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Title: Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health

Abstract

Bacteriophages, or phages, are considered the most abundant entities on the planet, with their total numbers ranging from 10 30 ± 10 31 particles. Phages are known to play an important role in driving the evolution of their bacterial hosts, mostly via generalized and specialized transduction mechanisms. Phage therapy as a means to eliminate bacterial pathogens was used first in the 1920s; however, its use declined due to the advent of antibiotics in the 1940s. Eastern European countries have performed human trials for phage therapy for a century now, including a phage therapy trial in 1938 at the Eliava Institute of Bacteriophage in Georgia that successfully eliminated bacterial dysentery in 74% of the 219 cases by using a phage cocktail that targeted a wide range of causative agents for dysentery. Here, we present some of the major contributions of phage research to human health.

Authors:
ORCiD logo [1]; ORCiD logo [1]
  1. Univ. of Connecticut, Storrs, CT (United States). Dept. of Molecular and Cell Biology
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC); National Institutes of Health (NIH)
OSTI Identifier:
1560551
Grant/Contract Number:  
[AC02-05CH11231]
Resource Type:
Accepted Manuscript
Journal Name:
PLoS Pathogens
Additional Journal Information:
[ Journal Volume: 14; Journal Issue: 5]; Journal ID: ISSN 1553-7374
Publisher:
Public Library of Science
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Asija, Kunica, and Teschke, Carolyn M. Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health. United States: N. p., 2018. Web. doi:10.1371/journal.ppat.1006970.
Asija, Kunica, & Teschke, Carolyn M. Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health. United States. doi:10.1371/journal.ppat.1006970.
Asija, Kunica, and Teschke, Carolyn M. Thu . "Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health". United States. doi:10.1371/journal.ppat.1006970. https://www.osti.gov/servlets/purl/1560551.
@article{osti_1560551,
title = {Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health},
author = {Asija, Kunica and Teschke, Carolyn M.},
abstractNote = {Bacteriophages, or phages, are considered the most abundant entities on the planet, with their total numbers ranging from 1030 ± 1031 particles. Phages are known to play an important role in driving the evolution of their bacterial hosts, mostly via generalized and specialized transduction mechanisms. Phage therapy as a means to eliminate bacterial pathogens was used first in the 1920s; however, its use declined due to the advent of antibiotics in the 1940s. Eastern European countries have performed human trials for phage therapy for a century now, including a phage therapy trial in 1938 at the Eliava Institute of Bacteriophage in Georgia that successfully eliminated bacterial dysentery in 74% of the 219 cases by using a phage cocktail that targeted a wide range of causative agents for dysentery. Here, we present some of the major contributions of phage research to human health.},
doi = {10.1371/journal.ppat.1006970},
journal = {PLoS Pathogens},
number = [5],
volume = [14],
place = {United States},
year = {2018},
month = {5}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 3 works
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Figures / Tables:

Fig 1 Fig 1: (A) Coevolution of phage with bacterial hosts. Mechanisms of coevolution by phages and their bacterial hosts. (B) Effects of phages on human health. Phages can affect human health directly or can be used after genetic manipulation to affect disease outcomes. Cas, CRISPR-associated protein; CD, Crohn disease; CRISPR, clusteredmore » regularly interspaced short palindromic repeat; DISARM, defense island system associated with restriction-modification; IBD, irritable bowel disorder.« less

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    Figures / Tables found in this record:

      Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.