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Title: Thermodynamic analysis of a MEMS based differential scanning calorimeter model

Abstract

Thin film based differential scanning calorimeter (DSC) was developed and utilized for the study of phase-transition kinetics in protein samples. In this paper, we proposed a MEMS based DSC model. The distance between the sample and reference cell was optimized based on the thermal analysis result. The influence of the response time to the shape of the DSC thermograms and the transition temperature was also studied systematically. Meanwhile, Lumry-Eyring model was used to investigate the relationship between the scanning rate and the transition temperature. The modeling result was verified by the lysozyme denaturation tests. This study provided a pathway for the optimization of MEMS based DSC array and the correction of the DSC thermograms.

Authors:
ORCiD logo [1];  [1];  [1];  [2];  [1]
+ Show Author Affiliations
  1. Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States)
  2. Brookhaven National Lab. (BNL), Upton, NY (United States). Center for Functional Nanomaterials (CFN)
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1562478
Report Number(s):
BNL-212086-2019-JAAM
Journal ID: ISSN 0924-4247; TRN: US2000718
Grant/Contract Number:  
SC0012704
Resource Type:
Accepted Manuscript
Journal Name:
Sensors and Actuators. A, Physical
Additional Journal Information:
Journal Volume: 291; Journal Issue: C; Journal ID: ISSN 0924-4247
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; calorimeter; response time; transition temperature; scanning ratae

Citation Formats

Yu, Shifeng, Wu, Yongjia, Wang, Shuyu, Lu, Ming, and Zuo, Lei. Thermodynamic analysis of a MEMS based differential scanning calorimeter model. United States: N. p., 2019. Web. doi:10.1016/j.sna.2019.04.001.
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Yu, Shifeng, Wu, Yongjia, Wang, Shuyu, Lu, Ming, & Zuo, Lei. Thermodynamic analysis of a MEMS based differential scanning calorimeter model. United States. https://doi.org/10.1016/j.sna.2019.04.001
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Yu, Shifeng, Wu, Yongjia, Wang, Shuyu, Lu, Ming, and Zuo, Lei. Wed . "Thermodynamic analysis of a MEMS based differential scanning calorimeter model". United States. https://doi.org/10.1016/j.sna.2019.04.001. https://www.osti.gov/servlets/purl/1562478.
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@article{osti_1562478,
title = {Thermodynamic analysis of a MEMS based differential scanning calorimeter model},
author = {Yu, Shifeng and Wu, Yongjia and Wang, Shuyu and Lu, Ming and Zuo, Lei},
abstractNote = {Thin film based differential scanning calorimeter (DSC) was developed and utilized for the study of phase-transition kinetics in protein samples. In this paper, we proposed a MEMS based DSC model. The distance between the sample and reference cell was optimized based on the thermal analysis result. The influence of the response time to the shape of the DSC thermograms and the transition temperature was also studied systematically. Meanwhile, Lumry-Eyring model was used to investigate the relationship between the scanning rate and the transition temperature. The modeling result was verified by the lysozyme denaturation tests. This study provided a pathway for the optimization of MEMS based DSC array and the correction of the DSC thermograms.},
doi = {10.1016/j.sna.2019.04.001},
journal = {Sensors and Actuators. A, Physical},
number = C,
volume = 291,
place = {United States},
year = {Wed Apr 03 00:00:00 EDT 2019},
month = {Wed Apr 03 00:00:00 EDT 2019}
}
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https://doi.org/10.1016/j.sna.2019.04.001
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    Works referencing / citing this record:

    Nanocalorimeters for biomolecular analysis and cell metabolism monitoring
    journal, January 2020

    • Wang, Shuyu; Sha, Xiaopeng; Yu, Shifeng
    • Biomicrofluidics, Vol. 14, Issue 1
    • DOI: 10.1063/1.5134870
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