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Title: Breast Tissue Biology Expands the Possibilities for Prevention of Age-Related Breast Cancers

Abstract

Preventing breast cancer before it is able to form is an ideal way to stop breast cancer. However, there are limited existing options for prevention of breast cancer. Changes in the breast tissue resulting from the aging process contribute to breast cancer susceptibility and progression and may therefore provide promising targets for prevention. Here, we describe new potential targets, immortalization and inflammaging, that may be useful for prevention of age-related breast cancers. We also summarize existing studies of warfarin and metformin, current drugs used for non-cancerous diseases, that also may be repurposed for breast cancer prevention.

Authors:
 [1];  [2];  [3];  [4];  [5];  [1];  [6]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Dept. of Biological Systems and Engineering
  2. Beckman Research Inst. at City of Hope, Duarte, CA (United States). Dept. of Population Sciences; Beckman Research Inst. at City of Hope, Duarte, CA (United States). Center for Cancer and Aging Research
  3. Beckman Research Inst. at City of Hope, Duarte, CA (United States). Dept. of Population Sciences; Beckman Research Inst. at City of Hope, Duarte, CA (United States). Center for Cancer and Aging Research; Al-Quds Univ., Jerusalem (Palestine)
  4. Univ. of California, San Francisco, CA (United States). Breast Science Advocacy Core, Breast Oncology Program
  5. Notes4Hope, Moraga, CA (United States)
  6. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Dept. of Biological Systems and Engineering; Beckman Research Inst. at City of Hope, Duarte, CA (United States). Dept. of Population Sciences; Beckman Research Inst. at City of Hope, Duarte, CA (United States). Center for Cancer and Aging Research
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1571952
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
Frontiers in Cell and Developmental Biology
Additional Journal Information:
Journal Volume: 7; Journal ID: ISSN 2296-634X
Publisher:
Frontiers Media S.A.
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; breast cancer; prevention; chemoprevention; immortality; inflammaging; warfarin; metformin

Citation Formats

Fresques, Tara, Zirbes, Arrianna, Shalabi, Sundus, Samson, Susan, Preto, Sandy, Stampfer, Martha R., and LaBarge, Mark A. Breast Tissue Biology Expands the Possibilities for Prevention of Age-Related Breast Cancers. United States: N. p., 2019. Web. doi:10.3389/fcell.2019.00174.
Fresques, Tara, Zirbes, Arrianna, Shalabi, Sundus, Samson, Susan, Preto, Sandy, Stampfer, Martha R., & LaBarge, Mark A. Breast Tissue Biology Expands the Possibilities for Prevention of Age-Related Breast Cancers. United States. doi:10.3389/fcell.2019.00174.
Fresques, Tara, Zirbes, Arrianna, Shalabi, Sundus, Samson, Susan, Preto, Sandy, Stampfer, Martha R., and LaBarge, Mark A. Wed . "Breast Tissue Biology Expands the Possibilities for Prevention of Age-Related Breast Cancers". United States. doi:10.3389/fcell.2019.00174. https://www.osti.gov/servlets/purl/1571952.
@article{osti_1571952,
title = {Breast Tissue Biology Expands the Possibilities for Prevention of Age-Related Breast Cancers},
author = {Fresques, Tara and Zirbes, Arrianna and Shalabi, Sundus and Samson, Susan and Preto, Sandy and Stampfer, Martha R. and LaBarge, Mark A.},
abstractNote = {Preventing breast cancer before it is able to form is an ideal way to stop breast cancer. However, there are limited existing options for prevention of breast cancer. Changes in the breast tissue resulting from the aging process contribute to breast cancer susceptibility and progression and may therefore provide promising targets for prevention. Here, we describe new potential targets, immortalization and inflammaging, that may be useful for prevention of age-related breast cancers. We also summarize existing studies of warfarin and metformin, current drugs used for non-cancerous diseases, that also may be repurposed for breast cancer prevention.},
doi = {10.3389/fcell.2019.00174},
journal = {Frontiers in Cell and Developmental Biology},
number = ,
volume = 7,
place = {United States},
year = {2019},
month = {8}
}

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