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Title: Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function

Abstract

Gut microbiota dysbiosis is a recognized contributing factor to many noncommunicable diseases, but more evidence is still needed to illustrate its causative impact on mental and brain health disorders and mechanism(s) for targeted mitigation.

Authors:
ORCiD logo [1];  [2];  [1];  [2];  [2];  [3]; ORCiD logo [1]
  1. College of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
  2. Infinitus (China) Company Ltd Research & Development Center, Guangzhou 510640, China
  3. Department of Food Science and Technology, The Ohio State University, Columbus, USA, Department of Microbiology
Publication Date:
Sponsoring Org.:
USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
OSTI Identifier:
1559347
Grant/Contract Number:  
D9163940
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Food & Function
Additional Journal Information:
Journal Name: Food & Function Journal Volume: 10 Journal Issue: 9; Journal ID: ISSN 2042-6496
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Qu, Wan, Liu, Shuo, Zhang, Weijie, Zhu, Huawei, Tao, Qian, Wang, Hua, and Yan, He. Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function. United Kingdom: N. p., 2019. Web. doi:10.1039/C9FO00399A.
Qu, Wan, Liu, Shuo, Zhang, Weijie, Zhu, Huawei, Tao, Qian, Wang, Hua, & Yan, He. Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function. United Kingdom. https://doi.org/10.1039/C9FO00399A
Qu, Wan, Liu, Shuo, Zhang, Weijie, Zhu, Huawei, Tao, Qian, Wang, Hua, and Yan, He. Wed . "Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function". United Kingdom. https://doi.org/10.1039/C9FO00399A.
@article{osti_1559347,
title = {Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function},
author = {Qu, Wan and Liu, Shuo and Zhang, Weijie and Zhu, Huawei and Tao, Qian and Wang, Hua and Yan, He},
abstractNote = {Gut microbiota dysbiosis is a recognized contributing factor to many noncommunicable diseases, but more evidence is still needed to illustrate its causative impact on mental and brain health disorders and mechanism(s) for targeted mitigation.},
doi = {10.1039/C9FO00399A},
journal = {Food & Function},
number = 9,
volume = 10,
place = {United Kingdom},
year = {Wed Sep 18 00:00:00 EDT 2019},
month = {Wed Sep 18 00:00:00 EDT 2019}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1039/C9FO00399A

Citation Metrics:
Cited by: 38 works
Citation information provided by
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Works referenced in this record:

The Central Nervous System and the Gut Microbiome
journal, November 2016


Possible role of the gut microbiota–brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model
journal, December 2017


Microbiota and host determinants of behavioural phenotype in maternally separated mice
journal, July 2015

  • De Palma, G.; Blennerhassett, P.; Lu, J.
  • Nature Communications, Vol. 6, Issue 1
  • DOI: 10.1038/ncomms8735

The effect of Chaihu-Shugan-San and its components on the expression of ERK5 in the hippocampus of depressed rats
journal, March 2014


Thinking from the Gut
journal, February 2015


Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex
journal, January 2017

  • Moussaoui, Nabila; Jacobs, Jonathan P.; Larauche, Muriel
  • Journal of Neurogastroenterology and Motility, Vol. 23, Issue 1
  • DOI: 10.5056/jnm16105

Impact of gut microbiota on neurological diseases: Diet composition and novel treatments
journal, July 2018

  • Larroya-García, Ana; Navas-Carrillo, Diana; Orenes-Piñero, Esteban
  • Critical Reviews in Food Science and Nutrition, Vol. 59, Issue 19
  • DOI: 10.1080/10408398.2018.1484340

Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys
journal, September 1999


Reduced microbiome alpha diversity in young patients with ADHD
journal, July 2018


New evidences on the altered gut microbiota in autism spectrum disorders
journal, February 2017


Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences
journal, November 2010


Major Depressive Disorder
journal, January 2008

  • Belmaker, R. H.; Agam, Galila
  • New England Journal of Medicine, Vol. 358, Issue 1
  • DOI: 10.1056/NEJMra073096

Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome
journal, May 2017


In vitro fermentation of B-GOS: impact on faecal bacterial populations and metabolic activity in autistic and non-autistic children
journal, November 2016

  • Grimaldi, Roberta; Cela, Drinalda; Swann, Jonathan R.
  • FEMS Microbiology Ecology, Vol. 93, Issue 2
  • DOI: 10.1093/femsec/fiw233

5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease
journal, December 2018

  • Klein, Christian; Roussel, Guy; Brun, Susana
  • Acta Neuropathologica Communications, Vol. 6, Issue 1
  • DOI: 10.1186/s40478-018-0640-z

Gut Microbial Diversity Is Reduced in Smokers with Crohnʼs Disease
journal, January 2016

  • Opstelten, Jorrit L.; Plassais, Jonathan; van Mil, Saskia W. C.
  • Inflammatory Bowel Diseases, Vol. 22, Issue 9
  • DOI: 10.1097/MIB.0000000000000875

Role of the Brain-Gut Axis in the Pathophysiology of Crohn’s Disease
journal, January 2008

  • Stasi, Cristina; Orlandelli, Ermes
  • Digestive Diseases, Vol. 26, Issue 2
  • DOI: 10.1159/000116774

Pathogenic potential of lactobacilli
journal, December 1994

  • Harty, D. W. S.; Oakey, H. J.; Patrikakis, M.
  • International Journal of Food Microbiology, Vol. 24, Issue 1-2
  • DOI: 10.1016/0168-1605(94)90117-1

Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress
journal, April 2017


Resources and Biological Activities of Natural Polyphenols
journal, December 2014

  • Li, An-Na; Li, Sha; Zhang, Yu-Jie
  • Nutrients, Vol. 6, Issue 12
  • DOI: 10.3390/nu6126020

Pathogenic relevance of Lactobacillus: a retrospective review of over 200 cases
journal, December 2004

  • Cannon, J. P.; Lee, T. A.; Bolanos, J. T.
  • European Journal of Clinical Microbiology & Infectious Diseases, Vol. 24, Issue 1
  • DOI: 10.1007/s10096-004-1253-y

Altered gut microbiota in Rett syndrome
journal, July 2016


Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
journal, August 2011

  • Bravo, J. A.; Forsythe, P.; Chew, M. V.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 38
  • DOI: 10.1073/pnas.1102999108

Gut Microbiota is Altered in Patients with Alzheimer’s Disease
journal, May 2018

  • Zhuang, Zhen-Qian; Shen, Lin-Lin; Li, Wei-Wei
  • Journal of Alzheimer's Disease, Vol. 63, Issue 4
  • DOI: 10.3233/JAD-180176

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat
journal, November 2016


Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes
journal, November 2016

  • Clark, Allison; Mach, Núria
  • Journal of the International Society of Sports Nutrition, Vol. 13, Issue 1
  • DOI: 10.1186/s12970-016-0155-6

Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies
journal, January 2007

  • Ruhé, H. G.; Mason, N. S.; Schene, A. H.
  • Molecular Psychiatry, Vol. 12, Issue 4
  • DOI: 10.1038/sj.mp.4001949

Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels
journal, August 2018

  • Sales, Amanda J.; Crestani, Carlos C.; Guimarães, Francisco S.
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 86
  • DOI: 10.1016/j.pnpbp.2018.06.002

Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish
journal, September 2016

  • Davis, Daniel J.; Doerr, Holly M.; Grzelak, Agata K.
  • Scientific Reports, Vol. 6, Issue 1
  • DOI: 10.1038/srep33726

Plasma Metabonomics as a Novel Diagnostic Approach for Major Depressive Disorder
journal, January 2012

  • Zheng, Peng; Gao, Hong C.; Li, Qi
  • Journal of Proteome Research, Vol. 11, Issue 3
  • DOI: 10.1021/pr2010082

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
journal, December 2013


Amino acid metabolic dysfunction revealed in the prefrontal cortex of a rat model of depression
journal, February 2015


Variations in gut microbiota and fecal metabolic phenotype associated with depression by 16S rRNA gene sequencing and LC/MS-based metabolomics
journal, May 2017


Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice
journal, April 2017

  • Yang, Chun; Fujita, Yuko; Ren, Qian
  • Scientific Reports, Vol. 7, Issue 1
  • DOI: 10.1038/srep45942

Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
journal, May 1997


Dietary modulation of clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitin–glucan fiber improves host metabolic alterations induced by high-fat diet in mice
journal, January 2012

  • Neyrinck, Audrey M.; Possemiers, Sam; Verstraete, Willy
  • The Journal of Nutritional Biochemistry, Vol. 23, Issue 1
  • DOI: 10.1016/j.jnutbio.2010.10.008

Modulation of Gut Microbiome Composition and Function in Experimental Colitis Treated with Sulfasalazine
journal, September 2017


Ruminococcus gnavus: An unusual pathogen in septic arthritis
journal, December 2014


Safety assessment of probiotics for human use
journal, May 2010

  • Sanders, Mary Ellen; Akkermans, Louis M. A.; Haller, Dirk
  • Gut Microbes, Vol. 1, Issue 3
  • DOI: 10.4161/gmic.1.3.12127

Metabolic factors-triggered inflammatory response drives antidepressant effects of exercise in CUMS rats
journal, August 2015


Gut Microbiota in Multiple Sclerosis: Possible Influence of Immunomodulators
journal, January 2015

  • Cantarel, Brandi L.; Waubant, Emmanuelle; Chehoud, Christel
  • Journal of Investigative Medicine, Vol. 63, Issue 5
  • DOI: 10.1097/JIM.0000000000000192

A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota
journal, January 2017

  • Zhao, Le; Zhang, Qi; Ma, Weini
  • Food & Function, Vol. 8, Issue 12
  • DOI: 10.1039/C7FO01383C

A metagenome-wide association study of gut microbiota in type 2 diabetes
journal, September 2012


The Many Faces of Glutathione in Bacteria
journal, May 2006

  • Masip, Lluis; Veeravalli, Karthik; Georgiou, George
  • Antioxidants & Redox Signaling, Vol. 8, Issue 5-6
  • DOI: 10.1089/ars.2006.8.753

GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice
journal, January 2015


Altered fecal microbiota composition in patients with major depressive disorder
journal, August 2015


A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)
journal, January 2017


Tightening the Case for Gut Microbiota in Autism-Spectrum Disorder
journal, March 2017


Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: Involving the inhibition of cyclooxygenase-2 in rat brain
journal, January 2013

  • Li, Yu-Cheng; Shen, Ji-Duo; Li, Jing
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 40
  • DOI: 10.1016/j.pnpbp.2012.09.007

Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
journal, June 2015

  • Chang, Chih-Jung; Lin, Chuan-Sheng; Lu, Chia-Chen
  • Nature Communications, Vol. 6, Issue 1
  • DOI: 10.1038/ncomms8489

Gastrointestinal microbiota in children with autism in Slovakia
journal, January 2015


Direction of the brain–gut pathway in functional gastrointestinal disorders
journal, March 2012


Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula
journal, October 2014


Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010
journal, November 2013


Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism
journal, April 2016

  • Zheng, P.; Zeng, B.; Zhou, C.
  • Molecular Psychiatry, Vol. 21, Issue 6
  • DOI: 10.1038/mp.2016.44

Correlation between the human fecal microbiota and depression
journal, June 2014

  • Naseribafrouei, A.; Hestad, K.; Avershina, E.
  • Neurogastroenterology & Motility, Vol. 26, Issue 8
  • DOI: 10.1111/nmo.12378