Epigenetic silencing of a multifunctional plant stress regulator

Zander, Mark; Willige, Björn C.; He, Yupeng; Nguyen, Thu A.; Langford, Amber E.; Nehring, Ramlah; Howell, Elizabeth; McGrath, Robert; Bartlett, Anna; Castanon, Rosa; Nery, Joseph R.; Chen, Huaming; Zhang, Zhuzhu; Jupe, Florian; Stepanova, Anna; Schmitz, Robert J.; Lewsey, Mathew G.; Chory, Joanne; Ecker, Joseph R.

doi:10.7554/eLife.47835

Title: Epigenetic silencing of a multifunctional plant stress regulator

Journal Article · 15 August 2019 · eLife

DOI: https://doi.org/10.7554/eLife.47835 · OSTI ID:1560888

^[1];

^[2];

^[3]; Nguyen, Thu A. ^[2];

^[2]; Nehring, Ramlah ^[2]; Howell, Elizabeth ^[2];

^[4]; Bartlett, Anna ^[3]; Castanon, Rosa ^[3]; Nery, Joseph R. ^[3];

^[3]; Zhang, Zhuzhu ^[3];

^[3]; Stepanova, Anna ^[2];

^[2];

^[2]; Chory, Joanne ^[5];

^[1]

Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, United States, Genomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, United States, Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, United States
Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, United States
Genomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, United States
Department of Biology, University of Pennsylvania, Philadelphia, United States
Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, United States, Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, United States

The central regulator of the ethylene (ET) signaling pathway, which controls a plethora of developmental programs and responses to environmental cues in plants, is ETHYLENE-INSENSITIVE2 (EIN2). Here we identify a chromatin-dependent regulatory mechanism at EIN2 requiring two genes: ETHYLENE-INSENSITIVE6 (EIN6), which is a H3K27me3 demethylase also known as RELATIVE OF EARLY FLOWERING6 (REF6), and EIN6 ENHANCER (EEN), the Arabidopsis homolog of the yeast INO80 chromatin remodeling complex subunit IES6 (INO EIGHTY SUBUNIT). Strikingly, EIN6 (REF6) and the INO80 complex redundantly control the level and the localization of the repressive histone modification H3K27me3 and the histone variant H2A.Z at the 5’ untranslated region (5’UTR) intron of EIN2. Concomitant loss of EIN6 (REF6) and the INO80 complex shifts the chromatin landscape at EIN2 to a repressive state causing a dramatic reduction of EIN2 expression. These results uncover a unique type of chromatin regulation which safeguards the expression of an essential multifunctional plant stress regulator.

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Research Organization:: Salk Institute for Biological Studies, San Diego, CA (United States)

Sponsoring Organization:: National Institute of Health (NIH); USDOE Office of Science (SC)

Grant/Contract Number:: FG02-04ER15517

OSTI ID:: 1560888

Journal Information:: eLife, Journal Name: eLife Vol. 8; ISSN 2050-084X

Publisher:: eLife Sciences Publications, Ltd.Copyright Statement

Country of Publication:: United States

Language:: English

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