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Title: One-pot synthesis of high molar activity 6-[ 18 F]fluoro- l -DOPA by Cu-mediated fluorination of a BPin precursor

Abstract

A one-pot two-step synthesis of 6-[ 18 F]fluoro- l -DOPA has been developed, involving Cu-mediated radiofluorination of the corresponding pinacol boronate ester precursor, and validated for production of doses for human use.

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [1]; ORCiD logo [3]; ORCiD logo [3];  [2];  [1];  [4]; ORCiD logo [3]; ORCiD logo [2]
  1. Department of Radiology, University of Michigan, Ann Arbor, USA
  2. Department of Radiology, University of Michigan, Ann Arbor, USA, Department of Medicinal Chemistry
  3. Department of Chemistry, University of Michigan, Ann Arbor, USA
  4. AbbVie Translational Imaging, North Chicago, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1562735
Grant/Contract Number:  
SC0012484
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Organic and Biomolecular Chemistry
Additional Journal Information:
Journal Name: Organic and Biomolecular Chemistry Journal Volume: 17 Journal Issue: 38; Journal ID: ISSN 1477-0520
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Mossine, Andrew V., Tanzey, Sean S., Brooks, Allen F., Makaravage, Katarina J., Ichiishi, Naoko, Miller, Jason M., Henderson, Bradford D., Skaddan, Marc B., Sanford, Melanie S., and Scott, Peter J. H. One-pot synthesis of high molar activity 6-[ 18 F]fluoro- l -DOPA by Cu-mediated fluorination of a BPin precursor. United Kingdom: N. p., 2019. Web. doi:10.1039/C9OB01758E.
Mossine, Andrew V., Tanzey, Sean S., Brooks, Allen F., Makaravage, Katarina J., Ichiishi, Naoko, Miller, Jason M., Henderson, Bradford D., Skaddan, Marc B., Sanford, Melanie S., & Scott, Peter J. H. One-pot synthesis of high molar activity 6-[ 18 F]fluoro- l -DOPA by Cu-mediated fluorination of a BPin precursor. United Kingdom. doi:10.1039/C9OB01758E.
Mossine, Andrew V., Tanzey, Sean S., Brooks, Allen F., Makaravage, Katarina J., Ichiishi, Naoko, Miller, Jason M., Henderson, Bradford D., Skaddan, Marc B., Sanford, Melanie S., and Scott, Peter J. H. Wed . "One-pot synthesis of high molar activity 6-[ 18 F]fluoro- l -DOPA by Cu-mediated fluorination of a BPin precursor". United Kingdom. doi:10.1039/C9OB01758E.
@article{osti_1562735,
title = {One-pot synthesis of high molar activity 6-[ 18 F]fluoro- l -DOPA by Cu-mediated fluorination of a BPin precursor},
author = {Mossine, Andrew V. and Tanzey, Sean S. and Brooks, Allen F. and Makaravage, Katarina J. and Ichiishi, Naoko and Miller, Jason M. and Henderson, Bradford D. and Skaddan, Marc B. and Sanford, Melanie S. and Scott, Peter J. H.},
abstractNote = {A one-pot two-step synthesis of 6-[ 18 F]fluoro- l -DOPA has been developed, involving Cu-mediated radiofluorination of the corresponding pinacol boronate ester precursor, and validated for production of doses for human use.},
doi = {10.1039/C9OB01758E},
journal = {Organic and Biomolecular Chemistry},
number = 38,
volume = 17,
place = {United Kingdom},
year = {2019},
month = {10}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1039/C9OB01758E

Citation Metrics:
Cited by: 6 works
Citation information provided by
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