A unified analysis of nano-to-microscale particle dispersion in tubular blood flow
Abstract
Transport of solid particles in blood flow exhibits qualitative differences in the transport mechanism when the particle varies from nanoscale to microscale size comparable to the red blood cell (RBC). The result of microscale particle margination has been investigated by several groups. Moreover, the transport of nanoscale particles (NPs) in blood has received considerable attention in the past. Our report attempts to bridge the gap by quantitatively showing how the transport mechanism varies with particle size from nano-to-microscale. Using a three-dimensional (3D) multiscale method, the dispersion of particles in microscale tubular flows is investigated for various hematocrits, vessel diameters, and particle sizes. NPs exhibit a nonuniform, smoothly dispersed distribution across the tube radius due to severe Brownian motion. The near-wall concentration of NPs can be moderately enhanced by increasing hematocrit and confinement. Furthermore, there exists a critical particle size (~1 μm) that leads to excessive retention of particles in the cell-free region near the wall, i.e., margination. Above this threshold, the margination propensity increases with the particle size. The dominance of RBC-enhanced shear-induced diffusivity (RESID) over Brownian diffusivity (BD) results in 10 times higher radial diffusion rates in the RBC-laden region compared to that in the cell-free layer, correlated withmore »
- Authors:
-
[1];
- Georgia Inst. of Technology, Atlanta, GA (United States)
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Publication Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE National Nuclear Security Administration (NNSA); National Science Foundation (NSF)
- OSTI Identifier:
- 1559521
- Alternate Identifier(s):
- OSTI ID: 1557915
- Report Number(s):
- SAND-2019-9751J
Journal ID: ISSN 1070-6631; 678638; TRN: US2000359
- Grant/Contract Number:
- AC04-94AL85000; 2506X36
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Physics of Fluids
- Additional Journal Information:
- Journal Volume: 31; Journal Issue: 8; Journal ID: ISSN 1070-6631
- Publisher:
- American Institute of Physics (AIP)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Liu, Z., Clausen, J. R., Rekha, R. R., and Aidun, C. K. A unified analysis of nano-to-microscale particle dispersion in tubular blood flow. United States: N. p., 2019.
Web. doi:10.1063/1.5110604.
Liu, Z., Clausen, J. R., Rekha, R. R., & Aidun, C. K. A unified analysis of nano-to-microscale particle dispersion in tubular blood flow. United States. doi:10.1063/1.5110604.
Liu, Z., Clausen, J. R., Rekha, R. R., and Aidun, C. K. Tue .
"A unified analysis of nano-to-microscale particle dispersion in tubular blood flow". United States. doi:10.1063/1.5110604. https://www.osti.gov/servlets/purl/1559521.
@article{osti_1559521,
title = {A unified analysis of nano-to-microscale particle dispersion in tubular blood flow},
author = {Liu, Z. and Clausen, J. R. and Rekha, R. R. and Aidun, C. K.},
abstractNote = {Transport of solid particles in blood flow exhibits qualitative differences in the transport mechanism when the particle varies from nanoscale to microscale size comparable to the red blood cell (RBC). The result of microscale particle margination has been investigated by several groups. Moreover, the transport of nanoscale particles (NPs) in blood has received considerable attention in the past. Our report attempts to bridge the gap by quantitatively showing how the transport mechanism varies with particle size from nano-to-microscale. Using a three-dimensional (3D) multiscale method, the dispersion of particles in microscale tubular flows is investigated for various hematocrits, vessel diameters, and particle sizes. NPs exhibit a nonuniform, smoothly dispersed distribution across the tube radius due to severe Brownian motion. The near-wall concentration of NPs can be moderately enhanced by increasing hematocrit and confinement. Furthermore, there exists a critical particle size (~1 μm) that leads to excessive retention of particles in the cell-free region near the wall, i.e., margination. Above this threshold, the margination propensity increases with the particle size. The dominance of RBC-enhanced shear-induced diffusivity (RESID) over Brownian diffusivity (BD) results in 10 times higher radial diffusion rates in the RBC-laden region compared to that in the cell-free layer, correlated with the high margination propensity of microscale particles. This work captures the particle size-dependent transition from Brownian-motion dominant dispersion to margination using a unified 3D multiscale computational approach and highlights the linkage between the radial distribution of RESID and the margination of particles in confined blood flows.},
doi = {10.1063/1.5110604},
journal = {Physics of Fluids},
number = 8,
volume = 31,
place = {United States},
year = {2019},
month = {8}
}
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