A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization

Cheung, Kit Wun Kathy; Groen, Bianca D.; Spaans, Edwin; van Borselen, Marjolein D.; de Bruijn, Adrianus C. J. M.; Simons‐Oosterhuis, Ytje; Tibboel, Dick; Samsom, Janneke N.; Verdijk, Robert M.; Smeets, Bart; Zhang, Lei; Huang, Shiew‐Mei; Giacomini, Kathleen M.; de Wildt, Saskia N.

doi:10.1002/cpt.1516

Title: A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization

Journal Article · 25 May 2019 · Clinical Pharmacology and Therapeutics

DOI: https://doi.org/10.1002/cpt.1516 · OSTI ID:1569304

Cheung, Kit Wun Kathy ^[1]; Groen, Bianca D. ^[2]; Spaans, Edwin ^[3]; van Borselen, Marjolein D. ^[4]; de Bruijn, Adrianus C. J. M. ^[5]; Simons‐Oosterhuis, Ytje ^[5]; Tibboel, Dick ^[2]; Samsom, Janneke N. ^[5]; Verdijk, Robert M. ^[6]; Smeets, Bart ^[7]; Zhang, Lei ^[8]; Huang, Shiew‐Mei ^[8]; Giacomini, Kathleen M. ^[9]; de Wildt, Saskia N. ^[10]

Univ. of California, San Francisco, CA (United States); U.S. Food and Drug Administration (FDA), Silver Spring, MD (United States). Center for Drug Evaluation & Research (CDER); Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)
Erasmus MC-Sophia Children's Hospital, Rotterdam, (Netherlands). Intensive Care and Department of Pediatric Surgery
Erasmus MC-Sophia Children's Hospital, Rotterdam, (Netherlands). Intensive Care and Department of Pediatric Surgery; CDTS Consulting BV, Etten-Leur (Netherlands); SDD Consulting BV, Etten-Leur (Netherlands)
Radboud Univ., Nijmegen (Netherlands)
Erasmus MC-Sophia Children's Hospital, Rotterdam, (Netherlands)
Erasmus MC, Rotterdam (Netherlands)
Radboud MC, Nijmegen (Netherlands)
U.S. Food and Drug Administration (FDA), Silver Spring, MD (United States). Center for Drug Evaluation and Research (CDER)
Univ. of California, San Francisco, CA (United States)
Erasmus MC-Sophia Children's Hospital, Rotterdam, (Netherlands). Intensive Care and Department of Pediatric Surgery; Radboud Univ., Nijmegen (Netherlands)

Human renal membrane transporters play key roles in the disposition of renally cleared drugs and endogenous substrates, but their ontogeny is largely unknown. Using 184 human postmortem frozen renal cortical tissues (preterm newborns to adults) and a subset of 62 tissue samples, we measured the mRNA levels of 11 renal transporters and the transcription factor pregnane X receptor (PXR) with quantitative real-time polymerase chain reaction, and protein abundance of nine transporters using liquid chromatography tandem mass spectrometry selective reaction monitoring, respectively. Expression levels of p-glycoprotein, urate transporter 1, organic anion transporter 1, organic anion transporter 3, and organic cation transporter 2 increased with age. Protein levels of multidrug and toxin extrusion transporter 2-K and breast cancer resistance protein showed no difference from newborns to adults, despite age-related changes in mRNA expression. Multidrug and toxin extrusion transporter 1, glucose transporter 2, multidrug resistance-associated protein 2, multidrug resistance-associated protein 4 (MRP4), and PXR expression levels were stable. Using immunohistochemistry, we found that MRP4 localization in pediatric samples was similar to that in adult samples. Collectively, our study revealed that renal drug transporters exhibited different rates and patterns of maturation, suggesting that renal handling of substrates may change with age.

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Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Institutes of Health (NIH); U.S. Food and Drug Administration (FDA)

Grant/Contract Number:: SC0014664; R01GM117163; R01DK103729; U01FD004979; UL1TR001872

OSTI ID:: 1569304

Alternate ID(s):: OSTI ID: 1569306; OSTI ID: 1904980

Journal Information:: Clinical Pharmacology and Therapeutics, Vol. 106, Issue 5; Conference: Annual Meeting of the American Society for Clinical Pharmacology & Therapeutics (ASCPT) , Orlando, FL (United States), 22-24 Mar 2018; ISSN 0009-9236

Publisher:: American Society for Clinical Pharmacology & Therapeutics - WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 60 works

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References (75)

Human renal function maturation: a quantitative description using weight and postmenstrual age Rhodin, Malin M.; Anderson, Brian J.; Peters, A. Michael Pediatric Nephrology, Vol. 24, Issue 1 https://doi.org/10.1007/s00467-008-0997-5	journal	October 2008
Current trends in quantitative proteomics - an update: Current trends in quantitative proteomics Li, H.; Han, J.; Pan, J. Journal of Mass Spectrometry, Vol. 52, Issue 5 https://doi.org/10.1002/jms.3932	journal	May 2017
Renal Organic Anion Transporters (SLC22 Family): Expression, Regulation, Roles in Toxicity, and Impact on Injury and Disease Wang, Li; Sweet, Douglas H. The AAPS Journal, Vol. 15, Issue 1 https://doi.org/10.1208/s12248-012-9413-y	journal	October 2012
Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions Prakash, Chandra; Zuniga, Baltazar; Seog Song, Chung Nuclear Receptor Research, Vol. 2 https://doi.org/10.11131/2015/101178	journal	January 2015
Environmental Health Hazards: How Children Are Different from Adults Bearer, Cynthia F. The Future of Children, Vol. 5, Issue 2 https://doi.org/10.2307/1602354	journal	July 1995
Recent advances on uric acid transporters Xu, Liuqing; Shi, Yingfeng; Zhuang, Shougang Oncotarget, Vol. 8, Issue 59 https://doi.org/10.18632/oncotarget.20135	journal	August 2017
Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium Evers, Raymond; Piquette-Miller, Micheline; Polli, Joseph W. Clinical Pharmacology & Therapeutics, Vol. 104, Issue 5 https://doi.org/10.1002/cpt.1115	journal	July 2018
The Human Genome Browser at UCSC Kent, W. J.; Sugnet, C. W.; Furey, T. S. Genome Research, Vol. 12, Issue 6 https://doi.org/10.1101/gr.229102	journal	May 2002
Regulation of mRNA Expression of Xenobiotic Transporters by the Pregnane X Receptor in Mouse Liver, Kidney, and Intestine Cheng, Xingguo; Klaassen, Curtis D. Drug Metabolism and Disposition, Vol. 34, Issue 11 https://doi.org/10.1124/dmd.106.010520	journal	August 2006
The Role of Dietary Experience in the Development of Eating Behavior during the First Years of Life Nicklaus, Sophie Annals of Nutrition and Metabolism, Vol. 70, Issue 3 https://doi.org/10.1159/000465532	journal	January 2017
Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics Prasad, Bhagwat; Johnson, Katherine; Billington, Sarah Drug Metabolism and Disposition, Vol. 44, Issue 12 https://doi.org/10.1124/dmd.116.072066	journal	September 2016
Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues Miki, Yasuhiro; Suzuki, Takashi; Tazawa, Chika Molecular and Cellular Endocrinology, Vol. 231, Issue 1-2 https://doi.org/10.1016/j.mce.2004.12.005	journal	February 2005
Universal sample preparation method for proteome analysis Wiśniewski, Jacek R.; Zougman, Alexandre; Nagaraj, Nagarjuna Nature Methods, Vol. 6, Issue 5 https://doi.org/10.1038/nmeth.1322	journal	April 2009
Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A) Motohashi, Hideyuki; Uwai, Yuichi; Hiramoto, Kiyo European Journal of Pharmacology, Vol. 503, Issue 1-3 https://doi.org/10.1016/j.ejphar.2004.09.032	journal	October 2004
Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics Mooij, Miriam G.; Nies, Anne T.; Knibbe, Catherijne A. J. Clinical Pharmacokinetics, Vol. 55, Issue 5 https://doi.org/10.1007/s40262-015-0328-5	journal	September 2015
Species differences in drug transporters and implications for translating preclinical findings to humans Chu, Xiaoyan; Bleasby, Kelly; Evers, Raymond Expert Opinion on Drug Metabolism & Toxicology, Vol. 9, Issue 3 https://doi.org/10.1517/17425255.2013.741589	journal	December 2012
Skyline: an open source document editor for creating and analyzing targeted proteomics experiments MacLean, Brendan; Tomazela, Daniela M.; Shulman, Nicholas Bioinformatics, Vol. 26, Issue 7 https://doi.org/10.1093/bioinformatics/btq054	journal	February 2010
Morphine Glucuronidation in Preterm Neonates, Infants and Children Younger than 3 Years Knibbe, Catherijne A. J.; Krekels, Elke H. J.; van den Anker, Johannes N. Clinical Pharmacokinetics, Vol. 48, Issue 6 https://doi.org/10.2165/00003088-200948060-00003	journal	January 2009
Detecting outliers when fitting data with nonlinear regression – a new method based on robust nonlinear regression and the false discovery rate Motulsky, Harvey J.; Brown, Ronald E. BMC Bioinformatics, Vol. 7, Issue 1 https://doi.org/10.1186/1471-2105-7-123	journal	March 2006
Alternative splicing as a regulator of development and tissue identity Baralle, Francisco E.; Giudice, Jimena Nature Reviews Molecular Cell Biology, Vol. 18, Issue 7 https://doi.org/10.1038/nrm.2017.27	journal	May 2017
Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life Mooij, M. G.; van de Steeg, E.; van Rosmalen, J. Drug Metabolism and Disposition, Vol. 44, Issue 7 https://doi.org/10.1124/dmd.115.068577	journal	April 2016
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics Zhang, Bin; Xie, Wen; Krasowski, Matthew D. Pharmacogenomics, Vol. 9, Issue 11 https://doi.org/10.2217/14622416.9.11.1695	journal	November 2008
Quantification of gene expression while taking into account RNA alternative splicing Zhang, Meiping; Liu, Yun-Hua; Chang, Chih-Sheng Genomics, Vol. 111, Issue 6 https://doi.org/10.1016/j.ygeno.2018.10.009	journal	December 2019
Developmental Pharmacokinetics in Pediatric Populations Lu, Hong; Rosenbaum, Sara The Journal of Pediatric Pharmacology and Therapeutics, Vol. 19, Issue 4 https://doi.org/10.5863/1551-6776-19.4.262	journal	October 2014
Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney11See Editorial by Sasaki, p. 1772. Nakajima, Noriko; Sekine, Takashi; Cha, Seok Ho Kidney International, Vol. 57, Issue 4 https://doi.org/10.1046/j.1523-1755.2000.00005.x	journal	April 2000
Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group Brouwer, Klr; Aleksunes, Lm; Brandys, B. Clinical Pharmacology & Therapeutics, Vol. 98, Issue 3 https://doi.org/10.1002/cpt.176	journal	August 2015
Precise comparison of protein localization among OCT, OAT, and MATE in human kidney Motohashi, Hideyuki; Nakao, Yumi; Masuda, Satohiro Journal of Pharmaceutical Sciences, Vol. 102, Issue 9 https://doi.org/10.1002/jps.23567	journal	September 2013
Tissue Distribution and Renal Developmental Changes in Rat Organic Cation Transporter mRNA levels Slitt, A. L.; Cherrington, N. J.; Hartley, D. P. Drug Metabolism and Disposition, Vol. 30, Issue 2 https://doi.org/10.1124/dmd.30.2.212	journal	February 2002
Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children Vet, Nienke J.; Brussee, Janneke M.; de Hoog, Matthijs American Journal of Respiratory and Critical Care Medicine, Vol. 194, Issue 1 https://doi.org/10.1164/rccm.201510-2114OC	journal	July 2016
Ontogeny of Renal P-glycoprotein Expression in Mice: Correlation with Digoxin Renal Clearance Pinto, Natasha; Halachmi, Naomi; Verjee, Zulfikarali Pediatric Research, Vol. 58, Issue 6 https://doi.org/10.1203/01.pdr.0000188697.99079.27	journal	December 2005
Fractional excretion of uric acid in infancy and childhood: Index of tubular maturation Passwell, J. H.; Modan, M.; Brish, M. Archives of Disease in Childhood, Vol. 49, Issue 11 https://doi.org/10.1136/adc.49.11.878	journal	November 1974
Renal Transporters in Drug Development Morrissey, Kari M.; Stocker, Sophie L.; Wittwer, Matthias B. Annual Review of Pharmacology and Toxicology, Vol. 53, Issue 1 https://doi.org/10.1146/annurev-pharmtox-011112-140317	journal	January 2013
Uric Acid Metabolism in Children Baldree, Lou Anne; Stapleton, F. Bruder Pediatric Clinics of North America, Vol. 37, Issue 2 https://doi.org/10.1016/S0031-3955(16)36876-6	journal	April 1990
Changes in Serum Urate and Urate Excretion With Age Stiburkova, Blanka; Bleyer, Anthony J. Advances in Chronic Kidney Disease, Vol. 19, Issue 6 https://doi.org/10.1053/j.ackd.2012.07.010	journal	November 2012
Morphogenesis and molecular mechanisms involved in human kidney development Faa, Gavino; Gerosa, Clara; Fanni, Daniela Journal of Cellular Physiology, Vol. 227, Issue 3 https://doi.org/10.1002/jcp.22985	journal	December 2011
Quantification of Four Efflux Drug Transporters in Liver and Kidney Across Species Using Targeted Quantitative Proteomics by Isotope Dilution NanoLC-MS/MS Fallon, John K.; Smith, Philip C.; Xia, Cindy Q. Pharmaceutical Research, Vol. 33, Issue 9 https://doi.org/10.1007/s11095-016-1966-5	journal	June 2016
Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics Prasad, B.; Gaedigk, A.; Vrana, M. Clinical Pharmacology & Therapeutics, Vol. 100, Issue 4 https://doi.org/10.1002/cpt.409	journal	August 2016
Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes Benson, Eric A.; Eadon, Michael T.; Desta, Zeruesenay Frontiers in Pharmacology, Vol. 7 https://doi.org/10.3389/fphar.2016.00111	journal	April 2016
What do drug transporters really do? Nigam, Sanjay K. Nature Reviews Drug Discovery, Vol. 14, Issue 1 https://doi.org/10.1038/nrd4461	journal	December 2014
Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin Chen, Eugene C.; Liang, Xiaomin; Yee, Sook Wah Molecular Pharmacology, Vol. 88, Issue 1 https://doi.org/10.1124/mol.114.096776	journal	April 2015
Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response Brackman, Deanna J.; Giacomini, Kathleen M. Clinical Pharmacology & Therapeutics, Vol. 103, Issue 2 https://doi.org/10.1002/cpt.903	journal	November 2017
Mechanism-Based Concepts of Size and Maturity in Pharmacokinetics Anderson, B. J.; Holford, N. H. G. Annual Review of Pharmacology and Toxicology, Vol. 48, Issue 1 https://doi.org/10.1146/annurev.pharmtox.48.113006.094708	journal	February 2008
Cellular Export of Drugs and Signaling Molecules by the ATP-binding Cassette Transporters MRP4 (ABCC4) and MRP5 (ABCC5) Ritter, Christoph A.; Jedlitschky, Gabriele; Meyer zu Schwabedissen, Henriette Drug Metabolism Reviews, Vol. 37, Issue 1 https://doi.org/10.1081/DMR-200047984	journal	January 2005
Functional Maturation of Drug Transporters in the Developing, Neonatal, and Postnatal Kidney Sweeney, Derina E.; Vallon, Volker; Rieg, Timo Molecular Pharmacology, Vol. 80, Issue 1 https://doi.org/10.1124/mol.110.070680	journal	April 2011
Tissue Distribution and Hepatic and Renal Ontogeny of the Multidrug Resistance-Associated Protein (Mrp) Family in mice Maher, Jonathan M.; Slitt, Angela L.; Cherrington, Nathan J. Drug Metabolism and Disposition, Vol. 33, Issue 7 https://doi.org/10.1124/dmd.105.003780	journal	March 2005
Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium Evers, Raymond; Piquette-Miller, Micheline; Polli, Joseph W. Clinical Pharmacology & Therapeutics, Vol. 104, Issue 5 https://doi.org/10.1002/cpt.1115	journal	July 2018
Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group Brouwer, Klr; Aleksunes, Lm; Brandys, B. Clinical Pharmacology & Therapeutics, Vol. 98, Issue 3 https://doi.org/10.1002/cpt.176	journal	August 2015
Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics Prasad, B.; Gaedigk, A.; Vrana, M. Clinical Pharmacology & Therapeutics, Vol. 100, Issue 4 https://doi.org/10.1002/cpt.409	journal	August 2016
Morphogenesis and molecular mechanisms involved in human kidney development Faa, Gavino; Gerosa, Clara; Fanni, Daniela Journal of Cellular Physiology, Vol. 227, Issue 3 https://doi.org/10.1002/jcp.22985	journal	December 2011
Precise comparison of protein localization among OCT, OAT, and MATE in human kidney Motohashi, Hideyuki; Nakao, Yumi; Masuda, Satohiro Journal of Pharmaceutical Sciences, Vol. 102, Issue 9 https://doi.org/10.1002/jps.23567	journal	September 2013
Human renal function maturation: a quantitative description using weight and postmenstrual age Rhodin, Malin M.; Anderson, Brian J.; Peters, A. Michael Pediatric Nephrology, Vol. 24, Issue 1 https://doi.org/10.1007/s00467-008-0997-5	journal	October 2008
Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A) Motohashi, Hideyuki; Uwai, Yuichi; Hiramoto, Kiyo European Journal of Pharmacology, Vol. 503, Issue 1-3 https://doi.org/10.1016/j.ejphar.2004.09.032	journal	October 2004
Quantification of gene expression while taking into account RNA alternative splicing Zhang, Meiping; Liu, Yun-Hua; Chang, Chih-Sheng Genomics, Vol. 111, Issue 6 https://doi.org/10.1016/j.ygeno.2018.10.009	journal	December 2019
The relevance of assessment of intestinal P-gp inhibition using digoxin as an in vivo probe substrate Shi, Jack G.; Zhang, Yan; Yeleswaram, Swamy Nature Reviews Drug Discovery, Vol. 10, Issue 1 https://doi.org/10.1038/nrd3028-c1	journal	December 2010
Molecular basis of organic anion and cation transport Sesaki, Sei Kidney International, Vol. 57, Issue 4 https://doi.org/10.1046/j.1523-1755.2000.00026.x	journal	April 2000
Changes in Serum Urate and Urate Excretion With Age Stiburkova, Blanka; Bleyer, Anthony J. Advances in Chronic Kidney Disease, Vol. 19, Issue 6 https://doi.org/10.1053/j.ackd.2012.07.010	journal	November 2012
Cellular Export of Drugs and Signaling Molecules by the ATP-binding Cassette Transporters MRP4 (ABCC4) and MRP5 (ABCC5) Ritter, Christoph; Jedlitschky, Gabriele; Meyer zu Schwabedissen, Henriette Drug Metabolism Reviews, Vol. 37, Issue 1 https://doi.org/10.1081/dmr-47984	journal	January 2005
Skyline: an open source document editor for creating and analyzing targeted proteomics experiments MacLean, Brendan; Tomazela, Daniela M.; Shulman, Nicholas Bioinformatics, Vol. 26, Issue 7 https://doi.org/10.1093/bioinformatics/btq054	journal	February 2010
The Human Genome Browser at UCSC Kent, W. J.; Sugnet, C. W.; Furey, T. S. Genome Research, Vol. 12, Issue 6 https://doi.org/10.1101/gr.229102	journal	May 2002
Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions Prakash, Chandra; Zuniga, Baltazar; Seog Song, Chung Nuclear Receptor Research, Vol. 2 https://doi.org/10.11131/2015/101178	journal	January 2015
Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life Mooij, M. G.; van de Steeg, E.; van Rosmalen, J. Drug Metabolism and Disposition, Vol. 44, Issue 7 https://doi.org/10.1124/dmd.115.068577	journal	April 2016
Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics Prasad, Bhagwat; Johnson, Katherine; Billington, Sarah Drug Metabolism and Disposition, Vol. 44, Issue 12 https://doi.org/10.1124/dmd.116.072066	journal	September 2016
Tissue Distribution and Renal Developmental Changes in Rat Organic Cation Transporter mRNA levels Slitt, A. L.; Cherrington, N. J.; Hartley, D. P. Drug Metabolism and Disposition, Vol. 30, Issue 2 https://doi.org/10.1124/dmd.30.2.212	journal	February 2002
Functional Maturation of Drug Transporters in the Developing, Neonatal, and Postnatal Kidney Sweeney, Derina E.; Vallon, Volker; Rieg, Timo Molecular Pharmacology, Vol. 80, Issue 1 https://doi.org/10.1124/mol.110.070680	journal	April 2011
Renal Transporters in Drug Development Morrissey, Kari M.; Stocker, Sophie L.; Wittwer, Matthias B. Annual Review of Pharmacology and Toxicology, Vol. 53, Issue 1 https://doi.org/10.1146/annurev-pharmtox-011112-140317	journal	January 2013
The Role of Dietary Experience in the Development of Eating Behavior during the First Years of Life Nicklaus, Sophie Annals of Nutrition and Metabolism, Vol. 70, Issue 3 https://doi.org/10.1159/000465532	journal	January 2017
Detecting outliers when fitting data with nonlinear regression – a new method based on robust nonlinear regression and the false discovery rate Motulsky, Harvey J.; Brown, Ronald E. BMC Bioinformatics, Vol. 7, Issue 1 https://doi.org/10.1186/1471-2105-7-123	journal	March 2006
Ontogeny of Renal P-glycoprotein Expression in Mice: Correlation with Digoxin Renal Clearance Pinto, Natasha; Halachmi, Naomi; Verjee, Zulfikarali Pediatric Research, Vol. 58, Issue 6 https://doi.org/10.1203/01.pdr.0000188697.99079.27	journal	December 2005
Renal Organic Anion Transporters (SLC22 Family): Expression, Regulation, Roles in Toxicity, and Impact on Injury and Disease Wang, Li; Sweet, Douglas H. The AAPS Journal, Vol. 15, Issue 1 https://doi.org/10.1208/s12248-012-9413-y	journal	October 2012
Species differences in drug transporters and implications for translating preclinical findings to humans Chu, Xiaoyan; Bleasby, Kelly; Evers, Raymond Expert Opinion on Drug Metabolism & Toxicology, Vol. 9, Issue 3 https://doi.org/10.1517/17425255.2013.741589	journal	December 2012
Recent advances on uric acid transporters Xu, Liuqing; Shi, Yingfeng; Zhuang, Shougang Oncotarget, Vol. 8, Issue 59 https://doi.org/10.18632/oncotarget.20135	journal	August 2017
Morphine Glucuronidation in Preterm Neonates, Infants and Children Younger than 3 Years Knibbe, Catherijne A. J.; Krekels, Elke H. J.; van den Anker, Johannes N. Clinical Pharmacokinetics, Vol. 48, Issue 6 https://doi.org/10.2165/00003088-200948060-00003	journal	January 2009
PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics Zhang, Bin; Xie, Wen; Krasowski, Matthew D. Pharmacogenomics, Vol. 9, Issue 11 https://doi.org/10.2217/14622416.9.11.1695	journal	November 2008
Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes Benson, Eric A.; Eadon, Michael T.; Desta, Zeruesenay Frontiers in Pharmacology, Vol. 7 https://doi.org/10.3389/fphar.2016.00111	journal	April 2016
Developmental Pharmacokinetics in Pediatric Populations Lu, Hong; Rosenbaum, Sara The Journal of Pediatric Pharmacology and Therapeutics, Vol. 19, Issue 4 https://doi.org/10.5863/1551-6776-19.4.262	journal	October 2014

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