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Title: Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo

Abstract

Metastatic cancer cells differ from their non-metastatic counterparts not only in terms of molecular composition and genetics, but also by the very strategy they employ for locomotion. Here, we analyzed large-scale statistics for cells migrating on linear microtracks to show that metastatic cancer cells follow a qualitatively different movement strategy than their non-invasive counterparts. The trajectories of metastatic cells display clusters of small steps that are interspersed with long “flights”. Such movements are characterized by heavy-tailed, truncated power law distributions of persistence times and are consistent with the Lévy walks that are also often employed by animal predators searching for scarce prey or food sources. In contrast, non-metastatic cancerous cells perform simple diffusive movements. These findings are supported by preliminary experiments with cancer cells migrating away from primary tumors in vivo. The use of chemical inhibitors targeting actin-binding proteins allows for “reprogramming” the Lévy walks into either diffusive or ballistic movements.

Authors:
 [1];  [2];  [3];  [4];  [5];  [1];  [6];  [1];  [4];  [7];  [1];  [1];  [1];  [1];  [2];  [8];  [5]; ORCiD logo [5]
  1. Northwestern Univ., Evanston, IL (United States)
  2. Radboud Univ. Medical Centre, Nijmegen (Netherlands); Univ. of Texas MD Cancer Genomics Center, Houston, TX (United States)
  3. Radboud Univ. Medical Centre, Nijmegen (Netherlands)
  4. Polish Academy of Sciences, Poznań (Poland)
  5. Ulsan National Inst. of Science and Technology (UNIST) (South Korea)
  6. Aichi Univ. (Japan)
  7. Adam Mickiewicz Univ., Poznań (Poland)
  8. Forsyth Inst., Cambridge, MA (United States)
Publication Date:
Research Org.:
Energy Frontier Research Centers (EFRC) (United States). Center for Bio-Inspired Energy Science (CBES); Northwestern Univ., Evanston, IL (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES); National Institutes of Health (NIH)
OSTI Identifier:
1566603
Grant/Contract Number:  
SC0000989
Resource Type:
Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 9; Journal Issue: 1; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; catalysis (homogeneous); solar (photovoltaic); bio-inspired; charge transport; mesostructured materials; materials and chemistry by design; synthesis (novel materials); synthesis (self-assembly)

Citation Formats

Huda, Sabil, Weigelin, Bettina, Wolf, Katarina, Tretiakov, Konstantin V., Polev, Konstantin, Wilk, Gary, Iwasa, Masatomo, Emami, Fateme S., Narojczyk, Jakub W., Banaszak, Michal, Soh, Siowling, Pilans, Didzis, Vahid, Amir, Makurath, Monika, Friedl, Peter, Borisy, Gary G., Kandere-Grzybowska, Kristiana, and Grzybowski, Bartosz A. Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo. United States: N. p., 2018. Web. doi:10.1038/s41467-018-06563-w.
Huda, Sabil, Weigelin, Bettina, Wolf, Katarina, Tretiakov, Konstantin V., Polev, Konstantin, Wilk, Gary, Iwasa, Masatomo, Emami, Fateme S., Narojczyk, Jakub W., Banaszak, Michal, Soh, Siowling, Pilans, Didzis, Vahid, Amir, Makurath, Monika, Friedl, Peter, Borisy, Gary G., Kandere-Grzybowska, Kristiana, & Grzybowski, Bartosz A. Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo. United States. doi:10.1038/s41467-018-06563-w.
Huda, Sabil, Weigelin, Bettina, Wolf, Katarina, Tretiakov, Konstantin V., Polev, Konstantin, Wilk, Gary, Iwasa, Masatomo, Emami, Fateme S., Narojczyk, Jakub W., Banaszak, Michal, Soh, Siowling, Pilans, Didzis, Vahid, Amir, Makurath, Monika, Friedl, Peter, Borisy, Gary G., Kandere-Grzybowska, Kristiana, and Grzybowski, Bartosz A. Wed . "Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo". United States. doi:10.1038/s41467-018-06563-w. https://www.osti.gov/servlets/purl/1566603.
@article{osti_1566603,
title = {Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo},
author = {Huda, Sabil and Weigelin, Bettina and Wolf, Katarina and Tretiakov, Konstantin V. and Polev, Konstantin and Wilk, Gary and Iwasa, Masatomo and Emami, Fateme S. and Narojczyk, Jakub W. and Banaszak, Michal and Soh, Siowling and Pilans, Didzis and Vahid, Amir and Makurath, Monika and Friedl, Peter and Borisy, Gary G. and Kandere-Grzybowska, Kristiana and Grzybowski, Bartosz A.},
abstractNote = {Metastatic cancer cells differ from their non-metastatic counterparts not only in terms of molecular composition and genetics, but also by the very strategy they employ for locomotion. Here, we analyzed large-scale statistics for cells migrating on linear microtracks to show that metastatic cancer cells follow a qualitatively different movement strategy than their non-invasive counterparts. The trajectories of metastatic cells display clusters of small steps that are interspersed with long “flights”. Such movements are characterized by heavy-tailed, truncated power law distributions of persistence times and are consistent with the Lévy walks that are also often employed by animal predators searching for scarce prey or food sources. In contrast, non-metastatic cancerous cells perform simple diffusive movements. These findings are supported by preliminary experiments with cancer cells migrating away from primary tumors in vivo. The use of chemical inhibitors targeting actin-binding proteins allows for “reprogramming” the Lévy walks into either diffusive or ballistic movements.},
doi = {10.1038/s41467-018-06563-w},
journal = {Nature Communications},
number = 1,
volume = 9,
place = {United States},
year = {2018},
month = {10}
}

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