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Title: A unified analysis of nano-to-microscale particle dispersion in tubular blood flow

Abstract

Transport of solid particles in blood flow exhibits qualitative differences in the transport mechanism when the particle varies from nanoscale to microscale size comparable to the red blood cell (RBC). The result of microscale particle margination has been investigated by several groups. Moreover, the transport of nanoscale particles (NPs) in blood has received considerable attention in the past. Our report attempts to bridge the gap by quantitatively showing how the transport mechanism varies with particle size from nano-to-microscale. Using a three-dimensional (3D) multiscale method, the dispersion of particles in microscale tubular flows is investigated for various hematocrits, vessel diameters, and particle sizes. NPs exhibit a nonuniform, smoothly dispersed distribution across the tube radius due to severe Brownian motion. The near-wall concentration of NPs can be moderately enhanced by increasing hematocrit and confinement. Furthermore, there exists a critical particle size (~1 μm) that leads to excessive retention of particles in the cell-free region near the wall, i.e., margination. Above this threshold, the margination propensity increases with the particle size. The dominance of RBC-enhanced shear-induced diffusivity (RESID) over Brownian diffusivity (BD) results in 10 times higher radial diffusion rates in the RBC-laden region compared to that in the cell-free layer, correlated withmore » the high margination propensity of microscale particles. This work captures the particle size-dependent transition from Brownian-motion dominant dispersion to margination using a unified 3D multiscale computational approach and highlights the linkage between the radial distribution of RESID and the margination of particles in confined blood flows.« less

Authors:
ORCiD logo [1];  [2];  [2];  [1]
  1. Georgia Inst. of Technology, Atlanta, GA (United States)
  2. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA); National Science Foundation (NSF)
OSTI Identifier:
1559521
Alternate Identifier(s):
OSTI ID: 1557915
Report Number(s):
SAND-2019-9751J
Journal ID: ISSN 1070-6631; 678638
Grant/Contract Number:  
AC04-94AL85000; 2506X36
Resource Type:
Accepted Manuscript
Journal Name:
Physics of Fluids
Additional Journal Information:
Journal Volume: 31; Journal Issue: 8; Journal ID: ISSN 1070-6631
Publisher:
American Institute of Physics (AIP)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Liu, Z., Clausen, J. R., Rekha, R. R., and Aidun, C. K. A unified analysis of nano-to-microscale particle dispersion in tubular blood flow. United States: N. p., 2019. Web. doi:10.1063/1.5110604.
Liu, Z., Clausen, J. R., Rekha, R. R., & Aidun, C. K. A unified analysis of nano-to-microscale particle dispersion in tubular blood flow. United States. doi:10.1063/1.5110604.
Liu, Z., Clausen, J. R., Rekha, R. R., and Aidun, C. K. Tue . "A unified analysis of nano-to-microscale particle dispersion in tubular blood flow". United States. doi:10.1063/1.5110604.
@article{osti_1559521,
title = {A unified analysis of nano-to-microscale particle dispersion in tubular blood flow},
author = {Liu, Z. and Clausen, J. R. and Rekha, R. R. and Aidun, C. K.},
abstractNote = {Transport of solid particles in blood flow exhibits qualitative differences in the transport mechanism when the particle varies from nanoscale to microscale size comparable to the red blood cell (RBC). The result of microscale particle margination has been investigated by several groups. Moreover, the transport of nanoscale particles (NPs) in blood has received considerable attention in the past. Our report attempts to bridge the gap by quantitatively showing how the transport mechanism varies with particle size from nano-to-microscale. Using a three-dimensional (3D) multiscale method, the dispersion of particles in microscale tubular flows is investigated for various hematocrits, vessel diameters, and particle sizes. NPs exhibit a nonuniform, smoothly dispersed distribution across the tube radius due to severe Brownian motion. The near-wall concentration of NPs can be moderately enhanced by increasing hematocrit and confinement. Furthermore, there exists a critical particle size (~1 μm) that leads to excessive retention of particles in the cell-free region near the wall, i.e., margination. Above this threshold, the margination propensity increases with the particle size. The dominance of RBC-enhanced shear-induced diffusivity (RESID) over Brownian diffusivity (BD) results in 10 times higher radial diffusion rates in the RBC-laden region compared to that in the cell-free layer, correlated with the high margination propensity of microscale particles. This work captures the particle size-dependent transition from Brownian-motion dominant dispersion to margination using a unified 3D multiscale computational approach and highlights the linkage between the radial distribution of RESID and the margination of particles in confined blood flows.},
doi = {10.1063/1.5110604},
journal = {Physics of Fluids},
number = 8,
volume = 31,
place = {United States},
year = {2019},
month = {8}
}

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Works referenced in this record:

The suspension balance model revisited
journal, April 2011

  • Nott, Prabhu R.; Guazzelli, Elisabeth; Pouliquen, Olivier
  • Physics of Fluids, Vol. 23, Issue 4
  • DOI: 10.1063/1.3570921

Particle dynamics modeling methods for colloid suspensions
journal, May 2014

  • Bolintineanu, Dan S.; Grest, Gary S.; Lechman, Jeremy B.
  • Computational Particle Mechanics, Vol. 1, Issue 3
  • DOI: 10.1007/s40571-014-0007-6

Margination of White Blood Cells in Microcapillary Flow
journal, January 2012


Nanoparticle diffusion in sheared cellular blood flow
journal, May 2019

  • Liu, Zixiang; Clausen, Jonathan R.; Rao, Rekha R.
  • Journal of Fluid Mechanics, Vol. 871
  • DOI: 10.1017/jfm.2019.320

Local viscosity distribution in bifurcating microfluidic blood flows
journal, March 2018

  • Kaliviotis, E.; Sherwood, J. M.; Balabani, S.
  • Physics of Fluids, Vol. 30, Issue 3
  • DOI: 10.1063/1.5011373

Multiscale modeling and simulation of brain blood flow
journal, February 2016

  • Perdikaris, Paris; Grinberg, Leopold; Karniadakis, George Em
  • Physics of Fluids, Vol. 28, Issue 2
  • DOI: 10.1063/1.4941315

The Viscosity of the Blood in Narrow Capillary Tubes
journal, March 1931


Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels
journal, July 2018


Red blood cell clustering in Poiseuille microcapillary flow
journal, May 2012

  • Tomaiuolo, Giovanna; Lanotte, Luca; Ghigliotti, Giovanni
  • Physics of Fluids, Vol. 24, Issue 5
  • DOI: 10.1063/1.4721811

Effects of shear rate, confinement, and particle parameters on margination in blood flow
journal, February 2016


Shear-induced platelet margination in a microchannel
journal, June 2011


Dynamic motion of red blood cells in simple shear flow
journal, November 2008

  • Sui, Y.; Chew, Y. T.; Roy, P.
  • Physics of Fluids, Vol. 20, Issue 11
  • DOI: 10.1063/1.3026569

Effects of Shear Rate on the Diffusion and Adhesion of Blood Platelets to a Foreign Surface
journal, May 1972

  • Grabowski, Eric F.; Friedman, Leonard I.; Leonard, Edward F.
  • Industrial & Engineering Chemistry Fundamentals, Vol. 11, Issue 2
  • DOI: 10.1021/i160042a013

Transport of Platelets in Flowing Blood
journal, December 1987

  • Eckstein, Eugene C.; Bilsker, David L.; Waters, Christopher M.
  • Annals of the New York Academy of Sciences, Vol. 516, Issue 1 Blood in Cont
  • DOI: 10.1111/j.1749-6632.1987.tb33065.x

Multiscale method based on coupled lattice‐Boltzmann and Langevin‐dynamics for direct simulation of nanoscale particle/polymer suspensions in complex flows
journal, July 2019

  • Liu, Zixiang; Zhu, Yuanzheng; Clausen, Jonathan R.
  • International Journal for Numerical Methods in Fluids, Vol. 91, Issue 5
  • DOI: 10.1002/fld.4752

Influence of red blood cells on nanoparticle targeted delivery in microcirculation
journal, January 2012

  • Tan, Jifu; Thomas, Antony; Liu, Yaling
  • Soft Matter, Vol. 8, Issue 6
  • DOI: 10.1039/C2SM06391C

Mechanistic theory of margination and flow-induced segregation in confined multicomponent suspensions: Simple shear and Poiseuille flows
journal, October 2016


Shear-Induced Augmentation of Oxygen Transfer in Blood
journal, February 1980

  • Diller, T. E.; Mikic, B. B.; Drinker, P. A.
  • Journal of Biomechanical Engineering, Vol. 102, Issue 1
  • DOI: 10.1115/1.3138201

Margination of micro- and nano-particles in blood flow and its effect on drug delivery
journal, May 2014

  • Müller, Kathrin; Fedosov, Dmitry A.; Gompper, Gerhard
  • Scientific Reports, Vol. 4, Issue 1
  • DOI: 10.1038/srep04871

Capture of microparticles by bolus flow of red blood cells in capillaries
journal, July 2017


Nanoparticle transport in cellular blood flow
journal, August 2018


Coupling the lattice-Boltzmann and spectrin-link methods for the direct numerical simulation of cellular blood flow
journal, February 2011

  • Reasor, Daniel A.; Clausen, Jonathan R.; Aidun, Cyrus K.
  • International Journal for Numerical Methods in Fluids, Vol. 68, Issue 6
  • DOI: 10.1002/fld.2534

Ten years of tension: single-molecule DNA mechanics
journal, January 2003

  • Bustamante, Carlos; Bryant, Zev; Smith, Steven B.
  • Nature, Vol. 421, Issue 6921
  • DOI: 10.1038/nature01405

The fluctuation-dissipation theorem
journal, January 1966


Theory to predict particle migration and margination in the pressure-driven channel flow of blood
journal, September 2017


Internal Viscosity-Dependent Margination of Red Blood Cells in Microfluidic Channels
journal, April 2018

  • Ahmed, Faisal; Mehrabadi, Marmar; Liu, Zixiang
  • Journal of Biomechanical Engineering, Vol. 140, Issue 6
  • DOI: 10.1115/1.4039897

Margination Propensity of Vascular-Targeted Spheres from Blood Flow in a Microfluidic Model of Human Microvessels
journal, February 2013

  • Namdee, Katawut; Thompson, Alex J.; Charoenphol, Phapanin
  • Langmuir, Vol. 29, Issue 8
  • DOI: 10.1021/la304746p

Efficient lattice Boltzmann algorithm for Brownian suspensions
journal, June 2011

  • Mynam, Mahesh; Sunthar, P.; Ansumali, Santosh
  • Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 369, Issue 1944
  • DOI: 10.1098/rsta.2011.0047

Molecularly based analysis of deformation of spectrin network and human erythrocyte
journal, September 2006


Determination of Critical Parameters in Platelet Margination
journal, September 2012

  • Reasor, Daniel A.; Mehrabadi, Marmar; Ku, David N.
  • Annals of Biomedical Engineering, Vol. 41, Issue 2
  • DOI: 10.1007/s10439-012-0648-7

Effect of tube diameter and capillary number on platelet margination and near-wall dynamics
journal, December 2015


The rheology and microstructure of concentrated non-colloidal suspensions of deformable capsules
journal, September 2011

  • Clausen, Jonathan R.; Reasor, Daniel A.; Aidun, Cyrus K.
  • Journal of Fluid Mechanics, Vol. 685
  • DOI: 10.1017/jfm.2011.307

Blood Flow in the Microcirculation
journal, January 2017


Microvascular Rheology and Hemodynamics
journal, February 2005


The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
journal, August 2012


A Continuum Model for Platelet Transport in Flowing Blood Based on Direct Numerical Simulations of Cellular Blood Flow
journal, October 2014

  • Mehrabadi, Marmar; Ku, David N.; Aidun, Cyrus K.
  • Annals of Biomedical Engineering, Vol. 43, Issue 6
  • DOI: 10.1007/s10439-014-1168-4

Noninertial lateral migration of vesicles in bounded Poiseuille flow
journal, November 2008

  • Coupier, Gwennou; Kaoui, Badr; Podgorski, Thomas
  • Physics of Fluids, Vol. 20, Issue 11
  • DOI: 10.1063/1.3023159

Simulation of a single polymer chain in solution by combining lattice Boltzmann and molecular dynamics
journal, November 1999

  • Ahlrichs, Patrick; Dünweg, Burkhard
  • The Journal of Chemical Physics, Vol. 111, Issue 17
  • DOI: 10.1063/1.480156

Predicting human blood viscosity in silico
journal, July 2011

  • Fedosov, D. A.; Pan, W.; Caswell, B.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 29
  • DOI: 10.1073/pnas.1101210108

Red blood cell and platelet diffusivity and margination in the presence of cross-stream gradients in blood flows
journal, March 2019

  • Závodszky, Gábor; van Rooij, Britt; Czaja, Ben
  • Physics of Fluids, Vol. 31, Issue 3
  • DOI: 10.1063/1.5085881

Analysis of red blood cell partitioning at bifurcations in simulated microvascular networks
journal, May 2018

  • Balogh, Peter; Bagchi, Prosenjit
  • Physics of Fluids, Vol. 30, Issue 5
  • DOI: 10.1063/1.5024783

Shear-induced particle migration and margination in a cellular suspension
journal, January 2012

  • Zhao, Hong; Shaqfeh, Eric S. G.; Narsimhan, Vivek
  • Physics of Fluids, Vol. 24, Issue 1
  • DOI: 10.1063/1.3677935

Rheological characterization of cellular blood in shear
journal, June 2013

  • Reasor, D. A.; Clausen, J. R.; Aidun, C. K.
  • Journal of Fluid Mechanics, Vol. 726
  • DOI: 10.1017/jfm.2013.229

Simulating 3D deformable particle suspensions using lattice Boltzmann method with discrete external boundary force
journal, January 2009

  • Wu, Jingshu; Aidun, Cyrus K.
  • International Journal for Numerical Methods in Fluids
  • DOI: 10.1002/fld.2043

A Multiscale Red Blood Cell Model with Accurate Mechanics, Rheology, and Dynamics
journal, May 2010

  • Fedosov, Dmitry A.; Caswell, Bruce; Karniadakis, George Em
  • Biophysical Journal, Vol. 98, Issue 10
  • DOI: 10.1016/j.bpj.2010.02.002

Thrombus Formation at High Shear Rates
journal, June 2017


The effect of in-plane arterial curvature on blood flow and oxygen transport in arterio-venous fistulae
journal, March 2015

  • Iori, F.; Grechy, L.; Corbett, R. W.
  • Physics of Fluids, Vol. 27, Issue 3
  • DOI: 10.1063/1.4913754

Analysis of mechanisms for platelet near-wall excess under arterial blood flow conditions
journal, April 2011


On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better
journal, June 2013

  • Lee, Tae-Rin; Choi, Myunghwan; Kopacz, Adrian M.
  • Scientific Reports, Vol. 3, Issue 1
  • DOI: 10.1038/srep02079

Lattice-Boltzmann Method for Complex Flows
journal, January 2010