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Title: Roles of the immune system in cancer: from tumor initiation to metastatic progression


The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here in this paper, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas.

 [1];  [1]; ORCiD logo [1]
  1. Univ. of California, San Francisco, CA (United States). Helen Diller Family Comprehensive Cancer Center, Dept. of Anatomy
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
Grant/Contract Number:  
Resource Type:
Accepted Manuscript
Journal Name:
Genes & Development
Additional Journal Information:
Journal Volume: 32; Journal Issue: 19-20; Journal ID: ISSN 0890-9369
Cold Springs Harbor Laboratory Press
Country of Publication:
United States
59 BASIC BIOLOGICAL SCIENCES; disseminated tumor cells; tumor-associated macrophages; metastasis-associated immune cells; patient-derived xenograft; immune cross-talk; cancer heterogeneity

Citation Formats

Gonzalez, Hugo, Hagerling, Catharina, and Werb, Zena. Roles of the immune system in cancer: from tumor initiation to metastatic progression. United States: N. p., 2018. Web. doi:10.1101/gad.314617.118.
Gonzalez, Hugo, Hagerling, Catharina, & Werb, Zena. Roles of the immune system in cancer: from tumor initiation to metastatic progression. United States.
Gonzalez, Hugo, Hagerling, Catharina, and Werb, Zena. Mon . "Roles of the immune system in cancer: from tumor initiation to metastatic progression". United States.
title = {Roles of the immune system in cancer: from tumor initiation to metastatic progression},
author = {Gonzalez, Hugo and Hagerling, Catharina and Werb, Zena},
abstractNote = {The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here in this paper, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas.},
doi = {10.1101/gad.314617.118},
journal = {Genes & Development},
number = 19-20,
volume = 32,
place = {United States},
year = {2018},
month = {10}

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