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Title: Target highlights in CASP13: Experimental target structures through the eyes of their authors

Abstract

The functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP13 experiment.

Authors:
ORCiD logo [1]; ORCiD logo [2];  [3];  [4];  [3];  [5];  [6];  [7];  [8];  [9];  [10];  [11]; ORCiD logo [2];  [12];  [9];  [13];  [14];  [4]; ORCiD logo [15];  [16] more »;  [17];  [18];  [14];  [3];  [19];  [20];  [21];  [22];  [8];  [6];  [20];  [23];  [24];  [25]; ORCiD logo [26] « less
+ Show Author Affiliations
  1. BSC‐CNS Barcelona Supercomputing Center, Barcelona (Spain)
  2. Univ. of California, Davis, CA (United States)
  3. National Renewable Energy Lab. (NREL), Golden, CO (United States)
  4. Max Planck Inst. for Developmental Biology, Tübingen (Germany)
  5. Univ. of Oxford (United Kingdom); Univ. of Bristol (United Kingdom)
  6. Univ. of Oxford (United Kingdom)
  7. Univ. of Windsor, ON (Canada)
  8. Univ. of Houston, TX (United States); Univ. of Wisconsin, Madison, WI (United States)
  9. Newcastle Univ., Newcastle upon Tyne (United Kingdom)
  10. Univ. of Auckland (Australia); Univ. Grenoble Alpes (France)
  11. Nutrition and Health, Zurich (Switzerland)
  12. Univ. of California, Irvine, CA (United States)
  13. Univ. Grenoble Alpes (France)
  14. Univ. of Birmingham (United Kingdom)
  15. Univ. of California, Santa Barbara, CA (United States)
  16. Midwest Center for Structural Genomics, Argonne, IL (United States); Univ. of Chicago, IL (United States)
  17. Univ. of Texas Medical Branch, Galveston, TX (United States)
  18. Univ. of Toronto, ON (Canada)
  19. Midwest Center for Structural Genomics, Argonne, IL (United States)
  20. Univ. of Chicago, IL (United States)
  21. Univ. of Auckland (Australia)
  22. Univ. of Maryland, Rockville, MD (United States)
  23. Univ. of Windsor, ON (Canada); Univ. of Toronto, ON (Canada)
  24. Univ. College London (United Kingdom)
  25. Michigan State Univ., East Lansing, MI (United States)
  26. Univ. of Basel (Switzerland)
Publication Date:
Research Org.:
National Renewable Energy Lab. (NREL), Golden, CO (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
OSTI Identifier:
1559927
Report Number(s):
NREL/JA-2700-74703
Journal ID: ISSN 0887-3585
Grant/Contract Number:  
AC36-08GO28308
Resource Type:
Accepted Manuscript
Journal Name:
Proteins
Additional Journal Information:
Journal Volume: 87; Journal Issue: 12; Journal ID: ISSN 0887-3585
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CASP; protein structure prediction; cryo-EM; X-ray crystallography

Citation Formats

Lepore, Rosalba, Kryshtafovych, Andriy, Alahuhta, Markus, Veraszto, Harshul A., Bomble, Yannick J., Bufton, Joshua C., Bullock, Alex N., Caba, Cody, Cao, Hongnan, Davies, Owen R., Desfosses, Ambroise, Dunne, Matthew, Fidelis, Krzysztof, Goulding, Celia W., Gurusaran, Manickam, Gutsche, Irina, Harding, Christopher J., Hartmann, Marcus D., Hayes, Christopher S., Joachimiak, Andrzej, Leiman, Petr G., Loppnau, Peter, Lovering, Andrew L., Lunin, Vladimir V., Michalska, Karolina, Mir‐Sanchis, Ignacio, Mitra, Alok, Moult, John, Phillips Jr, George N., Pinkas, Daniel M., Rice, Phoebe A., Tong, Yufeng, Topf, Maya, Walton, Jonathan D., and Schwede, Torsten. Target highlights in CASP13: Experimental target structures through the eyes of their authors. United States: N. p., 2019. Web. doi:10.1002/prot.25805.
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Lepore, Rosalba, Kryshtafovych, Andriy, Alahuhta, Markus, Veraszto, Harshul A., Bomble, Yannick J., Bufton, Joshua C., Bullock, Alex N., Caba, Cody, Cao, Hongnan, Davies, Owen R., Desfosses, Ambroise, Dunne, Matthew, Fidelis, Krzysztof, Goulding, Celia W., Gurusaran, Manickam, Gutsche, Irina, Harding, Christopher J., Hartmann, Marcus D., Hayes, Christopher S., Joachimiak, Andrzej, Leiman, Petr G., Loppnau, Peter, Lovering, Andrew L., Lunin, Vladimir V., Michalska, Karolina, Mir‐Sanchis, Ignacio, Mitra, Alok, Moult, John, Phillips Jr, George N., Pinkas, Daniel M., Rice, Phoebe A., Tong, Yufeng, Topf, Maya, Walton, Jonathan D., & Schwede, Torsten. Target highlights in CASP13: Experimental target structures through the eyes of their authors. United States. doi:10.1002/prot.25805.
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Lepore, Rosalba, Kryshtafovych, Andriy, Alahuhta, Markus, Veraszto, Harshul A., Bomble, Yannick J., Bufton, Joshua C., Bullock, Alex N., Caba, Cody, Cao, Hongnan, Davies, Owen R., Desfosses, Ambroise, Dunne, Matthew, Fidelis, Krzysztof, Goulding, Celia W., Gurusaran, Manickam, Gutsche, Irina, Harding, Christopher J., Hartmann, Marcus D., Hayes, Christopher S., Joachimiak, Andrzej, Leiman, Petr G., Loppnau, Peter, Lovering, Andrew L., Lunin, Vladimir V., Michalska, Karolina, Mir‐Sanchis, Ignacio, Mitra, Alok, Moult, John, Phillips Jr, George N., Pinkas, Daniel M., Rice, Phoebe A., Tong, Yufeng, Topf, Maya, Walton, Jonathan D., and Schwede, Torsten. Fri . "Target highlights in CASP13: Experimental target structures through the eyes of their authors". United States. doi:10.1002/prot.25805. https://www.osti.gov/servlets/purl/1559927.
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@article{osti_1559927,
title = {Target highlights in CASP13: Experimental target structures through the eyes of their authors},
author = {Lepore, Rosalba and Kryshtafovych, Andriy and Alahuhta, Markus and Veraszto, Harshul A. and Bomble, Yannick J. and Bufton, Joshua C. and Bullock, Alex N. and Caba, Cody and Cao, Hongnan and Davies, Owen R. and Desfosses, Ambroise and Dunne, Matthew and Fidelis, Krzysztof and Goulding, Celia W. and Gurusaran, Manickam and Gutsche, Irina and Harding, Christopher J. and Hartmann, Marcus D. and Hayes, Christopher S. and Joachimiak, Andrzej and Leiman, Petr G. and Loppnau, Peter and Lovering, Andrew L. and Lunin, Vladimir V. and Michalska, Karolina and Mir‐Sanchis, Ignacio and Mitra, Alok and Moult, John and Phillips Jr, George N. and Pinkas, Daniel M. and Rice, Phoebe A. and Tong, Yufeng and Topf, Maya and Walton, Jonathan D. and Schwede, Torsten},
abstractNote = {The functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP13 experiment.},
doi = {10.1002/prot.25805},
journal = {Proteins},
number = 12,
volume = 87,
place = {United States},
year = {2019},
month = {8}
}
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DOI:  10.1002/prot.25805
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Figures / Tables:

TABLE 1 TABLE 1: CASP13 target highlights
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    Critical assessment of methods of protein structure prediction (CASP)—Round XIII
    journal, August 2019

    • Kryshtafovych, Andriy; Schwede, Torsten; Topf, Maya
    • Proteins: Structure, Function, and Bioinformatics, Vol. 87, Issue 12
    • DOI: 10.1002/prot.25823
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      FIGURE 12 (p. 18)figure
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