Aging and drug discovery

Bakula, Daniela; Aliper, Alexander M.; Mamoshina, Polina; Petr, Michael A.; Teklu, Amanuel; Baur, Joseph A.; Campisi, Judith; Ewald, Collin Y.; Georgievskaya, Anastasia; Gladyshev, Vadim N.; Kovalchuk, Olga; Lamming, Dudley W.; Luijsterburg, Martijn S.; Martín-Montalvo, Alejandro; Maudsley, Stuart; Mkrtchyan, Garik V.; Moskalev, Alexey; Olshansky, S. Jay; Ozerov, Ivan V.; Pickett, Alexander; Ristow, Michael; Zhavoronkov, Alex; Scheibye-Knudsen, Morten

doi:10.18632/aging.101646

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Title: Aging and drug discovery

Journal Article · 12 November 2018 · Aging

DOI: https://doi.org/10.18632/aging.101646 · OSTI ID:1571119

Bakula, Daniela ^[1]; Aliper, Alexander M. ^[2]; Mamoshina, Polina ^[2]; Petr, Michael A. ^[1]; Teklu, Amanuel ^[1]; Baur, Joseph A. ^[3]; Campisi, Judith ^[4]; Ewald, Collin Y. ^[5]; Georgievskaya, Anastasia ^[6]; Gladyshev, Vadim N. ^[7]; Kovalchuk, Olga ^[8]; Lamming, Dudley W. ^[9]; Luijsterburg, Martijn S. ^[10]; Martín-Montalvo, Alejandro ^[11]; Maudsley, Stuart ^[12]; Mkrtchyan, Garik V. ^[1]; Moskalev, Alexey ^[13]; Olshansky, S. Jay ^[14]; Ozerov, Ivan V. ^[2]; Pickett, Alexander ^[15] more »

Univ. of Copenhagen, Copenhagen (Denmark)
Insilico Medicine, Inc., Baltimore, MD (United States)
Univ. of Pennsylvania, Philadelphia, PA (United States)
Buck Inst. for Research on Aging, Novato, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Swiss Federal Inst. for Technology (ETH), Zurich (Switzerland)
Youth Labs., Moscow (Russia)
Brigham and Women's Hospital, Boston, MA (United States); Moscow State Univ., Moscow (Russia)
Univ. of Lethbridge, Lethbridge, AB (Canada); Pathway Rx Ltd, Lethbridge, AB (Canada)
Univ. of Wisconsin, Madison, WI (United States)
Leiden Univ. Medical Center, Leiden (The Netherlands)
Univ. de Sevilla-CSIC-Univ. Pablo de Olavide, Seville (Spain)
Univ. of Antwerp, Antwerp (Belgium); VIB, Antwerp (Belgium)
Russian Academy of Sciences, Moscow (Russia); Inst. of Biology of Komi Science Center of Ural Branch of RAS, Syktyvar (Russia); Moscow Inst. of Physics and Technology, Dolgoprudny (Russia)
Univ. of Illinois at Chicago School of Public of Health, Chicago, IL (United States)
Juvenescence Ltd., Isle of Man (United Kingdom)

Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1571119

Journal Information:: Aging, Journal Name: Aging Journal Issue: 11 Vol. 10; ISSN 1945-4589

Publisher:: Impact JournalsCopyright Statement

Country of Publication:: United States

Language:: English

References (103)

GIT2—A keystone in ageing and age-related disease van Gastel, Jaana; Boddaert, Jan; Jushaj, Areta Ageing Research Reviews, Vol. 43 https://doi.org/10.1016/j.arr.2018.02.002	journal	May 2018
Widespread Proteome Remodeling and Aggregation in Aging C. elegans Walther, Dirk M.; Kasturi, Prasad; Zheng, Min Cell, Vol. 168, Issue 5 https://doi.org/10.1016/j.cell.2016.12.041	journal	February 2017
Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health Fontana, Luigi; Cummings, Nicole E.; Arriola Apelo, Sebastian I. Cell Reports, Vol. 16, Issue 2 https://doi.org/10.1016/j.celrep.2016.05.092	journal	July 2016
Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions Petkovich, Daniel A.; Podolskiy, Dmitriy I.; Lobanov, Alexei V. Cell Metabolism, Vol. 25, Issue 4 https://doi.org/10.1016/j.cmet.2017.03.016	journal	April 2017
Unmasking Transcriptional Heterogeneity in Senescent Cells Hernandez-Segura, Alejandra; de Jong, Tristan V.; Melov, Simon Current Biology, Vol. 27, Issue 17 https://doi.org/10.1016/j.cub.2017.07.033	journal	September 2017
The skin aging exposome Krutmann, Jean; Bouloc, Anne; Sore, Gabrielle Journal of Dermatological Science, Vol. 85, Issue 3 https://doi.org/10.1016/j.jdermsci.2016.09.015	journal	March 2017
NAD + in Aging: Molecular Mechanisms and Translational Implications Fang, Evandro F.; Lautrup, Sofie; Hou, Yujun Trends in Molecular Medicine, Vol. 23, Issue 10 https://doi.org/10.1016/j.molmed.2017.08.001	journal	October 2017
Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans Lashmanova, Ekaterina; Proshkina, Ekaterina; Zhikrivetskaya, Svetlana Pharmacological Research, Vol. 100 https://doi.org/10.1016/j.phrs.2015.08.009	journal	October 2015
Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data Aliper, Alexander; Plis, Sergey; Artemov, Artem Molecular Pharmaceutics, Vol. 13, Issue 7 https://doi.org/10.1021/acs.molpharmaceut.6b00248	journal	June 2016
In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development Ozerov, Ivan V.; Lezhnina, Ksenia V.; Izumchenko, Evgeny Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms13427	journal	November 2016
The transcriptional landscape of age in human peripheral blood Peters, Marjolein J.; Joehanes, Roby; Pilling, Luke C. Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms9570	journal	October 2015
Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits Ristow, Michael Nature Medicine, Vol. 20, Issue 7 https://doi.org/10.1038/nm.3624	journal	July 2014
Senolytics improve physical function and increase lifespan in old age Xu, Ming; Pirtskhalava, Tamar; Farr, Joshua N. Nature Medicine, Vol. 24, Issue 8 https://doi.org/10.1038/s41591-018-0092-9	journal	July 2018
Genome instability: a conserved mechanism of ageing? Vijg, Jan; Dong, Xiao; Milholland, Brandon Essays in Biochemistry, Vol. 61, Issue 3 https://doi.org/10.1042/ebc20160082	journal	May 2017
Antioxidants prevent health-promoting effects of physical exercise in humans Ristow, M.; Zarse, K.; Oberbach, A. Proceedings of the National Academy of Sciences, Vol. 106, Issue 21 https://doi.org/10.1073/pnas.0903485106	journal	May 2009
Meta-analysis of age-related gene expression profiles identifies common signatures of aging de Magalhães, João Pedro; Curado, João; Church, George M. Bioinformatics, Vol. 25, Issue 7 https://doi.org/10.1093/bioinformatics/btp073	journal	February 2009
Is Telomere Length a Biomarker of Aging? A Review Mather, K. A.; Jorm, A. F.; Parslow, R. A. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol. 66A, Issue 2 https://doi.org/10.1093/gerona/glq180	journal	October 2010
Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations Mamoshina, Polina; Kochetov, Kirill; Putin, Evgeny The Journals of Gerontology: Series A, Vol. 73, Issue 11 https://doi.org/10.1093/gerona/gly005	journal	January 2018
Gene expression defines natural changes in mammalian lifespan Fushan, Alexey A.; Turanov, Anton A.; Lee, Sang‐Goo Aging Cell, Vol. 14, Issue 3 https://doi.org/10.1111/acel.12283	journal	February 2015
Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity Ma, Siming; Avanesov, Andrei S.; Porter, Emily Aging Cell, Vol. 17, Issue 4 https://doi.org/10.1111/acel.12740	journal	April 2018
NAD+ in aging, metabolism, and neurodegeneration Verdin, E. Science, Vol. 350, Issue 6265 https://doi.org/10.1126/science.aac4854	journal	December 2015
Nuclear GIT2 Is an ATM Substrate and Promotes DNA Repair Lu, Daoyuan; Cai, Huan; Park, Sung-Soo Molecular and Cellular Biology, Vol. 35, Issue 7 https://doi.org/10.1128/mcb.01432-14	journal	April 2015
Artificial intelligence in healthcare: past, present and future Jiang, Fei; Jiang, Yong; Zhi, Hui Stroke and Vascular Neurology, Vol. 2, Issue 4 https://doi.org/10.1136/svn-2017-000101	journal	June 2017
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression Coppé, Jean-Philippe; Desprez, Pierre-Yves; Krtolica, Ana Annual Review of Pathology: Mechanisms of Disease, Vol. 5, Issue 1 https://doi.org/10.1146/annurev-pathol-121808-102144	journal	January 2010
Transcriptome analysis reveals mechanisms of geroprotective effects of fucoxanthin in Drosophila Moskalev, Alexey; Shaposhnikov, Mikhail; Zemskaya, Nadezhda BMC Genomics, Vol. 19, Issue S3 https://doi.org/10.1186/s12864-018-4471-x	journal	February 2018
Targeting NAD+ in Metabolic Disease: New Insights Into an Old Molecule Elhassan, Yasir S.; Philp, Andrew A.; Lavery, Gareth G. Journal of the Endocrine Society, Vol. 1, Issue 7 https://doi.org/10.1210/js.2017-00092	journal	May 2017
Minimal Peroxide Exposure of Neuronal Cells Induces Multifaceted Adaptive Responses Chadwick, Wayne; Zhou, Yu; Park, Sung-Soo PLoS ONE, Vol. 5, Issue 12 https://doi.org/10.1371/journal.pone.0014352	journal	December 2010
GIT2 Acts as a Potential Keystone Protein in Functional Hypothalamic Networks Associated with Age-Related Phenotypic Changes in Rats Chadwick, Wayne; Martin, Bronwen; Chapter, Megan C. PLoS ONE, Vol. 7, Issue 5 https://doi.org/10.1371/journal.pone.0036975	journal	May 2012
Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells Hwang, HyunTae V.; Tran, Darlene Thuy; Rebuffatti, Michelle Nicole PLOS ONE, Vol. 13, Issue 1 https://doi.org/10.1371/journal.pone.0190374	journal	January 2018
A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging Scheibye-Knudsen, Morten; Scheibye-Alsing, Karsten; Canugovi, Chandrika Aging, Vol. 5, Issue 3 https://doi.org/10.18632/aging.100546	journal	March 2013
In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state Aliper, Alexander; Belikov, Aleksey V.; Garazha, Andrew Aging, Vol. 8, Issue 9 https://doi.org/10.18632/aging.101047	journal	September 2016
Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption Siddiqui, Sana; Lustig, Ana; Carter, Arnell Aging, Vol. 9, Issue 3 https://doi.org/10.18632/aging.101185	journal	March 2017
Towards natural mimetics of metformin and rapamycin Aliper, Alexander; Jellen, Leslie; Cortese, Franco Aging, Vol. 9, Issue 11 https://doi.org/10.18632/aging.101319	journal	November 2017
Converging blockchain and next-generation artificial intelligence technologies to decentralize and accelerate biomedical research and healthcare Mamoshina, Polina; Ojomoko, Lucy; Yanovich, Yury Oncotarget, Vol. 9, Issue 5 https://doi.org/10.18632/oncotarget.22345	journal	November 2017
The Critical Role of Metabolic Pathways in Aging Barzilai, Nir; Huffman, Derek M.; Muzumdar, Radhika H. Diabetes, Vol. 61, Issue 6 https://doi.org/10.2337/db11-1300	journal	May 2012
Screening and personalizing nootropic drugs and cognitive modulator regimens in silico Jellen, Leslie C.; Aliper, Alexander; Buzdin, Anton Frontiers in Systems Neuroscience, Vol. 9 https://doi.org/10.3389/fnsys.2015.00004	journal	February 2015
Quantitative and Systems Pharmacology 3. Network-Based Identification of New Targets for Natural Products Enables Potential Uses in Aging-Associated Disorders Fang, Jiansong; Gao, Li; Ma, Huili Frontiers in Pharmacology, Vol. 8 https://doi.org/10.3389/fphar.2017.00747	journal	October 2017
G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes Leysen, Hanne; van Gastel, Jaana; Hendrickx, Jhana International Journal of Molecular Sciences, Vol. 19, Issue 10 https://doi.org/10.3390/ijms19102919	journal	September 2018
Nicotinamide adenine dinucleotide is transported into mammalian mitochondria Davila, Antonio; Liu, Ling; Chellappa, Karthikeyani eLife, Vol. 7 https://doi.org/10.7554/elife.33246	journal	June 2018
From Lifespan to Healthspan Olshansky, S. Jay JAMA, Vol. 320, Issue 13 https://doi.org/10.1001/jama.2018.12621	journal	October 2018
GIT2—A keystone in ageing and age-related disease van Gastel, Jaana; Boddaert, Jan; Jushaj, Areta Ageing Research Reviews, Vol. 43 https://doi.org/10.1016/j.arr.2018.02.002	journal	May 2018
Widespread Proteome Remodeling and Aggregation in Aging C. elegans Walther, Dirk M.; Kasturi, Prasad; Zheng, Min Cell, Vol. 161, Issue 4 https://doi.org/10.1016/j.cell.2015.03.032	journal	May 2015
Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health Fontana, Luigi; Cummings, Nicole E.; Arriola Apelo, Sebastian I. Cell Reports, Vol. 16, Issue 2 https://doi.org/10.1016/j.celrep.2016.05.092	journal	July 2016
Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress Schulz, Tim J.; Zarse, Kim; Voigt, Anja Cell Metabolism, Vol. 6, Issue 4 https://doi.org/10.1016/j.cmet.2007.08.011	journal	October 2007
The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice Solon-Biet, Samantha M.; McMahon, Aisling C.; Ballard, J. William O. Cell Metabolism, Vol. 19, Issue 3 https://doi.org/10.1016/j.cmet.2014.02.009	journal	March 2014
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging Kennedy, Brian K.; Lamming, Dudley W. Cell Metabolism, Vol. 23, Issue 6 https://doi.org/10.1016/j.cmet.2016.05.009	journal	June 2016
Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle Frederick, David W.; Loro, Emanuele; Liu, Ling Cell Metabolism, Vol. 24, Issue 2 https://doi.org/10.1016/j.cmet.2016.07.005	journal	August 2016
Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions Petkovich, Daniel A.; Podolskiy, Dmitriy I.; Lobanov, Alexei V. Cell Metabolism, Vol. 25, Issue 4 https://doi.org/10.1016/j.cmet.2017.03.016	journal	April 2017
NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR Yoshino, Jun; Baur, Joseph A.; Imai, Shin-ichiro Cell Metabolism, Vol. 27, Issue 3 https://doi.org/10.1016/j.cmet.2017.11.002	journal	March 2018
Unmasking Transcriptional Heterogeneity in Senescent Cells Hernandez-Segura, Alejandra; de Jong, Tristan V.; Melov, Simon Current Biology, Vol. 27, Issue 17 https://doi.org/10.1016/j.cub.2017.07.033	journal	September 2017
Cellular Senescence: A Translational Perspective Kirkland, James L.; Tchkonia, Tamara EBioMedicine, Vol. 21 https://doi.org/10.1016/j.ebiom.2017.04.013	journal	July 2017
The skin aging exposome Krutmann, Jean; Bouloc, Anne; Sore, Gabrielle Journal of Dermatological Science, Vol. 85, Issue 3 https://doi.org/10.1016/j.jdermsci.2016.09.015	journal	March 2017
Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates Hannum, Gregory; Guinney, Justin; Zhao, Ling Molecular Cell, Vol. 49, Issue 2 https://doi.org/10.1016/j.molcel.2012.10.016	journal	January 2013
NAD + in Aging: Molecular Mechanisms and Translational Implications Fang, Evandro F.; Lautrup, Sofie; Hou, Yujun Trends in Molecular Medicine, Vol. 23, Issue 10 https://doi.org/10.1016/j.molmed.2017.08.001	journal	October 2017
Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans Lashmanova, Ekaterina; Proshkina, Ekaterina; Zhikrivetskaya, Svetlana Pharmacological Research, Vol. 100 https://doi.org/10.1016/j.phrs.2015.08.009	journal	October 2015
Applications of Deep Learning in Biomedicine Mamoshina, Polina; Vieira, Armando; Putin, Evgeny Molecular Pharmaceutics, Vol. 13, Issue 5 https://doi.org/10.1021/acs.molpharmaceut.5b00982	journal	March 2016
Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data Aliper, Alexander; Plis, Sergey; Artemov, Artem Molecular Pharmaceutics, Vol. 13, Issue 7 https://doi.org/10.1021/acs.molpharmaceut.6b00248	journal	June 2016
Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity Ewald, Collin Y.; Landis, Jess N.; Abate, Jess Porter Nature, Vol. 519, Issue 7541 https://doi.org/10.1038/nature14021	journal	December 2014
Branched-chain amino acid catabolism is a conserved regulator of physiological ageing Mansfeld, Johannes; Urban, Nadine; Priebe, Steffen Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms10043	journal	December 2015
In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development Ozerov, Ivan V.; Lezhnina, Ksenia V.; Izumchenko, Evgeny Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms13427	journal	November 2016
The transcriptional landscape of age in human peripheral blood Peters, Marjolein J.; Joehanes, Roby; Pilling, Luke C. Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms9570	journal	October 2015
Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits Ristow, Michael Nature Medicine, Vol. 20, Issue 7 https://doi.org/10.1038/nm.3624	journal	July 2014
Stem cell aging: mechanisms, regulators and therapeutic opportunities Oh, Juhyun; Lee, Yang David; Wagers, Amy J. Nature Medicine, Vol. 20, Issue 8 https://doi.org/10.1038/nm.3651	journal	August 2014
Understanding nucleotide excision repair and its roles in cancer and ageing Marteijn, Jurgen A.; Lans, Hannes; Vermeulen, Wim Nature Reviews Molecular Cell Biology, Vol. 15, Issue 7 https://doi.org/10.1038/nrm3822	journal	June 2014
Senolytics improve physical function and increase lifespan in old age Xu, Ming; Pirtskhalava, Tamar; Farr, Joshua N. Nature Medicine, Vol. 24, Issue 8 https://doi.org/10.1038/s41591-018-0092-9	journal	July 2018
Genome instability: a conserved mechanism of ageing? Vijg, Jan; Dong, Xiao; Milholland, Brandon Essays in Biochemistry, Vol. 61, Issue 3 https://doi.org/10.1042/EBC20160082	journal	May 2017
Monogenic Diseases of DNA Repair Keijzers, Guido; Bakula, Daniela; Scheibye-Knudsen, Morten New England Journal of Medicine, Vol. 377, Issue 19 https://doi.org/10.1056/NEJMra1703366	journal	November 2017
Antioxidants prevent health-promoting effects of physical exercise in humans Ristow, M.; Zarse, K.; Oberbach, A. Proceedings of the National Academy of Sciences, Vol. 106, Issue 21 https://doi.org/10.1073/pnas.0903485106	journal	May 2009
Meta-analysis of age-related gene expression profiles identifies common signatures of aging de Magalhães, João Pedro; Curado, João; Church, George M. Bioinformatics, Vol. 25, Issue 7 https://doi.org/10.1093/bioinformatics/btp073	journal	February 2009
Is Telomere Length a Biomarker of Aging? A Review Mather, K. A.; Jorm, A. F.; Parslow, R. A. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol. 66A, Issue 2 https://doi.org/10.1093/gerona/glq180	journal	October 2010
Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations Mamoshina, Polina; Kochetov, Kirill; Putin, Evgeny The Journals of Gerontology: Series A, Vol. 73, Issue 11 https://doi.org/10.1093/gerona/gly005	journal	January 2018
Gene expression defines natural changes in mammalian lifespan Fushan, Alexey A.; Turanov, Anton A.; Lee, Sang‐Goo Aging Cell, Vol. 14, Issue 3 https://doi.org/10.1111/acel.12283	journal	February 2015
Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence Wiley, Christopher D.; Flynn, James M.; Morrissey, Christapher Aging Cell, Vol. 16, Issue 5 https://doi.org/10.1111/acel.12632	journal	July 2017
Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity Ma, Siming; Avanesov, Andrei S.; Porter, Emily Aging Cell, Vol. 17, Issue 4 https://doi.org/10.1111/acel.12740	journal	April 2018
Gene expression-based drug repurposing to target aging Dönertaş, Handan Melike; Fuentealba Valenzuela, Matías; Partridge, Linda Aging Cell, Vol. 17, Issue 5 https://doi.org/10.1111/acel.12819	journal	August 2018
Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice López-Noriega, Livia; Cobo-Vuilleumier, Nadia; Narbona-Pérez, Álvaro Jesús British Journal of Pharmacology, Vol. 174, Issue 21 https://doi.org/10.1111/bph.13975	journal	September 2017
Restoration of metabolic health by decreased consumption of branched-chain amino acids Cummings, Nicole E.; Williams, Elizabeth M.; Kasza, Ildiko The Journal of Physiology, Vol. 596, Issue 4 https://doi.org/10.1113/JP275075	journal	December 2017
NAD+ in aging, metabolism, and neurodegeneration Verdin, E. Science, Vol. 350, Issue 6265 https://doi.org/10.1126/science.aac4854	journal	December 2015
Co-regulatory networks of human serum proteins link genetics to disease Emilsson, Valur; Ilkov, Marjan; Lamb, John R. Science, Vol. 361, Issue 6404 https://doi.org/10.1126/science.aaq1327	journal	August 2018
Nuclear GIT2 Is an ATM Substrate and Promotes DNA Repair Lu, Daoyuan; Cai, Huan; Park, Sung-Soo Molecular and Cellular Biology, Vol. 35, Issue 7 https://doi.org/10.1128/MCB.01432-14	journal	April 2015
Artificial intelligence in healthcare: past, present and future Jiang, Fei; Jiang, Yong; Zhi, Hui Stroke and Vascular Neurology, Vol. 2, Issue 4 https://doi.org/10.1136/svn-2017-000101	journal	June 2017
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression Coppé, Jean-Philippe; Desprez, Pierre-Yves; Krtolica, Ana Annual Review of Pathology: Mechanisms of Disease, Vol. 5, Issue 1 https://doi.org/10.1146/annurev-pathol-121808-102144	journal	January 2010
DNA methylation age of human tissues and cell types Horvath, Steve Genome Biology, Vol. 14, Issue 10 https://doi.org/10.1186/gb-2013-14-10-r115	journal	January 2013
Aging of blood can be tracked by DNA methylation changes at just three CpG sites Weidner, Carola; Lin, Qiong; Koch, Carmen Genome Biology, Vol. 15, Issue 2 https://doi.org/10.1186/gb-2014-15-2-r24	journal	January 2014
Transcriptome analysis reveals mechanisms of geroprotective effects of fucoxanthin in Drosophila Moskalev, Alexey; Shaposhnikov, Mikhail; Zemskaya, Nadezhda BMC Genomics, Vol. 19, Issue S3 https://doi.org/10.1186/s12864-018-4471-x	journal	February 2018
Targeting NAD+ in Metabolic Disease: New Insights Into an Old Molecule Elhassan, Yasir S.; Philp, Andrew A.; Lavery, Gareth G. Journal of the Endocrine Society, Vol. 1, Issue 7 https://doi.org/10.1210/js.2017-00092	journal	May 2017
Minimal Peroxide Exposure of Neuronal Cells Induces Multifaceted Adaptive Responses Chadwick, Wayne; Zhou, Yu; Park, Sung-Soo PLoS ONE, Vol. 5, Issue 12 https://doi.org/10.1371/journal.pone.0014352	journal	December 2010
GIT2 Acts as a Potential Keystone Protein in Functional Hypothalamic Networks Associated with Age-Related Phenotypic Changes in Rats Chadwick, Wayne; Martin, Bronwen; Chapter, Megan C. PLoS ONE, Vol. 7, Issue 5 https://doi.org/10.1371/journal.pone.0036975	journal	May 2012
Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells Hwang, HyunTae V.; Tran, Darlene Thuy; Rebuffatti, Michelle Nicole PLOS ONE, Vol. 13, Issue 1 https://doi.org/10.1371/journal.pone.0190374	journal	January 2018
A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging Scheibye-Knudsen, Morten; Scheibye-Alsing, Karsten; Canugovi, Chandrika Aging, Vol. 5, Issue 3 https://doi.org/10.18632/aging.100546	journal	March 2013
Deep biomarkers of human aging: Application of deep neural networks to biomarker development Putin, Evgeny; Mamoshina, Polina; Aliper, Alexander Aging, Vol. 8, Issue 5 https://doi.org/10.18632/aging.100968	journal	May 2016
In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state Aliper, Alexander; Belikov, Aleksey V.; Garazha, Andrew Aging, Vol. 8, Issue 9 https://doi.org/10.18632/aging.101047	journal	September 2016
Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption Siddiqui, Sana; Lustig, Ana; Carter, Arnell Aging, Vol. 9, Issue 3 https://doi.org/10.18632/aging.101185	journal	March 2017
Machine learning for predicting lifespan-extending chemical compounds Barardo, Diogo G.; Newby, Danielle; Thornton, Daniel Aging, Vol. 9, Issue 7 https://doi.org/10.18632/aging.101264	journal	July 2017
Towards natural mimetics of metformin and rapamycin Aliper, Alexander; Jellen, Leslie; Cortese, Franco Aging, Vol. 9, Issue 11 https://doi.org/10.18632/aging.101319	journal	November 2017
Converging blockchain and next-generation artificial intelligence technologies to decentralize and accelerate biomedical research and healthcare Mamoshina, Polina; Ojomoko, Lucy; Yanovich, Yury Oncotarget, Vol. 9, Issue 5 https://doi.org/10.18632/oncotarget.22345	journal	November 2017
The Critical Role of Metabolic Pathways in Aging Barzilai, Nir; Huffman, Derek M.; Muzumdar, Radhika H. Diabetes, Vol. 61, Issue 6 https://doi.org/10.2337/db11-1300	journal	May 2012
GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging Martin, Bronwen; Chadwick, Wayne; Janssens, Jonathan Frontiers in Endocrinology, Vol. 6 https://doi.org/10.3389/fendo.2015.00191	journal	January 2016
Screening and personalizing nootropic drugs and cognitive modulator regimens in silico Jellen, Leslie C.; Aliper, Alexander; Buzdin, Anton Frontiers in Systems Neuroscience, Vol. 9 https://doi.org/10.3389/fnsys.2015.00004	journal	February 2015
Quantitative and Systems Pharmacology 3. Network-Based Identification of New Targets for Natural Products Enables Potential Uses in Aging-Associated Disorders Fang, Jiansong; Gao, Li; Ma, Huili Frontiers in Pharmacology, Vol. 8 https://doi.org/10.3389/fphar.2017.00747	journal	October 2017
G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes Leysen, Hanne; van Gastel, Jaana; Hendrickx, Jhana International Journal of Molecular Sciences, Vol. 19, Issue 10 https://doi.org/10.3390/ijms19102919	journal	September 2018
Transcriptome analysis reveals mechanisms of geroprotective effects of fucoxanthin in Drosophila Moskalev, Alexey; Shaposhnikov, Mikhail; Zemskaya, Nadezhda figshare https://doi.org/10.6084/m9.figshare.c.4001994	collection	January 2018
Nicotinamide adenine dinucleotide is transported into mammalian mitochondria Davila, Antonio; Liu, Ling; Chellappa, Karthikeyani eLife, Vol. 7 https://doi.org/10.7554/eLife.33246	journal	June 2018

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Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age Mehdipour, Melod; Etienne, Jessy; Chen, Chia-Chien Aging, Vol. 11, Issue 15 https://doi.org/10.18632/aging.102148	journal	August 2019
Latest advances in aging research and drug discovery Bakula, Daniela; Ablasser, Andrea; Aguzzi, Adriano Aging, Vol. 11, Issue 22 https://doi.org/10.18632/aging.102487	journal	November 2019

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