Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows

Blum, Thorsten B.; Hahn, Alexander; Meier, Thomas; Davies, Karen M.; Kühlbrandt, Werner

doi:10.1073/pnas.1816556116

Title: Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows

Journal Article · 13 February 2019 · Proceedings of the National Academy of Sciences of the United States of America

DOI: https://doi.org/10.1073/pnas.1816556116 · OSTI ID:1559185

Blum, Thorsten B. ^[1]; Hahn, Alexander ^[1];

^[1]; Davies, Karen M. ^[1];

^[1]

Max Planck Institute of Biophysics, Frankfurt (Germany)

Mitochondrial ATP synthases form dimers, which assemble into long ribbons at the rims of the inner membrane cristae. We reconstituted detergent-purified mitochondrial ATP synthase dimers from the green algae Polytomella sp. and the yeast Yarrowia lipolytica into liposomes and examined them by electron cryotomography. Tomographic volumes revealed that ATP synthase dimers from both species self-assemble into rows and bend the lipid bilayer locally. The dimer rows and the induced degree of membrane curvature closely resemble those in the inner membrane cristae. Monomers of mitochondrial ATP synthase reconstituted into liposomes do not bend membrane visibly and do not form rows. No specific lipids or proteins other than ATP synthase dimers are required for row formation and membrane remodelling. Long rows of ATP synthase dimers are a conserved feature of mitochondrial inner membranes. They are required for cristae formation and a main factor in mitochondrial morphogenesis.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1559185

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 10; ISSN 0027-8424

Publisher:: National Academy of Sciences, Washington, DC (United States)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 140 works

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59 BASIC BIOLOGICAL SCIENCES
mitochondria
ATP synthase
membrane curvature
electron cryotomography
subtomogram averaging

Title: Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows

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