Breast Tissue Biology Expands the Possibilities for Prevention of Age-Related Breast Cancers

Fresques, Tara; Zirbes, Arrianna; Shalabi, Sundus; Samson, Susan; Preto, Sandy; Stampfer, Martha R.; LaBarge, Mark A.

doi:10.3389/fcell.2019.00174

Title: Breast Tissue Biology Expands the Possibilities for Prevention of Age-Related Breast Cancers

Journal Article · 28 August 2019 · Frontiers in Cell and Developmental Biology

DOI: https://doi.org/10.3389/fcell.2019.00174 · OSTI ID:1571952

Fresques, Tara ^[1]; Zirbes, Arrianna ^[2]; Shalabi, Sundus ^[3]; Samson, Susan ^[4]; Preto, Sandy ^[5]; Stampfer, Martha R. ^[1]; LaBarge, Mark A. ^[6]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Dept. of Biological Systems and Engineering
Beckman Research Inst. at City of Hope, Duarte, CA (United States). Dept. of Population Sciences; Beckman Research Inst. at City of Hope, Duarte, CA (United States). Center for Cancer and Aging Research
Beckman Research Inst. at City of Hope, Duarte, CA (United States). Dept. of Population Sciences; Beckman Research Inst. at City of Hope, Duarte, CA (United States). Center for Cancer and Aging Research; Al-Quds Univ., Jerusalem (Palestine)
Univ. of California, San Francisco, CA (United States). Breast Science Advocacy Core, Breast Oncology Program
Notes4Hope, Moraga, CA (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Dept. of Biological Systems and Engineering; Beckman Research Inst. at City of Hope, Duarte, CA (United States). Dept. of Population Sciences; Beckman Research Inst. at City of Hope, Duarte, CA (United States). Center for Cancer and Aging Research

Preventing breast cancer before it is able to form is an ideal way to stop breast cancer. However, there are limited existing options for prevention of breast cancer. Changes in the breast tissue resulting from the aging process contribute to breast cancer susceptibility and progression and may therefore provide promising targets for prevention. Here, we describe new potential targets, immortalization and inflammaging, that may be useful for prevention of age-related breast cancers. We also summarize existing studies of warfarin and metformin, current drugs used for non-cancerous diseases, that also may be repurposed for breast cancer prevention.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1571952

Journal Information:: Frontiers in Cell and Developmental Biology, Journal Name: Frontiers in Cell and Developmental Biology Vol. 7; ISSN 2296-634X

Publisher:: Frontiers Media S.A.Copyright Statement

Country of Publication:: United States

Language:: English

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