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Title: Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies

Abstract

Abstract Background Tobacco and alcohol are well-established risk factors for numerous cancers, yet their relationship to biliary tract cancers remains unclear. Methods We pooled data from 26 prospective studies to evaluate associations of cigarette smoking and alcohol consumption with biliary tract cancer risk. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for associations with smoking and alcohol consumption were calculated. Random-effects meta-analysis produced summary estimates. All statistical tests were two-sided. Results Over a period of 38 369 156 person-years of follow-up, 1391 gallbladder, 758 intrahepatic bile duct, 1208 extrahepatic bile duct, and 623 ampulla of Vater cancer cases were identified. Ever, former, and current smoking were associated with increased extrahepatic bile duct and ampulla of Vater cancers risk (eg, current vs never smokers HR = 1.69, 95% CI = 1.34 to 2.13 and 2.22, 95% CI = 1.69 to 2.92, respectively), with dose-response effects for smoking pack-years, duration, and intensity (all Ptrend < .01). Current smoking and smoking intensity were also associated with intrahepatic bile duct cancer (eg, >40 cigarettes per day vs never smokers HR = 2.15, 95 % CI = 1.15 to 4.00; Ptrend = .001). No convincing association was observed between smoking and gallbladder cancer. Alcohol consumption was only associated with intrahepaticmore » bile duct cancer, with increased risk for individuals consuming five or more vs zero drinks per day (HR = 2.35, 95%CI = 1.46 to 3.78; Ptrend = .04). There was evidence of statistical heterogeneity among several cancer sites, particularly between gallbladder cancer and the other biliary tract cancers. Conclusions Smoking appears to increase the risk of developing all biliary tract cancers except gallbladder cancer. Alcohol may increase the risk of intrahepatic bile duct cancer. Findings highlight etiologic heterogeneity across the biliary tract.« less

Authors:
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  1. See the Notes section for the full list of authors’ affiliations
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1564293
Grant/Contract Number:  
HS0000031
Resource Type:
Published Article
Journal Name:
JNCI, Journal of the National Cancer Institute
Additional Journal Information:
Journal Name: JNCI, Journal of the National Cancer Institute; Journal ID: ISSN 0027-8874
Publisher:
Oxford University Press
Country of Publication:
United States
Language:
English

Citation Formats

McGee, Emma E., Jackson, Sarah S., Petrick, Jessica L., Van Dyke, Alison L., Adami, Hans-Olov, Albanes, Demetrius, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Chan, Andrew T., Chen, Yu, Fraser, Gary E., Freedman, Neal D., Gao, Yu-Tang, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Grant, Eric J., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kitahara, Cari M., Knutsen, Synnove F., Koh, Woon-Puay, Larsson, Susanna C., Lee, I-Min, Liao, Linda M., Luo, Juhua, Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O’Brien, Katie M., Peters, Ulrike, Poynter, Jenny N., Purdue, Mark P., Robien, Kim, Sandler, Dale P., Sawada, Norie, Schairer, Catherine, Sesso, Howard D., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Wang, Renwei, Weiderpass, Elisabete, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, Zhu, Bin, McGlynn, Katherine A., Campbell, Peter T., and Koshiol, Jill. Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies. United States: N. p., 2019. Web. doi:10.1093/jnci/djz103.
McGee, Emma E., Jackson, Sarah S., Petrick, Jessica L., Van Dyke, Alison L., Adami, Hans-Olov, Albanes, Demetrius, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Chan, Andrew T., Chen, Yu, Fraser, Gary E., Freedman, Neal D., Gao, Yu-Tang, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Grant, Eric J., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kitahara, Cari M., Knutsen, Synnove F., Koh, Woon-Puay, Larsson, Susanna C., Lee, I-Min, Liao, Linda M., Luo, Juhua, Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O’Brien, Katie M., Peters, Ulrike, Poynter, Jenny N., Purdue, Mark P., Robien, Kim, Sandler, Dale P., Sawada, Norie, Schairer, Catherine, Sesso, Howard D., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Wang, Renwei, Weiderpass, Elisabete, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, Zhu, Bin, McGlynn, Katherine A., Campbell, Peter T., & Koshiol, Jill. Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies. United States. doi:10.1093/jnci/djz103.
McGee, Emma E., Jackson, Sarah S., Petrick, Jessica L., Van Dyke, Alison L., Adami, Hans-Olov, Albanes, Demetrius, Andreotti, Gabriella, Beane-Freeman, Laura E., de Gonzalez, Amy Berrington, Buring, Julie E., Chan, Andrew T., Chen, Yu, Fraser, Gary E., Freedman, Neal D., Gao, Yu-Tang, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Grant, Eric J., Grodstein, Francine, Hartge, Patricia, Jenab, Mazda, Kitahara, Cari M., Knutsen, Synnove F., Koh, Woon-Puay, Larsson, Susanna C., Lee, I-Min, Liao, Linda M., Luo, Juhua, Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., O’Brien, Katie M., Peters, Ulrike, Poynter, Jenny N., Purdue, Mark P., Robien, Kim, Sandler, Dale P., Sawada, Norie, Schairer, Catherine, Sesso, Howard D., Simon, Tracey G., Sinha, Rashmi, Stolzenberg-Solomon, Rachael, Tsugane, Shoichiro, Wang, Renwei, Weiderpass, Elisabete, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Zhang, Xuehong, Zhu, Bin, McGlynn, Katherine A., Campbell, Peter T., and Koshiol, Jill. Sat . "Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies". United States. doi:10.1093/jnci/djz103.
@article{osti_1564293,
title = {Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies},
author = {McGee, Emma E. and Jackson, Sarah S. and Petrick, Jessica L. and Van Dyke, Alison L. and Adami, Hans-Olov and Albanes, Demetrius and Andreotti, Gabriella and Beane-Freeman, Laura E. and de Gonzalez, Amy Berrington and Buring, Julie E. and Chan, Andrew T. and Chen, Yu and Fraser, Gary E. and Freedman, Neal D. and Gao, Yu-Tang and Gapstur, Susan M. and Gaziano, J. Michael and Giles, Graham G. and Grant, Eric J. and Grodstein, Francine and Hartge, Patricia and Jenab, Mazda and Kitahara, Cari M. and Knutsen, Synnove F. and Koh, Woon-Puay and Larsson, Susanna C. and Lee, I-Min and Liao, Linda M. and Luo, Juhua and Milne, Roger L. and Monroe, Kristine R. and Neuhouser, Marian L. and O’Brien, Katie M. and Peters, Ulrike and Poynter, Jenny N. and Purdue, Mark P. and Robien, Kim and Sandler, Dale P. and Sawada, Norie and Schairer, Catherine and Sesso, Howard D. and Simon, Tracey G. and Sinha, Rashmi and Stolzenberg-Solomon, Rachael and Tsugane, Shoichiro and Wang, Renwei and Weiderpass, Elisabete and Weinstein, Stephanie J. and White, Emily and Wolk, Alicja and Yuan, Jian-Min and Zeleniuch-Jacquotte, Anne and Zhang, Xuehong and Zhu, Bin and McGlynn, Katherine A. and Campbell, Peter T. and Koshiol, Jill},
abstractNote = {Abstract Background Tobacco and alcohol are well-established risk factors for numerous cancers, yet their relationship to biliary tract cancers remains unclear. Methods We pooled data from 26 prospective studies to evaluate associations of cigarette smoking and alcohol consumption with biliary tract cancer risk. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for associations with smoking and alcohol consumption were calculated. Random-effects meta-analysis produced summary estimates. All statistical tests were two-sided. Results Over a period of 38 369 156 person-years of follow-up, 1391 gallbladder, 758 intrahepatic bile duct, 1208 extrahepatic bile duct, and 623 ampulla of Vater cancer cases were identified. Ever, former, and current smoking were associated with increased extrahepatic bile duct and ampulla of Vater cancers risk (eg, current vs never smokers HR = 1.69, 95% CI = 1.34 to 2.13 and 2.22, 95% CI = 1.69 to 2.92, respectively), with dose-response effects for smoking pack-years, duration, and intensity (all Ptrend < .01). Current smoking and smoking intensity were also associated with intrahepatic bile duct cancer (eg, >40 cigarettes per day vs never smokers HR = 2.15, 95 % CI = 1.15 to 4.00; Ptrend = .001). No convincing association was observed between smoking and gallbladder cancer. Alcohol consumption was only associated with intrahepatic bile duct cancer, with increased risk for individuals consuming five or more vs zero drinks per day (HR = 2.35, 95%CI = 1.46 to 3.78; Ptrend = .04). There was evidence of statistical heterogeneity among several cancer sites, particularly between gallbladder cancer and the other biliary tract cancers. Conclusions Smoking appears to increase the risk of developing all biliary tract cancers except gallbladder cancer. Alcohol may increase the risk of intrahepatic bile duct cancer. Findings highlight etiologic heterogeneity across the biliary tract.},
doi = {10.1093/jnci/djz103},
journal = {JNCI, Journal of the National Cancer Institute},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {5}
}

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