skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization

Authors:
 [1];  [2];  [3];  [4];  [5];  [5];  [2];  [5];  [6];  [7];  [8];  [9];  [10];  [11]
  1. Department of Bioengineering and Therapeutic SciencesUniversity of California, San Francisco San Francisco California USA, Office of Clinical PharmacologyOffice of Translational SciencesCenter for Drug Evaluation &, ResearchUS Food and Drug Administration Silver Spring Maryland USA, Oak Ridge Institute for Science and Education (ORISE Fellow) Oak Ridge Tennessee USA
  2. Intensive Care and Department of Pediatric SurgeryErasmus MC‐Sophia Children's Hospital Rotterdam The Netherlands
  3. Intensive Care and Department of Pediatric SurgeryErasmus MC‐Sophia Children's Hospital Rotterdam The Netherlands, CDTS Consulting BV &, SDD Consulting BV Etten‐Leur The Netherlands
  4. Department of Pharmacology and ToxicologyRadboud University Nijmegen The Netherlands
  5. Department of PediatricsErasmus MC‐Sophia Children's Hospital Rotterdam The Netherlands
  6. Department of PathologyErasmus MC Rotterdam The Netherlands
  7. Department of PathologyRadboudumc Nijmegen The Netherlands
  8. Office of Research and StandardsOffice of Generic DrugsCenter for Drug Evaluation &, ResearchUS Food and Drug Administration Silver Spring Maryland USA
  9. Office of Clinical PharmacologyOffice of Translational SciencesCenter for Drug Evaluation &, ResearchUS Food and Drug Administration Silver Spring Maryland USA
  10. Department of Bioengineering and Therapeutic SciencesUniversity of California, San Francisco San Francisco California USA
  11. Intensive Care and Department of Pediatric SurgeryErasmus MC‐Sophia Children's Hospital Rotterdam The Netherlands, Department of Pharmacology and ToxicologyRadboud University Nijmegen The Netherlands
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1569304
Alternate Identifier(s):
OSTI ID: 1569306
Resource Type:
Published Article
Journal Name:
Clinical Pharmacology and Therapeutics
Additional Journal Information:
Journal Name: Clinical Pharmacology and Therapeutics Journal Volume: 106 Journal Issue: 5; Journal ID: ISSN 0009-9236
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
United States
Language:
English

Citation Formats

Cheung, Kit Wun Kathy, Groen, Bianca D., Spaans, Edwin, Borselen, Marjolein D., Bruijn, Adrianus C. J. M., Simons‐Oosterhuis, Ytje, Tibboel, Dick, Samsom, Janneke N., Verdijk, Robert M., Smeets, Bart, Zhang, Lei, Huang, Shiew‐Mei, Giacomini, Kathleen M., and Wildt, Saskia N. A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization. United States: N. p., 2019. Web. doi:10.1002/cpt.1516.
Cheung, Kit Wun Kathy, Groen, Bianca D., Spaans, Edwin, Borselen, Marjolein D., Bruijn, Adrianus C. J. M., Simons‐Oosterhuis, Ytje, Tibboel, Dick, Samsom, Janneke N., Verdijk, Robert M., Smeets, Bart, Zhang, Lei, Huang, Shiew‐Mei, Giacomini, Kathleen M., & Wildt, Saskia N. A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization. United States. doi:10.1002/cpt.1516.
Cheung, Kit Wun Kathy, Groen, Bianca D., Spaans, Edwin, Borselen, Marjolein D., Bruijn, Adrianus C. J. M., Simons‐Oosterhuis, Ytje, Tibboel, Dick, Samsom, Janneke N., Verdijk, Robert M., Smeets, Bart, Zhang, Lei, Huang, Shiew‐Mei, Giacomini, Kathleen M., and Wildt, Saskia N. Wed . "A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization". United States. doi:10.1002/cpt.1516.
@article{osti_1569304,
title = {A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization},
author = {Cheung, Kit Wun Kathy and Groen, Bianca D. and Spaans, Edwin and Borselen, Marjolein D. and Bruijn, Adrianus C. J. M. and Simons‐Oosterhuis, Ytje and Tibboel, Dick and Samsom, Janneke N. and Verdijk, Robert M. and Smeets, Bart and Zhang, Lei and Huang, Shiew‐Mei and Giacomini, Kathleen M. and Wildt, Saskia N.},
abstractNote = {},
doi = {10.1002/cpt.1516},
journal = {Clinical Pharmacology and Therapeutics},
number = 5,
volume = 106,
place = {United States},
year = {2019},
month = {7}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1002/cpt.1516

Citation Metrics:
Cited by: 2 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Human renal function maturation: a quantitative description using weight and postmenstrual age
journal, October 2008

  • Rhodin, Malin M.; Anderson, Brian J.; Peters, A. Michael
  • Pediatric Nephrology, Vol. 24, Issue 1
  • DOI: 10.1007/s00467-008-0997-5

Current trends in quantitative proteomics - an update: Current trends in quantitative proteomics
journal, May 2017

  • Li, H.; Han, J.; Pan, J.
  • Journal of Mass Spectrometry, Vol. 52, Issue 5
  • DOI: 10.1002/jms.3932

Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions
journal, January 2015

  • Prakash, Chandra; Zuniga, Baltazar; Seog Song, Chung
  • Nuclear Receptor Research, Vol. 2
  • DOI: 10.11131/2015/101178

Environmental Health Hazards: How Children Are Different from Adults
journal, July 1995

  • Bearer, Cynthia F.
  • The Future of Children, Vol. 5, Issue 2
  • DOI: 10.2307/1602354

Recent advances on uric acid transporters
journal, August 2017


Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium
journal, July 2018

  • Evers, Raymond; Piquette-Miller, Micheline; Polli, Joseph W.
  • Clinical Pharmacology & Therapeutics, Vol. 104, Issue 5
  • DOI: 10.1002/cpt.1115

Regulation of mRNA Expression of Xenobiotic Transporters by the Pregnane X Receptor in Mouse Liver, Kidney, and Intestine
journal, August 2006

  • Cheng, Xingguo; Klaassen, Curtis D.
  • Drug Metabolism and Disposition, Vol. 34, Issue 11
  • DOI: 10.1124/dmd.106.010520

The Role of Dietary Experience in the Development of Eating Behavior during the First Years of Life
journal, January 2017

  • Nicklaus, Sophie
  • Annals of Nutrition and Metabolism, Vol. 70, Issue 3
  • DOI: 10.1159/000465532

Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics
journal, September 2016

  • Prasad, Bhagwat; Johnson, Katherine; Billington, Sarah
  • Drug Metabolism and Disposition, Vol. 44, Issue 12
  • DOI: 10.1124/dmd.116.072066

Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues
journal, February 2005

  • Miki, Yasuhiro; Suzuki, Takashi; Tazawa, Chika
  • Molecular and Cellular Endocrinology, Vol. 231, Issue 1-2
  • DOI: 10.1016/j.mce.2004.12.005

Universal sample preparation method for proteome analysis
journal, April 2009

  • Wiśniewski, Jacek R.; Zougman, Alexandre; Nagaraj, Nagarjuna
  • Nature Methods, Vol. 6, Issue 5
  • DOI: 10.1038/nmeth.1322

Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)
journal, October 2004


Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics
journal, September 2015

  • Mooij, Miriam G.; Nies, Anne T.; Knibbe, Catherijne A. J.
  • Clinical Pharmacokinetics, Vol. 55, Issue 5
  • DOI: 10.1007/s40262-015-0328-5

Species differences in drug transporters and implications for translating preclinical findings to humans
journal, December 2012

  • Chu, Xiaoyan; Bleasby, Kelly; Evers, Raymond
  • Expert Opinion on Drug Metabolism & Toxicology, Vol. 9, Issue 3
  • DOI: 10.1517/17425255.2013.741589

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
journal, February 2010


Morphine Glucuronidation in Preterm Neonates, Infants and Children Younger than 3 Years
journal, January 2009


Alternative splicing as a regulator of development and tissue identity
journal, May 2017

  • Baralle, Francisco E.; Giudice, Jimena
  • Nature Reviews Molecular Cell Biology, Vol. 18, Issue 7
  • DOI: 10.1038/nrm.2017.27

Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
journal, April 2016

  • Mooij, M. G.; van de Steeg, E.; van Rosmalen, J.
  • Drug Metabolism and Disposition, Vol. 44, Issue 7
  • DOI: 10.1124/dmd.115.068577

PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics
journal, November 2008


Quantification of gene expression while taking into account RNA alternative splicing
journal, December 2019


Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney11See Editorial by Sasaki, p. 1772.
journal, April 2000


Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group
journal, August 2015

  • Brouwer, Klr; Aleksunes, Lm; Brandys, B.
  • Clinical Pharmacology & Therapeutics, Vol. 98, Issue 3
  • DOI: 10.1002/cpt.176

Precise comparison of protein localization among OCT, OAT, and MATE in human kidney
journal, September 2013

  • Motohashi, Hideyuki; Nakao, Yumi; Masuda, Satohiro
  • Journal of Pharmaceutical Sciences, Vol. 102, Issue 9
  • DOI: 10.1002/jps.23567

Tissue Distribution and Renal Developmental Changes in Rat Organic Cation Transporter mRNA levels
journal, February 2002

  • Slitt, A. L.; Cherrington, N. J.; Hartley, D. P.
  • Drug Metabolism and Disposition, Vol. 30, Issue 2
  • DOI: 10.1124/dmd.30.2.212

Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children
journal, July 2016

  • Vet, Nienke J.; Brussee, Janneke M.; de Hoog, Matthijs
  • American Journal of Respiratory and Critical Care Medicine, Vol. 194, Issue 1
  • DOI: 10.1164/rccm.201510-2114OC

Ontogeny of Renal P-glycoprotein Expression in Mice: Correlation with Digoxin Renal Clearance
journal, December 2005


Fractional excretion of uric acid in infancy and childhood: Index of tubular maturation
journal, November 1974

  • Passwell, J. H.; Modan, M.; Brish, M.
  • Archives of Disease in Childhood, Vol. 49, Issue 11
  • DOI: 10.1136/adc.49.11.878

Renal Transporters in Drug Development
journal, January 2013


Uric Acid Metabolism in Children
journal, April 1990


Changes in Serum Urate and Urate Excretion With Age
journal, November 2012


Morphogenesis and molecular mechanisms involved in human kidney development
journal, December 2011

  • Faa, Gavino; Gerosa, Clara; Fanni, Daniela
  • Journal of Cellular Physiology, Vol. 227, Issue 3
  • DOI: 10.1002/jcp.22985

Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics
journal, August 2016

  • Prasad, B.; Gaedigk, A.; Vrana, M.
  • Clinical Pharmacology & Therapeutics, Vol. 100, Issue 4
  • DOI: 10.1002/cpt.409

Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes
journal, April 2016


What do drug transporters really do?
journal, December 2014

  • Nigam, Sanjay K.
  • Nature Reviews Drug Discovery, Vol. 14, Issue 1
  • DOI: 10.1038/nrd4461

Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin
journal, April 2015

  • Chen, Eugene C.; Liang, Xiaomin; Yee, Sook Wah
  • Molecular Pharmacology, Vol. 88, Issue 1
  • DOI: 10.1124/mol.114.096776

Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response
journal, November 2017

  • Brackman, Deanna J.; Giacomini, Kathleen M.
  • Clinical Pharmacology & Therapeutics, Vol. 103, Issue 2
  • DOI: 10.1002/cpt.903

Mechanism-Based Concepts of Size and Maturity in Pharmacokinetics
journal, February 2008


Cellular Export of Drugs and Signaling Molecules by the ATP-binding Cassette Transporters MRP4 (ABCC4) and MRP5 (ABCC5)
journal, January 2005

  • Ritter, Christoph A.; Jedlitschky, Gabriele; Meyer zu Schwabedissen, Henriette
  • Drug Metabolism Reviews, Vol. 37, Issue 1
  • DOI: 10.1081/DMR-200047984

Functional Maturation of Drug Transporters in the Developing, Neonatal, and Postnatal Kidney
journal, April 2011

  • Sweeney, Derina E.; Vallon, Volker; Rieg, Timo
  • Molecular Pharmacology, Vol. 80, Issue 1
  • DOI: 10.1124/mol.110.070680

Tissue Distribution and Hepatic and Renal Ontogeny of the Multidrug Resistance-Associated Protein (Mrp) Family in mice
journal, March 2005

  • Maher, Jonathan M.; Slitt, Angela L.; Cherrington, Nathan J.
  • Drug Metabolism and Disposition, Vol. 33, Issue 7
  • DOI: 10.1124/dmd.105.003780