Search Menu
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information
Search Scholarly Publications

Title: Nuclear localization of dirhodium (II) complexes in breast cancer cells by X-ray fluorescence microscopy

Journal Article · · ChemComm
DOI: https://doi.org/10.1039/c9cc00521h · OSTI ID:1572348
 [1];  [2];  [1]; ORCiD logo [3];  [1]; ORCiD logo [1]
  1. Univ. of Calgary, Calgary, AB (Canada)
  2. Argonne National Lab. (ANL), Argonne, IL (United States)
  3. The Univ. of Adelaide (Australia)
+ Show Author Affiliations

X-ray fluorescence microscopy confirms the necessity of vacant axial sites in dirhodium(II) carboxylates for their cellular uptake and cytotoxicity.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Organization:
Australian Synchrotron, International Synchrotron Access Program (ISAP); Natural Science and Engineering Research Council of Canada; USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1572348
Journal Information:
ChemComm, Journal Name: ChemComm Journal Issue: 57 Vol. 55; ISSN CHCOFS; ISSN 1359-7345
Publisher:
Royal Society of ChemistryCopyright Statement
Country of Publication:
United States
Language:
English

References (55)

Intracellular Localization of an Osmocenyl‐Tamoxifen Derivative in Breast Cancer Cells Revealed by Synchrotron Radiation X‐ray Fluorescence Nanoimaging journal March 2019
Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy journal July 2018
(Pentamethylcyclopentadienato)rhodium Complexes for Delivery of the Curcumin Anticancer Drug: (Pentamethylcyclopentadienato)rhodium Complexes for Delivery of the Curcumin Anticancer Drug journal February 2017
Hard X-ray microprobe studies of chromium(VI)-treated V79 Chinese hamster lung cells: intracellular mapping of the biotransformation products of a chromium carcinogen journal February 2002
Time-dependent uptake, distribution and biotransformation of chromium(VI) in individual and bulk human lung cells: application of synchrotron radiation techniques journal February 2005
Selenite-mediated production of superoxide radical anions in A549 cancer cells is accompanied by a selective increase in SOD1 concentration, enhanced apoptosis and Se–Cu bonding journal February 2014
Aerobic reactions of antitumor active dirhodium(II) tetraacetate Rh2(CH3COO)4 with glutathione journal December 2017
Clinical and biologic features of triple-negative breast cancers in a large cohort of patients with long-term follow-up journal November 2012
Properties of rhodium (II) complexes having cytostatic activity journal January 1996
Anticancer activity of palladium-based complexes against triple-negative breast cancer journal April 2019
Dirhodium (II) complex interferes with iron-transport system to exert antibacterial action against Streptococcus pneumoniae journal March 2019
Methionine Binding to Dirhodium(II) Tetraacetate journal September 2018
Reactions of Antitumor Active Dirhodium(II) Tetraacetate Rh 2 (CH 3 COO) 4 with Cysteine and Its Derivatives journal September 2017
Covalent Binding and Interstrand Cross-Linking of Duplex DNA by Dirhodium(II,II) Carboxylate Compounds † journal January 2005
Uptake, Distribution, and Speciation of Selenoamino Acids by Human Cancer Cells: X-ray Absorption and Fluorescence Methods journal March 2011
Elemental and Chemically Specific X-ray Fluorescence Imaging of Biological Systems journal January 2014
Reaction of 2,2'-bipyridine (bpy) with dirhodium carboxylates: mono-bpy products with variable chelate binding modes and insights into the reaction mechanism journal July 1993
NMR investigation of the Rh24+ complex Rh2(form)2(O2CCF3)2(H2O)2 (form = N,N'-Di-p-tolylformamidinate) in the presence of phosphorus donors. Evidence for the interconversion from the axial to equatorial adducts journal July 1989
Effect of Axial Coordination on the Electronic Structure and Biological Activity of Dirhodium(II,II) Complexes journal September 2007
Redox-Regulated Inhibition of T7 RNA Polymerase via Establishment of Disulfide Linkages by Substituted Dppz Dirhodium(II,II) Complexes journal May 2009
Reaction of Nitrogen Chelates with the [Rh 2 ] 4+ Core:  Bis-Chelate Products and Demonstration of Reversible, Chelate-Based Reduction Processes journal May 1997
Binding of 2,2'-bipyridine to the dirhodium(II) tetraacetate core: unusual structural features and biological relevance of the product Rh2(OAc)4(bpy) journal March 1991
Structural Evidence for a New Metal-Binding Mode for Guanine Bases: Implications for the Binding of Dinuclear Antitumor Agents to DNA journal March 1994
Unprecedented Head-to-Head Conformers of d(GpG) Bound to the Antitumor Active Compound Tetrakis (μ-carboxylato)dirhodium(II,II) journal September 2003
Novel Binding Interactions of the DNA Fragment d(pGpG) Cross-Linked by the Antitumor Active Compound Tetrakis(μ-carboxylato)dirhodium(II,II) journal September 2003
Metabolism of Selenite in Human Lung Cancer Cells: X-Ray Absorption and Fluorescence Studies journal November 2011
Confocal Fluorescence Microscopy Studies of a Fluorophore-Labeled Dirhodium Compound: Visualizing Metal–Metal Bonded Molecules in Lung Cancer (A549) Cells journal May 2014
A Breast Cancer Stem Cell-Selective, Mammospheres-Potent Osmium(VI) Nitrido Complex journal October 2014
Live Cell Cytotoxicity Studies: Documentation of the Interactions of Antitumor Active Dirhodium Compounds with Nuclear DNA journal August 2009
Dirhodium(II,II) Complexes:  Molecular Characteristics that Affect in Vitro Activity journal November 2006
In Vitro and in Vivo Evaluation of Water-Soluble Iminophosphorane Ruthenium(II) Compounds. A Potential Chemotherapeutic Agent for Triple Negative Breast Cancer journal November 2014
Microprobe XRF Mapping and XAS Investigations of the Intracellular Metabolism of Arsenic for Understanding Arsenic-Induced Toxicity journal September 2008
Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease journal May 2016
Linking the future of anticancer metal-complexes to the therapy of tumour metastases journal January 2015
Assessing the intracellular fate of rhodium( ii ) complexes journal January 2016
Intracellular distribution and stability of a luminescent rhenium( i ) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging journal January 2017
Identification of a rhodium( iii ) complex as a Wee1 inhibitor against TP53 -mutated triple-negative breast cancer cells journal January 2018
Transferrin binding and transferrin-mediated cellular uptake of the ruthenium coordination compound KP1019, studied by means of AAS, ESI-MS and CD spectroscopy journal January 2004
Guanine binding to dirhodium tetracarboxylate anticancer complexes: quantum chemical calculations unravel an elusive mechanism journal January 2007
Does cytotoxicity of metallointercalators correlate with cellular uptake or DNA affinity? journal January 2012
Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells journal January 2012
Anticancer dirhodium(ii,ii) carboxylates as potent inhibitors of ubiquitin-proteasome system journal January 2012
Reactions of the Rhodium Trifluoroacetate Dimer with Nucleosides and Nucleotides journal November 1996
Optimal strategies for the treatment of metastatic triple-negative breast cancer with currently approved agents journal August 2012
Tetraacetatodirhodium(II) complexes with tris(methoxyphenyl)phosphines, their reactivity, structure, and antitumor activity journal May 2001
Cellular responses of BRCA1-defective and triple-negative breast cancer cells and in vitro BRCA1 interactions induced by metallo-intercalator ruthenium(II) complexes containing chloro-substituted phenylazopyridine journal February 2014
Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro journal November 2016
Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer journal March 2010
TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer journal June 2015
Cytotoxicity and anti-tumor effects of new ruthenium complexes on triple negative breast cancer cells journal September 2017
TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer text January 2015
Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer text January 2009
Non-Platinum Metal Complexes as Potential Anti-Triple Negative Breast Cancer Agents journal September 2018
Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer journal June 2009
Biology, Metastatic Patterns, and Treatment of Patients With Triple-Negative Breast Cancer journal December 2009

Cited By (3)

Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X‐Ray Imaging journal December 2019
Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X‐Ray Imaging journal December 2019
Linear One-Dimensional Coordination Polymers Constructed by Dirhodium Paddlewheel and Tetracyanido-Metallate Building Blocks journal November 2019

Similar Records

Related Subjects

60 APPLIED LIFE SCIENCES