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Title: Roles of the immune system in cancer: from tumor initiation to metastatic progression

Abstract

The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here in this paper, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas.

Authors:
 [1];  [1]; ORCiD logo [1]
  1. Univ. of California, San Francisco, CA (United States). Helen Diller Family Comprehensive Cancer Center, Dept. of Anatomy
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1560566
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
Genes & Development
Additional Journal Information:
Journal Volume: 32; Journal Issue: 19-20; Journal ID: ISSN 0890-9369
Publisher:
Cold Springs Harbor Laboratory Press
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; disseminated tumor cells; tumor-associated macrophages; metastasis-associated immune cells; patient-derived xenograft; immune cross-talk; cancer heterogeneity

Citation Formats

Gonzalez, Hugo, Hagerling, Catharina, and Werb, Zena. Roles of the immune system in cancer: from tumor initiation to metastatic progression. United States: N. p., 2018. Web. doi:10.1101/gad.314617.118.
Gonzalez, Hugo, Hagerling, Catharina, & Werb, Zena. Roles of the immune system in cancer: from tumor initiation to metastatic progression. United States. doi:10.1101/gad.314617.118.
Gonzalez, Hugo, Hagerling, Catharina, and Werb, Zena. Mon . "Roles of the immune system in cancer: from tumor initiation to metastatic progression". United States. doi:10.1101/gad.314617.118. https://www.osti.gov/servlets/purl/1560566.
@article{osti_1560566,
title = {Roles of the immune system in cancer: from tumor initiation to metastatic progression},
author = {Gonzalez, Hugo and Hagerling, Catharina and Werb, Zena},
abstractNote = {The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here in this paper, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas.},
doi = {10.1101/gad.314617.118},
journal = {Genes & Development},
number = 19-20,
volume = 32,
place = {United States},
year = {2018},
month = {10}
}

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    Randomized Trial of Autologous Cellular Immunotherapy with Sipuleucel-T in Androgen-Dependent Prostate Cancer
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    Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer
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    Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
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    IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia
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    Myeloid-Derived Suppressor Cells
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    Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
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    • Journal of Clinical Investigation, Vol. 122, Issue 9
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    From mice to humans: developments in cancer immunoediting
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    • Journal of Clinical Investigation, Vol. 125, Issue 9
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    Origin of the vasculature supporting growth of primary patient tumor xenografts
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    • Journal of Translational Medicine, Vol. 11, Issue 1
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    Long-Term Survival for Patients With Non–Small-Cell Lung Cancer With Intratumoral Lymphoid Structures
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    Characteristics of circulating tumor cells in organ metastases, prognosis, and T lymphocyte mediated immune response
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    Infiltration of γ⁢δ T cells, IL-17+ T cells and FoxP3+ T cells in human breast cancer
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    Cancer Statistics, 2008
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    Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance
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    • Frontiers in Oncology, Vol. 9
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    Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies
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    Dendritic Cell-Specific ICAM-3–Grabbing Nonintegrin Expression on M2-Polarized and Tumor-Associated Macrophages Is Macrophage-CSF Dependent and Enhanced by Tumor-Derived IL-6 and IL-10
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    Tumor-Infiltrating Dendritic Cells in Cancer Pathogenesis
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    Dendritic Cell–Based Cancer Vaccines
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    Missing Self, NK Cells, and The White Album
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    The Generation and Application of Patient-Derived Xenograft Model for Cancer Research
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    Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance
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    • Frontiers in Oncology, Vol. 9
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    Emerging Biomimetic Materials for Studying Tumor and Immune Cell Behavior
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    Tumour-infiltrating cytotoxic T lymphocytes in somatotroph pituitary neuroendocrine tumours
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    Prognostic value of peripheral blood natural killer cells in colorectal cancer
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    Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-α
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    NF-kappa B Signaling-Related Signatures Are Connected with the Mesenchymal Phenotype of Circulating Tumor Cells in Non-Metastatic Breast Cancer
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    Active immunotherapy of cancer: An overview of therapeutic vaccines [Aktivna imunoterapija malignih tumora - pregled terapijskih vakcina]
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