Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness

Jaiganesh, Avinash; De-la-Torre, Pedro; Patel, Aniket A.; Termine, Domenic J.; Velez-Cortes, Florencia; Chen, Conghui; Sotomayor, Marcos

doi:10.1016/j.str.2018.06.003

Title: Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness

Full Record
Other Related Research

Authors:

Jaiganesh, Avinash; De-la-Torre, Pedro; Patel, Aniket A.; Termine, Domenic J.; Velez-Cortes, Florencia; Chen, Conghui;

Publication Date:: Sat Sep 01 00:00:00 EDT 2018

Sponsoring Org.:: USDOE

OSTI Identifier:: 1560267

Grant/Contract Number:: AC02-06CH11357; GUP 40277; 49774

Resource Type:: Published Article

Journal Name:: Structure

Additional Journal Information:: Journal Name: Structure Journal Volume: 26 Journal Issue: 9; Journal ID: ISSN 0969-2126

Publisher:: Elsevier

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Jaiganesh, Avinash, De-la-Torre, Pedro, Patel, Aniket A., Termine, Domenic J., Velez-Cortes, Florencia, Chen, Conghui, and Sotomayor, Marcos. Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.  United Kingdom: N. p., 2018. 
Web.  doi:10.1016/j.str.2018.06.003.

Copy to clipboard


                    Jaiganesh, Avinash, De-la-Torre, Pedro, Patel, Aniket A., Termine, Domenic J., Velez-Cortes, Florencia, Chen, Conghui, & Sotomayor, Marcos. Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.  United Kingdom.  https://doi.org/10.1016/j.str.2018.06.003

Copy to clipboard


                    Jaiganesh, Avinash, De-la-Torre, Pedro, Patel, Aniket A., Termine, Domenic J., Velez-Cortes, Florencia, Chen, Conghui, and Sotomayor, Marcos. Sat .  
"Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness".  United Kingdom.  https://doi.org/10.1016/j.str.2018.06.003.

Copy to clipboard


                    
@article{osti_1560267,

  title        = {Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness},

  author       = {Jaiganesh, Avinash and De-la-Torre, Pedro and Patel, Aniket A. and Termine, Domenic J. and Velez-Cortes, Florencia and Chen, Conghui and Sotomayor, Marcos},

  abstractNote = {},

  doi          = {10.1016/j.str.2018.06.003},

  journal      = {Structure},

  number       = 9,

  volume       = 26,

  place        = {United Kingdom},

  year         = {Sat Sep 01 00:00:00 EDT 2018},

  month        = {Sat Sep 01 00:00:00 EDT 2018}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Publisher's Version of Record
https://doi.org/10.1016/j.str.2018.06.003

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 13 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness

Journal Article Jaiganesh, Avinash ; De-la-Torre, Pedro ; Patel, Aniket A. ; ... - Structure
https://doi.org/10.1016/j.str.2018.06.003
Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception

Journal Article Choudhary, Deepanshu ; Narui, Yoshie ; Neel, Brandon L. ; ... - Proceedings of the National Academy of Sciences of the United States of America

The vertebrate inner ear, responsible for hearing and balance, is able to sense minute mechanical stimuli originating from an extraordinarily broad range of sound frequencies and intensities or from head movements. Integral to these processes is the tip-link protein complex, which conveys force to open the inner-ear transduction channels that mediate sensory perception. Protocadherin-15 and cadherin-23, two atypically large cadherins with 11 and 27 extracellular cadherin (EC) repeats, are involved in deafness and balance disorders and assemble as parallel homodimers that interact to form the tip link. Here we report the X-ray crystal structure of a protocadherin-15 + cadherin-23 heterotetramericmore »« less
https://doi.org/10.1073/pnas.1920444117

Full Text Available
Structural Determinants of Cadherin-23 Function in Hearing and Deafness

Journal Article Sotomayor, M ; Weihofen, W ; Gaudet, R ; ... - Neuron
https://doi.org/10.1016/j.neuron.2010.03.028
Structural Determinants of Cadherin-23 Function in Hearing and Deafness

Journal Article Sotomayor, Marcos ; Weihofen, Wilhelm A ; Gaudet, Rachelle ; ... - Neuron

The hair-cell tip link, a fine filament directly conveying force to mechanosensitive transduction channels, is composed of two proteins, protocadherin-15 and cadherin-23, whose mutation causes deafness. However, their molecular structure, elasticity, and deafness-related structural defects are unknown. We present crystal structures of the first and second extracellular cadherin repeats of cadherin-23. Overall, structures show typical cadherin folds, but reveal an elongated N terminus that precludes classical cadherin interactions and contributes to an N-terminal Ca{sup 2+}-binding site. The deafness mutation D101G, in the linker region between the repeats, causes a slight bend between repeats and decreases Ca{sup 2+} affinity. Molecular dynamicsmore »« less
https://doi.org/10.1016/j.neuron.2010.03.028
A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15

Journal Article De-la-Torre, Pedro ; Choudhary, Deepanshu ; Araya-Secchi, Raul ; ... - Biophysical Journal
Cited by 10
https://doi.org/10.1016/j.bpj.2018.11.010

Similar Records