Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health
Abstract
Bacteriophages, or phages, are considered the most abundant entities on the planet, with their total numbers ranging from 1030 ± 1031 particles. Phages are known to play an important role in driving the evolution of their bacterial hosts, mostly via generalized and specialized transduction mechanisms. Phage therapy as a means to eliminate bacterial pathogens was used first in the 1920s; however, its use declined due to the advent of antibiotics in the 1940s. Eastern European countries have performed human trials for phage therapy for a century now, including a phage therapy trial in 1938 at the Eliava Institute of Bacteriophage in Georgia that successfully eliminated bacterial dysentery in 74% of the 219 cases by using a phage cocktail that targeted a wide range of causative agents for dysentery. Here, we present some of the major contributions of phage research to human health.
- Authors:
-
- Univ. of Connecticut, Storrs, CT (United States). Dept. of Molecular and Cell Biology
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC); National Institutes of Health (NIH)
- OSTI Identifier:
- 1560551
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS Pathogens
- Additional Journal Information:
- Journal Volume: 14; Journal Issue: 5; Journal ID: ISSN 1553-7374
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Asija, Kunica, and Teschke, Carolyn M. Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health. United States: N. p., 2018.
Web. doi:10.1371/journal.ppat.1006970.
Asija, Kunica, & Teschke, Carolyn M. Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health. United States. https://doi.org/10.1371/journal.ppat.1006970
Asija, Kunica, and Teschke, Carolyn M. Thu .
"Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health". United States. https://doi.org/10.1371/journal.ppat.1006970. https://www.osti.gov/servlets/purl/1560551.
@article{osti_1560551,
title = {Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health},
author = {Asija, Kunica and Teschke, Carolyn M.},
abstractNote = {Bacteriophages, or phages, are considered the most abundant entities on the planet, with their total numbers ranging from 1030 ± 1031 particles. Phages are known to play an important role in driving the evolution of their bacterial hosts, mostly via generalized and specialized transduction mechanisms. Phage therapy as a means to eliminate bacterial pathogens was used first in the 1920s; however, its use declined due to the advent of antibiotics in the 1940s. Eastern European countries have performed human trials for phage therapy for a century now, including a phage therapy trial in 1938 at the Eliava Institute of Bacteriophage in Georgia that successfully eliminated bacterial dysentery in 74% of the 219 cases by using a phage cocktail that targeted a wide range of causative agents for dysentery. Here, we present some of the major contributions of phage research to human health.},
doi = {10.1371/journal.ppat.1006970},
journal = {PLoS Pathogens},
number = 5,
volume = 14,
place = {United States},
year = {Thu May 17 00:00:00 EDT 2018},
month = {Thu May 17 00:00:00 EDT 2018}
}
Web of Science
Figures / Tables:
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