article{osti_1572348,
title = {Nuclear localization of dirhodium (II) complexes in breast cancer cells by X-ray fluorescence microscopy},
author = {Garcia, Alejandra Enriquez and Lai, Barry and Gopinathan, Sesha Gopal and Harris, Hugh H. and Shemanko, Carrie S. and Jalilehvand, Farideh},
abstractNote = {X-ray fluorescence microscopy confirms the necessity of vacant axial sites in dirhodium(II) carboxylates for their cellular uptake and cytotoxicity.},
doi = {10.1039/c9cc00521h},
journal = {ChemComm},
number = 57,
volume = 55,
place = {United States},
year = {Wed Jun 05 00:00:00 EDT 2019},
month = {Wed Jun 05 00:00:00 EDT 2019}
}

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Cited by: 11 works
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Works referenced in this record:

Reactions of the Rhodium Trifluoroacetate Dimer with Nucleosides and Nucleotides
journal, November 1996


Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells
journal, January 2012

  • Aitken, Jade B.; Antony, Sumy; Weekley, Claire M.
  • Metallomics, Vol. 4, Issue 10
  • DOI: 10.1039/c2mt20072d

Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer
journal, June 2009


Selenite-mediated production of superoxide radical anions in A549 cancer cells is accompanied by a selective increase in SOD1 concentration, enhanced apoptosis and Se–Cu bonding
journal, February 2014

  • Weekley, Claire M.; Jeong, Gloria; Tierney, Michael E.
  • JBIC Journal of Biological Inorganic Chemistry, Vol. 19, Issue 6
  • DOI: 10.1007/s00775-014-1113-x

Unprecedented Head-to-Head Conformers of d(GpG) Bound to the Antitumor Active Compound Tetrakis (μ-carboxylato)dirhodium(II,II)
journal, September 2003

  • Chifotides, Helen T.; Koshlap, Karl M.; Pérez, Lisa M.
  • Journal of the American Chemical Society, Vol. 125, Issue 35
  • DOI: 10.1021/ja027779s

Confocal Fluorescence Microscopy Studies of a Fluorophore-Labeled Dirhodium Compound: Visualizing Metal–Metal Bonded Molecules in Lung Cancer (A549) Cells
journal, May 2014

  • Peña, Bruno; Barhoumi, Rola; Burghardt, Robert C.
  • Journal of the American Chemical Society, Vol. 136, Issue 22
  • DOI: 10.1021/ja503774m

Transferrin binding and transferrin-mediated cellular uptake of the ruthenium coordination compound KP1019, studied by means of AAS, ESI-MS and CD spectroscopy
journal, January 2004

  • Pongratz, Martina; Schluga, Petra; Jakupec, Michael A.
  • Journal of Analytical Atomic Spectrometry, Vol. 19, Issue 1
  • DOI: 10.1039/b309160k

Assessing the intracellular fate of rhodium( ii ) complexes
journal, January 2016

  • Minus, Matthew B.; Kang, Marci K.; Knudsen, Sarah E.
  • Chemical Communications, Vol. 52, Issue 78
  • DOI: 10.1039/C6CC05192H

Time-dependent uptake, distribution and biotransformation of chromium(VI) in individual and bulk human lung cells: application of synchrotron radiation techniques
journal, February 2005

  • Harris, Hugh H.; Levina, Aviva; Dillon, Carolyn T.
  • JBIC Journal of Biological Inorganic Chemistry, Vol. 10, Issue 2
  • DOI: 10.1007/s00775-004-0617-1

Microprobe XRF Mapping and XAS Investigations of the Intracellular Metabolism of Arsenic for Understanding Arsenic-Induced Toxicity
journal, September 2008

  • Munro, Kristie L.; Mariana, Anna; Klavins, Andrejs I.
  • Chemical Research in Toxicology, Vol. 21, Issue 9
  • DOI: 10.1021/tx800128d

Redox-Regulated Inhibition of T7 RNA Polymerase via Establishment of Disulfide Linkages by Substituted Dppz Dirhodium(II,II) Complexes
journal, May 2009

  • Aguirre, J. Dafhne; Chifotides, Helen T.; Angeles-Boza, Alfredo M.
  • Inorganic Chemistry, Vol. 48, Issue 10
  • DOI: 10.1021/ic900164j

Linking the future of anticancer metal-complexes to the therapy of tumour metastases
journal, January 2015

  • Bergamo, Alberta; Sava, Gianni
  • Chemical Society Reviews, Vol. 44, Issue 24
  • DOI: 10.1039/C5CS00134J

Elemental and Chemically Specific X-ray Fluorescence Imaging of Biological Systems
journal, January 2014

  • Pushie, M. Jake; Pickering, Ingrid J.; Korbas, Malgorzata
  • Chemical Reviews, Vol. 114, Issue 17
  • DOI: 10.1021/cr4007297

Anticancer dirhodium(ii,ii) carboxylates as potent inhibitors of ubiquitin-proteasome system
journal, January 2012

  • Siu, Fung-Ming; Lin, Iris Wing-Shan; Yan, Kun
  • Chemical Science, Vol. 3, Issue 6
  • DOI: 10.1039/c2sc00620k

Hard X-ray microprobe studies of chromium(VI)-treated V79 Chinese hamster lung cells: intracellular mapping of the biotransformation products of a chromium carcinogen
journal, February 2002

  • Dillon, Carolyn T.; Lay, Peter A.; Kennedy, Brendan J.
  • JBIC Journal of Biological Inorganic Chemistry, Vol. 7, Issue 6
  • DOI: 10.1007/s00775-002-0343-5

Cytotoxicity and anti-tumor effects of new ruthenium complexes on triple negative breast cancer cells
journal, September 2017


Structural Evidence for a New Metal-Binding Mode for Guanine Bases: Implications for the Binding of Dinuclear Antitumor Agents to DNA
journal, March 1994

  • Dunbar, Kim R.; Matonic, John H.; Saharan, Vijay P.
  • Journal of the American Chemical Society, Vol. 116, Issue 5
  • DOI: 10.1021/ja00084a093

Non-Platinum Metal Complexes as Potential Anti-Triple Negative Breast Cancer Agents
journal, September 2018

  • Domínguez-Martís, Eva; Mosteiro-Miguéns, Diego; Vigo-Gendre, Lucía
  • Crystals, Vol. 8, Issue 10
  • DOI: 10.3390/cryst8100369

Methionine Binding to Dirhodium(II) Tetraacetate
journal, September 2018


Uptake, Distribution, and Speciation of Selenoamino Acids by Human Cancer Cells: X-ray Absorption and Fluorescence Methods
journal, March 2011

  • Weekley, Claire M.; Aitken, Jade B.; Vogt, Stefan
  • Biochemistry, Vol. 50, Issue 10
  • DOI: 10.1021/bi101678a

TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer
journal, June 2015

  • Isakoff, Steven J.; Mayer, Erica L.; He, Lei
  • Journal of Clinical Oncology, Vol. 33, Issue 17
  • DOI: 10.1200/JCO.2014.57.6660

In Vitro and in Vivo Evaluation of Water-Soluble Iminophosphorane Ruthenium(II) Compounds. A Potential Chemotherapeutic Agent for Triple Negative Breast Cancer
journal, November 2014

  • Frik, Malgorzata; Martínez, Alberto; Elie, Benelita T.
  • Journal of Medicinal Chemistry, Vol. 57, Issue 23
  • DOI: 10.1021/jm5012337

Tetraacetatodirhodium(II) complexes with tris(methoxyphenyl)phosphines, their reactivity, structure, and antitumor activity
journal, May 2001

  • Pruchnik, Florian P.; Starosta, Radoslaw; Ciunik, Zbigniew
  • Canadian Journal of Chemistry, Vol. 79, Issue 5-6
  • DOI: 10.1139/v01-080

Guanine binding to dirhodium tetracarboxylate anticancer complexes: quantum chemical calculations unravel an elusive mechanism
journal, January 2007

  • Deubel, Dirk V.; Chifotides, Helen T.
  • Chemical Communications, Issue 33
  • DOI: 10.1039/b709209a

Covalent Binding and Interstrand Cross-Linking of Duplex DNA by Dirhodium(II,II) Carboxylate Compounds
journal, January 2005

  • Dunham, Shari U.; Chifotides, Helen T.; Mikulski, Szymon
  • Biochemistry, Vol. 44, Issue 3
  • DOI: 10.1021/bi0486637

Live Cell Cytotoxicity Studies: Documentation of the Interactions of Antitumor Active Dirhodium Compounds with Nuclear DNA
journal, August 2009

  • Aguirre, J. Dafhne; Angeles-Boza, Alfredo M.; Chouai, Abdellatif
  • Journal of the American Chemical Society, Vol. 131, Issue 32
  • DOI: 10.1021/ja9021717

Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer
journal, March 2010

  • Silver, Daniel P.; Richardson, Andrea L.; Eklund, Aron C.
  • Journal of Clinical Oncology, Vol. 28, Issue 7
  • DOI: 10.1200/JCO.2009.22.4725

Does cytotoxicity of metallointercalators correlate with cellular uptake or DNA affinity?
journal, January 2012

  • Davis, Kimberley J.; Carrall, Judith A.; Lai, Barry
  • Dalton Transactions, Vol. 41, Issue 31
  • DOI: 10.1039/c2dt30217a

Novel Binding Interactions of the DNA Fragment d(pGpG) Cross-Linked by the Antitumor Active Compound Tetrakis(μ-carboxylato)dirhodium(II,II)
journal, September 2003

  • Chifotides, Helen T.; Koshlap, Karl M.; Pérez, Lisa M.
  • Journal of the American Chemical Society, Vol. 125, Issue 35
  • DOI: 10.1021/ja0291585

Effect of Axial Coordination on the Electronic Structure and Biological Activity of Dirhodium(II,II) Complexes
journal, September 2007

  • Aguirre, J. Dafhne; Lutterman, Daniel A.; Angeles-Boza, Alfredo M.
  • Inorganic Chemistry, Vol. 46, Issue 18
  • DOI: 10.1021/ic700708g

Aerobic reactions of antitumor active dirhodium(II) tetraacetate Rh2(CH3COO)4 with glutathione
journal, December 2017

  • Enriquez Garcia, Alejandra; Jalilehvand, Farideh
  • JBIC Journal of Biological Inorganic Chemistry, Vol. 23, Issue 2
  • DOI: 10.1007/s00775-017-1524-6

Identification of a rhodium( iii ) complex as a Wee1 inhibitor against TP53 -mutated triple-negative breast cancer cells
journal, January 2018

  • Yang, Guan-Jun; Zhong, Hai-Jing; Ko, Chung-Nga
  • Chemical Communications, Vol. 54, Issue 20
  • DOI: 10.1039/C7CC09384E

Reaction of Nitrogen Chelates with the [Rh 2 ] 4+ Core:  Bis-Chelate Products and Demonstration of Reversible, Chelate-Based Reduction Processes
journal, May 1997

  • Crawford, Charles A.; Matonic, John H.; Huffman, John C.
  • Inorganic Chemistry, Vol. 36, Issue 11
  • DOI: 10.1021/ic9610288

Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro
journal, November 2016


Dirhodium(II,II) Complexes:  Molecular Characteristics that Affect in Vitro Activity
journal, November 2006

  • Angeles-Boza, Alfredo M.; Chifotides, Helen T.; Aguirre, J. Dafhne
  • Journal of Medicinal Chemistry, Vol. 49, Issue 23
  • DOI: 10.1021/jm060592h

Reactions of Antitumor Active Dirhodium(II) Tetraacetate Rh 2 (CH 3 COO) 4 with Cysteine and Its Derivatives
journal, September 2017

  • Jalilehvand, Farideh; Enriquez Garcia, Alejandra; Niksirat, Pantea
  • ACS Omega, Vol. 2, Issue 9
  • DOI: 10.1021/acsomega.7b01090

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease
journal, May 2016

  • Bianchini, Giampaolo; Balko, Justin M.; Mayer, Ingrid A.
  • Nature Reviews Clinical Oncology, Vol. 13, Issue 11
  • DOI: 10.1038/nrclinonc.2016.66

Anticancer activity of palladium-based complexes against triple-negative breast cancer
journal, April 2019

  • Vojtek, Martin; Marques, Maria P. M.; Ferreira, Isabel M. P. L. V. O.
  • Drug Discovery Today, Vol. 24, Issue 4
  • DOI: 10.1016/j.drudis.2019.02.012

A Breast Cancer Stem Cell-Selective, Mammospheres-Potent Osmium(VI) Nitrido Complex
journal, October 2014

  • Suntharalingam, Kogularamanan; Lin, Wei; Johnstone, Timothy C.
  • Journal of the American Chemical Society, Vol. 136, Issue 41
  • DOI: 10.1021/ja508808v

Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up
journal, November 2012

  • Malorni, L.; Shetty, P. B.; De Angelis, C.
  • Breast Cancer Research and Treatment, Vol. 136, Issue 3
  • DOI: 10.1007/s10549-012-2315-y

Properties of rhodium (II) complexes having cytostatic activity
journal, January 1996


Metabolism of Selenite in Human Lung Cancer Cells: X-Ray Absorption and Fluorescence Studies
journal, November 2011

  • Weekley, Claire M.; Aitken, Jade B.; Vogt, Stefan
  • Journal of the American Chemical Society, Vol. 133, Issue 45
  • DOI: 10.1021/ja206203c

Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy
journal, July 2018

  • Yang, Guan-Jun; Wang, Wanhe; Mok, Simon Wing Fai
  • Angewandte Chemie International Edition, Vol. 57, Issue 40
  • DOI: 10.1002/anie.201807305

Binding of 2,2'-bipyridine to the dirhodium(II) tetraacetate core: unusual structural features and biological relevance of the product Rh2(OAc)4(bpy)
journal, March 1991

  • Perlepes, Spiros P.; Huffman, John C.; Matonic, John H.
  • Journal of the American Chemical Society, Vol. 113, Issue 7
  • DOI: 10.1021/ja00007a071

Reaction of 2,2'-bipyridine (bpy) with dirhodium carboxylates: mono-bpy products with variable chelate binding modes and insights into the reaction mechanism
journal, July 1993

  • Crawford, Charles A.; Matonic, John H.; Streib, William E.
  • Inorganic Chemistry, Vol. 32, Issue 14
  • DOI: 10.1021/ic00066a026

Dirhodium (II) complex interferes with iron-transport system to exert antibacterial action against Streptococcus pneumoniae
journal, March 2019


TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer
text, January 2015

  • E., Goss, Paul; M., Finkelstein, Dianne; L., Mayer, Erica
  • The University of North Carolina at Chapel Hill University Libraries
  • DOI: 10.17615/e2bz-cn32

Biology, Metastatic Patterns, and Treatment of Patients With Triple-Negative Breast Cancer
journal, December 2009


Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer
text, January 2009

  • K., Anders, Carey; A., Carey, Lisa
  • The University of North Carolina at Chapel Hill University Libraries
  • DOI: 10.17615/z0n1-3y05

Works referencing / citing this record:

Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X‐Ray Imaging
journal, December 2019

  • Conesa, José Javier; Carrasco, Ana C.; Rodríguez‐Fanjul, Vanessa
  • Angewandte Chemie, Vol. 132, Issue 3
  • DOI: 10.1002/ange.201911510

Linear One-Dimensional Coordination Polymers Constructed by Dirhodium Paddlewheel and Tetracyanido-Metallate Building Blocks
journal, November 2019

  • Prior, David; Cortijo, Miguel; González-Prieto, Rodrigo
  • Crystals, Vol. 9, Issue 12
  • DOI: 10.3390/cryst9120614

Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X‐Ray Imaging
journal, December 2019

  • Conesa, José Javier; Carrasco, Ana C.; Rodríguez‐Fanjul, Vanessa
  • Angewandte Chemie International Edition, Vol. 59, Issue 3
  • DOI: 10.1002/anie.201911510