Synthesis and characterization of polylactide-PAMAM “Janus-type” linear-dendritic hybrids

Chandrasiri, Indika; Abebe, Daniel G.; Gupta, Sudipta; Williams, Jon Steven Dal; Rieger, William D.; Simms, Briana L.; Yaddehige, Mahesh Loku; Noh, YeRim; Payne, Molly E.; Fortenberry, Alexander W.; Smith, Adam E.; Ilavsky, Jan; Grayson, Scott M.; Schneider, Gerald J.; Watkins, Davita L.

doi:10.1002/pola.29409

Title: Synthesis and characterization of polylactide-PAMAM “Janus-type” linear-dendritic hybrids

Journal Article · 20 May 2019 · Journal of Polymer Science. Part A, Polymer Chemistry

DOI: https://doi.org/10.1002/pola.29409 · OSTI ID:1559534

Chandrasiri, Indika ^[1]; Abebe, Daniel G. ^[1]; Gupta, Sudipta ^[2]; Williams, Jon Steven Dal ^[1]; Rieger, William D. ^[1]; Simms, Briana L. ^[1]; Yaddehige, Mahesh Loku ^[1]; Noh, YeRim ^[2]; Payne, Molly E. ^[3]; Fortenberry, Alexander W. ^[1]; Smith, Adam E. ^[1]; Ilavsky, Jan ^[4]; Grayson, Scott M. ^[3]; Schneider, Gerald J. ^[2];

^[1]

Univ. of Mississippi, Oxford, MS (United States)
Louisiana State Univ., Baton Rouge, LA (United States)
Tulane Univ., New Orleans, LA (United States)
Argonne National Lab. (ANL), Lemont, IL (United States)

In this report, we introduce a facile and comprehensive synthetic methodology for the preparation of polyester-polyamidoamine (PAMAM) (i.e., polyester: polylactide [PLA] (hydrophobic) and polyamidoamine, PAMAM [hydrophilic]) polymers. A library of PLA-PAMAM linear dendritic block copolymers (LDBCs) in which both l and d, l polylactide were employed in mass ratios of 30:70, 50:50, 70:30, and 90:10 (PLA:PAMAM) were synthesized and analyzed. When placed in aqueous media, the immiscibility of the hydrophilic and hydrophobic segments leads to nanophase-segregation exhibited as the formation of aggregates (e.g., vesicles, worms, and/or micelles). By employing both stereochemical configurations of PLA, the differentiation in mass ratios of PLA-PAMAM aided in elucidating the structure–property relationships of the LDBC system and provided a means toward the control of nanoparticle morphology. Transmission electron microscopy and dynamic light scattering afford the size and shape of the nanoparticles with diameters ranging from 10.6 for low mass ratios to 122.4 nm for high mass ratios of PLA-PAMAM and positive zeta-potential values between +24 mV and +48.2 mV. Moreover, small-angle X-ray scattering (SAXS) studies were employed to obtain more detailed information on the morphological assemblies constructed via direct dissolution. Such insights provide a pathway toward nanomaterials with unique morphologies and tunable properties deemed relevant in the development of next generation biomaterials.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); Experimental Program to Stimulate Competitive Research (EPSCoR); Northwestern Univ.; Materials Research Science and Engineering Center (NU-MRSEC); National Science Foundation (NSF); USDOE

Grant/Contract Number:: AC02-06CH11357; SC0012432

OSTI ID:: 1559534

Alternate ID(s):: OSTI ID: 1514742

Journal Information:: Journal of Polymer Science. Part A, Polymer Chemistry, Vol. 57, Issue 13; ISSN 0887-624X

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 7 works

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
amphiphiles
block copolymers
drug delivery systems
nanoparticles
self‐assembly

Title: Synthesis and characterization of polylactide-PAMAM “Janus-type” linear-dendritic hybrids

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