Absence of estrogen receptor beta leads to abnormal adipogenesis during early tendon healing by an up‐regulation of PPARγ signalling

doi:10.1111/jcmm.14604

Title: Absence of estrogen receptor beta leads to abnormal adipogenesis during early tendon healing by an up‐regulation of PPARγ signalling

Full Record
Other Related Research

Authors:

^[1]; Liu, Tianyao ^[2]; Zhou, Mei ^[1]; He, Gang ^[1]; Ma, Yuanyuan ^[2]; Shi, Youxing ^[1];

^[1]; Tang, Hong ^[1]; Kang, Xia ^[1]; Yang, Mingyu ^[1]; Gustafsson, Jan‐Åke ^[3]; Fan, Xiaotang ^[2]; Tang, Kanglai ^[1]

Department of Orthopedic Surgery Southwest Hospital, Army Medical University Chongqing China
Department of Developmental Neuropsychology, School of Psychology Third Military Medical University, Army Medical University Chongqing China
Center for Nuclear Receptors and Cell Signaling University of Houston Houston TX, Department of Biosciences and Nutrition, Center for Innovative Medicine Karolinska Institute Novum Sweden

Publication Date:: 2019-09-02

Sponsoring Org.:: USDOE Office of Electricity Delivery and Energy Reliability (OE), Power Systems Engineering Research and Development (R&D) (OE-10)

OSTI Identifier:: 1560237

Alternate Identifier(s):: OSTI ID: 1560238

Grant/Contract Number:: 2016YFC1100500

Resource Type:: Published Article

Journal Name:: Journal of Cellular and Molecular Medicine

Additional Journal Information:: Journal Name: Journal of Cellular and Molecular Medicine; Journal ID: ISSN 1582-1838

Publisher:: Wiley-Blackwell

Country of Publication:: Country unknown/Code not available

Language:: English

Citation Formats


                    Bian, Xuting, Liu, Tianyao, Zhou, Mei, He, Gang, Ma, Yuanyuan, Shi, Youxing, Wang, Yunjiao, Tang, Hong, Kang, Xia, Yang, Mingyu, Gustafsson, Jan‐Åke, Fan, Xiaotang, and Tang, Kanglai. Absence of estrogen receptor beta leads to abnormal adipogenesis during early tendon healing by an up‐regulation of PPARγ signalling.  Country unknown/Code not available: N. p., 2019. 
        Web.  doi:10.1111/jcmm.14604.

Copy to clipboard


                    Bian, Xuting, Liu, Tianyao, Zhou, Mei, He, Gang, Ma, Yuanyuan, Shi, Youxing, Wang, Yunjiao, Tang, Hong, Kang, Xia, Yang, Mingyu, Gustafsson, Jan‐Åke, Fan, Xiaotang, & Tang, Kanglai. Absence of estrogen receptor beta leads to abnormal adipogenesis during early tendon healing by an up‐regulation of PPARγ signalling.  Country unknown/Code not available.  doi:10.1111/jcmm.14604.

Copy to clipboard


                    Bian, Xuting, Liu, Tianyao, Zhou, Mei, He, Gang, Ma, Yuanyuan, Shi, Youxing, Wang, Yunjiao, Tang, Hong, Kang, Xia, Yang, Mingyu, Gustafsson, Jan‐Åke, Fan, Xiaotang, and Tang, Kanglai. Mon .  
        "Absence of estrogen receptor beta leads to abnormal adipogenesis during early tendon healing by an up‐regulation of PPARγ signalling".  Country unknown/Code not available.  doi:10.1111/jcmm.14604.

Copy to clipboard


                    
@article{osti_1560237,

  title        = {Absence of estrogen receptor beta leads to abnormal adipogenesis during early tendon healing by an up‐regulation of PPARγ signalling},

  author       = {Bian, Xuting and Liu, Tianyao and Zhou, Mei and He, Gang and Ma, Yuanyuan and Shi, Youxing and Wang, Yunjiao and Tang, Hong and Kang, Xia and Yang, Mingyu and Gustafsson, Jan‐Åke and Fan, Xiaotang and Tang, Kanglai},

  abstractNote = {},

  doi          = {10.1111/jcmm.14604},

  journal      = {Journal of Cellular and Molecular Medicine},

  number       = ,

  volume       = ,

  place        = {Country unknown/Code not available},

  year         = {2019},

  month        = {9}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Publisher's Version of Record
DOI: 10.1111/jcmm.14604

Other availability

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Absence of estrogen receptor beta leads to abnormal adipogenesis during early tendon healing by an up‐regulation of PPARγ signalling

Journal Article Bian, Xuting ; Liu, Tianyao ; Zhou, Mei ; ... - Journal of Cellular and Molecular Medicine
DOI: 10.1111/jcmm.14604
Up-regulation of PI3K/Akt signaling by 17{beta}-estradiol through activation of estrogen receptor-{alpha}, but not estrogen receptor-{beta}, and stimulates cell growth in breast cancer cells

Journal Article Lee, Young-Rae ; Park, Jinny ; Yu, Hong-Nu ; ... - Biochemical and Biophysical Research Communications

Estrogen stimulates cell proliferation in breast cancer. The biological effects of estrogen are mediated through two intracellular receptors, estrogen receptor-{alpha} (ER{alpha}) and estrogen receptor-{beta} (ER{beta}). However, the role of ERs in the proliferative action of estrogen is not well established. Recently, it has been known that ER activates phosphatidylinositol-3-OH kinase (PI3K) through binding with the p85 regulatory subunit of PI3K. Therefore, possible mechanisms may include ER-mediated phosphoinositide metabolism with subsequent formation of phosphatidylinositol-3,4,5-trisphosphate (PIP{sub 3}), which is generated from phosphatidylinositol 4,5-bisphosphate via PI3K activation. The present study demonstrates that 17{beta}-estradiol (E2) up-regulates PI3K in an ER{alpha}-dependent manner, but not ER{beta},more »« less
DOI: 10.1016/j.bbrc.2005.08.256
Estrogen-related receptor {alpha} modulates the expression of adipogenesis-related genes during adipocyte differentiation

Journal Article Ijichi, Nobuhiro ; Ikeda, Kazuhiro ; Horie-Inoue, Kuniko ; ... - Biochemical and Biophysical Research Communications

Estrogen-related receptor {alpha} (ERR{alpha}) is an orphan nuclear receptor that regulates cellular energy metabolism by modulating gene expression involved in fatty acid oxidation and mitochondrial biogenesis in brown adipose tissue. However, the physiological role of ERR{alpha} in adipogenesis and white adipose tissue development has not been well studied. Here, we show that ERR{alpha} and ERR{alpha}-related transcriptional coactivators, peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) coactivator-1{alpha} (PGC-1{alpha}) and PGC-1{beta}, can be up-regulated in 3T3-L1 preadipocytes at mRNA levels under the adipogenic differentiation condition including the inducer of cAMP, glucocorticoid, and insulin. Gene knockdown by ERR{alpha}-specific siRNA results in mRNA down-regulation of fatty acidmore »« less
DOI: 10.1016/j.bbrc.2007.04.209
Combined Treatment With Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Ligands and Gamma Radiation Induces Apoptosis by PPARγ-Independent Up-Regulation of Reactive Oxygen Species-Induced Deoxyribonucleic Acid Damage Signals in Non-Small Cell Lung Cancer Cells

Journal Article Han, Eun Jong ; Im, Chang-Nim ; Park, Seon Hwa ; ... - International Journal of Radiation Oncology, Biology and Physics

Purpose: To investigate possible radiosensitizing activities of the well-known peroxisome proliferator-activated receptor (PPAR)γ ligand ciglitazone and novel PPARγ ligands CAY10415 and CAY10506 in non-small cell lung cancer (NSCLC) cells. Methods and Materials: Radiosensitivity was assessed using a clonogenic cell survival assay. To investigate the mechanism underlying PPARγ ligand-induced radiosensitization, the subdiploid cellular DNA fraction was analyzed by flow cytometry. Activation of the caspase pathway by combined PPARγ ligands and γ-radiation treatment was detected by immunoblot analysis. Reactive oxygen species (ROS) were measured using 2,7-dichlorodihydrofluorescein diacetate and flow cytometry. Results: The 3 PPARγ ligands induced cell death and ROS generation inmore »« less
DOI: 10.1016/J.IJROBP.2012.11.040
Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: Estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1

Journal Article Hwang, Yong Pil ; Jeong, Hye Gwang - Toxicology and Applied Pharmacology

Phytoestrogens are polyphenolic non-steroidal plant compounds with estrogen-like biological activity. The phytoestrogen puerarin, the main isoflavone glycoside found in the root of Pueraria lobata, has been used for various medicinal purposes in traditional Chinese medicines for thousands of years. Recent studies have indicated that the estrogen receptor (ER), through interaction with p85, regulates phosphoinositide 3-kinase (PI3K) activity, revealing a physiologic, non-nuclear function of ER that may be relevant in cytoprotection. In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent G{beta}1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway. Pretreatment of Hepa1c1c7 and HepG2 cellsmore »« less
DOI: 10.1016/j.taap.2008.09.006

Similar Records