Metabolic model guided strain design of cyanobacteria
Abstract
Cyanobacteria are oxygenic photoautotrophs that serve as potential platforms for the production of biochemicals from cheap and renewable raw materials – sunlight, water, and carbon dioxide. Systems level analysis of the metabolic network of these organisms could enable the successful engineering of these organisms for the enhanced production of target chemicals. Metabolic modeling techniques including both stoichiometric and kinetic modeling with a genome-wide coverage enable a global assessment of metabolic capabilities. Recent studies guided by such modeling techniques have engineered strains for the enhanced production of valuable chemicals such as ethanol, n-butanol, 1,3-propanediol, glycerol, limonene, and isoprene from CO2.
- Authors:
-
[2];
- Pennsylvania State Univ., University Park, PA (United States)
- Washington Univ., St. Louis, MO (United States)
- Publication Date:
- Research Org.:
- Washington Univ., St. Louis, MO (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1803770
- Alternate Identifier(s):
- OSTI ID: 1568904
- Grant/Contract Number:
- SC0019386
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Current Opinion in Biotechnology
- Additional Journal Information:
- Journal Volume: 64; Journal ID: ISSN 0958-1669
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Hendry, John I., Bandyopadhyay, Anindita, Srinivasan, Shyam, Pakrasi, Himadri B., and Maranas, Costas D. Metabolic model guided strain design of cyanobacteria. United States: N. p., 2019.
Web. doi:10.1016/j.copbio.2019.08.011.
Hendry, John I., Bandyopadhyay, Anindita, Srinivasan, Shyam, Pakrasi, Himadri B., & Maranas, Costas D. Metabolic model guided strain design of cyanobacteria. United States. https://doi.org/10.1016/j.copbio.2019.08.011
Hendry, John I., Bandyopadhyay, Anindita, Srinivasan, Shyam, Pakrasi, Himadri B., and Maranas, Costas D. Wed .
"Metabolic model guided strain design of cyanobacteria". United States. https://doi.org/10.1016/j.copbio.2019.08.011. https://www.osti.gov/servlets/purl/1803770.
@article{osti_1803770,
title = {Metabolic model guided strain design of cyanobacteria},
author = {Hendry, John I. and Bandyopadhyay, Anindita and Srinivasan, Shyam and Pakrasi, Himadri B. and Maranas, Costas D.},
abstractNote = {Cyanobacteria are oxygenic photoautotrophs that serve as potential platforms for the production of biochemicals from cheap and renewable raw materials – sunlight, water, and carbon dioxide. Systems level analysis of the metabolic network of these organisms could enable the successful engineering of these organisms for the enhanced production of target chemicals. Metabolic modeling techniques including both stoichiometric and kinetic modeling with a genome-wide coverage enable a global assessment of metabolic capabilities. Recent studies guided by such modeling techniques have engineered strains for the enhanced production of valuable chemicals such as ethanol, n-butanol, 1,3-propanediol, glycerol, limonene, and isoprene from CO2.},
doi = {10.1016/j.copbio.2019.08.011},
journal = {Current Opinion in Biotechnology},
number = ,
volume = 64,
place = {United States},
year = {Wed Oct 02 00:00:00 EDT 2019},
month = {Wed Oct 02 00:00:00 EDT 2019}
}
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