Differentially Expressed MiRNAs and tRNA Genes Affect Host Homeostasis During Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infections in Young Pigs
Abstract
Porcine respiratory and reproductive syndrome virus (PRRSV) is a single-stranded RNA virus member that infects pigs and causes losses to the commercial industry reaching upward of a billion dollars annually in combined direct and indirect costs. The virus can be separated into etiologies that contain multiple heterologous low and highly pathogenic strains. Recently, the United States has begun to see an increase in heterologous type 2 PRRSV strains of higher virulence (HP-PRRSV). The high pathogenicity of these strains can drastically alter host immune responses and the ability of the animal to maintain homeostasis. Because the loss of host homeostasis can denote underlying changes in gene and regulatory element expression profiles, the study aimed to examine the effect PRRSV infections has on miRNA and tRNA expression and the roles they play in host tolerance or susceptibility.
- Authors:
- Publication Date:
- Research Org.:
- Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE; USDA
- OSTI Identifier:
- 1567972
- Alternate Identifier(s):
- OSTI ID: 1580699
- Grant/Contract Number:
- AC05-06OR23100; 2013-67015-21236; 2015-67015-23216
- Resource Type:
- Published Article
- Journal Name:
- Frontiers in Genetics
- Additional Journal Information:
- Journal Name: Frontiers in Genetics Journal Volume: 10; Journal ID: ISSN 1664-8021
- Publisher:
- Frontiers
- Country of Publication:
- Switzerland
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; miRNA—microRNA; tRNA; differential gene expression; porcine reproductive and respiratory syndrome virus; whole blood; pigs (Sus scrofa)
Citation Formats
Fleming, Damarius S., and Miller, Laura C. Differentially Expressed MiRNAs and tRNA Genes Affect Host Homeostasis During Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infections in Young Pigs. Switzerland: N. p., 2019.
Web. doi:10.3389/fgene.2019.00691.
Fleming, Damarius S., & Miller, Laura C. Differentially Expressed MiRNAs and tRNA Genes Affect Host Homeostasis During Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infections in Young Pigs. Switzerland. doi:10.3389/fgene.2019.00691.
Fleming, Damarius S., and Miller, Laura C. Fri .
"Differentially Expressed MiRNAs and tRNA Genes Affect Host Homeostasis During Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infections in Young Pigs". Switzerland. doi:10.3389/fgene.2019.00691.
@article{osti_1567972,
title = {Differentially Expressed MiRNAs and tRNA Genes Affect Host Homeostasis During Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infections in Young Pigs},
author = {Fleming, Damarius S. and Miller, Laura C.},
abstractNote = {Porcine respiratory and reproductive syndrome virus (PRRSV) is a single-stranded RNA virus member that infects pigs and causes losses to the commercial industry reaching upward of a billion dollars annually in combined direct and indirect costs. The virus can be separated into etiologies that contain multiple heterologous low and highly pathogenic strains. Recently, the United States has begun to see an increase in heterologous type 2 PRRSV strains of higher virulence (HP-PRRSV). The high pathogenicity of these strains can drastically alter host immune responses and the ability of the animal to maintain homeostasis. Because the loss of host homeostasis can denote underlying changes in gene and regulatory element expression profiles, the study aimed to examine the effect PRRSV infections has on miRNA and tRNA expression and the roles they play in host tolerance or susceptibility.},
doi = {10.3389/fgene.2019.00691},
journal = {Frontiers in Genetics},
number = ,
volume = 10,
place = {Switzerland},
year = {2019},
month = {8}
}
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DOI: 10.3389/fgene.2019.00691
DOI: 10.3389/fgene.2019.00691
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